{"id":4759,"date":"2025-08-08T15:54:10","date_gmt":"2025-08-08T12:54:10","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=4759"},"modified":"2026-02-12T16:14:33","modified_gmt":"2026-02-12T14:14:33","slug":"ilektroforisi-lefkomaton-spep","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/ilektroforisi-lefkomaton-spep\/","title":{"rendered":"\u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd: \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd, M-Spike &#038; \u039c\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1"},"content":{"rendered":"<h1>\u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP): \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9, M-Spike, \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 &amp; \u03a4\u03b9\u03bc\u03ad\u03c2 \u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2<\/h1>\n<p style=\"font-size: 14px; color: #6b7280;\">\u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7:<br \/>\n<time datetime=\"2026-02-12T00:00:00+02:00\">12 \u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2026<\/time><\/p>\n<p><!-- MINI INFOBOX STANDARD --><\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7<br \/>\n\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 (M-spike), \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03cd \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, MGUS, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9<br \/>\n\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2, \u03b7\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c6\u03c1\u03c9\u03c3\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5.<\/div>\n<p><!-- TOC STANDARD 17 SECTIONS --><\/p>\n<nav id=\"toc\" style=\"background: #f9fafb; border-radius: 14px; padding: 16px; margin-bottom: 18px;\" aria-label=\"\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1\"><strong>\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/strong><\/p>\n<ol style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li><a style=\"color: #dc2626;\" href=\"#sec1\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec2\">\u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03b7 \u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec3\">\u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 (\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec4\">\u0394\u03b5\u03b9\u03b3\u03bc\u03b1\u03c4\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 &amp; \u03a0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec5\">\u039a\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 &amp; \u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03a4\u03b9\u03bc\u03ad\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec6\">\u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae vs \u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u0391\u03cd\u03be\u03b7\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec7\">\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u0391\u03b9\u03c7\u03bc\u03ae (M-Spike)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec8\">MGUS \u2013 \u03a4\u03b9 \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 &amp; \u03a0\u03ce\u03c2 \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec9\">\u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u039c\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 &amp; \u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 CRAB \/ SLiM-CRAB<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec10\">Immunofixation (IFE)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec11\">\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u0395\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u0391\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 (FLC)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec12\">UPEP &amp; Bence-Jones \u03a0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec13\">\u0395\u03b9\u03b4\u03b9\u03ba\u03ac \u039c\u03bf\u03c4\u03af\u03b2\u03b1 \u03c3\u03c4\u03bf \u0399\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec14\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 &amp; Follow-Up<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec15\">\u03a0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af &amp; \u03a0\u03b1\u03b3\u03af\u03b4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec16\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec17\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: none; border-top: 2px solid #d1d5db; margin: 24px 0;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<h2 id=\"sec1\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP)<\/span><\/h2>\n<p><strong>\u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bf\u03c1\u03bf\u03cd (SPEP \u2013 Serum Protein Electrophoresis)<\/strong><br \/>\n\u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd<br \/>\n\u03c3\u03b5 \u03b5\u03c0\u03b9\u03bc\u03ad\u03c1\u03bf\u03c5\u03c2 \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03bf \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03c4\u03af\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03cc\u03c2 \u03c4\u03bf\u03c5\u03c2,<br \/>\n\u03bc\u03ad\u03c3\u03c9 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd \u03c0\u03b5\u03b4\u03af\u03bf\u03c5.<\/p>\n<p>\u039f\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ad\u03bc\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b6\u03ce\u03bd\u03b5\u03c2:<\/p>\n<ul>\n<li><strong>\u0391\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7<\/strong><\/li>\n<li><strong>\u03b11-\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2<\/strong><\/li>\n<li><strong>\u03b12-\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2<\/strong><\/li>\n<li><strong>\u03b2-\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2<\/strong><\/li>\n<li><strong>\u03b3-\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2<\/strong> (\u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2)<\/li>\n<\/ul>\n<p>\u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 <strong>\u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 (densitogram)<\/strong>,<br \/>\n\u03c3\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03ba\u03ac\u03b8\u03b5 \u03ba\u03bf\u03c1\u03c5\u03c6\u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03cc \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1.<br \/>\n\u0397 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u03c4\u03bf \u03cd\u03c8\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03cd\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03bf\u03c1\u03c5\u03c6\u03ae\u03c2<br \/>\n\u03ba\u03b1\u03b8\u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1:<\/strong><br \/>\n\u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bf\u03c1\u03bf\u03cd (SPEP) \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b1\u03c0\u03bb\u03ae \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ae \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7.<br \/>\n\u0391\u03bd\u03b1\u03bb\u03cd\u03b5\u03b9 \u03c4\u03bf <em>\u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf<\/em> \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd,<br \/>\n\u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae<br \/>\n\u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2 \u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd.<\/div>\n<h3 style=\"margin-top: 22px; font-size: 18px; font-weight: 800;\">\u03a4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03cd\u03c8\u03b5\u03b9 \u03b7 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP);<\/h3>\n<ul>\n<li><strong>\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae (M-spike)<\/strong> \u2192 MGUS, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1, \u03bc\u03b1\u03ba\u03c1\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 Waldenstr\u00f6m, AL \u03b1\u03bc\u03c5\u03bb\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7<\/li>\n<li><strong>\u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u2192 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae, \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1, \u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2, \u03b7\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/li>\n<li><strong>\u03a5\u03c0\u03bf\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u2192 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03ae \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1<\/li>\n<li><strong>\u039d\u03b5\u03c6\u03c1\u03c9\u03c3\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf<\/strong> \u2192 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u2193 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7 \u03bc\u03b5 \u2191 \u03b12-\u03bc\u03b1\u03ba\u03c1\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7<\/li>\n<li><strong>\u039f\u03be\u03b5\u03af\u03b1 \u03c6\u03ac\u03c3\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2<\/strong> \u2192 \u2191 \u03b11 \u03ba\u03b1\u03b9 \u03b12 \u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2<\/li>\n<li><strong>\u039c\u03b5\u03c4\u03b1\u03c4\u03cc\u03c0\u03b9\u03c3\u03b7 IgA \u03c3\u03c4\u03b7 \u03b2-\u03b6\u03ce\u03bd\u03b7<\/strong> \u2192 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae IgA<\/li>\n<\/ul>\n<h3 style=\"margin-top: 22px; font-size: 18px; font-weight: 800;\">\u03a4\u03b9 \u0394\u0395\u039d \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03b7 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP);<\/h3>\n<ul>\n<li>\u0394\u03b5\u03bd \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b9\u03c3\u03cc\u03c4\u03c5\u03c0\u03bf \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 (\u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 <strong>\u0391\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u2013 IFE<\/strong>)<\/li>\n<li>\u0394\u03b5\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd (\u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 <strong>\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03c9\u03bd \u0395\u03bb\u03b1\u03c6\u03c1\u03ce\u03bd \u0391\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd \u2013 FLC<\/strong>)<\/li>\n<li>\u0394\u03b5\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 CRAB \u03ae SLiM<\/li>\n<li>\u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7<\/li>\n<\/ul>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 12px 14px; border-radius: 10px; margin: 18px 0;\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong><br \/>\n\u0397 SPEP \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b1\u03bd\u03b1\u03c4\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd.