{"id":8128,"date":"2025-12-22T15:23:08","date_gmt":"2025-12-22T13:23:08","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=8128"},"modified":"2025-12-24T22:59:30","modified_gmt":"2025-12-24T20:59:30","slug":"celebrex-asfaleia-parenergeies-ergastiriakos-elegxos","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/celebrex-asfaleia-parenergeies-ergastiriakos-elegxos\/","title":{"rendered":"Celebrex: \u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1, \u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 &#038; \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2"},"content":{"rendered":"<article>\n<h1>Celebrex (\u03a3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7): \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 &amp; \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2<\/h1>\n<p><!-- INFOBOX --><\/p>\n<div style=\"background: #f8fafc; border-left: 5px solid #b70000; padding: 16px; border-radius: 12px; margin: 18px 0;\"><strong>\u03a3\u03b5 1 \u03bb\u03b5\u03c0\u03c4\u03cc:<\/strong><br \/>\n\u03a4\u03bf <strong>celecoxib<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc<br \/>\n<strong>\u03bc\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03c2 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf (\u039c\u03a3\u0391\u03a6, COX-2)<\/strong>.<br \/>\n\u03a0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c6\u03b9\u03bb\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03b9 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1<br \/>\n\u03bc\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u039c\u03a3\u0391\u03a6, \u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af<br \/>\n<strong>\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2<\/strong>,<br \/>\n\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 <strong>\u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03b3\u03c9\u03b3\u03ae<\/strong> \u03ae \u03c3\u03b5<br \/>\n<strong>\u03b5\u03c5\u03c0\u03b1\u03b8\u03b5\u03af\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<\/strong>.<\/div>\n<p><!-- TOC --><\/p>\n<nav style=\"border: 1px solid #e5e7eb; border-radius: 12px; padding: 16px;\">\n<ol>\n<li>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Celebrex<\/li>\n<li>\u03a0\u03cc\u03c4\u03b5 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9<\/li>\n<li>\u03a0\u03ce\u03c2 \u03b4\u03c1\u03b1 (COX-2)<\/li>\n<li>\u0393\u03b9\u03b1\u03c4\u03af \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/li>\n<li>\u0392\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7<\/li>\n<li>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 &amp; Celebrex<\/li>\n<li>\u0389\u03c0\u03b1\u03c1 &amp; \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2<\/li>\n<li>\u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2<\/li>\n<li>\u0393\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2<\/li>\n<li>\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/li>\n<li>\u0395\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/li>\n<li>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd<\/li>\n<li>\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/li>\n<\/ol>\n<\/nav>\n<hr style=\"height: 2px; background: #d1d5db; border: 0; margin: 26px 0;\" \/>\n<p><!-- SECTION TEMPLATE --><br \/>\n<!-- \u03c7\u03c1\u03ae\u03c3\u03b7 premium diamond --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,0.35), inset 2px 2px 3px rgba(255,255,255,0.9), inset -3px -3px 5px rgba(0,0,0,0.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Celebrex<\/span><\/h2>\n<p>\u03a4\u03bf <strong>Celebrex<\/strong> \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 <strong>\u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7<\/strong>, \u03ad\u03bd\u03b1<br \/>\n<strong>\u03bc\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03c2 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf (\u039c\u03a3\u0391\u03a6)<\/strong><br \/>\n\u03c0\u03bf\u03c5 \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 <strong>\u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03bf\u03be\u03c5\u03b3\u03b5\u03bd\u03ac\u03c3\u03b7\u03c2-2 (COX-2)<\/strong>.<br \/>\n\u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 <strong>\u03c0\u03cc\u03bd\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2<br \/>\n<strong>\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2<\/strong> \u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5<br \/>\n\u03bc\u03c5\u03bf\u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<p>\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u039c\u03a3\u0391\u03a6 (\u03c0.\u03c7. \u03b9\u03b2\u03bf\u03c5\u03c0\u03c1\u03bf\u03c6\u03b1\u03af\u03bd\u03b7, \u03b4\u03b9\u03ba\u03bb\u03bf\u03c6\u03b1\u03b9\u03bd\u03ac\u03ba\u03b7),<br \/>\n\u03b7 \u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7 \u03b4\u03c1\u03b1 \u03c0\u03b9\u03bf <strong>\u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac<\/strong> \u03c3\u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf COX-2,<br \/>\n\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2,<br \/>\n\u03b5\u03bd\u03ce \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03bf COX-1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf\u03bd<br \/>\n<strong>\u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03cc \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03b7 <strong>\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7<\/strong>.