{"id":6461,"date":"2025-10-10T08:13:28","date_gmt":"2025-10-10T05:13:28","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=6461"},"modified":"2026-03-07T18:17:18","modified_gmt":"2026-03-07T16:17:18","slug":"prolia","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/prolia\/","title":{"rendered":"Prolia (Denosumab): \u03a6\u03b9\u03bb\u03b9\u03ba\u03cc\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2 \u03b3\u03b9\u03b1 \u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u2013 \u0394\u03c1\u03ac\u03c3\u03b7, \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 &#038; \u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2"},"content":{"rendered":"<p><!-- ====================================================== ARTICLE: PROLIA (DENOSUMAB) \u2014 \u03a6\u0399\u039b\u0399\u039a\u039f\u03a3 \u039f\u0394\u0397\u0393\u039f\u03a3 \u0391\u03a3\u0398\u0395\u039d\u03a9\u039d ====================================================== --><\/p>\n<h1 style=\"font-size: 34px; font-weight: 900; color: #111827; margin: 8px 0 10px;\">Prolia\u00ae (Denosumab): \u03a6\u03b9\u03bb\u03b9\u03ba\u03cc\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2 \u0391\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b3\u03b9\u03b1 \u0391\u03c3\u03c6\u03b1\u03bb\u03ae \u03a7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/h1>\n<div style=\"margin: 10px 0 12px; font-size: 13px; color: #6b7280;\">\u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: <time datetime=\"2026-03-07\">7 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time><\/div>\n<p><!-- ==================== DRUG DATA CARD ==================== --><\/p>\n<div style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 18px; box-shadow: 0 1px 6px rgba(0,0,0,0.04); margin: 14px 0 18px; overflow: hidden;\">\n<div style=\"height: 2px; background: #b70000;\"><\/div>\n<div style=\"height: 2px; background: #b70000; opacity: 0.6;\"><\/div>\n<div style=\"padding: 12px 20px 8px;\">\n<h2 style=\"margin: 0; font-size: 22px; line-height: 1.3; font-weight: 800; color: #111827;\">Prolia\u00ae \u2014 \u039a\u03ac\u03c1\u03c4\u03b1 \u0392\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd<\/h2>\n<\/div>\n<div style=\"padding: 16px 20px 20px;\">\n<div style=\"display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 16px;\">\n<div style=\"min-width: 0;\">\n<div style=\"font-size: 13px; font-weight: bold; color: #b70000; margin-bottom: 8px;\">\u0392\u0391\u03a3\u0399\u039a\u0391 \u03a3\u03a4\u039f\u0399\u03a7\u0395\u0399\u0391<\/div>\n<div style=\"font-size: 15px; line-height: 1.7; color: #111827; word-break: break-word;\"><strong>\u0395\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1:<\/strong> Prolia\u00ae<br \/>\n<strong>\u0394\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1:<\/strong> Denosumab<br \/>\n<strong>\u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1:<\/strong> \u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1, \u03b1\u03bd\u03c4\u03b9\u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2<br \/>\n<strong>\u039c\u03bf\u03c1\u03c6\u03ae:<\/strong> \u03a0\u03c1\u03bf\u03b3\u03b5\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c3\u03cd\u03c1\u03b9\u03b3\u03b3\u03b1 60 mg\/mL<\/div>\n<\/div>\n<div style=\"min-width: 0;\">\n<div style=\"font-size: 13px; font-weight: bold; color: #b70000; margin-bottom: 8px;\">\u0395\u039d\u0394\u0395\u0399\u039e\u0395\u0399\u03a3<\/div>\n<div style=\"font-size: 15px; line-height: 1.7; color: #111827; word-break: break-word;\">\u039c\u03b5\u03c4\u03b5\u03bc\u03bc\u03b7\u03bd\u03bf\u03c0\u03b1\u03c5\u03c3\u03b9\u03b1\u03ba\u03ae \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<br \/>\n\u039f\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<br \/>\n\u039f\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b1\u03c0\u03cc \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7<br \/>\n\u03a0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2<\/div>\n<\/div>\n<div style=\"min-width: 0;\">\n<div style=\"font-size: 13px; font-weight: bold; color: #b70000; margin-bottom: 8px;\">\u0394\u039f\u03a3\u039f\u039b\u039f\u0393\u0399\u0391<\/div>\n<div style=\"font-size: 15px; line-height: 1.7; color: #111827; word-break: break-word;\"><strong>\u03a4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03cc\u03c3\u03b7:<\/strong> 60 mg \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1<br \/>\n<strong>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1:<\/strong> \u039a\u03ac\u03b8\u03b5 6 \u03bc\u03ae\u03bd\u03b5\u03c2<br \/>\n<strong>\u03a3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2:<\/strong> \u0392\u03c1\u03b1\u03c7\u03af\u03bf\u03bd\u03b1\u03c2, \u03bc\u03b7\u03c1\u03cc\u03c2 \u03ae \u03ba\u03bf\u03b9\u03bb\u03b9\u03ac<br \/>\n<strong>\u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7:<\/strong> \u0391\u03c0\u03cc \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2<\/div>\n<\/div>\n<div style=\"min-width: 0;\">\n<div style=\"font-size: 13px; font-weight: bold; color: #b70000; margin-bottom: 8px;\">\u03a0\u0391\u03a1\u0391\u039a\u039f\u039b\u039f\u03a5\u0398\u0397\u03a3\u0397<\/div>\n<div style=\"font-size: 15px; line-height: 1.7; color: #111827; word-break: break-word;\">\u0391\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03bf\u03c1\u03bf\u03cd \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03ba\u03ac\u03b8\u03b5 \u03b4\u03cc\u03c3\u03b7<br \/>\n25-OH \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ac<br \/>\n\u03a6\u03ce\u03c3\u03c6\u03bf\u03c1\u03bf\u03c2 \/ \u03bc\u03b1\u03b3\u03bd\u03ae\u03c3\u03b9\u03bf \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<br \/>\nDEXA \u03b1\u03bd\u03ac 12\u201324 \u03bc\u03ae\u03bd\u03b5\u03c2<\/div>\n<\/div>\n<div style=\"min-width: 0;\">\n<div style=\"font-size: 13px; font-weight: bold; color: #b70000; margin-bottom: 8px;\">\u03a3\u0397\u039c\u0391\u039d\u03a4\u0399\u039a\u0395\u03a3 \u03a0\u03a1\u039f\u0395\u0399\u0394\u039f\u03a0\u039f\u0399\u0397\u03a3\u0395\u0399\u03a3<\/div>\n<div style=\"font-size: 15px; line-height: 1.7; color: #111827; word-break: break-word;\">\u0394\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7<br \/>\n\u0395\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D<br \/>\n\u03a0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae \u03c3\u03b5 \u03a7\u039d\u039d \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c0\u03b1\u03c1\u03b1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc<br \/>\n\u038c\u03c7\u03b9 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c7\u03ad\u03b4\u03b9\u03bf \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7\u03c2<\/div>\n<\/div>\n<div style=\"min-width: 0;\">\n<div style=\"font-size: 13px; font-weight: bold; color: #b70000; margin-bottom: 8px;\">\u03a3\u03a5\u03a7\u039d\u0395\u03a3 \u0391\u039d\u0395\u03a0\u0399\u0398\u03a5\u039c\u0397\u03a4\u0395\u03a3<\/div>\n<div style=\"font-size: 15px; line-height: 1.7; color: #111827; word-break: break-word;\">\u039c\u03c5\u03bf\u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c2<br \/>\n\u0391\u03c1\u03b8\u03c1\u03b1\u03bb\u03b3\u03af\u03b5\u03c2 \u03ae \u03c0\u03cc\u03bd\u03bf\u03c2 \u03c3\u03c4\u03b1 \u03ac\u03ba\u03c1\u03b1<br \/>\n\u0389\u03c0\u03b9\u03bf \u03b5\u03be\u03ac\u03bd\u03b8\u03b7\u03bc\u03b1 \u03ae \u03b5\u03ba\u03b6\u03b5\u03bc\u03b1\u03c4\u03ce\u03b4\u03b5\u03b9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2<br \/>\n\u03a5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03c3\u03b5 \u03b5\u03c5\u03c0\u03b1\u03b8\u03b5\u03af\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong> \u03a4\u03bf <strong>Prolia\u00ae (denosumab)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5. \u03a7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 <strong>\u03ba\u03ac\u03b8\u03b5 6 \u03bc\u03ae\u03bd\u03b5\u03c2<\/strong>, \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 <strong>\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D<\/strong>, \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03c3\u03c7\u03ad\u03b4\u03b9\u03bf \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7\u03c2.<\/div>\n<nav id=\"toc\" style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 14px; padding: 16px; margin: 0 0 18px;\"><strong>\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 \u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd<\/strong><\/p>\n<ol style=\"margin: 10px 0 0 18px; padding-left: 0;\">\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#ti-einai\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Prolia<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#se-poious-endeiknytai\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#pos-leitourgei\">\u03a0\u03ce\u03c2 \u03b4\u03c1\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#posologia-chorigisi\">\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#prin-xekiniseis\">\u03a0\u03c1\u03b9\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#parakolouthisi\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#sychnes-energeies\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#sovares\">\u03a3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#diakopi-rebound\">\u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ba\u03b1\u03b9 \u201crebound\u201d \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#odontiatros\">\u039f\u03b4\u03bf\u03bd\u03c4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#idika-plithysmia\">\u0395\u03b9\u03b4\u03b9\u03ba\u03bf\u03af \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03af<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#apothikefsi\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#faq\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#bibliografia\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: 0; border-top: 2px solid #d1d5db; margin: 0 0 22px;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<section id=\"ti-einai\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf Prolia<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u03a4\u03bf Prolia\u00ae (denosumab) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/strong> \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 <strong>\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1<\/strong> \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 <strong>RANKL<\/strong>, \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7-\u03ba\u03bb\u03b5\u03b9\u03b4\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03b1\u03c3\u03c4\u03ce\u03bd, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c3\u03c0\u03bf\u03cd\u03bd \u03c4\u03bf \u03bf\u03c3\u03c4\u03cc. \u039c\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 RANKL, \u03c4\u03bf Prolia <strong>\u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c6\u03b8\u03bf\u03c1\u03ac \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd<\/strong> \u03ba\u03b1\u03b9 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1\u03c2 \u03b1\u03bd\u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03ac\u03b6\u03b1\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03c4\u03bf Prolia \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c0\u03bf\u03c5 \u201c\u03c7\u03c4\u03af\u03b6\u03b5\u03b9\u201d \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bd\u03ad\u03bf \u03bf\u03c3\u03c4\u03cc. \u0394\u03c1\u03b1 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 <strong>\u03b5\u03c0\u03b9\u03b2\u03c1\u03b1\u03b4\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bf\u03c3\u03c4\u03bf\u03cd<\/strong>, \u03ce\u03c3\u03c4\u03b5 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 <strong>\u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7\u03c2<\/strong> \u03ae <strong>\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03ae \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b7 \u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 <strong>\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 <strong>\u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D<\/strong> \u03c3\u03b5 \u03cc\u03bb\u03b7 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-top: 10px;\">\n<p><strong>\u0395\u03bd \u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03af\u03b1:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li><strong>\u039c\u03bf\u03c1\u03c6\u03ae:<\/strong> \u03b5\u03bd\u03ad\u03c3\u03b9\u03bc\u03bf \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03b3\u03b5\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c3\u03cd\u03c1\u03b9\u03b3\u03b3\u03b1.<\/li>\n<li><strong>\u0394\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1:<\/strong> denosumab.<\/li>\n<li><strong>\u03a4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2:<\/strong> \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae RANKL \u2192 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2.<\/li>\n<li><strong>\u0394\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2:<\/strong> \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 6 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03b1\u03bd\u03ac \u03ad\u03bd\u03b5\u03c3\u03b7.<\/li>\n<li><strong>\u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1:<\/strong> \u03b1\u03bd\u03c4\u03b9\u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2.<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 2 ==================== --><\/p>\n<section id=\"se-poious-endeiknytai\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u03a4\u03bf Prolia \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd.<\/strong> \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0397 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (<strong>DEXA<\/strong>) \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039f\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 <strong>\u03bc\u03b5\u03c4\u03b5\u03bc\u03bc\u03b7\u03bd\u03bf\u03c0\u03b1\u03c5\u03c3\u03b9\u03b1\u03ba\u03ae \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7<\/strong>, \u03c4\u03b7\u03bd <strong>\u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd <strong>\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b1\u03c0\u03cc \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7<\/strong>, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae \u03ae \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03b1\u03c1\u03c9\u03bc\u03b1\u03c4\u03ac\u03c3\u03b7\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03b5\u03bd\u03af\u03b1<\/strong> \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03cc\u03c0\u03c9\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03bf\u03c1\u03c9\u03c4\u03b9\u03ba\u03cc \u03ba\u03ac\u03c4\u03b1\u03b3\u03bc\u03b1, \u03c0\u03bf\u03bb\u03cd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc <strong>T-score<\/strong>, \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1 \u03ae \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ae \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; padding: 10px 14px; border-radius: 8px; margin: 10px 0;\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong> \u03c4\u03bf Prolia \u03b4\u03b5\u03bd \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bb\u03ae \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03c0\u03b9\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ae\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03bd\u03c4\u03b9\u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03bf\u03c1\u03c9\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03ae \u03cc\u03c4\u03b1\u03bd <strong>\u03c4\u03b1 \u03b4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bd\u03b9\u03ba\u03ac \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03b4\u03b5\u03bd \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b5\u03ba\u03c4\u03ac \u03ae \u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03bd\u03c4\u03b1\u03b9<\/strong>.<\/div>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u0397 \u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b5 Prolia \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac <strong>\u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03cc\u03c3\u03bf \u03c4\u03c9\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 3 ==================== --><\/p>\n<section id=\"pos-leitourgei\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">3<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03b4\u03c1\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u03a4\u03bf Prolia \u03b4\u03c1\u03b1 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd RANKL, \u03ac\u03c1\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c3\u03c4\u03bf\u03cd.<\/strong> \u03a4\u03bf <strong>denosumab<\/strong> \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd <strong>RANKL<\/strong> \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 <strong>RANK<\/strong> \u03c0\u03ac\u03bd\u03c9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf-\u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2. \u0388\u03c4\u03c3\u03b9 <strong>\u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7<\/strong> \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03b1\u03c3\u03c4\u03ce\u03bd, \u03bc\u03b5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7 <strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2<\/strong>.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03c4\u03bf Prolia \u201c\u03c6\u03c1\u03b5\u03bd\u03ac\u03c1\u03b5\u03b9\u201d \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03c5\u03bd \u03c4\u03bf \u03bf\u03c3\u03c4\u03cc. \u0391\u03c5\u03c4\u03cc \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03b7 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03bc\u03ac\u03b6\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd \u03cc\u03c3\u03bf \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ce\u03c1\u03b1 \u03c4\u03b7\u03c2. \u0397 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c1\u03c7\u03af\u03b6\u03b5\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1, \u03bc\u03b5 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 \u03bb\u03af\u03b3\u03b5\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2, \u03b5\u03bd\u03ce \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (<em>BMD<\/em>) \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039f \u03ac\u03be\u03bf\u03bd\u03b1\u03c2 <strong>RANK \/ RANKL \/ OPG<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2: \u03c4\u03bf <strong>RANKL<\/strong> \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c9\u03c2 \u03c3\u03ae\u03bc\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03b1\u03c3\u03c4\u03ce\u03bd, \u03c4\u03bf <strong>RANK<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf-\u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b7 <strong>OPG<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc\u03c2 \u201c\u03c0\u03b1\u03b3\u03b9\u03b4\u03b5\u03c5\u03c4\u03ae\u03c2\u201d \u03c4\u03bf\u03c5 RANKL. \u03a4\u03bf denosumab \u03b4\u03c1\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03bb\u03bf\u03b3\u03b9\u03ba\u03ae, \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03b1\u03c3\u03c4\u03ce\u03bd.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-top: 10px;\">\n<p><strong>\u03a4\u03b9 \u03ba\u03b5\u03c1\u03b4\u03af\u03b6\u03b5\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd.<\/li>\n<li>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03bc\u03b7 \u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<\/li>\n<li>\u0392\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 BMD \u03cc\u03c4\u03b1\u03bd \u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03bf\u03b9 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \/ \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin-top: 12px; line-height: 1.7; color: #374151;\">\u0397 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 Prolia \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <strong>\u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 \u03c3\u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03bf\u03b4\u03b9\u03ac\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1<\/strong>. \u038c\u03c3\u03bf \u03c0\u03bb\u03b7\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03ae \u03be\u03b5\u03c0\u03b5\u03c1\u03bd\u03b9\u03ad\u03c4\u03b1\u03b9 \u03bf 6\u03bf\u03c2 \u03bc\u03ae\u03bd\u03b1\u03c2, \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03b1\u03b8\u03b5\u03af \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 4 ==================== --><\/p>\n<section id=\"posologia-chorigisi\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">4<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u0397 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b7 \u03c4\u03bf\u03c5 Prolia \u03b5\u03af\u03bd\u03b1\u03b9 60 mg \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 6 \u03bc\u03ae\u03bd\u03b5\u03c2.