{"id":6283,"date":"2025-09-29T10:21:33","date_gmt":"2025-09-29T07:21:33","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=6283"},"modified":"2026-03-30T20:44:33","modified_gmt":"2026-03-30T17:44:33","slug":"anti-scl-70","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/anti-scl-70\/","title":{"rendered":"\u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 anti-Scl-70: \u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9, \u03c0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9, \u03c0\u03ce\u03c2 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u2013 \u03a6\u03b9\u03bb\u03b9\u03ba\u03cc\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2"},"content":{"rendered":"<article style=\"max-width: 1000px; margin: 0 auto; font-family: system-ui,-apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif; color: #111827;\">\n<h1 style=\"font-size: 44px; line-height: 1.15; font-weight: 800; margin: 0 0 14px; color: #111827;\">Anti-Scl-70 (\u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03a4\u03bf\u03c0\u03bf\u03ca\u03c3\u03bf\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7\u03c2 I): \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd, \u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9, \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 &amp; \u03a3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03a3\u03ba\u03bb\u03b7\u03c1\u03cc\u03b4\u03b5\u03c1\u03bc\u03b1<\/h1>\n<div style=\"margin: 10px 0 12px; font-size: 13px; color: #6b7280;\">\u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: <time datetime=\"2025-09-29\">29 \u03a3\u03b5\u03c0\u03c4\u03b5\u03bc\u03b2\u03c1\u03af\u03bf\u03c5 2025<\/time> \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: <time datetime=\"2026-03-30\">30 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time><\/div>\n<p><!-- ==================== MINI INFOBOX ==================== --><\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0 16px;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03be\u03ad\u03c1\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b1\u03c4\u03b9\u03ac:<\/strong> \u03a4\u03b1 <strong>anti-Scl-70<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 <strong>DNA \u03c4\u03bf\u03c0\u03bf\u03ca\u03c3\u03bf\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7\u03c2 I<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03c4\u03b7 <strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf <strong>\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2<\/strong>. \u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5, \u03ba\u03b1\u03b9 <strong>\u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2<\/strong> \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7. \u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 <strong>Raynaud<\/strong>, \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b4\u03cd\u03c3\u03c0\u03bd\u03bf\u03b9\u03b1, \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2, ANA, capillaroscopy \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd.<\/div>\n<p><!-- ==================== TOC ==================== --><\/p>\n<nav id=\"toc\" style=\"background: #f9fafb; border-radius: 14px; padding: 18px 18px 14px; margin: 0 0 18px;\">\n<div style=\"font-size: 18px; font-weight: 800; margin: 0 0 10px; color: #111827;\">\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/div>\n<ol style=\"margin: 0; padding-left: 18px; line-height: 1.8;\">\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section1\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 anti-Scl-70<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section2\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ac<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section3\">\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section4\">\u03a0\u03bf\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03bd\u03b1 \u03c4\u03b7 \u03b6\u03b7\u03c4\u03ae\u03c3\u03b5\u03b9<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section5\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section6\">\u03a0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section7\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section8\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-Scl-70 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section9\">\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc anti-Scl-70: \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf;<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section10\">\u03a8\u03b5\u03c5\u03b4\u03ce\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section11\">Anti-Scl-70, anti-centromere \u03ba\u03b1\u03b9 anti-RNA polymerase III<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section12\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section13\">\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac\u03c2, \u03bd\u03b5\u03c6\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section14\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section15\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section16\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section17\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: none; border-top: 2px solid #d1d5db; margin: 0 0 24px;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<section id=\"section1\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">1<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 anti-Scl-70<\/span><\/h2>\n<p>\u03a4\u03b1 <strong>anti-Scl-70<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong>, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c9\u03c2 \u00ab\u03c3\u03c4\u03cc\u03c7\u03bf\u00bb \u03ad\u03bd\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd. \u03a3\u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 <strong>DNA \u03c4\u03bf\u03c0\u03bf\u03ca\u03c3\u03bf\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7\u03c2 I<\/strong>, \u03b5\u03bd\u03cc\u03c2 \u03b5\u03bd\u03b6\u03cd\u03bc\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 DNA. \u03a4\u03bf \u03cc\u03bd\u03bf\u03bc\u03b1 <strong>Scl-70<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03bf\u03c1\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u03b3\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7 \u03b8\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03cc\u03c1\u03bf\u03b9: <em>anti-Scl-70<\/em> \u03ba\u03b1\u03b9 <em>anti-topoisomerase I<\/em>.<\/p>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03b3\u03b9\u03b1\u03c4\u03af \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03b3\u03bd\u03c9\u03c3\u03c4\u03ac \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7 <strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7<\/strong> \u03ae <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03cc\u03b4\u03b5\u03c1\u03bc\u03b1<\/strong>. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03bc\u03c9\u03c2 \u00ab\u03b3\u03b5\u03bd\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2\u00bb. \u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-Scl-70 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b3\u03b9\u03b1 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae.<\/p>\n<p>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03be\u03ae\u03c2: \u03c4\u03b1 anti-Scl-70 <strong>\u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/strong>. \u0395\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 <strong>\u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2<\/strong> \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf. \u0397 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc, \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03b9\u03bc\u03b5\u03bd\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03b7\u03bd capillaroscopy (\u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03bf\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03bf\u03bd\u03c5\u03c7\u03bf\u03c6\u03cc\u03c1\u03bf\u03c5 \u03c0\u03c4\u03c5\u03c7\u03ae\u03c2) \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03c4\u03b1 anti-Scl-70 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2, \u03cc\u03c0\u03c9\u03c2 <strong>ELISA<\/strong>, <strong>multiplex assays<\/strong>, <strong>immunoblot<\/strong> \u03ae \u03ac\u03bb\u03bb\u03b1 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac panels. \u0391\u03c5\u03c4\u03ae \u03b7 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03ad\u03c1\u03b5\u03b9\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae. \u0388\u03c7\u03b5\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03b3\u03b9\u03b1\u03c4\u03af \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc.<\/p>\n<p>\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae, \u03b7 \u03c0\u03b9\u03bf \u03c3\u03c9\u03c3\u03c4\u03ae \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ae: \u03c4\u03bf anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 <strong>\u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03b1\u03c5\u03c4\u03ac\u03c1\u03ba\u03b7\u03c2<\/strong> \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7. \u0391\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c0\u03bf\u03c5 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03ad\u03c1\u03b5\u03b9\u03b5\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03c9\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 2 ==================== --><\/p>\n<section id=\"section2\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">2<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03ac<\/span><\/h2>\n<p>\u0397 <strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd. \u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03c1\u03b5\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2: <strong>\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7<\/strong>, <strong>\u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 <strong>\u03af\u03bd\u03c9\u03c3\u03b7<\/strong>. \u0391\u03c5\u03c4\u03cc \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03bc\u03b9\u03ba\u03c1\u03ac \u03b1\u03b3\u03b3\u03b5\u03af\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9, \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b9\u03c3\u03c4\u03bf\u03af \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03c5\u03bd \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03ba\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03ac\u03c7\u03c5\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b4\u03ad\u03c1\u03bc\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1.