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03c4\u03bf Celebrex \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9<br \/>\n<strong>\u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac \u03c0\u03b9\u03bf \u03b1\u03bd\u03b5\u03ba\u03c4\u03cc<\/strong> \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u039c\u03a3\u0391\u03a6,<br \/>\n\u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03bd\u03b1 \u03c3\u03c4\u03b5\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 <strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd<\/strong>,<br \/>\n\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 <strong>\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03cc<\/strong> \u03ba\u03b1\u03b9<br \/>\n<strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf<\/strong>.<br \/>\n\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc, \u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc<br \/>\n<strong>\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong>,<br \/>\n\u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,0.35), inset 2px 2px 3px rgba(255,255,255,0.9), inset -3px -3px 5px rgba(0,0,0,0.25);\"><span style=\"transform: rotate(-45deg); display: inline-block;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9<br \/>\n<\/span><\/h2>\n<p>\u03a4\u03bf Celebrex \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7<br \/>\n<strong>\u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03cc\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2<\/strong><br \/>\n\u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03ae \u03b5\u03ba\u03c6\u03c5\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2,<br \/>\n\u03cc\u03c4\u03b1\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7<br \/>\n\u03bc\u03b5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac <strong>\u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; padding: 14px; border-radius: 10px; margin: 14px 0;\">\n<p><strong>\u039a\u03cd\u03c1\u03b9\u03b5\u03c2 \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2:<\/strong><\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.7;\">\n<li><strong>\u039f\u03c3\u03c4\u03b5\u03bf\u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u2013 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c5 \u03b1\u03c1\u03b8\u03c1\u03b9\u03ba\u03bf\u03cd \u03c0\u03cc\u03bd\u03bf\u03c5<br \/>\n\u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<\/li>\n<li><strong>\u03a1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u2013 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<br \/>\n\u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03bc\u03b5 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1.<\/li>\n<li><strong>\u0391\u03b3\u03ba\u03c5\u03bb\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u2013 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2<br \/>\n\u03ba\u03b1\u03b9 \u03c0\u03c1\u03c9\u03b9\u03bd\u03ae\u03c2 \u03b4\u03c5\u03c3\u03ba\u03b1\u03bc\u03c8\u03af\u03b1\u03c2.<\/li>\n<\/ul>\n<\/div>\n<p>\u0397 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2<br \/>\n\u03bc\u03b5 <strong>\u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1\u03c2<\/strong>,<br \/>\n\u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b2\u03bb\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2<br \/>\n\u03c4\u03bf\u03c5 <strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>.<\/p>\n<p><!-- 3 --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,0.35), inset 2px 2px 3px rgba(255,255,255,0.9), inset -3px -3px 5px rgba(0,0,0,0.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">3<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 (COX-2)<\/span><\/h2>\n<p>\u0397 \u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7 \u03b4\u03c1\u03b1 \u03bc\u03ad\u03c3\u03c9 <strong>\u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03bf\u03be\u03c5\u03b3\u03b5\u03bd\u03ac\u03c3\u03b7\u03c2-2 (COX-2)<\/strong>,<br \/>\n\u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<br \/>\n<strong>\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2, \u03c4\u03c1\u03b1\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c0\u03cc\u03bd\u03bf\u03c5<\/strong>.<br \/>\n\u0397 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 COX-2 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5<br \/>\n<strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03b9\u03bd\u03ce\u03bd<\/strong>,<br \/>\n\u03bf\u03c5\u03c3\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03c5\u03b8\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03cc\u03bd\u03bf, \u03c4\u03bf \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae.<\/p>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 14px; border-radius: 10px; margin: 14px 0;\">\n<p><strong>COX-1 vs COX-2:<\/strong><\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.7;\">\n<li><strong>COX-1:<\/strong> \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7, \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1<\/li>\n<li><strong>COX-2:<\/strong> \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03b9\u03bd\u03ce\u03bd \u03c3\u03b5 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03ba\u03b1\u03b9 \u03c0\u03cc\u03bd\u03bf<\/li>\n<\/ul>\n<\/div>\n<p>\u0397 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 COX-1 \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03c4\u03b7<br \/>\n<strong>\u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><br \/>\n\u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u039c\u03a3\u0391\u03a6.