<\/strong> \u0397 \u03ad\u03bd\u03b5\u03c3\u03b7 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03ae \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03c5\u03c4\u03ae, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 <strong>\u03b2\u03c1\u03b1\u03c7\u03af\u03bf\u03bd\u03b1, \u03bc\u03b7\u03c1\u03cc \u03ae \u03ba\u03bf\u03b9\u03bb\u03b9\u03ac<\/strong>. \u0397 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03bf\u03bd\u03bf\u03b4\u03b9\u03b1\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf rebound \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03bf\u03c3\u03c4\u03bf\u03cd.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-top: 10px;\">\n<p><strong>\u0395\u03ac\u03bd \u03be\u03b5\u03c7\u03b1\u03c3\u03c4\u03b5\u03af \u03b7 \u03b4\u03cc\u03c3\u03b7:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u039a\u03ac\u03bd\u03b5 \u03c4\u03b7\u03bd \u03ad\u03bd\u03b5\u03c3\u03b7 <strong>\u03c4\u03bf \u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03cc\u03c4\u03b5\u03c1\u03bf \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03bd<\/strong>.<\/li>\n<li>\u039f\u03b9 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b4\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 6 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bd\u03ad\u03b1 \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1.<\/li>\n<li>\u039c\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03b9\u03c2 \u03c4\u03b7\u03bd \u201c\u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7\u201d \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b7\u03bc\u03ad\u03c1\u03b1\u00b7 \u03b7 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac, \u03b7 \u03c3\u03cd\u03c1\u03b9\u03b3\u03b3\u03b1 \u03c6\u03c5\u03bb\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c8\u03c5\u03b3\u03b5\u03af\u03bf (<strong>2\u20138\u00b0C<\/strong>) \u03ba\u03b1\u03b9 \u03b1\u03c6\u03ae\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>15\u201330 \u03bb\u03b5\u03c0\u03c4\u03ac<\/strong> \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7. \u03a4\u03bf \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03ba\u03b9\u03bd\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1, \u03cc\u03c7\u03b9 \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03ad\u03b2\u03b9\u03b1 \u03ae \u03b5\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ac.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-top: 10px;\">\n<p><strong>\u03a0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u0391\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b7 <strong>\u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D<\/strong> \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/li>\n<li>\u0391\u03bd \u03ad\u03c7\u03b5\u03b9\u03c2 <strong>\u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong>, \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03bf\u03c1\u03b8\u03c9\u03b8\u03b5\u03af \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7.<\/li>\n<li>\u0395\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b5 \u03c4\u03bf\u03bd \u03b9\u03b1\u03c4\u03c1\u03cc \u03b1\u03bd \u03ad\u03c7\u03b5\u03b9\u03c2 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc <strong>\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2<\/strong> \u03ae <strong>\u03c0\u03b1\u03c1\u03b1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2<\/strong>.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin-top: 12px; line-height: 1.7; color: #374151;\">\u0397 \u03b4\u03cc\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03af\u03b4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2. \u0394\u03b5\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ae \u03c4\u03bf \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<section id=\"prin-xekiniseis\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">5<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03c1\u03b9\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9\u03c2<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u03a0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03ad\u03bd\u03b5\u03c3\u03b7 Prolia \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5, \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D \u03ba\u03b1\u03b9 \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/strong> \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd, \u03ba\u03b1\u03b9 \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 <strong>\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5, \u03c6\u03c9\u03c3\u03c6\u03cc\u03c1\u03bf\u03c5, \u03bc\u03b1\u03b3\u03bd\u03b7\u03c3\u03af\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 <strong>\u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D<\/strong> \u03bf\u03c1\u03bf\u03cd. \u0391\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c7\u03b1\u03bc\u03b7\u03bb\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2, \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7. \u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03bc\u03b5 \u03bf\u03c5\u03c1\u03af\u03b1, \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 <strong>eGFR<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03ae \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03ae \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd, \u03cc\u03c0\u03c9\u03c2 <strong>\u03b4\u03b9\u03bf\u03c5\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b1\u03b3\u03ba\u03cd\u03bb\u03b7\u03c2, \u03b1\u03bd\u03c4\u03b9\u03b5\u03c0\u03b9\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae<\/strong>. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03af \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 <strong>\u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf 1.000\u20131.200 mg \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2<\/strong> \u03ba\u03b1\u03b9 <strong>\u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D 800\u20131.000 IU \u03b7\u03bc\u03b5\u03c1\u03b7\u03c3\u03af\u03c9\u03c2<\/strong>, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; padding: 10px 12px; border-radius: 8px; margin-bottom: 10px;\"><strong>\u039f\u03b4\u03bf\u03bd\u03c4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7:<\/strong> \u039f\u03b4\u03bf\u03bd\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1, \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ad\u03c2, \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ad\u03c2 \u03ae \u03ba\u03b1\u03ba\u03ae \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03b3\u03b9\u03b5\u03b9\u03bd\u03ae \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7. \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 Prolia \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03bc\u03b5 <strong>\u03bf\u03c3\u03c4\u03b5\u03bf\u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7 \u03b3\u03bd\u03ac\u03b8\u03bf\u03c5<\/strong>, \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf.<\/div>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-bottom: 10px;\">\n<p><strong>\u0391\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u03a5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03bf\u03c1\u03b8\u03c9\u03b8\u03b5\u03af.<\/li>\n<li>\u03a5\u03c0\u03b5\u03c1\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf denosumab \u03ae \u03c3\u03c4\u03b1 \u03ad\u03ba\u03b4\u03bf\u03c7\u03b1.<\/li>\n<li>\u0395\u03bd\u03b5\u03c1\u03b3\u03ae \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03c3\u03c4\u03b1 \u03bf\u03c3\u03c4\u03ac \u03ae \u03c3\u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1.<\/li>\n<li>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03b5\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03b6\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 Prolia \u03b8\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03bc\u03b5 <strong>\u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong>. \u039f \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b5 <strong>\u03ac\u03c3\u03ba\u03b7\u03c3\u03b7, \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd<\/strong>.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<section id=\"parakolouthisi\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">6<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 Prolia \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D.<\/strong> \u0397 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b2\u03bb\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03ae \u03b1\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2 \u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf <strong>\u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03bf\u03c1\u03bf\u03cd<\/strong> \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03ba\u03ac\u03b8\u03b5 \u03b4\u03cc\u03c3\u03b7 \u03ba\u03b1\u03b9, \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, 1\u20132 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac. \u0397 <strong>25-OH \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D<\/strong> \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03ad\u03c0\u03b5\u03b9\u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ac, \u03b5\u03bd\u03ce \u03bf <strong>\u03c6\u03ce\u03c3\u03c6\u03bf\u03c1\u03bf\u03c2<\/strong>, \u03c4\u03bf <strong>\u03bc\u03b1\u03b3\u03bd\u03ae\u03c3\u03b9\u03bf<\/strong> \u03ba\u03b1\u03b9 \u03b7 <strong>\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong> \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03ae \u03c5\u03c0\u03bf\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2. \u0397 <strong>DEXA<\/strong> \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03bd\u03ac 12\u201324 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 12px; padding: 10px 12px; margin-bottom: 10px;\">\u2194\ufe0f <strong>\u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1<\/strong> \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1.