<br \/>\n\u0397 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc<br \/>\nSPEP + \u0391\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 (IFE) + FLC<br \/>\n\u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/div>\n<div style=\"font-size: 13px; color: #6b7280; margin: 6px 0 10px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div class=\"table-mobile\">\n<table>\n<thead>\n<tr>\n<th>\u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/th>\n<th>\u03a4\u03b9 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9<\/th>\n<th>\u03a0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u039f\u03c1\u03bf\u03cd (SPEP)<\/strong><\/td>\n<td>\u039c\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf &amp; M-spike<\/td>\n<td>\u0391\u03c1\u03c7\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0391\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 (IFE \u2013 Immunofixation)<\/strong><\/td>\n<td>\u0399\u03c3\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2 (IgG, IgA, IgM \u2013 \u03ba\/\u03bb)<\/td>\n<td>\u0395\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u0395\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u0391\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 (FLC)<\/strong><\/td>\n<td>\u039b\u03cc\u03b3\u03bf\u03c2 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03c9\u03bd \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd<\/td>\n<td>\u03a5\u03c0\u03bf\u03c8\u03af\u03b1 light-chain \u03bd\u03cc\u03c3\u03bf\u03c5<\/td>\n<\/tr>\n<tr>\n<td><strong>\u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u039f\u03cd\u03c1\u03c9\u03bd (UPEP \u2013 Urine Protein Electrophoresis)<\/strong><\/td>\n<td>Bence-Jones \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/td>\n<td>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b5\u03bc\u03c0\u03bb\u03bf\u03ba\u03ae<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 12px 14px; border-radius: 10px; margin: 18px 0;\"><strong>\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 Section 1:<\/strong><br \/>\n\u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bf\u03c1\u03bf\u03cd (SPEP) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<br \/>\n<strong>\u03c0\u03c1\u03bf\u03c3\u03b1\u03bd\u03b1\u03c4\u03bf\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd<\/strong>.<br \/>\n\u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7<br \/>\n\u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc SPEP + IFE + FLC<br \/>\n\u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/div>\n<h2 id=\"sec2\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03b7 \u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/span><\/h2>\n<p>\u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03b5\u03ac\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9<br \/>\n<strong>\u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ae \u03ae \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae<\/strong> \u03c3\u03c4\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ac \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1<br \/>\n\u03ba\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03ac\u03bd \u03c5\u03c6\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 <strong>\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2<\/strong>.<\/p>\n<h3>\u03a4\u03c5\u03c0\u03b9\u03ba\u03ac \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1<\/h3>\n<ul>\n<li><strong>\u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7:<\/strong> \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03b3-\u03b6\u03ce\u03bd\u03b7 \u2192 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae, \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1, \u03b7\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/li>\n<li><strong>\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae (M-spike):<\/strong> \u03c3\u03c4\u03b5\u03bd\u03ae, \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03c1\u03b9\u03ba\u03ae \u03ba\u03bf\u03c1\u03c5\u03c6\u03ae \u2192 MGUS, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1, Waldenstr\u00f6m<\/li>\n<li><strong>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03b3-\u03b6\u03ce\u03bd\u03b7\u03c2:<\/strong> \u03c5\u03c0\u03bf\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \/ \u03b1\u03bd\u03bf\u03c3\u03bf\u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1<\/li>\n<li><strong>\u03a7\u03b1\u03bc\u03b7\u03bb\u03ae \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7:<\/strong> \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2, \u03bd\u03b5\u03c6\u03c1\u03c9\u03c3\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf<\/li>\n<li><strong>\u0391\u03cd\u03be\u03b7\u03c3\u03b7 \u03b11\/\u03b12:<\/strong> \u03bf\u03be\u03b5\u03af\u03b1 \u03c6\u03ac\u03c3\u03b7 (CRP\u2191, \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7)<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03ba\u03bb\u03b5\u03b9\u03b4\u03af:<\/strong><br \/>\n\u0397 SPEP \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf \u00ab\u03bc\u03bf\u03c4\u03af\u03b2\u03bf\u00bb.<br \/>\n\u0397 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af <strong>Immunofixation (IFE)<\/strong> \u03ba\u03b1\u03b9<br \/>\n<strong>\u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 (FLC)<\/strong>.<\/div>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5:<br \/>\n\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7, \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03b1\u03c4\u03af\u03bd\u03b7, \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2,<br \/>\n\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<br \/>\n<!-- ==================== SERP BOOST BLOCK ==================== --><\/p>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b3-\u03b6\u03ce\u03bd\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd;<\/h3>\n<p>\u0397 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>\u03b3-\u03b6\u03ce\u03bd\u03b7\u03c2<\/strong> \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd.<br \/>\n\u0397 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03b7\u03c2 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7:<\/p>\n<ul>\n<li><strong>\u0395\u03c5\u03c1\u03b5\u03af\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 (\u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae)<\/strong> \u2192 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae, \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2, \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1, \u03b7\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/li>\n<li><strong>\u03a3\u03c4\u03b5\u03bd\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae (M-spike)<\/strong> \u2192 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 (MGUS, \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1)<\/li>\n<li><strong>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03b3-\u03b6\u03ce\u03bd\u03b7\u03c2<\/strong> \u2192 \u03c5\u03c0\u03bf\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong><br \/>\n\u0397 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3-\u03b6\u03ce\u03bd\u03b7\u03c2 \u03b4\u03b5\u03bd \u03b9\u03c3\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b5\u03af \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1.<br \/>\n\u0397 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5.<\/div>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7;<\/h3>\n<p>\u038c\u03c4\u03b1\u03bd \u03b7 <strong>\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae,<br \/>\n\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf <strong>protein gap<\/strong><br \/>\n(\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u2212 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7).<\/p>\n<ul>\n<li>Protein gap &gt;4 g\/dL \u2192 \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b3\u03b9\u03b1 <strong>SPEP<\/strong><\/li>\n<li>\u0395\u03ac\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03b9\u03c7\u03bc\u03ae \u2192 IFE + FLC<\/li>\n<li>\u0395\u03ac\u03bd \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u2192 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2 \u03ae \u03b7\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2<\/li>\n<\/ul>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae SPEP;<\/h3>\n<p>\u039d\u03b1\u03b9. \u03a3\u03b5 <strong>light-chain \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/strong>,<br \/>\n\u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2<br \/>\n\u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae M-spike \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc.<\/p>\n<p>\u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2:<\/p>\n<ul>\n<li>\u0397 <strong>FLC<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae<\/li>\n<li>\u0397 <strong>UPEP<\/strong> \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03b9 Bence-Jones \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/li>\n<li>\u0397 SPEP \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae<\/li>\n<\/ul>\n<p>\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae SPEP <strong>\u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9<\/strong> \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<br \/>\n\u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae.<!-- ==================== SERP SNIPPET OPTIMIZATION BLOCK ==================== --><\/p>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u2013 \u03a4\u03b9 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c3\u03c5\u03bd\u03bf\u03c0\u03c4\u03b9\u03ba\u03ac;<\/h3>\n<p>\u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd \u03c3\u03b5 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03b6\u03ce\u03bd\u03b5\u03c2 (\u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7, \u03b11, \u03b12, \u03b2, \u03b3) \u03ba\u03b1\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2 \u03ae \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (M-spike), \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 MGUS \u03ae \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u03a3\u03b5 \u03bc\u03af\u03b1 \u03c0\u03c1\u03cc\u03c4\u03b1\u03c3\u03b7:<\/strong><br \/>\n\u0397 SPEP \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03b9 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03ac\u03bd \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7.<\/div>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">M-spike \u03c4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9;<\/h3>\n<p>\u03a4\u03bf M-spike \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae \u03c3\u03c4\u03b7 \u03b3 \u03ae \u03b2 \u03b6\u03ce\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7\u03c2 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03bc\u03cc\u03bd\u03bf \u03ba\u03bb\u03ce\u03bd\u03bf \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0394\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u00b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af \u03c3\u03b5 MGUS, smoldering \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1.<\/p>\n<p>\u0393\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9:<\/p>\n<ul>\n<li>Immunofixation (IFE)<\/li>\n<li>\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 (FLC)<\/li>\n<li>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 CRAB \/ SLiM<\/li>\n<\/ul>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">Protein gap \u2013 \u03a0\u03cc\u03c4\u03b5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc;<\/h3>\n<p>Protein gap \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7\u03c2. \u03a4\u03b9\u03bc\u03ae \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc 4 g\/dL \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ae \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03c5\u03c7\u03bd\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b1 SPEP.