<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd COX-2<br \/>\n\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1<\/strong>,<br \/>\n\u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7<br \/>\n<strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2<\/strong>.<\/p>\n<p><!-- 4 --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,0.35), inset 2px 2px 3px rgba(255,255,255,0.9), inset -3px -3px 5px rgba(0,0,0,0.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">4<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u0393\u03b9\u03b1\u03c4\u03af \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/span><\/h2>\n<p>\u03a0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03c4\u03bf Celebrex (\u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7) \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9<br \/>\n<strong>\u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong><br \/>\n\u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03bc\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u039c\u03a3\u0391\u03a6,<br \/>\n\u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03ad\u03bd\u03b1<br \/>\n<strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03c2 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf<\/strong><br \/>\n\u03bc\u03b5 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5<br \/>\n<strong>\u03bd\u03b5\u03c6\u03c1\u03bf\u03cd\u03c2, \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03ae\u03c0\u03b1\u03c1<\/strong>.<br \/>\n\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc, \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd,<br \/>\n\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc<br \/>\n<strong>\u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b5\u03c0\u03b9\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; padding: 14px; border-radius: 10px; margin: 14px 0;\">\n<ul style=\"margin: 0 0 0 18px; line-height: 1.7;\">\n<li><strong>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1:<\/strong><br \/>\n\u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 \u03bf\u03c1\u03bf\u03cd<br \/>\n\u03ba\u03b1\u03b9 <strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 eGFR<\/strong>,<br \/>\n\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03ae \u03b1\u03c6\u03c5\u03b4\u03b1\u03c4\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<\/li>\n<li><strong>\u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1:<\/strong><br \/>\n\u03b5\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd<br \/>\n<strong>\u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf,<br \/>\n\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7.<\/li>\n<li><strong>\u0389\u03c0\u03b1\u03c1:<\/strong><br \/>\n\u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae<br \/>\n<strong>\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd<\/strong>,<br \/>\n\u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03c0\u03b1\u03bd\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2.<\/li>\n<\/ul>\n<\/div>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,0.35), inset 2px 2px 3px rgba(255,255,255,0.9), inset -3px -3px 5px rgba(0,0,0,0.25);\"><span style=\"transform: rotate(-45deg); display: inline-block;\">5<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/span><\/h2>\n<p>\u03a0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 Celebrex (\u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7),<br \/>\n\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 <strong>\u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong><br \/>\n(\u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9, \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2,<br \/>\n\u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ac\u03bb\u03bb\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd),<br \/>\n\u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 <strong>\u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/strong>,<br \/>\n\u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03b8\u03b5\u03af \u03b7 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae\u03c2 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<br \/>\n\u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/p>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px; border-radius: 8px; margin-bottom: 10px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<table style=\"width: 100%; border-collapse: collapse;\">\n<thead>\n<tr>\n<th style=\"border: 1px solid #e5e7eb; padding: 8px; text-align: left;\">\u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/th>\n<th style=\"border: 1px solid #e5e7eb; padding: 8px; text-align: left;\">\u03a3\u03ba\u03bf\u03c0\u03cc\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #e5e7eb; padding: 8px;\">\u039a\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7 \u03bf\u03c1\u03bf\u03cd, eGFR<\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 8px;\">\u0395\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #e5e7eb; padding: 8px;\">AST (SGOT), ALT (SGPT)<\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 8px;\">\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #e5e7eb; padding: 8px;\">\u0393\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 8px;\">\u0391\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ae \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03af\u03b1\u03c2<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; padding: 12px; border-radius: 10px; margin-top: 14px;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c3\u03b7:<\/strong><br \/>\n\u039f \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c9\u03c2<br \/>\n<strong>baseline<\/strong>.