<\/div>\n<div style=\"overflow-x: auto;\">\n<table style=\"width: 100%; border-collapse: collapse; min-width: 680px;\">\n<thead>\n<tr>\n<th style=\"border-bottom: 2px solid #e5e7eb; text-align: left; padding: 8px;\">\u0394\u03b5\u03af\u03ba\u03c4\u03b7\u03c2<\/th>\n<th style=\"border-bottom: 2px solid #e5e7eb; text-align: left; padding: 8px;\">\u03a0\u03cc\u03c4\u03b5<\/th>\n<th style=\"border-bottom: 2px solid #e5e7eb; text-align: left; padding: 8px;\">\u03a3\u03c4\u03cc\u03c7\u03bf\u03c2 \/ \u03a3\u03c7\u03cc\u03bb\u03b9\u03bf<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u0391\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03bf\u03c1\u03bf\u03cd (Ca)<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u03a0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03ba\u03ac\u03b8\u03b5 \u03b4\u03cc\u03c3\u03b7 \u03ba\u03b1\u03b9 1\u20132 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u0391\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">25-OH \u0392\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u03a0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 6\u201312 \u03bc\u03ae\u03bd\u03b5\u03c2<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u03a3\u03c4\u03cc\u03c7\u03bf\u03c2 \u226530 ng\/mL<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u03a6\u03ce\u03c3\u03c6\u03bf\u03c1\u03bf\u03c2 (P), \u039c\u03b1\u03b3\u03bd\u03ae\u03c3\u03b9\u03bf (Mg)<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u038c\u03c0\u03bf\u03c4\u03b5 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u039f\u03c5\u03c1\u03af\u03b1, \u039a\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7, eGFR<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u03a0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03a7\u039d\u039d<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u0391\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u039f\u03c3\u03c4\u03b9\u03ba\u03ae \u03a0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 (DEXA)<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u0391\u03bd\u03ac 12\u201324 \u03bc\u03ae\u03bd\u03b5\u03c2<\/td>\n<td style=\"border-bottom: 1px solid #f3f4f6; padding: 8px;\">\u0391\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2, \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03b1\u03c0\u03cc <strong>8.5 \u03ad\u03c9\u03c2 10.2 mg\/dL<\/strong>. \u03a4\u03b9\u03bc\u03ad\u03c2 \u03ba\u03ac\u03c4\u03c9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03b5\u03cd\u03c1\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03ae\u03c3\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7, \u03b5\u03bd\u03ce \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D \u03ba\u03ac\u03c4\u03c9 \u03b1\u03c0\u03cc <strong>20 ng\/mL<\/strong> \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03b9\u03c3\u03c4\u03b5\u03af.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-top: 10px;\"><strong>\u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7:<\/strong> \u0391\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03bc\u03c5\u03c1\u03bc\u03b7\u03ba\u03b9\u03ac\u03c3\u03b5\u03b9\u03c2, \u03ba\u03c1\u03ac\u03bc\u03c0\u03b5\u03c2, \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03ae \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b5\u03c3\u03b7, \u03b5\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03bf\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2.<\/div>\n<p style=\"margin-top: 12px; line-height: 1.7; color: #374151;\">\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b5\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd <strong>\u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong> \u03c4\u03bf\u03c5 Prolia, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u039f\u03b9 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<section id=\"sychnes-energeies\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">7<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c4\u03bf\u03c5 Prolia \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03c0\u03b9\u03b5\u03c2 \u03ad\u03c9\u03c2 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/strong> \u03a0\u03b1\u03c1\u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac, \u03b7 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b9\u03b1\u03c4\u03c1\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039f\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd <strong>\u03bc\u03c5\u03bf\u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf<\/strong>, \u03cc\u03c0\u03c9\u03c2 \u03c0\u03cc\u03bd\u03bf \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03ac\u03c4\u03b7, \u03c3\u03c4\u03b9\u03c2 \u03b1\u03c1\u03b8\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ae \u03c3\u03c4\u03b1 \u03c0\u03cc\u03b4\u03b9\u03b1, \u03ae\u03c0\u03b9\u03bf \u03c0\u03cc\u03bd\u03bf \u03c3\u03c4\u03b1 \u03ac\u03ba\u03c1\u03b1, <strong>\u03b5\u03be\u03ac\u03bd\u03b8\u03b7\u03bc\u03b1<\/strong> \u03ae \u03b5\u03ba\u03b6\u03b5\u03bc\u03b1\u03c4\u03ce\u03b4\u03b5\u03b9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 <strong>\u03ba\u03b5\u03c6\u03b1\u03bb\u03b1\u03bb\u03b3\u03af\u03b1<\/strong> \u03ae \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b5\u03c3\u03b7. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03ae\u03c0\u03b9\u03b5\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c1\u03b9\u03bd\u03bf\u03c6\u03b1\u03c1\u03c5\u03b3\u03b3\u03af\u03c4\u03b9\u03b4\u03b1, \u03bf\u03c5\u03c1\u03bf\u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03ae \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039c\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 <strong>\u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong>, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03bc\u03c5\u03c1\u03bc\u03b7\u03ba\u03af\u03b1\u03c3\u03b7, \u03ba\u03c1\u03ac\u03bc\u03c0\u03b5\u03c2, \u03c0\u03b1\u03c1\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b5\u03c2 \u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-bottom: 10px;\">\n<p><strong>\u0391\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03ae\u03c0\u03b9\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u0391\u03bd\u03b1\u03bb\u03b3\u03b7\u03c4\u03b9\u03ba\u03ac, \u03cc\u03c0\u03c9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03b5\u03c4\u03b1\u03bc\u03cc\u03bb\u03b7 \u03ae \u039c\u03a3\u0391\u03a6, \u03b3\u03b9\u03b1 \u03bc\u03c5\u03b1\u03bb\u03b3\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c1\u03b8\u03c1\u03b1\u03bb\u03b3\u03af\u03b5\u03c2.<\/li>\n<li>\u03a4\u03bf\u03c0\u03b9\u03ba\u03ae \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b5\u03c1\u03b5\u03b8\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2.<\/li>\n<li>\u03a0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03bd \u03c5\u03b3\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae\u03c2 \u03b4\u03b9\u03b1\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2.<\/li>\n<li>\u03a4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03bf\u03c7\u03c9\u03c1\u03bf\u03cd\u03bd \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 2\u20133 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2.<\/li>\n<\/ul>\n<\/div>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px;\">\n<p><strong>\u0395\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03ce\u03bd\u03b7\u03c3\u03b5 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03b5 \u03b9\u03b1\u03c4\u03c1\u03cc \u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u0388\u03bd\u03c4\u03bf\u03bd\u03bf\u03c2 \u03ae \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03bf\u03c2 \u03bc\u03c5\u03ca\u03ba\u03cc\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c2 \u03ae \u03ba\u03c1\u03ac\u03bc\u03c0\u03b5\u03c2.<\/li>\n<li>\u039c\u03bf\u03cd\u03b4\u03b9\u03b1\u03c3\u03bc\u03b1 \u03c3\u03c4\u03b1 \u03c7\u03b5\u03af\u03bb\u03b7 \u03ae \u03c3\u03c4\u03b1 \u03b4\u03ac\u03c7\u03c4\u03c5\u03bb\u03b1.<\/li>\n<li>\u03a3\u03b7\u03bc\u03ac\u03b4\u03b9\u03b1 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c0\u03c5\u03c1\u03b5\u03c4\u03cc\u03c2, \u03c1\u03af\u03b3\u03b7, \u03b5\u03c1\u03c5\u03b8\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ae \u03c0\u03c1\u03ae\u03be\u03b9\u03bc\u03bf.<\/li>\n<li>\u039f\u03af\u03b4\u03b7\u03bc\u03b1 \u03ae \u03c0\u03cc\u03bd\u03bf\u03c2 \u03c3\u03c4\u03b7 \u03b3\u03bd\u03ac\u03b8\u03bf.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin-top: 12px; line-height: 1.7; color: #374151;\">\u0397 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03ae\u03c0\u03b9\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd <strong>\u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2<\/strong>. \u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03b1\u03c0\u03c1\u03cc\u03c3\u03ba\u03bf\u03c0\u03c4\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b5\u03c6\u03cc\u03c3\u03bf\u03bd \u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 8 ==================== --><\/p>\n<section id=\"sovares\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">8<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u039f\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c4\u03bf\u03c5 Prolia \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7.