<\/p>\n<p>\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1:<\/p>\n<ul>\n<li>\u03a5\u03c8\u03b7\u03bb\u03cc protein gap + M-spike \u2192 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2<\/li>\n<li>\u03a5\u03c8\u03b7\u03bb\u03cc protein gap + \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03b3-\u03b6\u03ce\u03bd\u03b7 \u2192 \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae<\/li>\n<\/ul>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae SPEP \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1;<\/h3>\n<p>\u038c\u03c7\u03b9. \u03a3\u03b5 light-chain \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae\u03c2 M-spike \u03c3\u03c4\u03bf \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03bf\u03c1\u03bf\u03cd. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 FLC \u03ba\u03b1\u03b9 UPEP \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf\u03c2.<\/p>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 12px 14px; border-radius: 10px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/strong><br \/>\n\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae SPEP \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1,<br \/>\n\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ae \u03bf\u03c3\u03c4\u03b9\u03ba\u03ac \u03ac\u03bb\u03b3\u03b7.<\/div>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a0\u03cc\u03c4\u03b5 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03bf\u03cd\u03bc\u03b5 \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd;<\/h3>\n<p>\u0391\u03bd\u03b7\u03c3\u03c5\u03c7\u03b7\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n<ul>\n<li>\u03a4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2<\/li>\n<li>\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 FLC<\/li>\n<li>\u03a3\u03c5\u03bd\u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2, \u03c5\u03c0\u03b5\u03c1\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2<\/li>\n<li>\u039d\u03ad\u03b1 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ac \u03ac\u03bb\u03b3\u03b7<\/li>\n<\/ul>\n<p>\u0397 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03bc\u03af\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7.<br \/>\n<!-- ==================== SECTION 3 ==================== --><\/p>\n<h2 id=\"sec3\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">3<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 (\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2)<\/span><\/h2>\n<p>\u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP) \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1<br \/>\n\u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03bf\u03c1\u03bf\u03cd \u03ae \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae\u03c2 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2.<\/p>\n<h3>\u039a\u03cd\u03c1\u03b9\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h3>\n<ul>\n<li>\u0391\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 <strong>\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2<\/strong><\/li>\n<li><strong>Protein gap &gt;4 g\/dL<\/strong> (\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u2013 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7)<\/li>\n<li>\u0391\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ac\u03b3\u03bd\u03c9\u03c3\u03c4\u03b7\u03c2 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2<\/li>\n<li>\u03a5\u03c0\u03b5\u03c1\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/li>\n<li>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03b1\u03c6\u03ae \u03b1\u03b9\u03c4\u03af\u03b1<\/li>\n<li>\u039f\u03c3\u03c4\u03b9\u03ba\u03ac \u03ac\u03bb\u03b3\u03b7 \u03ae \u03bb\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 (\u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 CRAB)<\/li>\n<li>\u0391\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03bf\u03c5\u03c1\u03af\u03b1 \u03ae \u03bd\u03b5\u03c6\u03c1\u03c9\u03c3\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf<\/li>\n<li>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 MGUS \u03ae \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03cd \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<\/li>\n<\/ul>\n<h3>\u03a0\u03cc\u03c4\u03b5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2;<\/h3>\n<p>\u03a3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5 protein gap \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf\u03c5 \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2,<br \/>\n\u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2:<\/p>\n<ul>\n<li><strong>SPEP<\/strong><\/li>\n<li><strong>Immunofixation (IFE)<\/strong><\/li>\n<li><strong>Free Light Chains (FLC)<\/strong><\/li>\n<li>\u0395\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 <strong>UPEP<\/strong> \u03c3\u03b5 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 light-chain \u03bd\u03cc\u03c3\u03bf\u03c5<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae:<\/strong><br \/>\n\u0397 SPEP \u03b4\u03b5\u03bd \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<br \/>\n\u0397 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1.<\/div>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u201cprotein gap\u201d \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1;<\/h3>\n<p>\u03a4\u03bf <strong>protein gap<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7\u03c2.<\/p>\n<ul>\n<li>\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac: \u03bc\u03b9\u03ba\u03c1\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac<\/li>\n<li>&gt;4 g\/dL: \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2<\/li>\n<li>\u0395\u03ac\u03bd \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u2192 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7<\/li>\n<\/ul>\n<p>\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03c5\u03c7\u03bd\u03ac \u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1<br \/>\n\u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b3\u03b9\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1.<br \/>\n<!-- ==================== SECTION 4 ==================== --><\/p>\n<h2 id=\"sec4\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">4<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0394\u03b5\u03b9\u03b3\u03bc\u03b1\u03c4\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 &amp; \u03a0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1<\/span><\/h2>\n<p>\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2<br \/>\n\u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n<h3>\u03a5\u03bb\u03b9\u03ba\u03cc<\/h3>\n<ul>\n<li>\u03a0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 <strong>\u03bf\u03c1\u03cc\u03c2<\/strong> (\u03c3\u03c9\u03bb\u03b7\u03bd\u03ac\u03c1\u03b9\u03bf \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc)<\/li>\n<li>\u0391\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae EDTA \u03ae \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7\u03c2 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03ac\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1<\/li>\n<li>\u0394\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bf\u03c1\u03bf\u03cd \u03b5\u03bd\u03c4\u03cc\u03c2 2 \u03c9\u03c1\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1<\/li>\n<\/ul>\n<h3>\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1;<\/h3>\n<ul>\n<li>\u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03c9\u03c4\u03b9\u03ba\u03ae<\/li>\n<li>\u03a3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 8\u201312 \u03ce\u03c1\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03bb\u03b9\u03c0\u03b1\u03b9\u03bc\u03af\u03b1\u03c2<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf:<\/strong><br \/>\n\u0397 \u03bb\u03b9\u03c0\u03b1\u03b9\u03bc\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03c5\u03c3\u03c7\u03b5\u03c1\u03ac\u03bd\u03b5\u03b9<br \/>\n\u03c4\u03b7\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2.<\/div>\n<h3>\u03a0\u03c1\u03bf\u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03bf\u03af \u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u0395\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd SPEP<\/h3>\n<div style=\"font-size: 13px; color: #6b7280; margin: 6px 0 10px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div class=\"table-mobile\">\n<table>\n<thead>\n<tr>\n<th>\u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2<\/th>\n<th>\u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7<\/th>\n<th>\u03a3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u039b\u03b9\u03c0\u03b1\u03b9\u03bc\u03af\u03b1<\/td>\n<td>\u0398\u03bf\u03bb\u03cc \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf, \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03bf\u03bb\u03ae<\/td>\n<td>\u039d\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \/ \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2<\/td>\n<\/tr>\n<tr>\n<td>\u0391\u03b9\u03bc\u03cc\u03bb\u03c5\u03c3\u03b7<\/td>\n<td>\u0391\u03bb\u03bb\u03bf\u03af\u03c9\u03c3\u03b7 \u03ba\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd<\/td>\n<td>\u039d\u03ad\u03b1 \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1<\/td>\n<\/tr>\n<tr>\n<td>IVIG<\/td>\n<td>\u03a8\u03b5\u03c5\u03b4\u03ae\u03c2 \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7<\/td>\n<td>\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bc\u03b5\u03c4\u03ac 2\u20133 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/td>\n<\/tr>\n<tr>\n<td>\u039a\u03c1\u03c5\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2<\/td>\n<td>\u0391\u03bb\u03bb\u03bf\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae\u03c2<\/td>\n<td>\u0394\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 37\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u0391\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7<\/td>\n<td>\u03a8\u03b5\u03c5\u03b4\u03bf-\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2<\/td>\n<td>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03b7 \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1;<\/h3>\n<p>\u039d\u03b1\u03b9. \u0397 \u03ba\u03b1\u03ba\u03ae \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1:<\/p>\n<ul>\n<li>\u0394\u03ce\u03c3\u03b5\u03b9 \u03c8\u03b5\u03c5\u03b4\u03ce\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/li>\n<li>\u039a\u03c1\u03cd\u03c8\u03b5\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ae M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/li>\n<li>\u0394\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1<\/li>\n<\/ul>\n<p>\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c4\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03b3\u03bc\u03b1<br \/>\n\u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1.