<\/p>\n<p>\u0397 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7, \u03b5\u03bd\u03ce \u03c3\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03ba\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf \u03b4\u03ad\u03c1\u03bc\u03b1 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 <strong>\u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2<\/strong>, \u03c4\u03bf\u03bd <strong>\u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf<\/strong>, \u03c4\u03b7\u03bd <strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03ac<\/strong>, \u03c4\u03bf\u03c5\u03c2 <strong>\u03bd\u03b5\u03c6\u03c1\u03bf\u03cd\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c3\u03c4\u03b1 \u03ac\u03ba\u03c1\u03b1. \u0391\u03c5\u03c4\u03ae \u03b7 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1: \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bd\u03b1 \u03c3\u03c4\u03b7\u03c1\u03b9\u03c7\u03b8\u03b5\u03af \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03b5\u03af <strong>\u03c0\u03bf\u03b9\u03bf\u03c2 \u03c5\u03c0\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2<\/strong>.<\/p>\n<p>\u03a4\u03b1 anti-Scl-70 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 <strong>\u03b4\u03b9\u03ac\u03c7\u03c5\u03c4\u03b7 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae<\/strong> \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 <strong>\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/strong>. \u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b8\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03af\u03bd\u03c9\u03c3\u03b7 \u03ae \u03cc\u03c4\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2. \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03cc\u03c4\u03b9, \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03b1\u03b9\u03c1\u03b9\u03ac\u03b6\u03b5\u03b9, \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03ce\u03c3\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd \u03b1\u03c0\u03cc \u03bd\u03c9\u03c1\u03af\u03c2.<\/p>\n<p>\u0397 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b4\u03b5\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03bc\u03b5 \u03b5\u03bd\u03c4\u03c5\u03c0\u03c9\u03c3\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c1\u03c7\u03af\u03c3\u03b5\u03b9 \u03bc\u03b5 <strong>Raynaud<\/strong>, \u03c0\u03c1\u03ae\u03be\u03b9\u03bc\u03bf \u03ae \u03b4\u03c5\u03c3\u03ba\u03b1\u03bc\u03c8\u03af\u03b1 \u03c4\u03c9\u03bd \u03b4\u03b1\u03ba\u03c4\u03cd\u03bb\u03c9\u03bd, \u03b1\u03af\u03c3\u03b8\u03b7\u03bc\u03b1 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b4\u03ad\u03c1\u03bc\u03b1 \u00ab\u03c4\u03c1\u03b1\u03b2\u03ac\u03b5\u03b9\u00bb, \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b5\u03c2 \u03ba\u03b1\u03bf\u03cd\u03c1\u03b5\u03c2, \u03b4\u03c5\u03c3\u03c6\u03b1\u03b3\u03af\u03b1, \u03b4\u03cd\u03c3\u03c0\u03bd\u03bf\u03b9\u03b1 \u03ae \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03ad\u03bd\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf anti-Scl-70, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03bd\u03b1 \u03be\u03b5\u03c7\u03c9\u03c1\u03af\u03c3\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b1\u03c0\u03cc \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03ae \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2.<\/p>\n<p>\u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1, \u03b7 \u03c3\u03c4\u03b5\u03bd\u03ae \u03c3\u03c7\u03ad\u03c3\u03b7 \u03c4\u03c9\u03bd anti-Scl-70 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03ba\u03bb\u03b7\u03c1\u03cc\u03b4\u03b5\u03c1\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae. \u0395\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b2\u03bf\u03b7\u03b8\u03ac \u03c4\u03bf\u03bd \u03b9\u03b1\u03c4\u03c1\u03cc \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c8\u03af\u03b1, \u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03c9\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd-\u03c3\u03c4\u03cc\u03c7\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c7\u03b5\u03b4\u03b9\u03ac\u03c3\u03b5\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 3 ==================== --><\/p>\n<section id=\"section3\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">3<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/span><\/h2>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 <strong>anti-Scl-70<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1\u03c2, \u03bf\u03cd\u03c4\u03b5 \u03ad\u03c7\u03b5\u03b9 \u03bb\u03cc\u03b3\u03bf \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc. \u0396\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03ad\u03c7\u03b5\u03b9 <strong>\u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1<\/strong> \u03b3\u03b9\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03ae \u03b8\u03ad\u03bb\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03b9\u03bd\u03af\u03c3\u03b5\u03b9 \u03b1\u03bd \u03bc\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03c4\u03bf \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03c9\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n<p>\u039f \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03cc\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 <strong>Raynaud<\/strong>, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b1\u03ba\u03c4\u03c5\u03bb\u03af\u03b1, \u03c0\u03c1\u03ae\u03be\u03b9\u03bc\u03bf \u03c7\u03b5\u03c1\u03b9\u03ce\u03bd, \u03c0\u03ac\u03c7\u03c5\u03bd\u03c3\u03b7 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 ANA. \u03a3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf anti-Scl-70 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03ae \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf <strong>panel \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>, \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 <strong>anti-centromere<\/strong>, <strong>anti-RNA polymerase III<\/strong>, \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 ENA \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1 \u03b1\u03c0\u03cc \u03bd\u03cc\u03c3\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03cd\u03c3\u03c0\u03bd\u03bf\u03b9\u03b1, \u03b2\u03ae\u03c7\u03b1, \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7\u03bd \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7 \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03b1\u03c0\u03b5\u03b9\u03ba\u03cc\u03bd\u03b9\u03c3\u03b7 \u03b8\u03ce\u03c1\u03b1\u03ba\u03bf\u03c2, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf Raynaud \u03ae \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2, \u03c4\u03bf anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03c3\u03c4\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc workup.<\/p>\n<p>\u0386\u03bb\u03bb\u03b7 \u03c3\u03c5\u03c7\u03bd\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 <strong>\u03c5\u03c0\u03bf\u03c4\u03c5\u03c0\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae\u03c2 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2<\/strong>. \u039f \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b8\u03ad\u03bb\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bd\u03b1 \u03b2\u03ac\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bb\u03ac\u03b2\u03b5\u03b9 \u03c0\u03bf\u03b9\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ad\u03c7\u03b5\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2, \u03c0\u03bf\u03b9\u03b1 \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03c0\u03cc\u03c3\u03bf \u03c3\u03c4\u03b5\u03bd\u03ae \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7. \u0395\u03ba\u03b5\u03af \u03c4\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1.<\/p>\n<p>\u03a3\u03b5 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03c4\u03bf anti-Scl-70 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>overlap \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf<\/strong>, \u03cc\u03c4\u03b1\u03bd \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1. \u0391\u03bd \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bc\u03c5\u03b1\u03bb\u03b3\u03af\u03b5\u03c2, \u03b1\u03c1\u03b8\u03c1\u03b1\u03bb\u03b3\u03af\u03b5\u03c2, ANA, Raynaud \u03ba\u03b1\u03b9 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae, \u03c4\u03bf anti-Scl-70 \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03c6\u03b1\u03bd\u03b5\u03af \u03b1\u03bd \u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03ac\u03be\u03bf\u03bd\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 4 ==================== --><\/p>\n<section id=\"section4\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">4<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bf\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03bd\u03b1 \u03c4\u03b7 \u03b6\u03b7\u03c4\u03ae\u03c3\u03b5\u03b9<\/span><\/h2>\n<p>\u03a4\u03bf \u03c3\u03cd\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03bf\u03bb\u03cd \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03bd\u03bf\u03af\u03b3\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf <strong>\u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf Raynaud<\/strong>: \u03c4\u03b1 \u03b4\u03ac\u03ba\u03c4\u03c5\u03bb\u03b1 \u03b1\u03bb\u03bb\u03ac\u03b6\u03bf\u03c5\u03bd \u03c7\u03c1\u03ce\u03bc\u03b1 \u03c3\u03c4\u03bf \u03ba\u03c1\u03cd\u03bf \u03ae \u03c3\u03c4\u03bf stress, \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bb\u03b5\u03c5\u03ba\u03ac, \u03bc\u03b5\u03c4\u03ac \u03bc\u03b5\u03bb\u03b1\u03bd\u03ac \u03ae \u03bc\u03c9\u03b2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03cc\u03c0\u03b9\u03bd \u03ba\u03bf\u03ba\u03ba\u03b9\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03cc\u03c4\u03b1\u03bd \u03b5\u03c0\u03b1\u03bd\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b1\u03b9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7. \u038c\u03c4\u03b1\u03bd \u03c4\u03bf Raynaud \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03bf, \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7\u03c2 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2, \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03cc\u03bd\u03bf, \u03ad\u03bb\u03ba\u03b7, \u03b1\u03bd\u03ce\u03bc\u03b1\u03bb\u03b7 \u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03bf\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd, \u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2.