<\/strong> \u039c\u03b5 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7, \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039c\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03b3\u03bd\u03c9\u03c3\u03c4\u03ad\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 <strong>\u03bf\u03c3\u03c4\u03b5\u03bf\u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bd\u03ac\u03b8\u03bf\u03c5 (ONJ)<\/strong>, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03ba\u03b1\u03ba\u03ae \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03b3\u03b9\u03b5\u03b9\u03bd\u03ae \u03ae \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ad\u03c2. \u03a3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 <strong>\u03c0\u03cc\u03bd\u03bf\u03c2, \u03bf\u03af\u03b4\u03b7\u03bc\u03b1, \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03bf\u03c3\u03c4\u03bf\u03cd \u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03b5\u03c0\u03bf\u03cd\u03bb\u03c9\u03c3\u03b7\u03c2<\/strong> \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7. \u0397 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03ae \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03ac \u03c4\u03b7\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u0386\u03bb\u03bb\u03b7 \u03c0\u03bf\u03bb\u03cd \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 <strong>\u03ac\u03c4\u03c5\u03c0\u03b1 \u03ba\u03b1\u03c4\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b7\u03c1\u03b9\u03b1\u03af\u03bf\u03c5 \u03bf\u03c3\u03c4\u03bf\u03cd<\/strong>, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7. \u03a0\u03c1\u03bf\u03b5\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf <strong>\u03c0\u03cc\u03bd\u03bf\u03c2 \u03c3\u03c4\u03bf\u03bd \u03bc\u03b7\u03c1\u03cc \u03ae \u03c3\u03c4\u03b7 \u03b2\u03bf\u03c5\u03b2\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae<\/strong> \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ae \u03bc\u03ae\u03bd\u03b5\u03c2 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03ac\u03c4\u03b1\u03b3\u03bc\u03b1, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u0397 <strong>\u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D. \u03a3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03bc\u03c5\u03c1\u03bc\u03b7\u03ba\u03af\u03b1\u03c3\u03b7, \u03ba\u03c1\u03ac\u03bc\u03c0\u03b5\u03c2, \u03c4\u03b5\u03c4\u03b1\u03bd\u03af\u03b1, \u03b1\u03af\u03c3\u03b8\u03b7\u03bc\u03b1 \u201c\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd\u201d \u03c3\u03c4\u03b1 \u03ac\u03ba\u03c1\u03b1 \u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf, \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px;\">\n<p><strong>\u039b\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u03a3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2, \u03bf\u03c5\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03ae \u03b1\u03c5\u03c4\u03b9\u03bf\u03cd, \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/li>\n<li>\u0391\u03bb\u03bb\u03b5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03ae \u03b1\u03bd\u03b1\u03c6\u03c5\u03bb\u03b1\u03be\u03af\u03b1, \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin-top: 12px; line-height: 1.7; color: #374151;\">\u039f\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b4\u03b9\u03b1\u03c7\u03b5\u03b9\u03c1\u03af\u03c3\u03b9\u03bc\u03b5\u03c2<\/strong> \u03cc\u03c4\u03b1\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b1. \u039f \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b8\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03b5\u03b9 \u03c4\u03bf \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03bf \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03b5\u03ac\u03bd \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 9 ==================== --><\/p>\n<section id=\"diakopi-rebound\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">9<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0394\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03ba\u03b1\u03b9 \u201crebound\u201d \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7\u03c2<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u03a4\u03bf Prolia \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03ba\u03cc\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03c3\u03c7\u03ad\u03b4\u03b9\u03bf \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7\u03c2.<\/strong> \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03c3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2<\/strong>, \u03b3\u03b9\u03b1\u03c4\u03af \u03b7 \u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03ba\u03b1\u03c4\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ae \u03c3\u03c4\u03ae\u03bb\u03b7.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u03a4\u03bf \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf <strong>\u201crebound\u201d \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf<\/strong> \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd, \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03bf\u03c5 denosumab, <strong>\u03bf RANKL \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03be\u03b1\u03bd\u03ac<\/strong> \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 \u201c\u03c5\u03c0\u03b5\u03c1\u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd\u201d. \u0391\u03c5\u03c4\u03cc \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 <strong>\u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2<\/strong> \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 3\u20136 \u03bc\u03ae\u03bd\u03b5\u03c2. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7 \u03ae \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd, \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ac \u03ba\u03b1\u03c4\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1<\/strong> \u03c3\u03b5 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u0397 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03bd\u03b1 <strong>\u03bc\u03b7 \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ac \u03c0\u03bf\u03c4\u03ad \u03b7 \u03b1\u03b3\u03c9\u03b3\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7<\/strong>. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bf \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03bd\u03b5\u03b9 <strong>\u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03b4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bd\u03b9\u03ba\u03cc<\/strong>, \u03cc\u03c0\u03c9\u03c2 \u03b6\u03bf\u03bb\u03b5\u03bd\u03b4\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03bf\u03be\u03cd \u03ae \u03b1\u03bb\u03b5\u03bd\u03b4\u03c1\u03bf\u03bd\u03ac\u03c4\u03b7, \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03b7\u03bd \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03ad\u03c0\u03c1\u03b5\u03c0\u03b5 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03b7 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b4\u03cc\u03c3\u03b7 Prolia. \u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03bf <strong>\u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf<\/strong>, \u03b7 <strong>\u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D<\/strong>, \u03b7 <strong>BMD<\/strong> \u03ba\u03b1\u03b9, \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9, \u03bf\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-bottom: 10px;\">\n<p><strong>\u0395\u03bd\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03cc \u03c0\u03bb\u03ac\u03bd\u03bf \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7\u03c2 (\u03c5\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03ba\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7):<\/strong><\/p>\n<ol style=\"margin: 8px 0 0 18px;\">\n<li>6 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b4\u03cc\u03c3\u03b7 Prolia \u2192 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd, \u03c0.\u03c7. \u03b6\u03bf\u03bb\u03b5\u03bd\u03b4\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc 5 mg IV.<\/li>\n<li>\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 <strong>Ca, \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D \u03ba\u03b1\u03b9 BMD<\/strong> \u03c3\u03c4\u03bf\u03c5\u03c2 6\u201312 \u03bc\u03ae\u03bd\u03b5\u03c2.<\/li>\n<li>\u0391\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7 \u03b4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd.<\/li>\n<\/ol>\n<\/div>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px;\">\n<p><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u0397 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03ad\u03c3\u03c4\u03c9 \u03ba\u03b1\u03b9 \u03bb\u03af\u03b3\u03c9\u03bd \u03bc\u03b7\u03bd\u03ce\u03bd \u03c3\u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c4\u03bf\u03c5 Prolia \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd.<\/li>\n<li>\u03a3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c3\u03c0\u03bf\u03bd\u03b4\u03c5\u03bb\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd, \u03b7 <strong>\u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03b9\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03b7.<\/li>\n<li>\u0397 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>BMD<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd <strong>\u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd<\/strong> \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin-top: 12px; line-height: 1.7; color: #374151;\">\u0397 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03c4\u03bf\u03c5 Prolia \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af <strong>\u03c3\u03c5\u03bd\u03c4\u03bf\u03bd\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae<\/strong> \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b8\u03b5\u03c1\u03ac\u03c0\u03bf\u03bd\u03c4\u03b1 \u03b9\u03b1\u03c4\u03c1\u03cc. \u039f \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03c5\u03c7\u03b8\u03b5\u03af \u03b7 \u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03ac\u03b6\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03c4\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 10 ==================== --><\/p>\n<section id=\"odontiatros\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">10<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039f\u03b4\u03bf\u03bd\u03c4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac \u03bc\u03ad\u03c4\u03c1\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u0397 \u03ba\u03b1\u03bb\u03ae \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03b3\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c3\u03c6\u03b1\u03bb\u03bf\u03cd\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 Prolia.