<br \/>\n\u03a3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ce\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2,<br \/>\n\u03b4\u03b9\u03b5\u03c5\u03ba\u03bf\u03bb\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7<br \/>\n<strong>\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ce\u03bd \u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2.<\/div>\n<p><!-- 6 --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,0.35), inset 2px 2px 3px rgba(255,255,255,0.9), inset -3px -3px 5px rgba(0,0,0,0.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">6<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1<\/span><\/h2>\n<p>\u0397 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03b9\u03bd\u03ce\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5<br \/>\n<strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7\u03c2<\/strong>,<br \/>\n\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03ae \u03b1\u03c6\u03c5\u03b4\u03b1\u03c4\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; padding: 14px; border-radius: 10px; margin: 14px 0;\">\n<p><strong>\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae\u03c2:<\/strong><\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.7;\">\n<li>\u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 &gt;30% \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03c4\u03b9\u03bc\u03ae<\/li>\n<li>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 eGFR<\/li>\n<li>\u039f\u03af\u03b4\u03b7\u03bc\u03b1 \u03ae \u03bf\u03bb\u03b9\u03b3\u03bf\u03c5\u03c1\u03af\u03b1<\/li>\n<\/ul>\n<\/div>\n<p><!-- 7 --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,.35),inset 2px 2px 3px rgba(255,255,255,.9),inset -3px -3px 5px rgba(0,0,0,.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">7<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u0389\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1<\/span><\/h2>\n<p>\u0397 \u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf <strong>\u03ae\u03c0\u03b1\u03c1<\/strong>.<br \/>\n\u03a3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af<br \/>\n<strong>\u03ae\u03c0\u03b9\u03b1 \u03ad\u03c9\u03c2 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd<\/strong>,<br \/>\n\u03b9\u03b4\u03af\u03c9\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 <strong>\u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/strong><br \/>\n\u03ae \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03cb\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03c3\u03b1 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<br \/>\n\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 <strong>\u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03ad\u03c8\u03b9\u03bc\u03b5\u03c2<\/strong><br \/>\n\u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5.<\/p>\n<ul style=\"line-height: 1.7;\">\n<li><strong>AST (SGOT) \u03ba\u03b1\u03b9 ALT (SGPT):<\/strong><br \/>\n\u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2<br \/>\n\u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd Celebrex \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1.<\/li>\n<li><strong>\u0391\u03cd\u03be\u03b7\u03c3\u03b7 &gt;3\u00d7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03bf\u03c1\u03af\u03bf\u03c5 (ULN):<\/strong><br \/>\n\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b3\u03b9\u03b1 <strong>\u03ac\u03bc\u03b5\u03c3\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2.<\/li>\n<li><strong>\u03a3\u03c5\u03bd\u03bf\u03b4\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> (\u03ba\u03cc\u03c0\u03c9\u03c3\u03b7, \u03bd\u03b1\u03c5\u03c4\u03af\u03b1, \u03af\u03ba\u03c4\u03b5\u03c1\u03bf\u03c2):<br \/>\n\u03b5\u03c0\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf,<br \/>\n\u03b1\u03bd\u03b5\u03be\u03b1\u03c1\u03c4\u03ae\u03c4\u03c9\u03c2 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; padding: 12px; border-radius: 10px; margin-top: 14px;\"><strong>\u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7:<\/strong><br \/>\n\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5<br \/>\n\u03ae \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03ac\u03bb\u03bb\u03c9\u03bd \u03b7\u03c0\u03b1\u03c4\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd,<br \/>\n\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9<br \/>\n<strong>\u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7<\/strong> \u03ba\u03b1\u03b9<br \/>\n<strong>\u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/strong>.<\/div>\n<p><!-- 8 --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,.35),inset 2px 2px 3px rgba(255,255,255,.9),inset -3px -3px 5px rgba(0,0,0,.