<\/p>\n<p>\u0395\u03be\u03af\u03c3\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf <strong>\u03b4\u03ad\u03c1\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c7\u03ad\u03c1\u03b9\u03b1<\/strong>. \u03a0\u03c1\u03ae\u03be\u03b9\u03bc\u03bf \u03b4\u03b1\u03ba\u03c4\u03cd\u03bb\u03c9\u03bd, \u03b1\u03af\u03c3\u03b8\u03b7\u03bc\u03b1 \u00ab\u03c3\u03c6\u03b9\u03be\u03af\u03bc\u03b1\u03c4\u03bf\u03c2\u00bb, \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b1 \u03bd\u03b1 \u03b1\u03c6\u03b1\u03b9\u03c1\u03b5\u03b8\u03bf\u03cd\u03bd \u03b4\u03b1\u03c7\u03c4\u03c5\u03bb\u03af\u03b4\u03b9\u03b1, \u03c0\u03ac\u03c7\u03c5\u03bd\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b1\u03ba\u03c4\u03c5\u03bb\u03af\u03b1, \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b4\u03b1\u03ba\u03c4\u03cd\u03bb\u03c9\u03bd, \u03c4\u03b7\u03bb\u03b1\u03b3\u03b3\u03b5\u03b9\u03b5\u03ba\u03c4\u03b1\u03c3\u03af\u03b5\u03c2 \u03ae \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03bf\u03c5\u03bb\u03ad\u03c2\/\u03ad\u03bb\u03ba\u03b7 \u03c3\u03c4\u03b1 \u03b1\u03ba\u03c1\u03bf\u03b4\u03ac\u03ba\u03c4\u03c5\u03bb\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c8\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7.<\/p>\n<p>\u03a0\u03bf\u03bb\u03bb\u03bf\u03af \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c6\u03c4\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bb\u03cc\u03b3\u03c9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf <strong>\u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03cc<\/strong> \u03ae \u03c4\u03bf <strong>\u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc<\/strong>. \u03a0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03cd\u03c3\u03c0\u03bd\u03bf\u03b9\u03b1, \u03be\u03b7\u03c1\u03cc\u03c2 \u03b2\u03ae\u03c7\u03b1\u03c2, \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7\u03bd \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7 \u03ae \u03bc\u03b7 \u03b1\u03bd\u03b1\u03bc\u03b5\u03bd\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c0\u03b9\u03c1\u03bf\u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03ae \u03c3\u03c4\u03b7\u03bd HRCT \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf anti-Scl-70. \u03a4\u03bf \u03af\u03b4\u03b9\u03bf \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b5\u03c2 \u03ba\u03b1\u03bf\u03cd\u03c1\u03b5\u03c2, \u03c0\u03b1\u03bb\u03b9\u03bd\u03b4\u03c1\u03cc\u03bc\u03b7\u03c3\u03b7, \u03b1\u03af\u03c3\u03b8\u03b7\u03bc\u03b1 \u03cc\u03c4\u03b9 \u03b7 \u03c4\u03c1\u03bf\u03c6\u03ae \u00ab\u03ba\u03bf\u03bb\u03bb\u03ac\u03b5\u03b9\u00bb, \u03bc\u03b5\u03c4\u03b5\u03c9\u03c1\u03b9\u03c3\u03bc\u03cc \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf\u03c5.<\/p>\n<p>\u0386\u03bb\u03bb\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03b1\u03b6\u03bb \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 <strong>\u03ba\u03cc\u03c0\u03c9\u03c3\u03b7<\/strong>, \u03bf\u03b9 <strong>\u03b1\u03c1\u03b8\u03c1\u03b1\u03bb\u03b3\u03af\u03b5\u03c2<\/strong>, \u03bf\u03b9 <strong>\u03bc\u03c5\u03b1\u03bb\u03b3\u03af\u03b5\u03c2<\/strong>, \u03b7 \u03b4\u03c5\u03c3\u03ba\u03b1\u03bc\u03c8\u03af\u03b1, \u03b7 \u03be\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ae \u03bc\u03b9\u03b1 \u03b1\u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03af\u03bd\u03b9\u03c3\u03c4\u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2. \u0391\u03c0\u03cc \u03bc\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5 Raynaud, ANA \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1, \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03c4\u03b5\u03b8\u03b5\u03af \u03c4\u03bf anti-Scl-70 \u03c3\u03c4\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c7\u03ae\u03bc\u03b1.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b4\u03b5\u03bd \u03c8\u03ac\u03c7\u03bd\u03b5\u03b9 \u03c0\u03bf\u03c4\u03ad \u03ad\u03bd\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c3\u03cd\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1. \u03a8\u03ac\u03c7\u03bd\u03b5\u03b9 \u03ad\u03bd\u03b1 <strong>\u03bc\u03bf\u03c4\u03af\u03b2\u03bf<\/strong>. \u038c\u03c3\u03bf \u03c0\u03b9\u03bf \u03be\u03b5\u03ba\u03ac\u03b8\u03b1\u03c1\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03bc\u03bf\u03c4\u03af\u03b2\u03bf, \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd anti-Scl-70.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 16px 0 12px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div style=\"overflow-x: auto;\">\n<table style=\"width: 100%; border-collapse: collapse; min-width: 760px; font-size: 15px;\">\n<thead>\n<tr>\n<th style=\"text-align: left; padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1<\/th>\n<th style=\"text-align: left; padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u0393\u03b9\u03b1\u03c4\u03af \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc<\/th>\n<th style=\"text-align: left; padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u0393\u03b9\u03b1\u03c4\u03af \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af anti-Scl-70<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">Raynaud<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u03a3\u03c5\u03c7\u03bd\u03cc \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u0392\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b1\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bb\u03cc \u03b1\u03b3\u03b3\u03b5\u03b9\u03cc\u03c3\u03c0\u03b1\u03c3\u03bc\u03bf \u03ae \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u03a3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b1\u03ba\u03c4\u03c5\u03bb\u03af\u03b1 \/ \u03c0\u03ac\u03c7\u03c5\u03bd\u03c3\u03b7 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u039a\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u03a3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u0394\u03cd\u03c3\u03c0\u03bd\u03bf\u03b9\u03b1 \/ \u03b2\u03ae\u03c7\u03b1\u03c2<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u03a4\u03b1 anti-Scl-70 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u039a\u03b1\u03bf\u03cd\u03c1\u03b5\u03c2 \/ \u03b4\u03c5\u03c3\u03c6\u03b1\u03b3\u03af\u03b1<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03ba\u03b9\u03bd\u03b7\u03c3\u03af\u03b1<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u0395\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px;\">\u0398\u03b5\u03c4\u03b9\u03ba\u03ac ANA \/ \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf pattern<\/td>\n<td style=\"padding: 10px;\">\u03a5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1<\/td>\n<td style=\"padding: 10px;\">\u039f\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c0\u03b9\u03bf \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 anti-Scl-70<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<section id=\"section5\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">5<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/span><\/h2>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03b1\u03c0\u03bb\u03ae \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1<\/strong> \u03b1\u03c0\u03cc \u03c6\u03bb\u03ad\u03b2\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03c1\u03b9\u03ad\u03c4\u03b1\u03b9 \u03c3\u03b5 <strong>\u03bf\u03c1\u03cc \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong>. \u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b4\u03b5\u03bd \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2. \u0397 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03b4\u03b9\u03b1\u03b9\u03c4\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b5\u03bd \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 \u03b1\u03bb\u03bb\u03ac \u03c3\u03c4\u03b7 <strong>\u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<p>\u03a3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03ac \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1 \u03c4\u03bf anti-Scl-70 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 <strong>panel \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03c5\u03bc\u03ad\u03bd\u03c9\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac ANA \u03ae \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd. \u03a3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1. \u03a3\u03c5\u03c7\u03bd\u03ac \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b8\u03b1 \u03c4\u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03c3\u03b5\u03b9 \u03bc\u03b5 ANA by IFA, anti-centromere, anti-RNA polymerase III \u03ba\u03b1\u03b9, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7, \u03bc\u03b5 ENA, \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/p>\n<p>\u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c9\u03c2 <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc<\/strong>, <strong>\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc<\/strong> \u03ae <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc<\/strong>, \u03b5\u03bd\u03ce \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 <strong>\u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2<\/strong> \u03ae <strong>\u03c4\u03af\u03c4\u03bb\u03bf<\/strong>. \u0397 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b1\u03c1\u03b9\u03b8\u03bc\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b9\u03bc\u03ae\u03c2 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03cc\u03c4\u03b9 \u03bf \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03b9\u03c3\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b5\u03af \u03bc\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u03a3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf anti-Scl-70, \u03b1\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03af\u03c7\u03b9\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b7 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b1.<\/p>\n<p>\u0391\u03be\u03af\u03b6\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03c0\u03b9\u03c3\u03c4\u03af\u03b1. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03bc\u03c6\u03af\u03b2\u03bf\u03bb\u03bf \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b4\u03b5\u03bd \u03c4\u03b1\u03b9\u03c1\u03b9\u03ac\u03b6\u03b5\u03b9, \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03ae\u03c3\u03b5\u03b9 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03ae \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf.<\/p>\n<p>\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1: \u03b7 \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ae, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7. \u0391\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03c0\u03b9\u03bf \u03b1\u03c0\u03bb\u03cc \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<section id=\"section6\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">6<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1<\/span><\/h2>\n<p>\u0393\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd anti-Scl-70 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 <strong>\u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c3\u03c4\u03b7\u03c1\u03ae \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1<\/strong>. \u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03cc\u03bc\u03c9\u03c2 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2, \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03ae \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03cc \u03bd\u03b1 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03cd \u03ae \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03c0\u03b1\u03ba\u03ad\u03c4\u03bf \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd. \u0391\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03c3\u03ac\u03ba\u03c7\u03b1\u03c1\u03bf, \u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03ae \u03ac\u03bb\u03bb\u03bf\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03bd\u03b1 \u03c0\u03ac\u03c4\u03b5 \u03c0\u03c1\u03c9\u03b9\u03bd\u03ad\u03c2 \u03ce\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b7\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2\/\u03ae.<\/p>\n<p>\u03a0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03bd\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03ce\u03c3\u03b5\u03c4\u03b5 \u03b3\u03b9\u03b1 <strong>\u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1<\/strong> \u03ba\u03b1\u03b9 <strong>\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong>, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03b1\u03bb\u03c4\u03b9\u03ba\u03ac, \u03ba\u03bf\u03c1\u03c4\u03b9\u03ba\u03bf\u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae, \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ae \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b2\u03b9\u03bf\u03c4\u03af\u03bd\u03b7\u03c2. \u03a4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03b1\u03c5\u03c4\u03ac \u03b4\u03b5\u03bd \u00ab\u03bc\u03b7\u03b4\u03b5\u03bd\u03af\u03b6\u03bf\u03c5\u03bd\u00bb \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ae \u03c4\u03b7 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae \u03c0\u03bf\u03c5 \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af \u03c0\u03b9\u03bf \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2.<\/p>\n<p>\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b5 \u03b1\u03bd \u03c5\u03c0\u03ae\u03c1\u03be\u03b5 <strong>\u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7<\/strong>, \u03ad\u03bd\u03c4\u03bf\u03bd\u03bf \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03c2 \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf \u03ae \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03bf\u03c2 \u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2. \u038c\u03c7\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03ba\u03ac\u03b8\u03b5 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03c7\u03b1\u03bb\u03ac\u03b5\u03b9 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b3\u03b9\u03b1\u03c4\u03af \u03c3\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc workup \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b1\u03af\u03b6\u03b5\u03b9 \u03c1\u03cc\u03bb\u03bf. \u039f \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b8\u03ad\u03bb\u03b5\u03b9 \u03bd\u03b1 \u03be\u03ad\u03c1\u03b5\u03b9 \u03b1\u03bd \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af \u03c3\u03b5 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ae \u03c3\u03b5 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cc \u03bd\u03b1 \u03c0\u03ac\u03c4\u03b5 \u03b3\u03b9\u03b1 \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 <strong>\u03be\u03b5\u03ba\u03bf\u03cd\u03c1\u03b1\u03c3\u03c4\u03bf\u03c2\/\u03b7<\/strong>, \u03ba\u03b1\u03bb\u03ac \u03b5\u03bd\u03c5\u03b4\u03b1\u03c4\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2\/\u03b7 \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03b1\u03b3\u03c9\u03bd\u03af\u03b1. \u0391\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03bb\u03b9\u03c0\u03bf\u03b8\u03c5\u03bc\u03af\u03b1\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b5\u03c2, \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03ce\u03c3\u03c4\u03b5 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b9\u03ba\u03cc. \u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03ba\u03ac\u03c0\u03bf\u03b9\u03b1 \u03c0\u03bf\u03bb\u03cd\u03c0\u03bb\u03bf\u03ba\u03b7 \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03ba\u03b1\u03bb\u03ae \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03bb\u03b7\u03c6\u03b8\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac \u03cc\u03bb\u03bf\u03c2 \u03bf \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b7\u03bc\u03ad\u03c1\u03b1.<\/p>\n<p>\u0399\u03b4\u03b1\u03bd\u03b9\u03ba\u03ac, \u03c4\u03bf anti-Scl-70 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u00ab\u03bc\u03bf\u03bd\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u00bb, \u03b1\u03bb\u03bb\u03ac \u03c9\u03c2 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03b5\u03bd\u03cc\u03c2 <strong>\u03c3\u03c9\u03c3\u03c4\u03ac \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5<\/strong>. \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03ae\u03c8\u03b5\u03b9\u03c2, \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b3\u03c1\u03b7\u03b3\u03bf\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<section id=\"section7\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">7<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd<\/span><\/h2>\n<p>\u0397 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 anti-Scl-70 \u03b4\u03b5\u03bd \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ac. \u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc<\/strong>, <strong>\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc<\/strong> \u03ae <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5 \u03b1\u03be\u03af\u03b1 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03c1\u03af\u03b1 \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1: <strong>\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1<\/strong>, <strong>\u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7\u03c2<\/strong> \u03ba\u03b1\u03b9 <strong>\u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb<\/strong>.<\/p>\n<p>\u0388\u03bd\u03b1 <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 Raynaud, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b1\u03ba\u03c4\u03c5\u03bb\u03af\u03b1, \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac ANA \u03ba\u03b1\u03b9 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1. \u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03b9 \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c3\u03c4\u03bf \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03bf <em>pre-test probability<\/em>, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c3\u03c4\u03bf \u03c0\u03cc\u03c3\u03bf \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03ae\u03c4\u03b1\u03bd \u03ae\u03b4\u03b7 \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c0\u03c1\u03b9\u03bd \u03b3\u03af\u03bd\u03b5\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7.<\/p>\n<p>\u0388\u03bd\u03b1 <strong>\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc<\/strong> anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c4\u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae. \u0394\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03b3\u03bd\u03bf\u03b5\u03af\u03c4\u03b1\u03b9, \u03b1\u03bb\u03bb\u03ac \u03bf\u03cd\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf, \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 ANA by IFA, \u03b5\u03c0\u03b1\u03bd\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7. \u0397 \u03b2\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03bb\u03ac\u03b8\u03bf\u03c2.<\/p>\n<p>\u0388\u03bd\u03b1 <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03cd \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03c0\u03c1\u03bf\u03c6\u03af\u03bb, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf. \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ac\u03bb\u03bb\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03cc\u03c0\u03c9\u03c2 anti-centromere \u03ae anti-RNA polymerase III, \u03ba\u03b1\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03bd\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c4\u03c1\u03af\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1-\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1.<\/p>\n<p>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac, \u03c4\u03bf anti-Scl-70 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03bd\u03c4\u03ac \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u00ab\u03ad\u03c7\u03c9 \u03ae \u03b4\u03b5\u03bd \u03ad\u03c7\u03c9 \u03bd\u03cc\u03c3\u03bf\u00bb. \u03a3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u00ab\u03c4\u03b9 \u03b5\u03af\u03b4\u03bf\u03c5\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae;\u00bb, \u00ab\u03c0\u03bf\u03b9\u03b1 \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1 \u03ba\u03b9\u03bd\u03b4\u03c5\u03bd\u03b5\u03cd\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf;\u00bb, \u03ba\u03b1\u03b9 \u00ab\u03c0\u03cc\u03c3\u03bf \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2;\u00bb. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c0\u03bb\u03ae \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03bf\u03cd \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\/\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 8 ==================== --><\/p>\n<section id=\"section8\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">8<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-Scl-70 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7<\/span><\/h2>\n<p>\u0388\u03bd\u03b1 <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-Scl-70<\/strong> \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 \u03c4\u03bf\u03c0\u03bf\u03ca\u03c3\u03bf\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7\u03c2 I. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7 \u03b1\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 <strong>\u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac<\/strong> \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1. \u0394\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03cc\u03c4\u03b9 \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b5\u03b8\u03b5\u03af \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1, \u03bf\u03cd\u03c4\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1.<\/p>\n<p>\u0397 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c4\u03bf\u03bd \u03b9\u03b1\u03c4\u03c1\u03cc \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b3\u03b9\u03b1 <strong>\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/strong>. \u0395\u03ac\u03bd \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03b3\u03af\u03bd\u03b5\u03b9, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c5\u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bc\u03b5 <strong>\u03c3\u03c0\u03b9\u03c1\u03bf\u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7<\/strong>, <strong>DLCO<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac <strong>HRCT \u03b8\u03ce\u03c1\u03b1\u03ba\u03bf\u03c2<\/strong>, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u039f \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c4\u03c1\u03bf\u03bc\u03ac\u03be\u03b5\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2, \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b1 \u03c4\u03c5\u03c7\u03cc\u03bd \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd \u03c0\u03c1\u03b9\u03bd \u03b4\u03ce\u03c3\u03b5\u03b9 \u03c0\u03b9\u03bf \u03c3\u03bf\u03b2\u03b1\u03c1\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1.<\/p>\n<p>\u03a3\u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-Scl-70 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03c0\u03b5\u03ba\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2. \u0395\u03ba\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03c4\u03bf \u03b4\u03ad\u03c1\u03bc\u03b1, \u03b7 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1, \u03c4\u03bf \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc, \u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac, \u03b7 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7, \u03b5\u03bd\u03ce \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2\u00b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c3\u03c9\u03c3\u03c4\u03cc\u03c2 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c2 \u03bd\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03b5\u03af \u03b7 <strong>\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03b8\u03b5\u03af \u03bc\u03b9\u03b1 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2.<\/p>\n<p>\u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c4\u03bf\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-Scl-70 <strong>\u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf<\/strong>. \u039c\u03b5\u03c1\u03b9\u03ba\u03bf\u03af \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf, \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03c3\u03ba\u03ad\u03c6\u03c4\u03b7\u03ba\u03b5 \u03c3\u03c9\u03c3\u03c4\u03ac \u03ba\u03b1\u03b9 \u03b6\u03ae\u03c4\u03b7\u03c3\u03b5 \u03b5\u03b3\u03ba\u03b1\u03af\u03c1\u03c9\u03c2 \u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7, \u03b7 \u03b1\u03be\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03c9\u03c1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03cc\u03c4\u03b9 \u00ab\u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u00bb.<\/p>\n<p>\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9: <strong>\u03c3\u03c5\u03bd\u03b5\u03bd\u03bd\u03cc\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf, \u03bf\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 workup, \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ae\u03c1\u03b5\u03bc\u03b7, \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong>. \u039f\u03cd\u03c4\u03b5 \u03c0\u03b1\u03bd\u03b9\u03ba\u03cc\u03c2 \u03bf\u03cd\u03c4\u03b5 \u03b5\u03c6\u03b7\u03c3\u03c5\u03c7\u03b1\u03c3\u03bc\u03cc\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 9 ==================== --><\/p>\n<section id=\"section9\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">9<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc anti-Scl-70: \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf;<\/span><\/h2>\n<p>\u038c\u03c7\u03b9. \u0388\u03bd\u03b1 <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc anti-Scl-70 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7<\/strong>. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03af\u03c3\u03c9\u03c2 \u03c4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c5\u03c0\u03ac\u03c1\u03be\u03bf\u03c5\u03bd \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1. \u0397 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ad\u03c2 \u03bd\u03cc\u03c3\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03cc\u03bb\u03bf\u03b9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb.<\/p>\n<p>\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd <strong>anti-centromere<\/strong>, \u03ac\u03bb\u03bb\u03bf\u03b9 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd <strong>anti-RNA polymerase III<\/strong>, \u03ac\u03bb\u03bb\u03bf\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03b9 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03ba\u03b1\u03bd\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03b3\u03bd\u03c9\u03c3\u03c4\u03ac \u03ba\u03c1\u03b9\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03bf\u03c4\u03ad \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf anti-Scl-70.<\/p>\n<p>\u0388\u03bd\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03b1\u03b8\u03b7\u03c3\u03c5\u03c7\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03bc\u03b9\u03ba\u03c1\u03ae. \u0391\u03bd \u03cc\u03bc\u03c9\u03c2 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 Raynaud, capillaroscopic \u03b1\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b1\u03ba\u03c4\u03c5\u03bb\u03af\u03b1, \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac ANA \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae, \u03c4\u03cc\u03c4\u03b5 \u03bf \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03ad\u03bd\u03b1 \u03ba\u03bf\u03bc\u03bc\u03ac\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b6\u03bb, \u03cc\u03c7\u03b9 \u03b7 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03bb\u03ad\u03be\u03b7.<\/p>\n<p>\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b8\u03b5\u03c9\u03c1\u03ae\u03c3\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03cd \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03ae \u03c3\u03b5 \u03b1\u03c4\u03b5\u03bb\u03ae \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u03a4\u03cc\u03c4\u03b5 \u03c4\u03bf anti-Scl-70 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03bd\u03b1 \u03c0\u03ad\u03c6\u03c4\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u03c3\u03c4\u03b7\u03bd capillaroscopy, \u03c3\u03c4\u03b1 ANA \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd.<\/p>\n<p>\u03a3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2, \u03b1\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc anti-Scl-70 \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9, \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u00ab\u03cc\u03bb\u03b1 \u03c4\u03b5\u03bb\u03b5\u03af\u03c9\u03c3\u03b1\u03bd\u00bb. \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03bf\u03b9\u03c4\u03ac\u03be\u03b5\u03c4\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03b7\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03ad\u03bd\u03b1\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 10 ==================== --><\/p>\n<section id=\"section10\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">10<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a8\u03b5\u03c5\u03b4\u03ce\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2<\/span><\/h2>\n<p>\u0395\u03b4\u03ce \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b3\u03af\u03b4\u03b5\u03c2. \u03a0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03c4\u03bf anti-Scl-70 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7, \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 <strong>\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03ce\u03c3\u03bf\u03c5\u03bd \u03c8\u03b5\u03c5\u03b4\u03ce\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b4\u03b5\u03bd \u03c4\u03b1\u03b9\u03c1\u03b9\u03ac\u03b6\u03b5\u03b9.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 <strong>\u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bf\u03bc\u03bc\u03ad\u03bd\u03bf<\/strong> \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1. \u0391\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 Raynaud, \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac ANA \u03bc\u03b5 IFA, \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03ae \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf anti-Scl-70 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03c5\u03c7\u03b1\u03af\u03b1 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd panel, \u03bf \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2. \u03a3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03b9\u03bf \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03ae \u03b5\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03b5 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf.<\/p>\n<p>\u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 <strong>ANA by IFA<\/strong>. \u03a3\u03b5 \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03cd\u03c2 \u03b1\u03bb\u03b3\u03bf\u03c1\u03af\u03b8\u03bc\u03bf\u03c5\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5, \u03c4\u03bf anti-Scl-70 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03bd\u03cc\u03b7\u03bc\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 <strong>\u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc ANA<\/strong> \u03ae \u03c3\u03b1\u03c6\u03ae\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1. \u0391\u03bd \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 ANA \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b5 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03ad\u03bc\u03bc\u03b5\u03c3\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c6\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c3\u03b5 HEp-2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b8\u03cc\u03bb\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc anti-Scl-70 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03c0\u03b9\u03c6\u03cd\u03bb\u03b1\u03be\u03b7.