<\/strong> \u0391\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af <strong>\u03bf\u03c3\u03c4\u03b5\u03bf\u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bd\u03ac\u03b8\u03bf\u03c5 (ONJ)<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ad\u03c2, \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ad\u03c2 \u03ae \u03ba\u03b1\u03ba\u03ae \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03b3\u03b9\u03b5\u03b9\u03bd\u03ae. \u039c\u03b5 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7, \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u03a0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 <strong>\u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/strong>. \u0391\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c4\u03b5\u03c1\u03b7\u03b4\u03cc\u03bd\u03b5\u03c2, \u03bf\u03c5\u03bb\u03af\u03c4\u03b9\u03b4\u03b1 \u03ae \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ad\u03c2, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03cc\u03c4\u03b5\u03c1\u03bf \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7. \u0397 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c6\u03c1\u03bf\u03bd\u03c4\u03af\u03b4\u03b1 \u03bc\u03b5 \u03c3\u03c9\u03c3\u03c4\u03cc \u03b2\u03bf\u03cd\u03c1\u03c4\u03c3\u03b9\u03c3\u03bc\u03b1, \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03ba\u03cc \u03bd\u03ae\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03ae \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c5\u03b3\u03b9\u03b5\u03b9\u03bd\u03ae \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039a\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cc \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03af \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03b9, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03ba\u03ac\u03b8\u03b5 6 \u03bc\u03ae\u03bd\u03b5\u03c2. \u039f\u03b9 \u03bc\u03b7 \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b5\u03c2 \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03bb\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03b7\u03bd \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1 \u03c4\u03b7\u03c2 \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2, \u03b5\u03bd\u03ce \u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ae \u03ae \u03ac\u03bb\u03bb\u03b7 \u03c0\u03c1\u03ac\u03be\u03b7, \u03bf \u03bf\u03b4\u03bf\u03bd\u03c4\u03af\u03b1\u03c4\u03c1\u03bf\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 denosumab.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; padding: 10px 12px; border-radius: 8px; margin-bottom: 10px;\">\n<p><strong>\u03a3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u03a0\u03cc\u03bd\u03bf\u03c2 \u03ae \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03c3\u03c4\u03b1 \u03bf\u03cd\u03bb\u03b1 \u03ae \u03c3\u03c4\u03b7 \u03b3\u03bd\u03ac\u03b8\u03bf.<\/li>\n<li>\u0388\u03ba\u03b8\u03b5\u03c3\u03b7 \u03bf\u03c3\u03c4\u03bf\u03cd \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1.<\/li>\n<li>\u0391\u03af\u03c3\u03b8\u03b7\u03bc\u03b1 \u201c\u03b2\u03b1\u03c1\u03b9\u03ac\u03c2 \u03b3\u03bd\u03ac\u03b8\u03bf\u03c5\u201d \u03ae \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b1 \u03c3\u03c4\u03bf \u03ac\u03bd\u03bf\u03b9\u03b3\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2.<\/li>\n<li>\u0391\u03c1\u03b3\u03ae \u03b5\u03c0\u03bf\u03cd\u03bb\u03c9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ae.<\/li>\n<\/ul>\n<\/div>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-bottom: 10px;\">\n<p><strong>\u0395\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b5 \u03c0\u03ac\u03bd\u03c4\u03b1:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u03a4\u03bf\u03bd <strong>\u03bf\u03b4\u03bf\u03bd\u03c4\u03af\u03b1\u03c4\u03c1\u03bf<\/strong> \u03c3\u03bf\u03c5 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03ba\u03ac\u03b8\u03b5 \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7.<\/li>\n<li>\u03a4\u03bf\u03bd <strong>\u03b8\u03b5\u03c1\u03ac\u03c0\u03bf\u03bd\u03c4\u03b1 \u03b9\u03b1\u03c4\u03c1\u03cc<\/strong> \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c0\u03cc\u03bd\u03bf\u03c5 \u03ae \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2 \u03c3\u03c4\u03bf \u03c3\u03c4\u03cc\u03bc\u03b1.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin-top: 12px; line-height: 1.7; color: #374151;\">\u0397 ONJ \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c3\u03c4\u03b5\u03bd\u03ae \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b9\u03b1\u03c4\u03c1\u03bf\u03cd, \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03ac\u03c4\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03b5\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 <strong>\u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1<\/strong> \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 Prolia \u03ba\u03b1\u03b9 \u03c4\u03b7 <strong>\u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2<\/strong> \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b1.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 11 ==================== --><\/p>\n<section id=\"idika-plithysmia\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">11<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03b9\u03b4\u03b9\u03ba\u03bf\u03af \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03af<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c4\u03b5\u03bd\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 Prolia.<\/strong> \u0397 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5 Prolia\u00ae \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03cc\u03c4\u03b1\u03bd \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03ae \u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039f\u03b9 <strong>\u03bc\u03b5\u03c4\u03b5\u03bc\u03bc\u03b7\u03bd\u03bf\u03c0\u03b1\u03c5\u03c3\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2<\/strong> \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03ba\u03cd\u03c1\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03b5 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>BMD<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 <strong>\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5<\/strong>. \u039f\u03b9 <strong>\u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03b5 \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7<\/strong> \u03ae \u03bc\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03c5\u03c0\u03cc \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03c4\u03bf Prolia \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf (\u03a7\u039d\u039d)<\/strong>, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf <strong>\u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2<\/strong> \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b5\u03c3\u03b7. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 <strong>\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5, \u03c6\u03c9\u03c3\u03c6\u03cc\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D<\/strong> \u03c0\u03c1\u03b9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7, \u03b5\u03bd\u03ce \u03c3\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03a7\u039d\u039d \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03bb\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u03a4\u03bf Prolia <strong>\u03b1\u03bd\u03c4\u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03bd <strong>\u03b8\u03b7\u03bb\u03b1\u03c3\u03bc\u03cc<\/strong>, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03ad\u03bc\u03b2\u03c1\u03c5\u03bf \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ad\u03c2 \u03b1\u03bd \u03b1\u03c0\u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03cc \u03b3\u03ac\u03bb\u03b1. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd 5 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; padding: 10px 12px; border-radius: 8px; margin-bottom: 10px;\">\n<p><strong>\u0386\u03bb\u03bb\u03b5\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li><strong>\u03a5\u03c0\u03bf\u03c0\u03b1\u03c1\u03b1\u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03b9\u03c3\u03bc\u03cc\u03c2:<\/strong> \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2\u00b7 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 Ca \u03ba\u03b1\u03b9 D.<\/li>\n<li><strong>\u0394\u03c5\u03c3\u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7<\/strong> \u03cc\u03c0\u03c9\u03c2 \u03ba\u03bf\u03b9\u03bb\u03b9\u03bf\u03ba\u03ac\u03ba\u03b7 \u03ae \u03b3\u03b1\u03c3\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03ac\u03ba\u03b1\u03bc\u03c8\u03b7: \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03b8\u03c1\u03b5\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03bb\u03bb\u03b5\u03af\u03c8\u03b5\u03c9\u03bd \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/li>\n<li><strong>\u0391\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b5\u03c3\u03c4\u03b1\u03bb\u03bc\u03ad\u03bd\u03bf\u03b9:<\/strong> \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03c9\u03bd\u00b7 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c0\u03b1\u03b3\u03c1\u03cd\u03c0\u03bd\u03b7\u03c3\u03b7.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin-top: 12px; line-height: 1.7; color: #374151;\">\u03a3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2, \u03b7 <strong>\u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bb\u03c5\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D<\/strong> \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf \u03ba\u03bb\u03b5\u03b9\u03b4\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae \u03c3\u03c5\u03bd\u03ad\u03c7\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 Prolia.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 12 ==================== --><\/p>\n<section id=\"apothikefsi\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">12<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0391\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5 Prolia<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u03a4\u03bf Prolia \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03c3\u03c4\u03bf \u03c8\u03c5\u03b3\u03b5\u03af\u03bf, \u03b3\u03b9\u03b1\u03c4\u03af \u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1.