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">8<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2<\/span><\/h2>\n<p>\u0397 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 COX-2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd<br \/>\n<strong>\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1<\/strong>,<br \/>\n\u03ba\u03b1\u03b8\u03ce\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03b9\u03bd\u03ce\u03bd.<br \/>\n\u0391\u03c5\u03c4\u03cc \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5<br \/>\n<strong>\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03bf\u03c5<br \/>\n<strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>,<br \/>\n\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 <strong>\u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2<\/strong><br \/>\n\u03ae \u03c3\u03b5 <strong>\u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/strong>.<\/p>\n<p>\u039f \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5<br \/>\n<strong>\u03c0\u03c1\u03bf\u03cb\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03c3\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf<\/strong><br \/>\n\u03ae \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5,<br \/>\n\u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7<br \/>\n\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/p>\n<ul style=\"line-height: 1.7;\">\n<li><strong>\u03a4\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2:<\/strong><br \/>\n\u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<br \/>\n\u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2.<\/li>\n<li><strong>\u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03c4\u03b5\u03c6\u03b1\u03bd\u03b9\u03b1\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf \u03ae \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u0391\u0395\u0395:<\/strong><br \/>\n\u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7<br \/>\n\u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2\u2013\u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c0\u03c1\u03b9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; padding: 12px; border-radius: 10px; margin-top: 14px;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c3\u03ae\u03bc\u03b1\u03bd\u03c3\u03b7:<\/strong><br \/>\n\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5,<br \/>\n\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 Celebrex \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9<br \/>\n<strong>\u03c3\u03c4\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf <strong>\u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03cc\u03c4\u03b5\u03c1\u03bf \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1<\/strong>.<\/div>\n<p><!-- 9 --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,.35),inset 2px 2px 3px rgba(255,255,255,.9),inset -3px -3px 5px rgba(0,0,0,.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">9<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u0393\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2<\/span><\/h2>\n<p>\u03a4\u03bf Celebrex (\u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7) \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5<br \/>\n<strong>\u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf<\/strong><br \/>\n\u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03bc\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u039c\u03a3\u0391\u03a6,<br \/>\n\u03ba\u03b1\u03b8\u03ce\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03b7\u03bd COX-2 \u03ba\u03b1\u03b9<br \/>\n<strong>\u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03b7\u03bd COX-1<\/strong><br \/>\n\u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03cc \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf.<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 <strong>\u03b4\u03b5\u03bd \u03bc\u03b7\u03b4\u03b5\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9<\/strong>,<br \/>\n\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b5\u03c5\u03ac\u03bb\u03c9\u03c4\u03bf\u03c5\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2.<\/p>\n<ul style=\"line-height: 1.7;\">\n<li><strong>\u0399\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c0\u03b5\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03ad\u03bb\u03ba\u03bf\u03c5\u03c2 \u03ae \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03af\u03b1\u03c2:<\/strong><br \/>\n\u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2, \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u039c\u03a3\u0391\u03a6.<\/li>\n<li><strong>\u03a3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7 \u03ae \u03ac\u03bb\u03bb\u03b1 \u039c\u03a3\u0391\u03a6:<\/strong><br \/>\n\u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7\u03c2<br \/>\n\u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd.<\/li>\n<li><strong>\u0397\u03bb\u03b9\u03ba\u03af\u03b1 &gt;65 \u03b5\u03c4\u03ce\u03bd:<\/strong><br \/>\n\u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5,<br \/>\n\u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; padding: 12px; border-radius: 10px; margin-top: 14px;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c3\u03ae\u03bc\u03b1\u03bd\u03c3\u03b7:<\/strong><br \/>\n\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5,<br \/>\n\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 Celebrex \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9<br \/>\n<strong>\u03c3\u03c4\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7<\/strong><br \/>\n\u03ba\u03b1\u03b9, \u03cc\u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9, \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5<br \/>\n<strong>\u03b3\u03b1\u03c3\u03c4\u03c1\u03bf\u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<\/strong>.<\/div>\n<p><!-- 10 --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,.35),inset 2px 2px 3px rgba(255,255,255,.9),inset -3px -3px 5px rgba(0,0,0,.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">10<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u0391\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/h2>\n<p>\u0397 \u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03ae \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03b1\u03c3\u03c4\u03b5\u03af \u03b1\u03c0\u03cc<br \/>\n\u03ac\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<br \/>\n<strong>\u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03b5 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2<\/strong>.<br \/>\n\u0397 \u03b3\u03bd\u03ce\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae,<br \/>\n\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd<br \/>\n<strong>\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<\/strong>.<\/p>\n<ul style=\"line-height: 1.7;\">\n<li><strong>\u039a\u03bf\u03c5\u03bc\u03b1\u03c1\u03b9\u03bd\u03b9\u03ba\u03ac (\u03c0.\u03c7. \u03b2\u03b1\u03c1\u03c6\u03b1\u03c1\u03af\u03bd\u03b7):<\/strong><br \/>\n\u03c0\u03b9\u03b8\u03b1\u03bd\u03ae <strong>\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 INR<\/strong>,<br \/>\n\u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03af\u03b1\u03c2.<br \/>\n\u03a3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<br \/>\n\u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2.<\/li>\n<li><strong>ACE-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \/ ARB \/ \u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac:<\/strong><br \/>\n\u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b7\u03b8\u03b5\u03af<br \/>\n<strong>\u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2<\/strong>,<br \/>\n\u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03ae \u03b1\u03c6\u03c5\u03b4\u03b1\u03c4\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<br \/>\n\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 <strong>\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 eGFR<\/strong> \u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf\u03c2.<\/li>\n<li><strong>\u039b\u03af\u03b8\u03b9\u03bf:<\/strong><br \/>\n\u03b7 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5<br \/>\n<strong>\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03bb\u03b9\u03b8\u03af\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1<\/strong>,<br \/>\n\u03bc\u03b5 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<br \/>\n\u0391\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; padding: 12px; border-radius: 10px; margin-top: 14px;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7:<\/strong><br \/>\n\u03a3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c5\u03b3\u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1,<br \/>\n\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 Celebrex \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc<br \/>\n<strong>\u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf<\/strong>,<br \/>\n\u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/div>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,.35),inset 2px 2px 3px rgba(255,255,255,.9),inset -3px -3px 5px rgba(0,0,0,.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">11<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u0395\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<\/span><\/h2>\n<ul style=\"line-height: 1.7;\">\n<li><strong>\u0397\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 &gt;65 \u03b5\u03c4\u03ce\u03bd:<\/strong><br \/>\n\u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03b5 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2,<br \/>\n\u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/li>\n<li><strong>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2:<\/strong><br \/>\n\u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd\u00b7<br \/>\n\u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b4\u03cc\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<br \/>\n<strong>\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2, eGFR \u03ba\u03b1\u03b9 \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd<\/strong>.<\/li>\n<li><strong>\u03a5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2:<\/strong><br \/>\n\u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9<br \/>\n\u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5,<br \/>\n\u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7.<\/li>\n<\/ul>\n<p><!-- 12 --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,.35), inset 2px 2px 3px rgba(255,255,255,.9), inset -3px -3px 5px rgba(0,0,0,.