<\/p>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a0\u03bf\u03b9\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc \u03c3\u03c9\u03bb\u03b7\u03bd\u03ac\u03c1\u03b9\u03bf \u03b3\u03b9\u03b1 SPEP;<\/h3>\n<p>\u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP) \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 <strong>\u03bf\u03c1\u03cc<\/strong>.<br \/>\n\u0397 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b5\u03c2.<\/p>\n<h4 style=\"margin-top: 16px; font-size: 17px; font-weight: bold;\">\u0393\u03b9\u03b1\u03c4\u03af \u03cc\u03c7\u03b9 EDTA;<\/h4>\n<ul>\n<li>\u03a4\u03bf EDTA \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd<\/li>\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1<\/li>\n<li>\u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc \u03bc\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c0\u03b9\u03bb\u03b9\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7\u03c2<\/li>\n<\/ul>\n<h4 style=\"margin-top: 16px; font-size: 17px; font-weight: bold;\">\u0393\u03b9\u03b1\u03c4\u03af \u03cc\u03c7\u03b9 \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7;<\/h4>\n<ul>\n<li>\u0397 \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u00ab\u03bf\u03c5\u03c1\u03ad\u03c2\u00bb \u03c3\u03c4\u03bf \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1<\/li>\n<li>\u0395\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae:<\/strong><br \/>\n\u0397 SPEP \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2.<br \/>\n\u0397 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03bc\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5 \u03c3\u03c9\u03bb\u03b7\u03bd\u03b1\u03c1\u03af\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf<br \/>\n\u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1.<\/div>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a0\u03cc\u03c3\u03bf \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03bf\u03c1\u03bf\u03cd;<\/h3>\n<p>\u0397 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2.<\/p>\n<ul>\n<li>\u0398\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u03b4\u03c9\u03bc\u03b1\u03c4\u03af\u03bf\u03c5: \u03ad\u03c9\u03c2 24 \u03ce\u03c1\u03b5\u03c2 (\u03b5\u03ac\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac)<\/li>\n<li>\u03a8\u03cd\u03be\u03b7 2\u20138\u00b0C: \u03ad\u03c9\u03c2 5\u20137 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2<\/li>\n<li>\u039a\u03b1\u03c4\u03ac\u03c8\u03c5\u03be\u03b7: \u03b3\u03b9\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 (\u03b9\u03b4\u03b1\u03bd\u03b9\u03ba\u03ac -20\u00b0C)<\/li>\n<\/ul>\n<p>\u0397 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03cc \u03bf\u03c1\u03bf\u03cd \u03b1\u03c0\u03cc \u03c4\u03bf \u03c0\u03ae\u03b3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1:<\/p>\n<ul>\n<li>\u039c\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7\u03c2<\/li>\n<li>\u0395\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03bf protein gap<\/li>\n<li>\u0391\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03c4\u03b7\u03c2 \u03b3-\u03b6\u03ce\u03bd\u03b7\u03c2<\/li>\n<\/ul>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2;<\/h3>\n<p>\u0397 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 SPEP \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03cc\u03c4\u03b1\u03bd:<\/p>\n<ul>\n<li>\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03bf\u03bb\u03ae (\u03bb\u03b9\u03c0\u03b1\u03b9\u03bc\u03af\u03b1, \u03b1\u03b9\u03bc\u03cc\u03bb\u03c5\u03c3\u03b7)<\/li>\n<li>\u03a4\u03bf \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b8\u03b1\u03c1\u03cc<\/li>\n<li>\u0395\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03ad\u03b1 \u03ae \u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae<\/li>\n<li>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 MGUS \u03ae \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/li>\n<\/ul>\n<p>\u03a3\u03b5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2,<br \/>\n\u03b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9:<\/p>\n<ul>\n<li>\u039c\u03b5 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf (\u03b1\u03b3\u03b1\u03c1\u03cc\u03b6\u03b7 \u03ae \u03ba\u03b1\u03c0\u03b9\u03bb\u03b9\u03b1\u03c1\u03b9\u03ba\u03ae)<\/li>\n<li>\u03a3\u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf<\/li>\n<li>\u039c\u03b5 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2<\/li>\n<\/ul>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 12px 14px; border-radius: 10px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf:<\/strong><br \/>\n\u0397 \u03c4\u03ac\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae\u03c2 \u03c4\u03b7\u03c2 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<br \/>\n\u03b1\u03c0\u03cc \u03bc\u03af\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7.<\/div>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03bf\u03bb\u03ad\u03c2 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd SPEP;<\/h3>\n<p>\u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1:<\/p>\n<ul>\n<li><strong>IVIG:<\/strong> \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7<\/li>\n<li><strong>\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2:<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c9\u03c2 M-spike<\/li>\n<li><strong>\u03a7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1:<\/strong> \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ce\u03bd Ig<\/li>\n<\/ul>\n<p>\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c0\u03cc \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1,<br \/>\n\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03b9\u03c7\u03bc\u03ae\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9<br \/>\n\u03bc\u03b5 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03bf\u03cd.<\/p>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a0\u03ce\u03c2 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03b1\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7;<\/h3>\n<p>\u0397 \u03b1\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03b9\u03bc\u03bf\u03c3\u03c5\u03bc\u03c0\u03cd\u03ba\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5:<\/p>\n<ul>\n<li>\u03a8\u03b5\u03c5\u03b4\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2<\/li>\n<li>\u03a8\u03b5\u03c5\u03b4\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7\u03c2<\/li>\n<li>\u03a0\u03b1\u03c1\u03b1\u03c0\u03bb\u03b1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc protein gap<\/li>\n<\/ul>\n<p>\u0397 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9<br \/>\n\u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03bf\u03c5\u03c1\u03af\u03b1, \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7<br \/>\n\u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b5\u03bd\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7\u03c2.<\/p>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03ba\u03c1\u03c5\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2;<\/h3>\n<p>\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03ba\u03c1\u03c5\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1:<\/p>\n<ul>\n<li>\u03a4\u03bf \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 37\u00b0C \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03bf\u03bd \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03cc<\/li>\n<li>\u0397 \u03c8\u03cd\u03be\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03ba\u03b1\u03b8\u03af\u03b6\u03b7\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd<\/li>\n<li>\u03a4\u03bf \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b5\u03c2<\/li>\n<\/ul>\n<p>\u0397 \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1<br \/>\n\u03b1\u03c0\u03bf\u03ba\u03c1\u03cd\u03c8\u03b5\u03b9 \u03ae \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03bf\u03c1\u03c6\u03ce\u03c3\u03b5\u03b9 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7.<\/p>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a0\u03c1\u03bf\u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c6\u03ac\u03bb\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03b9\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 M-spike<\/h3>\n<p>\u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c8\u03b5\u03c5\u03b4\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b9\u03c7\u03bc\u03ae\u03c2:<\/p>\n<ul>\n<li>\u03a3\u03c5\u03bc\u03c0\u03cd\u03ba\u03bd\u03c9\u03c3\u03b7 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2<\/li>\n<li>\u03a0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ac \u03b9\u03b6\u03ae\u03bc\u03b1\u03c4\u03b1<\/li>\n<li>\u03a5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1<\/li>\n<li>\u03a4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03b1\u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03c1\u03af\u03b1 \u03ba\u03b1\u03c0\u03b9\u03bb\u03b9\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5<\/li>\n<\/ul>\n<p>\u03a3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1:<\/p>\n<ul>\n<li>\u0395\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 SPEP<\/li>\n<li>\u0394\u03b9\u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 Immunofixation<\/li>\n<li>\u0395\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 FLC<\/li>\n<\/ul>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a0\u03ce\u03c2 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 (\u03b1\u03b3\u03b1\u03c1\u03cc\u03b6\u03b7 vs \u03ba\u03b1\u03c0\u03b9\u03bb\u03b9\u03b1\u03c1\u03b9\u03ba\u03ae);<\/h3>\n<p>\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b4\u03cd\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2:<\/p>\n<h4 style=\"margin-top: 14px; font-size: 17px; font-weight: bold;\">\u0391\u03b3\u03b1\u03c1\u03cc\u03b6\u03b7<\/h4>\n<ul>\n<li>\u039a\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2<\/li>\n<li>\u039f\u03c0\u03c4\u03b9\u03ba\u03ac \u03c3\u03b1\u03c6\u03ad\u03c2 \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1<\/li>\n<li>\u0395\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2<\/li>\n<\/ul>\n<h4 style=\"margin-top: 14px; font-size: 17px; font-weight: bold;\">\u039a\u03b1\u03c0\u03b9\u03bb\u03b9\u03b1\u03c1\u03b9\u03ba\u03ae \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7<\/h4>\n<ul>\n<li>\u03a5\u03c8\u03b7\u03bb\u03ae \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1<\/li>\n<li>\u039a\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03bc\u03b9\u03ba\u03c1\u03ce\u03bd \u03b1\u03b9\u03c7\u03bc\u03ce\u03bd<\/li>\n<li>\u0394\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 baseline<\/li>\n<\/ul>\n<p>\u0397 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ce\u03bd<br \/>\n\u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae.<\/p>\n<h3 style=\"margin-top: 26px; font-size: 20px; font-weight: 800;\">\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03a0\u03c1\u03bf\u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u0394\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7\u03c2<\/h3>\n<p>\u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP):<\/p>\n<ul>\n<li>\u0395\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2<\/li>\n<li>\u0395\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bb\u03b9\u03c0\u03b1\u03b9\u03bc\u03af\u03b1, \u03b1\u03b9\u03bc\u03cc\u03bb\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03bf\u03bb\u03ad\u03c2<\/li>\n<li>\u0391\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c3\u03c9\u03bb\u03b7\u03bd\u03b1\u03c1\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03bf \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03cc<\/li>\n<li>\u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u03a4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae:<\/strong><br \/>\n\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 \u03b4\u03b5\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03b9\u03c7\u03bc\u03ae.