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03be\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03b5\u03af \u03c3\u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c4\u03b7\u03c2 \u03b8\u03ad\u03c3\u03b7. \u03a4\u03bf anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03be\u03ad\u03c1\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 <strong>\u03c0\u03cc\u03c4\u03b5 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bb\u03b7\u03b8\u03b9\u03bd\u03ac \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc<\/strong> \u03ba\u03b1\u03b9 \u03c0\u03cc\u03c4\u03b5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03b8\u03cc\u03c1\u03c5\u03b2\u03bf\u03c2.<\/p>\n<p>\u03a4\u03bf \u03c0\u03b9\u03bf \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b5\u03be\u03ae\u03c2: <strong>\u03cc\u03c3\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong>. \u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03b4\u03b9\u03ac\u03ba\u03c1\u03b9\u03c4\u03b1.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 11 ==================== --><\/p>\n<section id=\"section11\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">11<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">Anti-Scl-70, anti-centromere \u03ba\u03b1\u03b9 anti-RNA polymerase III<\/span><\/h2>\n<p>\u03a4\u03b1 \u03c4\u03c1\u03af\u03b1 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03bf\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 <strong>anti-Scl-70<\/strong>, <strong>anti-centromere<\/strong> \u03ba\u03b1\u03b9 <strong>anti-RNA polymerase III<\/strong>. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bd\u03b1\u03bb\u03bb\u03ac\u03be\u03b9\u03bc\u03b1. \u03a4\u03bf \u03ba\u03b1\u03b8\u03ad\u03bd\u03b1 \u03b4\u03af\u03bd\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03c5\u03c0\u03cc\u03c4\u03c5\u03c0\u03bf \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1.<\/p>\n<p>\u03a4\u03bf <strong>anti-Scl-70<\/strong> \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03bc\u03b5 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03ac\u03c7\u03c5\u03c4\u03b7 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 <strong>\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/strong>. \u03a4\u03bf <strong>anti-centromere<\/strong> \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03c0\u03b9\u03bf \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb. \u03a4\u03bf <strong>anti-RNA polymerase III<\/strong> \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b3\u03b9\u03b1\u03c4\u03af \u03c3\u03b5 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ba\u03c1\u03af\u03c3\u03b7<\/strong>.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b5\u03c2 \u03c4\u03b1\u03be\u03b9\u03bd\u03bf\u03bc\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1. \u039f \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b4\u03b5\u03bd \u03b8\u03ad\u03bb\u03b5\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bd\u03b1 \u03c0\u03b5\u03b9 \u00ab\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ae \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u00bb. \u0398\u03ad\u03bb\u03b5\u03b9 \u03bd\u03b1 \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae\u03c3\u03b5\u03b9 \u03c0\u03bf\u03b9\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03bc\u03bf\u03c4\u03af\u03b2\u03bf \u03c4\u03b1\u03b9\u03c1\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c6\u03b8\u03bf\u03cd\u03bd \u03ae \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c0\u03c1\u03ce\u03b9\u03bc\u03b1.<\/p>\n<p>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac, \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-Scl-70 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c0\u03b1\u03b3\u03c1\u03cd\u03c0\u03bd\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae, \u03b5\u03bd\u03ce \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 anti-RNA polymerase III \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03b5 \u03c0\u03b9\u03bf \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2, \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03b5\u03be\u03b7\u03b3\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1\u03c4\u03af \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ae \u00ab\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u00bb, \u03b1\u03bb\u03bb\u03ac \u03ad\u03c7\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 16px 0 12px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div style=\"overflow-x: auto;\">\n<table style=\"width: 100%; border-collapse: collapse; min-width: 820px; font-size: 15px;\">\n<thead>\n<tr>\n<th style=\"text-align: left; padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u0391\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1<\/th>\n<th style=\"text-align: left; padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u039c\u03b5 \u03c4\u03b9 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1<\/th>\n<th style=\"text-align: left; padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u03a4\u03b9 \u03c0\u03c1\u03bf\u03c3\u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\"><strong>Anti-Scl-70<\/strong><\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7, \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5 \u03b4\u03b9\u03ac\u03c7\u03c5\u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ba\u03b1\u03b9 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf ILD<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u03a0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2, \u03b4\u03cd\u03c3\u03c0\u03bd\u03bf\u03b9\u03b1, HRCT, \u03c3\u03c0\u03b9\u03c1\u03bf\u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7, DLCO<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\"><strong>Anti-centromere<\/strong><\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03b9\u03bf \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb<\/td>\n<td style=\"padding: 10px; border-bottom: 1px solid #e5e7eb;\">\u039c\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03bf\u03c1\u03b5\u03af\u03b1, \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2, \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px;\"><strong>Anti-RNA polymerase III<\/strong><\/td>\n<td style=\"padding: 10px;\">\u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03bc\u03b5 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ba\u03c1\u03af\u03c3\u03b7<\/td>\n<td style=\"padding: 10px;\">\u03a0\u03af\u03b5\u03c3\u03b7, \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 12 ==================== --><\/p>\n<section id=\"section12\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">12<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/span><\/h2>\n<p>\u03a4\u03bf anti-Scl-70 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bd\u03cc\u03b7\u03bc\u03b1 \u03c9\u03c2 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1. \u03a3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c0\u03ac\u03bd\u03c4\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf <strong>\u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf<\/strong>. \u03a0\u03c1\u03ce\u03c4\u03bf \u03b2\u03ae\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03b1 <strong>ANA by IFA<\/strong> \u03c3\u03b5 HEp-2, \u03b3\u03b9\u03b1\u03c4\u03af \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03c0\u03bf\u03b9\u03bf\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b8\u03b1 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03b5\u03b9.<\/p>\n<p>\u0391\u03c0\u03cc \u03b5\u03ba\u03b5\u03af \u03ba\u03b1\u03b9 \u03c0\u03ad\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03bf\u03cd\u03bd <strong>anti-centromere<\/strong>, <strong>anti-RNA polymerase III<\/strong>, ENA, anti-RNP, SSA\/SSB, PM-Scl, Ku \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1. \u039f \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03bf\u03c5\u03bd \u00ab\u03cc\u03bb\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2\u00bb, \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bf\u03cd\u03bd \u03cc\u03c3\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5.<\/p>\n<p>\u03a7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bf\u03b9 \u03bc\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03af\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2: <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong>, <strong>\u03a4\u039a\u0395<\/strong>, <strong>CRP<\/strong>, <strong>\u03bf\u03c5\u03c1\u03af\u03b1<\/strong>, <strong>\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7<\/strong>, <strong>\u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ac \u03ad\u03bd\u03b6\u03c5\u03bc\u03b1<\/strong>, \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bb\u03cd\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03bf\u03cd\u03c1\u03c9\u03bd<\/strong>. \u0391\u03c5\u03c4\u03ad\u03c2 \u03b4\u03b5\u03bd \u03b2\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03ba\u03b1\u03b9 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03c5\u03bd \u03b5\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u03ae \u03c3\u03c5\u03bd\u03bf\u03b4\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1.<\/p>\n<p>\u03a3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 <strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc\u03c2 \u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2<\/strong> \u03ae \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b4\u03cd\u03c3\u03c0\u03bd\u03bf\u03b9\u03b1, \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7. \u0395\u03ba\u03b5\u03af \u03cc\u03bc\u03c9\u03c2 \u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03b9\u03ba\u03cc\u03bd\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7, \u03b1\u03c0\u03bb\u03ce\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bd\u03b5\u03b9.