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">12<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/span><\/h2>\n<details>\n<summary><strong>\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03b2\u03c1\u03b1\u03c7\u03b5\u03af\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 Celebrex;<\/strong><\/summary>\n<p>\u03a3\u03b5 <strong>\u03b2\u03c1\u03b1\u03c7\u03b5\u03af\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/strong> (\u03bb\u03af\u03b3\u03b5\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2) \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2<br \/>\n\u03c5\u03c0\u03bf\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 <strong>\u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/strong>.<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03ae \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5<br \/>\n<strong>\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf, \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc<\/strong>,<br \/>\n\u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03b8\u03b5\u03af \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2.<\/p>\n<\/details>\n<details>\n<summary><strong>\u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2 \u03c4\u03bf Celebrex \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7;<\/strong><\/summary>\n<p>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af, \u03b1\u03bb\u03bb\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9<br \/>\n<strong>\u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2<\/strong>,<br \/>\n\u03ba\u03b1\u03b8\u03ce\u03c2 \u03c4\u03b1 \u039c\u03a3\u0391\u03a6 \u2013 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7\u03c2 \u2013<br \/>\n\u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd <strong>\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2<\/strong><br \/>\n\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c5\u03c0\u03b5\u03c1\u03c4\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd.<\/p>\n<\/details>\n<details>\n<summary><strong>\u03a0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1;<\/strong><\/summary>\n<p>\u0397 \u03c0\u03b9\u03bf \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7<br \/>\n<strong>\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7 \u03bf\u03c1\u03bf\u03cd \u03bc\u03b5 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03c3\u03bc\u03cc eGFR<\/strong>,<br \/>\n\u03ba\u03b1\u03b8\u03ce\u03c2 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03bf\u03c0\u03c4\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7<br \/>\n<strong>\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong>,<br \/>\n\u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03b1\u03c3\u03c4\u03b5\u03af \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2<br \/>\n\u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc.<\/p>\n<\/details>\n<details>\n<summary><strong>\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 Celebrex;<\/strong><\/summary>\n<p>\u03a3\u03b5 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ae \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5<br \/>\n<strong>\u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf<\/strong>,<br \/>\n\u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<br \/>\n<strong>AST \u03ba\u03b1\u03b9 ALT<\/strong>,<br \/>\n\u03ba\u03b1\u03b8\u03ce\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd.<\/p>\n<\/details>\n<details>\n<summary><strong>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03c4\u03bf Celebrex \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2;<\/strong><\/summary>\n<p>\u039d\u03b1\u03b9. \u03a3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd:<\/p>\n<ul>\n<li>\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 <strong>INR<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03ba\u03bf\u03c5\u03bc\u03b1\u03c1\u03b9\u03bd\u03b9\u03ba\u03ac,<\/li>\n<li>\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 <strong>\u03ba\u03b1\u03bb\u03af\u03bf\u03c5<\/strong> \u03bc\u03b5 ACE-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03ae ARB,<\/li>\n<li>\u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03b7 <strong>\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong>.<\/li>\n<\/ul>\n<\/details>\n<p>&nbsp;<\/p>\n<p><!-- 13 --><\/p>\n<h2 style=\"display: flex; align-items: center; margin: 22px 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,.35),inset 2px 2px 3px rgba(255,255,255,.9),inset -3px -3px 5px rgba(0,0,0,.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">13<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd<\/span><\/h2>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center;\">\n<div><strong>\u0394\u03b5\u03af\u03c4\u03b5 \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ae \u03ba\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03c1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd.<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\"><br \/>\n\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<br \/>\n<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\"><br \/>\n\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<br \/>\n<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<p><!