<br \/>\n\u039e\u03b5\u03ba\u03b9\u03bd\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc \u03b4\u03b5\u03af\u03b3\u03bc\u03b1.<\/div>\n<p>\u03a0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03bc\u03c0\u03bb\u03bf\u03c5\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7, \u03b4\u03b9\u03bf\u03c1\u03b8\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf authority-level \u03b5\u03ba\u03b4\u03bf\u03c7\u03ae \u03c4\u03c9\u03bd Sections 5\u20137, \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c4\u03c4\u03ae \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03ba\u03b1\u03b8\u03b1\u03c1\u03ae \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c1\u03bf\u03ae.<\/p>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<h2 id=\"sec5\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"> <span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">5<\/span> <\/span> <span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 &amp; \u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03a4\u03b9\u03bc\u03ad\u03c2<\/span><\/h2>\n<p>\u0397 <strong>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bf\u03c1\u03bf\u03cd (SPEP)<\/strong> \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2<br \/>\n\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03bf\u03cd \u03c3\u03b5 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b6\u03ce\u03bd\u03b5\u03c2:<br \/>\n<strong>\u0391\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7, \u03b11, \u03b12, \u03b2 \u03ba\u03b1\u03b9 \u03b3<\/strong>.<\/p>\n<p>\u0397 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c9\u03c2 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc (%) \u03c4\u03b7\u03c2 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2,<br \/>\n\u03b5\u03bd\u03ce \u03b3\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 <strong>g\/dL<\/strong>.<br \/>\n\u039f\u03b9 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf<br \/>\n(\u03b1\u03b3\u03b1\u03c1\u03cc\u03b6\u03b7 \u03ae \u03ba\u03b1\u03c0\u03b9\u03bb\u03b9\u03b1\u03c1\u03b9\u03ba\u03ae \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7).<\/p>\n<div style=\"font-size: 13px; color: #6b7280; margin: 6px 0 10px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div class=\"table-mobile\">\n<table>\n<thead>\n<tr>\n<th>\u039a\u03bb\u03ac\u03c3\u03bc\u03b1<\/th>\n<th>% \u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2<\/th>\n<th>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u0391\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7<\/strong><\/td>\n<td>53\u201366%<\/td>\n<td>\u2193 \u03b7\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1, \u03bd\u03b5\u03c6\u03c1\u03c9\u03c3\u03b9\u03ba\u03cc, \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u2022 \u2191 \u03b1\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7<\/td>\n<\/tr>\n<tr>\n<td><strong>\u03b11<\/strong><\/td>\n<td>2\u20134%<\/td>\n<td>\u2191 \u03bf\u03be\u03b5\u03af\u03b1 \u03c6\u03ac\u03c3\u03b7 \u2022 \u2193 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b11-\u03b1\u03bd\u03c4\u03b9\u03b8\u03c1\u03c5\u03c8\u03af\u03bd\u03b7\u03c2<\/td>\n<\/tr>\n<tr>\n<td><strong>\u03b12<\/strong><\/td>\n<td>6\u201313%<\/td>\n<td>\u2191 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u2022 \u2191 \u03b12-\u03bc\u03b1\u03ba\u03c1\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7 \u03c3\u03c4\u03bf \u03bd\u03b5\u03c6\u03c1\u03c9\u03c3\u03b9\u03ba\u03cc<\/td>\n<\/tr>\n<tr>\n<td><strong>\u03b2<\/strong><\/td>\n<td>7\u201314%<\/td>\n<td>\u2191 \u03c4\u03c1\u03b1\u03bd\u03c3\u03c6\u03b5\u03c1\u03c1\u03af\u03bd\u03b7 (\u03c3\u03b9\u03b4\u03b7\u03c1\u03bf\u03c0\u03b5\u03bd\u03af\u03b1) \u2022 \u2191 \u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u2022 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03bc\u03b5\u03c4\u03b1\u03ba\u03af\u03bd\u03b7\u03c3\u03b7 IgA<\/td>\n<\/tr>\n<tr>\n<td><strong>\u03b3<\/strong><\/td>\n<td>11\u201322%<\/td>\n<td>\u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03ae \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h3 style=\"margin-top: 20px; font-size: 18px; font-weight: 800;\">\u039c\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae % \u03c3\u03b5 g\/dL<\/h3>\n<p>\u0397 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03bf\u03c0\u03ae \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b5\u03be\u03ae\u03c2:<\/p>\n<p><strong>\u03a4\u03b9\u03bc\u03ae \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 (g\/dL) = (% \/ 100) \u00d7 \u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/strong><\/p>\n<p>\u03a0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1:<br \/>\n\u039f\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 8,0 g\/dL \u03ba\u03b1\u03b9 \u03b3-\u03b6\u03ce\u03bd\u03b7 20%<br \/>\n\u2192 0,20 \u00d7 8,0 = 1,6 g\/dL<\/p>\n<p>\u0397 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c3\u03b5 g\/dL \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7 \u03b3\u03b9\u03b1:<\/p>\n<ul>\n<li>\u0391\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2<\/li>\n<li>\u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03b5\u03c0\u03b1\u03bd\u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5\u03c2<\/li>\n<li>\u0394\u03b9\u03b1\u03c3\u03c4\u03c1\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03b5 MGUS<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong> \u0397 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b1 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac \u03b5\u03cd\u03c1\u03b7 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2 (IgG, IgA, IgM) \u03ba\u03b1\u03b9 FLC.<\/div>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<h2 id=\"sec6\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"> <span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">6<\/span> <\/span> <span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae vs \u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u0391\u03cd\u03be\u03b7\u03c3\u03b7<\/span><\/h2>\n<p>\u0397 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd <strong>SPEP<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7<br \/>\n\u03c4\u03b7\u03c2 \u03b3-\u03b6\u03ce\u03bd\u03b7\u03c2 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5:<\/p>\n<p><strong>1\ufe0f\u20e3 \u0391\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae (\u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae) \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae<\/strong><br \/>\n<strong>2\ufe0f\u20e3 \u039a\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae (\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae) \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae<\/strong><\/p>\n<h3 style=\"margin-top: 20px; font-size: 18px; font-weight: 800;\">\u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7<\/h3>\n<ul>\n<li>\u0395\u03c5\u03c1\u03b5\u03af\u03b1 \u03b2\u03ac\u03c3\u03b7 (\u00ab\u03bb\u03cc\u03c6\u03bf\u03c2\u00bb)<\/li>\n<li>\u0391\u03bd\u03bf\u03bc\u03bf\u03b9\u03cc\u03bc\u03bf\u03c1\u03c6\u03b7, \u03b4\u03b9\u03ac\u03c7\u03c5\u03c4\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae<\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u2191 \u03b11\/\u03b12<\/li>\n<\/ul>\n<p><strong>\u0391\u03af\u03c4\u03b9\u03b1:<\/strong> \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae, \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2, \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1, \u03b7\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1.<\/p>\n<h3 style=\"margin-top: 20px; font-size: 18px; font-weight: 800;\">\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 (M-spike)<\/h3>\n<ul>\n<li>\u03a3\u03c4\u03b5\u03bd\u03ae, \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae<\/li>\n<li>\u039a\u03b1\u03b8\u03b1\u03c1\u03cc \u03cc\u03c1\u03b9\u03bf \u03b1\u03c0\u03cc \u03b3\u03b5\u03b9\u03c4\u03bf\u03bd\u03b9\u03ba\u03ac \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1<\/li>\n<li>\u03a0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 g\/dL<\/li>\n<\/ul>\n<p><strong>\u03a3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5:<\/strong><br \/>\nMGUS, smoldering \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1,<br \/>\n\u03bc\u03b1\u03ba\u03c1\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 Waldenstr\u00f6m, AL \u03b1\u03bc\u03c5\u03bb\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7.<\/p>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin: 18px 0;\"><strong>\u039c\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae:<\/strong> \u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae = \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae. \u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae = \u03c3\u03c4\u03b5\u03bd\u03ae \u00ab\u03bb\u03b5\u03c0\u03af\u03b4\u03b1\u00bb.<\/div>\n<p>\u0397 \u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03b5\u03af \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<br \/>\n\u039a\u03ac\u03b8\u03b5 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03b1\u03b9\u03c7\u03bc\u03ae \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af:<\/p>\n<ul>\n<li><strong>Immunofixation (IFE)<\/strong><\/li>\n<li><strong>FLC<\/strong><\/li>\n<li>\u0395\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 <strong>UPEP<\/strong><\/li>\n<\/ul>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<h2 id=\"sec7\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"> <span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">7<\/span> <\/span> <span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u0391\u03b9\u03c7\u03bc\u03ae (M-Spike)<\/span><\/h2>\n<p>\u0397 <strong>M-spike<\/strong> \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03bc\u03af\u03b1\u03c2<br \/>\n\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n<p>\u0394\u03b5\u03bd \u03b9\u03c3\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b5\u03af \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1,<br \/>\n\u03b1\u03bb\u03bb\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b4\u03bf\u03bc\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7.