<\/p>\n<p>\u039f \u03ba\u03b1\u03bb\u03ac \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03cd\u03bf \u03c0\u03bb\u03b5\u03bf\u03bd\u03b5\u03ba\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1: \u03c0\u03c1\u03ce\u03c4\u03bf\u03bd, \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03c4\u03b5\u03b8\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bd\u03c9\u03c1\u03af\u03c2, \u03ba\u03b1\u03b9 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf\u03bd, \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03b5\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03bd\u03b1 \u03b4\u03bf\u03b8\u03b5\u03af \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bc\u03c6\u03af\u03b2\u03bf\u03bb\u03bf \u03ae \u03bc\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 13 ==================== --><\/p>\n<section id=\"section13\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">13<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac\u03c2, \u03bd\u03b5\u03c6\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd<\/span><\/h2>\n<p>\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf anti-Scl-70, \u03c4\u03bf \u03c0\u03b9\u03bf \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03b2\u03ae\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03bc\u03b5\u03af\u03bd\u03bf\u03c5\u03bc\u03b5 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1. \u0397 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1, \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03c0\u03bf\u03bb\u03c5\u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b7<\/strong>.<\/p>\n<p>\u0397 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ad\u03bc\u03c6\u03b1\u03c3\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b4\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 <strong>\u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2<\/strong>. \u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 <strong>\u03c3\u03c0\u03b9\u03c1\u03bf\u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7<\/strong>, \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 <strong>DLCO<\/strong> \u03ba\u03b1\u03b9, \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03ae \u03ba\u03b1\u03c4\u03ac \u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2, <strong>HRCT \u03b8\u03ce\u03c1\u03b1\u03ba\u03bf\u03c2<\/strong>. \u039f \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03b5\u03b3\u03ba\u03b1\u03af\u03c1\u03c9\u03c2 <strong>\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/strong>, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03af\u03bd\u03c9\u03c3\u03b7 \u03ae \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf\u03c5 \u03b9\u03c3\u03c4\u03bf\u03cd, \u03c0\u03c1\u03b9\u03bd \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b9\u03c9\u03c0\u03b7\u03bb\u03ac.<\/p>\n<p>\u0397 <strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03ac<\/strong> \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03b3\u03bd\u03bf\u03b5\u03af\u03c4\u03b1\u03b9. \u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1, \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03ae \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae. \u0397 \u03b4\u03cd\u03c3\u03c0\u03bd\u03bf\u03b9\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b4\u03b5\u03bd \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2\u00b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac \u03ae \u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1.<\/p>\n<p>\u039f\u03b9 <strong>\u03bd\u03b5\u03c6\u03c1\u03bf\u03af<\/strong> \u03ba\u03b1\u03b9 \u03b7 <strong>\u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7<\/strong> \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c0\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03ba\u03c1\u03af\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c0\u03af\u03b5\u03c3\u03b7\u03c2, <strong>\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2<\/strong>, \u03bf\u03c5\u03c1\u03af\u03b1\u03c2, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bb\u03c5\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae\u03c2 \u03bf\u03cd\u03c1\u03c9\u03bd, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03b3\u03ba\u03b1\u03af\u03c1\u03c9\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae\u03c2 \u03ae \u03b1\u03b9\u03c6\u03bd\u03af\u03b4\u03b9\u03b1\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7\u03c2.<\/p>\n<p>\u03a4\u03bf <strong>\u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc<\/strong> \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03b1\u03bb\u03b9\u03bd\u03b4\u03c1\u03cc\u03bc\u03b7\u03c3\u03b7, \u03ba\u03b1\u03bf\u03cd\u03c1\u03b5\u03c2, \u03b4\u03c5\u03c3\u03c6\u03b1\u03b3\u03af\u03b1, \u03b2\u03ae\u03c7\u03b1\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03bf \u03c6\u03b1\u03b3\u03b7\u03c4\u03cc \u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2. \u03a3\u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03bf \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03b1\u03c3\u03c4\u03b5\u03af \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ac, \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae. \u03a3\u03c5\u03c7\u03bd\u03ac \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c5, \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\u03c5, \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03bf\u03bb\u03cc\u03b3\u03bf\u03c5.<\/p>\n<p>\u0397 \u03b1\u03be\u03af\u03b1 \u03c4\u03bf\u03c5 anti-Scl-70, \u03bb\u03bf\u03b9\u03c0\u03cc\u03bd, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae. \u0395\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 <strong>\u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03c4\u03b9\u03ba\u03ae<\/strong>: \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03c3\u03c4\u03b7\u03b8\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac \u03c4\u03bf \u03c0\u03bb\u03ac\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b7 \u03c7\u03b1\u03b8\u03b5\u03af \u03c0\u03bf\u03bb\u03cd\u03c4\u03b9\u03bc\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b2\u03bb\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03b9\u03c9\u03c0\u03b7\u03bb\u03ac.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<section id=\"section14\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">14<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2<\/span><\/h2>\n<p>\u0388\u03bd\u03b1 \u03c3\u03c5\u03c7\u03bd\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c4\u03bf <strong>anti-Scl-70<\/strong>. \u0397 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 <strong>\u03b4\u03b5\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03cc\u03c0\u03c9\u03c2 \u03ad\u03bd\u03b1\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2<\/strong> \u03c4\u03cd\u03c0\u03bf\u03c5 CRP \u03ae \u03a4\u039a\u0395. \u0394\u03b7\u03bb\u03b1\u03b4\u03ae, \u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03c4\u03af\u03c4\u03bb\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03bf\u03c0\u03c4\u03c1\u03af\u03b6\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b5 \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 \u03c4\u03bf \u03b1\u03bd \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba\u03b5\u03af\u03bd\u03b7 \u03c4\u03b7 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae \u03c0\u03b9\u03bf \u03ae\u03c0\u03b9\u03b1 \u03ae \u03c0\u03b9\u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03ae.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03bf. \u0391\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03b1\u03bc\u03c6\u03af\u03b2\u03bf\u03bb\u03bf, \u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03c7\u03c9\u03c1\u03af\u03c2 \u03be\u03b5\u03ba\u03ac\u03b8\u03b1\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03b5\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03ae \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf. \u0391\u03bd \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03c4\u03b5\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac, \u03c4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c0\u03ad\u03c6\u03c4\u03b5\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u03c3\u03c4\u03b7 \u03c3\u03c0\u03b9\u03c1\u03bf\u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7, \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03b5\u03b9\u03ba\u03cc\u03bd\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd, \u03cc\u03c7\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<p>\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd, \u03b2\u03ad\u03b2\u03b1\u03b9\u03b1, \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03bf \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u03b8\u03b1 \u03b6\u03b7\u03c4\u03ae\u03c3\u03b5\u03b9 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03c3\u03b5\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf, \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03ae\u03c3\u03b5\u03b9 \u03b1\u03bc\u03c6\u03af\u03b2\u03bf\u03bb\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ae \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03bd\u03ad\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u038c\u03bc\u03c9\u03c2 \u03b7 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b4\u03b5\u03bd \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03bf\u03cd\u03c4\u03b5 \u03c3\u03b5 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03b1\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03bf <strong>\u03c0\u03ce\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf <strong>\u03c0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c4\u03b1 \u03cc\u03c1\u03b3\u03b1\u03bd\u03ac \u03c4\u03bf\u03c5<\/strong> \u03c0\u03b1\u03c1\u03ac \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03b1\u03ba\u03cd\u03bc\u03b1\u03bd\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2. \u0386\u03c1\u03b1 \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c1\u03ce\u03c4\u03b7\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u00ab\u03bd\u03b1 \u03be\u03b1\u03bd\u03b1\u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03c9 \u03c4\u03bf anti-Scl-70;\u00bb, \u03b1\u03bb\u03bb\u03ac \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u00ab\u03ad\u03c7\u03c9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c3\u03c9\u03c3\u03c4\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac\u03c2, \u03bd\u03b5\u03c6\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2;\u00bb.