-- 14 --><\/p>\n<div style=\"margin-top: 22px;\">\n<h2 style=\"display: flex; align-items: center; margin: 0 0 10px; line-height: 1.25;\"><span style=\"display: inline-flex; align-items: center; justify-content: center; width: 36px; height: 36px; margin-right: 14px; flex-shrink: 0; font-weight: 900; font-size: 15px; color: #0f172a; background: linear-gradient(145deg,#f1f5f9,#9ca3af); transform: rotate(45deg); border-radius: 6px; border: 1px solid #9ca3af; box-shadow: 0 8px 14px rgba(0,0,0,0.35), inset 2px 2px 3px rgba(255,255,255,0.9), inset -3px -3px 5px rgba(0,0,0,0.25);\"><br \/>\n<span style=\"transform: rotate(-45deg); display: inline-block;\">14<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-weight: 900; color: #111827;\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<div style=\"border-left: 2px solid #d1d5db; padding-left: 10px; line-height: 1.45; margin-bottom: 4px;\"><strong>Celecoxib: Drug Safety Communication.<\/strong><br \/>\n<em> U.S. Food and Drug Administration (FDA).<\/em><a style=\"display: block; color: #374151; font-size: 13px; text-decoration: none;\" href=\"https:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\" target=\"_blank\" rel=\"nofollow noopener\">FDA \u2013 Drug Safety Communication<br \/>\n<\/a><\/div>\n<div style=\"border-left: 2px solid #d1d5db; padding-left: 10px; line-height: 1.45; margin-bottom: 4px;\"><strong>Cardiovascular safety of celecoxib, naproxen, or ibuprofen.<\/strong><br \/>\n<em> New England Journal of Medicine.<\/em><a style=\"display: block; color: #374151; font-size: 13px; text-decoration: none;\" href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1611593\" target=\"_blank\" rel=\"nofollow noopener\">NEJM \u2013 Full Article<br \/>\n<\/a><\/div>\n<div style=\"border-left: 2px solid #d1d5db; padding-left: 10px; line-height: 1.45; margin-bottom: 4px;\"><strong>Nonsteroidal anti-inflammatory drugs and kidney function.<\/strong><br \/>\n<em> Clinical Journal of the American Society of Nephrology.<\/em><a style=\"display: block; color: #374151; font-size: 13px; text-decoration: none;\" href=\"https:\/\/cjasn.asnjournals.org\/content\/15\/6\/897\" target=\"_blank\" rel=\"nofollow noopener\">CJASN \u2013 Review<br \/>\n<\/a><\/div>\n<div style=\"border-left: 2px solid #d1d5db; padding-left: 10px; line-height: 1.45; margin-bottom: 4px;\"><strong>\u039c\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1: \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/strong><br \/>\n<em> \u0395\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae \u03a1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1.<\/em><a style=\"display: block; color: #374151; font-size: 13px; text-decoration: none;\" href=\"https:\/\/www.ere.gr\" target=\"_blank\" rel=\"nofollow noopener\">\u0395\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae \u03a1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1<br \/>\n<\/a><\/div>\n<div style=\"border-left: 2px solid #d1d5db; padding-left: 10px; line-height: 1.45;\"><strong>\u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2.<\/strong><br \/>\n<em> \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1 \u2013 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/em><a style=\"display: block; color: #374151; font-size: 13px; text-decoration: none;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">mikrobiologikolamia.gr<br \/>\n<\/a><\/div>\n<\/div>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>Celebrex (\u03a3\u03b5\u03bb\u03b5\u03ba\u03bf\u03be\u03af\u03bc\u03c0\u03b7): \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 &amp; \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2 \u03a3\u03b5 1 \u03bb\u03b5\u03c0\u03c4\u03cc: \u03a4\u03bf celecoxib \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03bc\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03c2 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf (\u039c\u03a3\u0391\u03a6, COX-2). \u03a0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c6\u03b9\u03bb\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03b9 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03bc\u03b7 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u039c\u03a3\u0391\u03a6, \u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03b3\u03c9\u03b3\u03ae \u03ae \u03c3\u03b5 \u03b5\u03c5\u03c0\u03b1\u03b8\u03b5\u03af\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd. [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":8134,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2541],"tags":[2715,947,2716,916,144,943,502,110],"class_list":["post-8128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-odigoi-farmakon","tag-celebrex","tag-antiflegmonodi","tag-gastrenteriki-asfaleia","tag-ergastiriakos-elegchos","tag-kardiangeiakos-kindynos","tag-msaf","tag-nefriki-leitourgia","tag-parenergeies-farmakon"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/8128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=8128"}],"version-history":[{"count":7,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/8128\/revisions"}],"predecessor-version":[{"id":8201,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/8128\/revisions\/8201"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/8134"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=8128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=8128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=8128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}