<\/p>\n<h3 style=\"margin-top: 20px; font-size: 18px; font-weight: 800;\">\u0394\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03a0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7<\/h3>\n<ol>\n<li><strong>\u03a0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7<\/strong> M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (g\/dL)<\/li>\n<li><strong>IFE<\/strong> \u03b3\u03b9\u03b1 \u03b9\u03c3\u03bf\u03c4\u03c5\u03c0\u03af\u03b1 (IgG\/IgA\/IgM \u2013 \u03ba \u03ae \u03bb)<\/li>\n<li><strong>FLC<\/strong> \u03b3\u03b9\u03b1 \u03bb\u03cc\u03b3\u03bf \u03ba\/\u03bb<\/li>\n<li>\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 <strong>CRAB \/ SLiM<\/strong><\/li>\n<\/ol>\n<h3 style=\"margin-top: 20px; font-size: 18px; font-weight: 800;\">\u03a0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1 \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1\u03c2<\/h3>\n<p>M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 1,2 g\/dL \u03ba\u03b1\u03b9 \u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 8,5 g\/dL:<\/p>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 12px 14px; border-radius: 10px; margin: 18px 0;\"><strong>\u0392\u03ae\u03bc\u03b1 1:<\/strong> IFE + FLC<\/div>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u0392\u03ae\u03bc\u03b1 2:<\/strong> \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 Hb, Ca, \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2, \u03b1\u03c0\u03b5\u03b9\u03ba\u03cc\u03bd\u03b9\u03c3\u03b7\u03c2 \u03bf\u03c3\u03c4\u03ce\u03bd<\/div>\n<p>\u0395\u03ac\u03bd \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd CRAB\/SLiM \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1<br \/>\n\u03ba\u03b1\u03b9 \u03b7 \u03c4\u03b9\u03bc\u03ae \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u2192 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc <strong>MGUS<\/strong>.<\/p>\n<p>\u0395\u03ac\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u2192<br \/>\n\u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1<br \/>\n<strong>\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf:<\/strong> \u0397 \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc \u03bc\u03af\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c4\u03b9\u03bc\u03ae.<\/div>\n<h2 id=\"sec8\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">8<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">MGUS \u2013 \u03a4\u03b9 \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 &amp; \u03a0\u03ce\u03c2 \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9<\/span><\/h2>\n<p>\u0397 <strong>MGUS (\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u0393\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u0391\u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03af\u03bd\u03b9\u03c3\u03c4\u03b7\u03c2 \u03a3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2)<\/strong><br \/>\n\u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03cc\u03c0\u03bf\u03c5 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ae \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 (M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7)<br \/>\n\u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03cd \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2.<\/p>\n<h3>\u0394\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac<\/h3>\n<ul>\n<li>M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 &lt;3 g\/dL<\/li>\n<li>&lt;10% \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd<\/li>\n<li>\u0391\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 CRAB \u03ae SLiM \u03ba\u03c1\u03b9\u03c4\u03b7\u03c1\u03af\u03c9\u03bd<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf:<\/strong><br \/>\n\u0397 MGUS \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1, \u03b1\u03bb\u03bb\u03ac \u03c6\u03ad\u03c1\u03b5\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc \u03b5\u03c4\u03ae\u03c3\u03b9\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2<br \/>\n(~1% \u03b1\u03bd\u03ac \u03ad\u03c4\u03bf\u03c2) \u03c3\u03b5 \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u03ae \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2.<\/div>\n<h3>\u03a3\u03c4\u03c1\u03c9\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (\u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac)<\/h3>\n<div style=\"font-size: 13px; color: #6b7280; margin: 6px 0 10px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div class=\"table-mobile\">\n<table>\n<thead>\n<tr>\n<th>\u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2<\/th>\n<th>\u03a7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/th>\n<th>\u03a5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u0399\u03c3\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2<\/td>\n<td>IgG<\/td>\n<td>IgA \/ IgM<\/td>\n<\/tr>\n<tr>\n<td>M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/td>\n<td>&lt;1,5 g\/dL<\/td>\n<td>\u22651,5 g\/dL<\/td>\n<\/tr>\n<tr>\n<td>\u039b\u03cc\u03b3\u03bf\u03c2 FLC<\/td>\n<td>\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2<\/td>\n<td>\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h3>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/h3>\n<ul>\n<li>\u0395\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 6\u201312 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/li>\n<li>\u0395\u03ac\u03bd \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u2192 \u03b5\u03c4\u03ae\u03c3\u03b9\u03bf\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/li>\n<li>\u03a0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b5 \u03af\u03b4\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b3\u03b9\u03b1 \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1<\/li>\n<\/ul>\n<p>\u0397 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 <strong>SPEP + IFE + FLC<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b3\u03b9\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1.<br \/>\n<!-- ==================== SECTION 9 ==================== --><\/p>\n<h2 id=\"sec9\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">9<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u039c\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 &amp; \u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 CRAB \/ SLiM-CRAB<\/span><\/h2>\n<p>\u03a4\u03bf <strong>\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<br \/>\n\u03c0\u03bf\u03c5 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2<br \/>\n\u03ba\u03b1\u03b9 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd. \u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af<br \/>\n\u03c3\u03c5\u03c7\u03bd\u03ac \u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1.<\/p>\n<h3>\u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 CRAB (\u03b2\u03bb\u03ac\u03b2\u03b7 \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd)<\/h3>\n<ul>\n<li><strong>C \u2013 \u03a5\u03c0\u03b5\u03c1\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> (&gt;11 mg\/dL)<\/li>\n<li><strong>R \u2013 \u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong><\/li>\n<li><strong>A \u2013 \u0391\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/strong><\/li>\n<li><strong>B \u2013 \u039f\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bb\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2<\/strong><\/li>\n<\/ul>\n<h3>SLiM \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 (\u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03cd \u03bd\u03cc\u03c3\u03bf\u03c5)<\/h3>\n<ul>\n<li>\u226560% \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd<\/li>\n<li>\u039b\u03cc\u03b3\u03bf\u03c2 \u03b5\u03bc\u03c0\u03bb\u03b5\u03ba\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2\/\u03bc\u03b7 \u03b5\u03bc\u03c0\u03bb\u03b5\u03ba\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 FLC \u2265100<\/li>\n<li>&gt;1 \u03b5\u03c3\u03c4\u03af\u03b1 MRI &gt;5 mm<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u0394\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae:<\/strong><br \/>\n\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 CRAB\/SLiM \u2192 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc MGUS \u03ae smoldering.<br \/>\n\u03a0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 CRAB\/SLiM \u2192 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1.<\/div>\n<h3>\u0395\u03c0\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b2\u03ae\u03bc\u03b1\u03c4\u03b1<\/h3>\n<ul>\n<li>IFE \u03b3\u03b9\u03b1 \u03b9\u03c3\u03bf\u03c4\u03c5\u03c0\u03af\u03b1<\/li>\n<li>FLC \u03b3\u03b9\u03b1 \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/li>\n<li>UPEP \u03b3\u03b9\u03b1 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2<\/li>\n<li>\u0391\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b4\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7<\/li>\n<\/ul>\n<p>\u0397 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7,<br \/>\n\u03b1\u03bb\u03bb\u03ac \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n<h2 id=\"sec10\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">10<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">Immunofixation (IFE)<\/span><\/h2>\n<p>\u0397 <strong>\u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u03bf\u03c1\u03bf\u03cd (Immunofixation, IFE)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<br \/>\n\u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b9\u03c3\u03cc\u03c4\u03c5\u03c0\u03bf<br \/>\n(<strong>IgG, IgA, IgM<\/strong>) \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 (<strong>\u03ba \u03ae \u03bb<\/strong>).<\/p>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03ba\u03bb\u03b5\u03b9\u03b4\u03af:<\/strong> \u0397 SPEP \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c4\u03bf \u00ab\u03c3\u03c7\u03ae\u03bc\u03b1\u00bb.<br \/>\n\u0397 IFE \u00ab\u03bf\u03bd\u03bf\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03b9\u00bb \u03c4\u03bf\u03bd \u03ba\u03bb\u03ce\u03bd\u03bf.<\/div>\n<h3>\u03a0\u03cc\u03c4\u03b5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7<\/h3>\n<ul>\n<li>\u038c\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae\u03c2 M-spike<\/li>\n<li>\u038c\u03c4\u03b1\u03bd \u03b7 \u03b3- \u03ae \u03b2-\u03b6\u03ce\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7<\/li>\n<li>\u038c\u03c4\u03b1\u03bd \u03b7 SPEP \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03bb\u03bb\u03ac \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae<\/li>\n<li>\u03a3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae\u03c2 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5<\/li>\n<\/ul>\n<p>\u0397 IFE \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 SPEP \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03c3\u03b5\u03b9<br \/>\n\u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c6\u03b5\u03cd\u03b3\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03b1\u03c0\u03bb\u03cc \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1.<\/p>\n<h2 id=\"sec11\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">11<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u0395\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u0391\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 (FLC)<\/span><\/h2>\n<p>\u0397 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 <strong>\u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03c9\u03bd \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd (Free Light Chains \u2013 \u03ba\/\u03bb)<\/strong><br \/>\n\u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2,<br \/>\n\u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae <strong>light-chain \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong>.