<\/p>\n<p>\u0391\u03c5\u03c4\u03ae \u03b7 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03b1\u03c0\u03cc \u03ac\u03c3\u03ba\u03bf\u03c0\u03b5\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03ae\u03c8\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9, \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1, \u03b5\u03be\u03b1\u03c3\u03c6\u03b1\u03bb\u03af\u03b6\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03ba\u03b5\u03af \u03cc\u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 15 ==================== --><\/p>\n<section id=\"section15\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">15<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf anti-Scl-70;<\/summary>\n<p style=\"margin: 10px 0 0;\">\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03cc\u03c7\u03b9. \u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03cc\u03bc\u03c9\u03c2 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03ae \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2, \u03ba\u03b1\u03bb\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03bf\u03c5 \u03ae \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1\u03c4\u03c1\u03bf\u03cd \u03c3\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03c0\u03b1\u03ba\u03ad\u03c4\u03bf \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03bd \u03c4\u03bf anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc, \u03ad\u03c7\u03c9 \u03c3\u03af\u03b3\u03bf\u03c5\u03c1\u03b1 \u03c3\u03ba\u03bb\u03b7\u03c1\u03cc\u03b4\u03b5\u03c1\u03bc\u03b1;<\/summary>\n<p style=\"margin: 10px 0 0;\">\u038c\u03c7\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1. \u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1, \u03b1\u03bb\u03bb\u03ac \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03bf\u03c4\u03b5 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03b1 ANA, \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf. \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c8\u03b5\u03c5\u03b4\u03ce\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03bd \u03c4\u03bf anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc, \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7;<\/summary>\n<p style=\"margin: 10px 0 0;\">\u038c\u03c7\u03b9. \u0397 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03cc\u03c0\u03c9\u03c2 anti-centromere \u03ae anti-RNA polymerase III, \u03b5\u03bd\u03ce \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03b5 \u03c0\u03bf\u03b9\u03b1 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ae \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03bf anti-Scl-70;<\/summary>\n<p style=\"margin: 10px 0 0;\">\u03a4\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03ae \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-Scl-70 \u03b4\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03ad\u03bc\u03c6\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03c9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7;<\/summary>\n<p style=\"margin: 10px 0 0;\">\u038c\u03c7\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1. \u0397 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u03c0\u03b1\u03c1\u03ac \u03bf\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af;<\/summary>\n<p style=\"margin: 10px 0 0;\">\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 ANA by IFA, anti-centromere, anti-RNA polymerase III, \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, CRP, \u03a4\u039a\u0395, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03bf\u03cd\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1, \u03c3\u03c0\u03b9\u03c1\u03bf\u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7, DLCO, HRCT \u03b8\u03ce\u03c1\u03b1\u03ba\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2.<\/p>\n<\/details>\n<details style=\"border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af anti-Scl-70 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1;<\/summary>\n<p style=\"margin: 10px 0 0;\">\u039d\u03b1\u03b9, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03ae \u03b1\u03c4\u03b5\u03bb\u03ae \u03c6\u03ac\u03c3\u03b7 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c8\u03b5\u03c5\u03b4\u03ce\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf. \u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03c0\u03bf\u03c4\u03ad \u03b7 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c4\u03b9\u03bc\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/p>\n<\/details>\n<\/section>\n<p><!-- ==================== SECTION 16 ==================== --><\/p>\n<section id=\"section16\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">16<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/span><\/h2>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px;\">\n<p style=\"margin: 0 0 8px;\"><strong>\u03a4\u03bf anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03b1\u03c5\u03c4\u03ac\u03c1\u03ba\u03b5\u03c2.<\/strong> \u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac ANA, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>\u0397 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5 \u03b1\u03be\u03af\u03b1 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03c5\u03c2 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2.<\/strong> \u03a4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2, \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf.<\/strong> \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03cc\u03c0\u03c9\u03c2 anti-centromere \u03ba\u03b1\u03b9 anti-RNA polymerase III, \u03b5\u03bd\u03ce \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/p>\n<p style=\"margin: 0 0 8px;\"><strong>\u03a4\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03ae \u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b8\u03ad\u03bb\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7.<\/strong> \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03b1\u03c6\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c8\u03b5\u03c5\u03b4\u03ce\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac.<\/p>\n<p style=\"margin: 0;\"><strong>\u03a4\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u201c\u03b2\u03b3\u03ae\u03ba\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc;\u201d.<\/strong> \u03a4\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd \u03ad\u03b3\u03b9\u03bd\u03b5 \u03bf \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2: \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7, ANA, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, capillaroscopy \u03ba\u03b1\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac\u03c2, \u03bd\u03b5\u03c6\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9.<\/p>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 17 ==================== --><\/p>\n<section id=\"section17\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">17<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<p>\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 anti-Scl-70 \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<div style=\"margin-top: 18px;\">\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Kowal-Bielecka O, Fransen J, Avouac J, et al. <em>Update of EULAR recommendations for the treatment of systemic sclerosis.<\/em> Annals of the Rheumatic Diseases.<br \/>\n<a href=\"https:\/\/ard.bmj.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/ard.bmj.com\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Van den Hoogen F, Khanna D, Fransen J, et al. <em>2013 classification criteria for systemic sclerosis.<\/em> Annals of the Rheumatic Diseases.<br \/>\n<a href=\"https:\/\/ard.bmj.com\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/ard.bmj.com\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Komura K, et al. <em>The clinical utility of autoantibodies in systemic sclerosis.<\/em> Review literature.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41208971\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/41208971\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Lam BH, et al. <em>False positive anti-Topoisomerase I (Scl-70) antibody results in clinical practice.<\/em><br \/>\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10061056\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10061056\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Homer K, et al. <em>Performance of anti-topoisomerase I antibody testing in routine practice.<\/em><br \/>\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6586532\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6586532\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/section>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>Anti-Scl-70 (\u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03a4\u03bf\u03c0\u03bf\u03ca\u03c3\u03bf\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7\u03c2 I): \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd, \u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9, \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 &amp; \u03a3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03a3\u03ba\u03bb\u03b7\u03c1\u03cc\u03b4\u03b5\u03c1\u03bc\u03b1 \u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: 29 \u03a3\u03b5\u03c0\u03c4\u03b5\u03bc\u03b2\u03c1\u03af\u03bf\u03c5 2025 \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 30 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u03a4\u03b9 \u03bd\u03b1 \u03be\u03ad\u03c1\u03b5\u03c4\u03b5 \u03bc\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03b1\u03c4\u03b9\u03ac: \u03a4\u03b1 anti-Scl-70 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 DNA \u03c4\u03bf\u03c0\u03bf\u03ca\u03c3\u03bf\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7\u03c2 I \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":6285,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2534],"tags":[2092,583,2095,2097,2096,2098,2094,2093],"class_list":["post-6283","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exetaseis-aimatos","tag-antisomata-anti-scl-70","tag-avtoanosa-nosimata","tag-diachyti-morfi-sklirodermatos","tag-exetasi-anti-scl-70","tag-pnevmoniki-inosi","tag-revmatologikos-elegchos","tag-skliroderma","tag-systimatiki-sklirynsi"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/6283","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=6283"}],"version-history":[{"count":3,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/6283\/revisions"}],"predecessor-version":[{"id":10597,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/6283\/revisions\/10597"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/6285"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=6283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=6283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=6283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}