<\/strong> \u03a4\u03bf denosumab \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03bc\u03cc\u03bd\u03bf \u03cc\u03c4\u03b1\u03bd \u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u03a4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c6\u03c5\u03bb\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 <strong>\u03c8\u03c5\u03b3\u03b5\u03af\u03bf 2\u20138\u00b0C<\/strong>, \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c8\u03cd\u03c7\u03b5\u03c4\u03b1\u03b9, \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03cc\u03c4\u03c5\u03c0\u03b7 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1<\/strong> \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c9\u03c2. \u0397 \u03c3\u03cd\u03c1\u03b9\u03b3\u03b3\u03b1 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03ba\u03bf\u03c5\u03bc\u03c0\u03ac \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03b5 \u03c8\u03c5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03ae \u03c3\u03c4\u03bf \u03c0\u03af\u03c3\u03c9 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c8\u03c5\u03b3\u03b5\u03af\u03bf\u03c5, \u03b3\u03b9\u03b1\u03c4\u03af \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c0\u03b1\u03b3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039a\u03b1\u03c4\u03ac \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03cc\u03c4\u03b5\u03c1\u03bf \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 <strong>\u03b9\u03c3\u03bf\u03b8\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03b8\u03ae\u03ba\u03b7<\/strong> \u03ae \u03c6\u03bf\u03c1\u03b7\u03c4\u03cc \u03c8\u03c5\u03b3\u03b5\u03af\u03bf \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03ae\u03bb\u03b9\u03bf \u03ae \u03c5\u03c8\u03b7\u03bb\u03ae \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1. \u0391\u03bd \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03b5\u03b9 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03c8\u03c5\u03b3\u03b5\u03af\u03bf\u03c5, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03ad\u03c9\u03c2 <strong>30\u00b0C \u03b3\u03b9\u03b1 30 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2<\/strong> \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03bc\u03cc\u03bd\u03bf. \u0391\u03bd \u03b4\u03b5\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1, \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03b9\u03c6\u03b8\u03b5\u03af.<\/p>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; padding: 10px 12px; border-radius: 8px; margin-bottom: 10px;\">\n<p><strong>\u03a0\u03c1\u03b9\u03bd \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u0391\u03c6\u03ae\u03c3\u03c4\u03b5 \u03c4\u03b7 \u03c3\u03cd\u03c1\u03b9\u03b3\u03b3\u03b1 <strong>\u03c3\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5 (15\u201325\u00b0C) \u03b3\u03b9\u03b1 15\u201330 \u03bb\u03b5\u03c0\u03c4\u03ac<\/strong> \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7.<\/li>\n<li>\u039c\u03b7\u03bd \u03b1\u03bd\u03b1\u03ba\u03b9\u03bd\u03b5\u03af\u03c4\u03b5 \u03c4\u03b7 \u03c3\u03cd\u03c1\u03b9\u03b3\u03b3\u03b1.<\/li>\n<li>\u0395\u03bb\u03ad\u03b3\u03be\u03c4\u03b5 \u03bf\u03c0\u03c4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b4\u03b9\u03b1\u03c5\u03b3\u03ad\u03c2, \u03ac\u03c7\u03c1\u03c9\u03bc\u03bf \u03ae \u03b5\u03bb\u03b1\u03c6\u03c1\u03ac \u03ba\u03b9\u03c4\u03c1\u03b9\u03bd\u03c9\u03c0\u03cc<\/strong>, \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c9\u03bc\u03b1\u03c4\u03af\u03b4\u03b9\u03b1.<\/li>\n<\/ul>\n<\/div>\n<div style=\"background: #f3f4f6; border-left: 4px solid #b70000; border-radius: 10px; padding: 10px 12px; margin-bottom: 10px;\">\n<p><strong>\u039c\u03b7\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03b1\u03bd:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u0388\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03b5\u03b9 <strong>\u03b5\u03ba\u03c4\u03cc\u03c2 \u03c8\u03c5\u03b3\u03b5\u03af\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc 30 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2<\/strong>.<\/li>\n<li>\u03a4\u03bf \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03bf\u03bb\u03cc \u03ae \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c9\u03bc\u03b1\u03c4\u03af\u03b4\u03b9\u03b1.<\/li>\n<li>\u0397 \u03c3\u03cd\u03c1\u03b9\u03b3\u03b3\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c7\u03c4\u03c5\u03c0\u03b7\u03b8\u03b5\u03af \u03ae \u03ba\u03b1\u03c4\u03b1\u03c8\u03c5\u03c7\u03b8\u03b5\u03af.<\/li>\n<\/ul>\n<\/div>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u039f\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03cd\u03c1\u03b9\u03b3\u03b3\u03b5\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03af\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9 <strong>\u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03b4\u03bf\u03c7\u03b5\u03af\u03bf \u03b1\u03b9\u03c7\u03bc\u03b7\u03c1\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c3\u03c4\u03b1 \u03ba\u03bf\u03b9\u03bd\u03ac \u03b1\u03c0\u03bf\u03c1\u03c1\u03af\u03bc\u03bc\u03b1\u03c4\u03b1 \u03ae \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c7\u03ad\u03c4\u03b5\u03c5\u03c3\u03b7. \u039f \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03c0\u03bf\u03b9\u03cc\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03ce\u03c3\u03b5\u03b9 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae \u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7.<\/p>\n<p style=\"margin-top: 12px; line-height: 1.7; color: #374151;\">\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03b4\u03b9\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03b6\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf Prolia \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 <strong>\u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc<\/strong> \u03ba\u03b1\u03b8\u2019 \u03cc\u03bb\u03b7 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5. \u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03bf denosumab \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03bf \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c7\u03b5\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 13 ==================== --><\/p>\n<section id=\"faq\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">13<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\"><strong>\u039f\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c0\u03b1\u03bd\u03c4\u03bf\u03cd\u03bd \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b1\u03c0\u03bf\u03c1\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf Prolia.<\/strong> \u039f\u03b9 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 patient-friendly, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03b5\u03c1\u03ac\u03c0\u03bf\u03bd\u03c4\u03bf\u03c2 \u03b9\u03b1\u03c4\u03c1\u03bf\u03cd.<\/p>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c3\u03bf \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03b4\u03c1\u03b1 \u03c4\u03bf Prolia;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u039f\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 <strong>\u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/strong> \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7. \u0397 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 (BMD) \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c0\u03b9\u03bf \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae\u03c2 <strong>\u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 6\u201312 \u03bc\u03ae\u03bd\u03b5\u03c2<\/strong> \u03c3\u03c5\u03bd\u03b5\u03c7\u03bf\u03cd\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bc\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u039d\u03b1\u03b9. \u03a4\u03bf Prolia \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 <strong>\u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5<\/strong> \u03b1\u03bd \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1. \u0397 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03bb\u03ae\u03c8\u03b7 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03ce\u03b4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03c9 \u03b1\u03bd \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03ae\u03c3\u03c9 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u0391\u03bd \u03c0\u03b5\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 6 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03ad\u03bd\u03b5\u03c3\u03b7, <strong>\u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03ac\u03c4\u03b9\u03c3\u03b5 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd<\/strong>. \u039c\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03b9\u03c2 \u03c4\u03bf\u03bd \u201c\u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03ba\u03cd\u03ba\u03bb\u03bf\u201d, \u03b3\u03b9\u03b1\u03c4\u03af \u03b7 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf rebound \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03bf\u03c3\u03c4\u03bf\u03cd.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039d\u03b9\u03ce\u03b8\u03c9 \u03bc\u03c5\u03c1\u03bc\u03b7\u03ba\u03af\u03b1\u03c3\u03b7 \u03ae \u03ba\u03c1\u03ac\u03bc\u03c0\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b5\u03c3\u03b7. \u0395\u03af\u03bd\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd <strong>\u03ae\u03c0\u03b9\u03b1 \u03c5\u03c0\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong>. \u0395\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03ce\u03bd\u03b7\u03c3\u03b5 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ba\u03ac\u03bd\u03b5 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd. \u03a3\u03c5\u03c7\u03bd\u03ac \u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 D.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03ba\u03ac\u03bd\u03c9 \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ae \u03b4\u03bf\u03bd\u03c4\u03b9\u03bf\u03cd \u03b5\u03bd\u03ce \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03c9 Prolia;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u039d\u03b1\u03b9, \u03b1\u03bb\u03bb\u03ac \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae. \u0399\u03b4\u03b1\u03bd\u03b9\u03ba\u03ac, \u03bf\u03b9 \u03b5\u03c0\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 <strong>\u03bc\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1 \u03c4\u03b7\u03c2 \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b5 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03b4\u03bf\u03bd\u03c4\u03b9\u03ac\u03c4\u03c1\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9\u03c2 denosumab.