<\/p>\n<h3>\u03a4\u03b9 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9<\/h3>\n<ul>\n<li>\u0391\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03ba \u03ba\u03b1\u03b9 \u03bb<\/li>\n<li>\u039b\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb (\u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03ba\u03bb\u03b9\u03c3\u03b7 \u2192 \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1)<\/li>\n<\/ul>\n<h3>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/h3>\n<ul>\n<li>\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03ae \u03bf\u03c1\u03b9\u03b1\u03ba\u03ae SPEP \u03bc\u03b5 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1<\/li>\n<li>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03b1\u03b3\u03bd\u03ce\u03c3\u03c4\u03bf\u03c5 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2<\/li>\n<li>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b8\u03b5\u03c1\u03b1<!-- ==================== SECTION 12 ==================== --><br \/>\n<h2 id=\"sec12\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">12<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">UPEP &amp; Bence-Jones \u03a0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/span><\/h2>\n<p>\u0397 <strong>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bf\u03cd\u03c1\u03c9\u03bd (UPEP)<\/strong> \u03ba\u03b1\u03b9 \u03b7<br \/>\n<strong>\u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u03bf\u03cd\u03c1\u03c9\u03bd (Urine IFE)<\/strong> \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03c5\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2<br \/>\n\u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 (\u03ba \u03ae \u03bb), \u03b3\u03bd\u03c9\u03c3\u03c4\u03ad\u03c2 \u03c9\u03c2 <strong>Bence-Jones \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/strong>.<br \/>\n\u0395\u03af\u03bd\u03b1\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b5\u03c2 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1\u03c2<br \/>\n<strong>light-chain \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03cd \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong>, \u03cc\u03c0\u03bf\u03c5 \u03b7 SPEP \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1:<\/strong> \u0397 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 M-spike \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9<br \/>\n\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf. \u0397 UPEP \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1.<\/div>\n<h3>\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9<\/h3>\n<ul>\n<li>\u03a5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd<\/li>\n<li>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b1\u03b3\u03bd\u03ce\u03c3\u03c4\u03bf\u03c5 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2<\/li>\n<li>\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae SPEP \u03bc\u03b5 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1<\/li>\n<li>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03b5 light-chain \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/li>\n<\/ul>\n<h3>\u03a4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1<\/h3>\n<ul>\n<li><strong>\u03a0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 24\u03c9\u03c1\u03b7 \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae<\/strong> \u03b3\u03b9\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7<\/li>\n<li>\u0391\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c8\u03cd\u03be\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae<\/li>\n<li>\u0397 Urine IFE \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03b9\u03c3\u03bf\u03c4\u03c5\u03c0\u03af\u03b1 (\u03ba\/\u03bb)<\/li>\n<\/ul>\n<p>\u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 <strong>SPEP + IFE \u03bf\u03c1\u03bf\u03cd + FLC + UPEP<\/strong> \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7<br \/>\n\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c3\u03b5 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"sec13\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">13<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03b9\u03b4\u03b9\u03ba\u03ac \u039c\u03bf\u03c4\u03af\u03b2\u03b1 \u03c3\u03c4\u03bf \u0399\u03c7\u03bd\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1<\/span><\/h2>\n<p>\u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1 \u03c3\u03c4\u03b7\u03bd <strong>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9<br \/>\n\u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd<br \/>\n\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<h3>\u0397\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \/ \u039a\u03af\u03c1\u03c1\u03c9\u03c3\u03b7<\/h3>\n<ul>\n<li>\u2193 \u0391\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7<\/li>\n<li>\u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u2191 \u03b3-\u03b6\u03ce\u03bd\u03b7\u03c2 (\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 IgA)<\/li>\n<li>\u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae <strong>\u03b2-\u03b3 \u03b3\u03ad\u03c6\u03c5\u03c1\u03b1<\/strong><\/li>\n<\/ul>\n<h3>\u039d\u03b5\u03c6\u03c1\u03c9\u03c3\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf<\/h3>\n<ul>\n<li>\u0388\u03bd\u03c4\u03bf\u03bd\u03b7 \u2193 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7\u03c2<\/li>\n<li>\u2191 \u03b12-\u03bc\u03b1\u03ba\u03c1\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 (\u03b1\u03b9\u03c7\u03bc\u03ae \u03c3\u03c4\u03b7\u03bd \u03b12 \u03b6\u03ce\u03bd\u03b7)<\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bd\u03bf\u03b4\u03cc\u03c2 \u03c5\u03c0\u03b5\u03c1\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1<\/li>\n<\/ul>\n<h3>\u03a7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \/ \u0391\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1<\/h3>\n<ul>\n<li>\u0395\u03c5\u03c1\u03b5\u03af\u03b1 \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03b3-\u03b6\u03ce\u03bd\u03b7\u03c2<\/li>\n<li>\u0389\u03c0\u03b9\u03b1 \u2193 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7\u03c2<\/li>\n<\/ul>\n<h3>\u03a5\u03c0\u03bf\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/h3>\n<ul>\n<li>\u2193 \u03b3-\u03b6\u03ce\u03bd\u03b7\u03c2<\/li>\n<li>\u03a3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae\u03c2 \u03ae \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1<\/li>\n<\/ul>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong>\u0394\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae:<\/strong> \u03a4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03b9,<br \/>\n\u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03c5\u03c0\u03bf\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 IFE.<\/div>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<h2 id=\"sec14\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">14<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 &amp; Follow-Up<\/span><\/h2>\n<p>\u0397 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9<br \/>\n\u03c3\u03c4\u03b9\u03c2 <strong>\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/strong> \u03c4\u03b7\u03c2 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2, \u03c3\u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf<br \/>\n<strong>FLC (\u03ba\/\u03bb)<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7.<\/p>\n<h3>MGUS<\/h3>\n<ul>\n<li>\u0395\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 6\u201312 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/li>\n<li>\u0395\u03ac\u03bd \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc \u2192 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03af\u03ba\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2<\/li>\n<\/ul>\n<h3>Smoldering \u039c\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/h3>\n<ul>\n<li>\u03a3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/li>\n<li>\u0391\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03c4\u03ac\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03bd\u03cc\u03c3\u03bf<\/li>\n<\/ul>\n<h3>\u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u039c\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/h3>\n<ul>\n<li>\u03a4\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc <strong>SPEP + IFE + FLC<\/strong><\/li>\n<li>\u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd <strong>\u03af\u03b4\u03b9\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf<\/strong><\/li>\n<li>\u03a3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 CRAB \/ SLiM-CRAB<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u03a3\u03b7\u03bc\u03b5\u03af\u03bf \u03ba\u03bb\u03b5\u03b9\u03b4\u03af:<\/strong> \u0397 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5<br \/>\n\u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc \u03bc\u03af\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c4\u03b9\u03bc\u03ae.<\/div>\n<h2 id=\"sec15\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: bold; color: #111827;\">15<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af &amp; \u03a0\u03b1\u03b3\u03af\u03b4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<br \/>\n<\/span><\/h2>\n<p>\u0397 <strong>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bf\u03c1\u03bf\u03cd (SPEP)<\/strong> \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<br \/>\n\u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9<br \/>\n\u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7\u03c2 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2 \u03ae \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u0397 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1<br \/>\n\u03bd\u03b1 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 18px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae:<\/strong> \u0397 SPEP \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd.<br \/>\n\u0397 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af <strong>Immunofixation (IFE)<\/strong><br \/>\n\u03ba\u03b1\u03b9\/\u03ae <strong>\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u0395\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u0391\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 (FLC)<\/strong>.<\/div>\n<h3>1) \u039c\u03b9\u03ba\u03c1\u03cc \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03c4\u03af\u03bf<\/h3>\n<ul>\n<li>\u039c\u03b9\u03ba\u03c1\u03ad\u03c2 M-\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 (&lt;0,2\u20130,3 g\/dL, \u03b1\u03bd\u03ac \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1.<\/li>\n<li>\u0397 <strong>IFE<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7.<\/li>\n<\/ul>\n<h3>2) \u039d\u03cc\u03c3\u03bf\u03c2 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd (Light-chain disease)<\/h3>\n<ul>\n<li>\u0395\u03bd\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 M-spike \u03c3\u03c4\u03b7 SPEP.<\/li>\n<li>\u0391\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf\u03c2 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 <strong>FLC (\u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb)<\/strong>.<\/li>\n<\/ul>\n<h3>3) \u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b7 \u03b2-\u03b6\u03ce\u03bd\u03b7<\/h3>\n<ul>\n<li>IgA \u03ae IgM \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03b2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae.<\/li>\n<li>\u0391\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 IFE \u03cc\u03c4\u03b1\u03bd \u03b7 \u03b2-\u03b6\u03ce\u03bd\u03b7 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03b1\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7.<\/li>\n<\/ul>\n<h3>4) \u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 M-spike<\/h3>\n<ul>\n<li>\u03a3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03ae \u03b7\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1, \u03b7 \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03b3-\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u00ab\u03c3\u03ba\u03b5\u03c0\u03ac\u03c3\u03b5\u03b9\u00bb \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae.<\/li>\n<li>\u0397 IFE \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7\u03c2.<\/li>\n<\/ul>\n<h3>5) \u03a0\u03c1\u03bf\u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2<\/h3>\n<ul>\n<li><strong>\u039b\u03b9\u03c0\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u2192 \u03b1\u03bb\u03bb\u03bf\u03af\u03c9\u03c3\u03b7 \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2<\/li>\n<li><strong>\u0391\u03b9\u03bc\u03cc\u03bb\u03c5\u03c3\u03b7<\/strong> \u2192 \u03c8\u03b5\u03c5\u03b4\u03b5\u03af\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03ba\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd<\/li>\n<li><strong>IVIG<\/strong> \u2192 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7<\/li>\n<li><strong>\u0391\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7<\/strong> \u2192 \u03c8\u03b5\u03c5\u03b4\u03bf-\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2<\/li>\n<li><strong>\u039a\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2<\/strong> \u2192 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03b9\u03ce\u03bd<\/li>\n<\/ul>\n<h3>6) \u03a0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/h3>\n<ul>\n<li>\u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1.<\/li>\n<li>\u039a\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 <strong>MGUS<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1.<\/li>\n<li>\u0397 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 <strong>CRAB \/ SLiM-CRAB<\/strong>.<\/li>\n<\/ul>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7:<\/strong><br \/>\n\u038c\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b7 SPEP \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae,<br \/>\n\u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03ae\u03c3\u03c4\u03b5 \u03c3\u03b5 <strong>IFE + FLC \u00b1 UPEP<\/strong>.<\/div>\n<p><!-- ==================== SECTION 16 ==================== --><\/p>\n<h2 id=\"sec16\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">16<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP);<\/summary>\n<p>\u0397 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c7\u03c1\u03b5\u03c9\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 8\u201312 \u03ce\u03c1\u03b5\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bb\u03b9\u03c0\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b9\u03c7\u03bd\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u00ab\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae\u00bb (M-spike);<\/summary>\n<p>\u03a3\u03c4\u03b5\u03bd\u03ae \u03b1\u03b9\u03c7\u03bc\u03ae \u03c3\u03c4\u03b7 \u03b3 \u03ae \u03b2 \u03b6\u03ce\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03bc\u03cc\u03bd\u03bf \u03ba\u03bb\u03ce\u03bd\u03bf \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af IFE \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 M-spike \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1;<\/summary>\n<p>\u038c\u03c7\u03b9, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 MGUS, \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03bf\u03ae\u03b8\u03b7\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 Immunofixation (IFE);<\/summary>\n<p>\u038c\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 M-spike, \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b1 \u03c3\u03c4\u03b7 \u03b3 \u03ae \u03b2 \u03b6\u03ce\u03bd\u03b7 \u03ae \u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03c0\u03b1\u03c1\u03ac \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae SPEP.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03c1\u03cc\u03bb\u03bf \u03ad\u03c7\u03bf\u03c5\u03bd \u03bf\u03b9 \u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u0395\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u0391\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 (FLC);<\/summary>\n<p>\u0391\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03c5\u03bd \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b5\u03c2 \u03c3\u03b5 light-chain \u03bd\u03cc\u03c3\u03bf \u03ae \u03cc\u03c4\u03b1\u03bd \u03b7 SPEP \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u00abprotein gap\u00bb;<\/summary>\n<p>\u0397 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7\u03c2\u00b7 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c4\u03b9\u03bc\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b3\u03b1\u03bc\u03bc\u03b1\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ae \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c4\u03b5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03ce \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf;<\/summary>\n<p>\u038c\u03c4\u03b1\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03ae \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03c5\u03c0\u03b5\u03c1\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ae \u03bf\u03c3\u03c4\u03b9\u03ba\u03ac \u03ac\u03bb\u03b3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03b7 \u03b1\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1;<\/summary>\n<p>\u039d\u03b1\u03b9, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b1\u03b9\u03bc\u03bf\u03c3\u03c5\u03bc\u03c0\u03cd\u03ba\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c8\u03b5\u03c5\u03b4\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03b1\u03bb\u03b2\u03bf\u03c5\u03bc\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c3\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 MGUS;<\/summary>\n<p>\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03ba\u03ac\u03b8\u03b5 6\u201312 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2.<\/p>\n<\/details>\n<p><!-- ==================== SECTION 17 ==================== --><\/p>\n<h2 id=\"sec17\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 8px 18px rgba(17,24,39,.18),inset 0 2px 0 rgba(255,255,255,.6);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 900; color: #111827;\">17<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<p><strong>\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2.<\/strong> \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center; margin-top: 14px; margin-bottom: 26px;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP) \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<p><!-- ===== Ultra Mini NEJM Style Bibliography ===== --><\/p>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 12px; margin-bottom: 10px; font-size: 14px;\">Rajkumar SV, et al. Updated Diagnostic Criteria for Multiple Myeloma. <em>Lancet Oncology<\/em>, 2014.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25439696\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/25439696\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 12px; margin-bottom: 10px; font-size: 14px;\">Dimopoulos MA, et al. EHA-ESMO Clinical Practice Guidelines for Multiple Myeloma. <em>Ann Oncol<\/em>, 2021.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33549387\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33549387\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 12px; margin-bottom: 10px; font-size: 14px;\">O\u2019Connell TX, et al. Understanding and Interpreting Serum Protein Electrophoresis. <em>Am Fam Physician<\/em>, 2005.<br \/>\n<a href=\"https:\/\/www.aafp.org\/pubs\/afp\/issues\/2005\/0101\/p105.html\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.aafp.org\/pubs\/afp\/issues\/2005\/0101\/p105.html<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 12px; margin-bottom: 10px; font-size: 14px;\">British Society for Haematology. Investigation and Management of MGUS, 2023.<br \/>\n<a href=\"https:\/\/b-s-h.org.uk\/guidelines\/guidelines\/investigation-and-management-of-monoclonal-gammopathy-of-undermined-significance\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/b-s-h.org.uk\/&#8230;<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 12px; margin-bottom: 10px; font-size: 14px;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 14px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP): \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9, M-Spike, \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 &amp; \u03a4\u03b9\u03bc\u03ad\u03c2 \u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 12 \u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2026 \u0397 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 (M-spike), \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03cd \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, MGUS, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2, \u03b7\u03c0\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c6\u03c1\u03c9\u03c3\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5. \u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1 \u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u039b\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (SPEP) \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03b7 \u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 (\u0395\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2) \u0394\u03b5\u03b9\u03b3\u03bc\u03b1\u03c4\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 &amp; [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":9749,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2534],"tags":[1407,1408,1404,1403,1413],"class_list":["post-4759","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exetaseis-aimatos","tag-m-spike","tag-mgus","tag-spep","tag-ilektroforisi-lefkomaton","tag-pollaplo-myeloma"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/4759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=4759"}],"version-history":[{"count":60,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/4759\/revisions"}],"predecessor-version":[{"id":9751,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/4759\/revisions\/9751"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/9749"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=4759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=4759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=4759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}