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03c9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 <strong>\u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03c6\u03c9\u03c3\u03c6\u03cc\u03c1\u03bf\u03c2 \u03bf\u03c1\u03bf\u03cd<\/strong> \u03c0\u03c1\u03b9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b5\u03c3\u03b7, <strong>\u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D<\/strong> \u03ba\u03ac\u03b8\u03b5 6\u201312 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 <strong>DEXA<\/strong> \u03ba\u03ac\u03b8\u03b5 1\u20132 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1. \u0391\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2 \u03ae \u03ac\u03bb\u03bb\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1, \u03bf\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03b9 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03ba\u03ac\u03bd\u03c9 \u03c4\u03bf Prolia \u03bc\u03cc\u03bd\u03bf\u03c2 \u03ae \u03bc\u03cc\u03bd\u03b7 \u03bc\u03bf\u03c5 \u03c3\u03c4\u03bf \u03c3\u03c0\u03af\u03c4\u03b9;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u038c\u03c7\u03b9. \u0397 \u03ad\u03bd\u03b5\u03c3\u03b7 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 <strong>\u03b1\u03c0\u03cc \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2<\/strong> \u03bc\u03b5 \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 \u03c3\u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c1\u03af\u03c9\u03bd \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03bd \u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ae\u03c3\u03c9 \u03c4\u03bf Prolia;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u0397 \u03b4\u03b9\u03b1\u03ba\u03bf\u03c0\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 <strong>\u201crebound\u201d \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bf\u03c3\u03c4\u03bf\u03cd<\/strong> \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03c3\u03c7\u03ad\u03b4\u03b9\u03bf \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7\u03c2, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bd\u03b9\u03ba\u03cc.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u039d\u03b1\u03b9, \u03bc\u03b5 <strong>\u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong>. \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 10 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03cc\u03c4\u03b1\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b2\u03b9\u03c4\u03b1\u03bc\u03af\u03bd\u03b7 D.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03ce \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03c3\u03c9 \u03c4\u03bf Prolia \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7\u03c2;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 <strong>\u03cc\u03c7\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1<\/strong> \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1. \u039f\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7 \u03ae \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03b5 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03bf.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c3\u03ba\u03bf\u03cd\u03bc\u03b1\u03b9 \u03b5\u03bd\u03ce \u03c0\u03b1\u03af\u03c1\u03bd\u03c9 Prolia;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u039d\u03b1\u03b9. \u0397 <strong>\u03ac\u03c3\u03ba\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03b2\u03ac\u03c1\u03bf\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03b7 <strong>\u03bc\u03c5\u03ca\u03ba\u03ae \u03b5\u03bd\u03b4\u03c5\u03bd\u03ac\u03bc\u03c9\u03c3\u03b7<\/strong> \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2, \u03c3\u03c4\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd.<\/div>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9\u03c1\u03cc \u03b8\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03c3\u03c9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1;<\/summary>\n<div style=\"margin-top: 10px; line-height: 1.7; color: #374151;\">\u0397 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03bf\u03c5. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd <strong>3\u20135 \u03ad\u03c4\u03b7<\/strong> \u03c3\u03c5\u03bd\u03b5\u03c7\u03bf\u03cd\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03bc\u03b5 \u03b5\u03c0\u03b1\u03bd\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03ac\u03b8\u03b5 1\u20132 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1.<\/div>\n<\/details>\n<p style=\"margin-top: 14px; line-height: 1.7; color: #374151;\">\u0397 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b9\u03b1\u03c4\u03c1\u03cc \u03ba\u03b1\u03b9 \u03bf \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b5\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03b6\u03bf\u03c5\u03bd <strong>\u03b1\u03c3\u03c6\u03b1\u03bb\u03ae \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/strong> \u03bc\u03b5 Prolia. \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03bb\u03ac\u03b8\u03b7, \u03c4\u03b9\u03c2 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<section id=\"bibliografia\" style=\"margin: 14px 0;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(135deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: inset 0 1px 0 rgba(255,255,255,0.75),0 6px 16px rgba(17,24,39,0.12); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-weight: 900; font-size: 14px; color: #111827;\">14<\/span><\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b7\u03b3\u03ad\u03c2<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.7; color: #374151;\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<p style=\"margin: 14px 0 14px; line-height: 1.7; color: #374151;\">\u0397 \u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b5\u03c2 \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b7\u03b3\u03ad\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf denosumab (Prolia\u00ae), \u03c4\u03b7\u03bd \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c5\u03c0\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/p>\n<div style=\"margin: 6px 0; padding-left: 10px; border-left: 3px solid #e5e7eb; line-height: 1.35;\">Cummings SR, San Martin J, McClung MR, et al. <em>Denosumab for prevention of fractures in postmenopausal women with osteoporosis.<\/em><br \/>\n<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa0809493\" target=\"_blank\" rel=\"nofollow noopener\">New England Journal of Medicine, 2009;361:756\u2013765<\/a><\/div>\n<div style=\"margin: 6px 0; padding-left: 10px; border-left: 3px solid #e5e7eb; line-height: 1.35;\">Bone HG, et al. <em>Ten years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension trial.<\/em><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29154451\/\" target=\"_blank\" rel=\"nofollow noopener\">Journal of Bone and Mineral Research, 2017<\/a><\/div>\n<div style=\"margin: 6px 0; padding-left: 10px; border-left: 3px solid #e5e7eb; line-height: 1.35;\">Eastell R, et al. <em>Management of hypocalcemia during denosumab therapy for osteoporosis.<\/em><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27237051\/\" target=\"_blank\" rel=\"nofollow noopener\">Journal of Clinical Endocrinology &amp; Metabolism, 2016<\/a><\/div>\n<div style=\"margin: 6px 0; padding-left: 10px; border-left: 3px solid #e5e7eb; line-height: 1.35;\">Tsourdi E, Zillikens MC, et al. <em>Fracture risk and management after discontinuation of denosumab: a systematic review and position statement by ECTS.<\/em><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31612557\/\" target=\"_blank\" rel=\"nofollow noopener\">Bone, 2019<\/a><\/div>\n<div style=\"margin: 6px 0; padding-left: 10px; border-left: 3px solid #e5e7eb; line-height: 1.35;\">European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO). <em>Practical guidance for long-term management of osteoporosis with denosumab.<\/em><br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34741399\/\" target=\"_blank\" rel=\"nofollow noopener\">Aging Clinical and Experimental Research, 2022<\/a><\/div>\n<div style=\"margin: 6px 0; padding-left: 10px; border-left: 3px solid #e5e7eb; line-height: 1.35;\">\u0395\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae \u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1. <em>\u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u0394\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u039c\u03b5\u03c4\u03b5\u03bc\u03bc\u03b7\u03bd\u03bf\u03c0\u03b1\u03c5\u03c3\u03b9\u03b1\u03ba\u03ae\u03c2 \u039f\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7\u03c2.<\/em><br \/>\n<a href=\"https:\/\/www.endo.gr\" target=\"_blank\" rel=\"nofollow noopener\">www.endo.gr<\/a><\/div>\n<div style=\"margin: 6px 0; padding-left: 10px; border-left: 3px solid #e5e7eb; line-height: 1.35;\">\u0395\u039f\u03a6 (\u0395\u03b8\u03bd\u03b9\u03ba\u03cc\u03c2 \u039f\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd). <em>\u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03a0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 (\u03a0\u03a7\u03a0) Prolia\u00ae 60 mg\/ml.<\/em><br \/>\n<a href=\"https:\/\/www.eof.gr\/web\/guest\/medicine\" target=\"_blank\" rel=\"nofollow noopener\">www.eof.gr<\/a><\/div>\n<div style=\"margin: 6px 0; padding-left: 10px; border-left: 3px solid #e5e7eb; line-height: 1.35;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Prolia\u00ae (Denosumab): \u03a6\u03b9\u03bb\u03b9\u03ba\u03cc\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2 \u0391\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b3\u03b9\u03b1 \u0391\u03c3\u03c6\u03b1\u03bb\u03ae \u03a7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 7 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 Prolia\u00ae \u2014 \u039a\u03ac\u03c1\u03c4\u03b1 \u0392\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd \u03a3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd \u0392\u0391\u03a3\u0399\u039a\u0391 \u03a3\u03a4\u039f\u0399\u03a7\u0395\u0399\u0391 \u0395\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ae \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1: Prolia\u00ae \u0394\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1: Denosumab \u039a\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1: \u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1, \u03b1\u03bd\u03c4\u03b9\u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u039c\u03bf\u03c1\u03c6\u03ae: \u03a0\u03c1\u03bf\u03b3\u03b5\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c3\u03cd\u03c1\u03b9\u03b3\u03b3\u03b1 60 mg\/mL \u0395\u039d\u0394\u0395\u0399\u039e\u0395\u0399\u03a3 \u039c\u03b5\u03c4\u03b5\u03bc\u03bc\u03b7\u03bd\u03bf\u03c0\u03b1\u03c5\u03c3\u03b9\u03b1\u03ba\u03ae \u03bf\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u039f\u03c3\u03c4\u03b5\u03bf\u03c0\u03cc\u03c1\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u039f\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b1\u03c0\u03cc \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03a0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c4\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd 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