{"id":4683,"date":"2025-08-05T14:58:18","date_gmt":"2025-08-05T11:58:18","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=4683"},"modified":"2026-03-18T21:48:03","modified_gmt":"2026-03-18T19:48:03","slug":"jak2-metallaxi","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/jak2-metallaxi\/","title":{"rendered":"JAK2 \u039c\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 (V617F): \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9, \u0394\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 &#038; \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1"},"content":{"rendered":"<div style=\"max-width: 1000px; margin: 0 auto;\">\n<h1 style=\"font-size: 32px; font-weight: 900; color: #111827; margin-bottom: 10px;\">JAK2 \u039c\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 (V617F): \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9, \u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9, \u03a0\u03ce\u03c2 \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03a4\u03b9 \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/h1>\n<div style=\"margin: 10px 0 12px; color: #6b7280; font-size: 13px;\">\u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: <time datetime=\"2026-03-18\">18 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time> \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: <time datetime=\"2026-03-18\">18 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time><\/div>\n<div style=\"background: #f8fafc; border-left: 5px solid #b70000; padding: 16px 18px; border-radius: 12px; margin: 18px 0;\">\n<p><strong>\u03a3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03c0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7:<\/strong><\/p>\n<ul style=\"margin: 10px 0 0; padding-left: 18px; line-height: 1.7;\">\n<li>\u0397 <strong>JAK2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<\/strong>, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b7 <strong>JAK2 V617F<\/strong>, \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 <strong>\u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 (MPNs)<\/strong>, \u03cc\u03c0\u03c9\u03c2 \u03b7 <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong>, \u03b7 <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong> \u03ba\u03b1\u03b9 \u03b7 <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong>.<\/li>\n<li>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd <strong>\u03c5\u03c8\u03b7\u03bb\u03cc\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7\u03c2, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1, \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1<\/strong> \u03ae \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b1 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1.<\/li>\n<li>\u0388\u03bd\u03b1 <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 MPN, \u03b1\u03bb\u03bb\u03ac <strong>\u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5<\/strong>. \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u03b2\u03b9\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2.<\/li>\n<li>\u0391\u03bd \u03b7 <strong>JAK2 V617F<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae, \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03c3\u03c5\u03c7\u03bd\u03ac \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>JAK2 \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 12<\/strong>, <strong>CALR<\/strong>, <strong>MPL<\/strong> \u03ae \u03ba\u03b1\u03b9 <strong>\u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7 \u03bd\u03ad\u03b1\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 (NGS)<\/strong>.<\/li>\n<li>\u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd <strong>\u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae<\/strong>. \u0393\u03b9\u03b1 \u03c0\u03b9\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b4\u03b5\u03af\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd <a style=\"color: #b70000; font-weight: bold; text-decoration: none;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/jak2-to-gonidio-i-metallaxi-v617f-kai-i-therapeftiki-tou-simasia\/\">\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bf\u03b4\u03b7\u03b3\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b7 JAK2 V617F \u03c3\u03c4\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1<\/a>.<\/li>\n<\/ul>\n<\/div>\n<nav id=\"toc\" style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 14px; padding: 16px 18px; margin: 18px 0;\">\n<div style=\"font-weight: 800; font-size: 18px; color: #111827; margin-bottom: 10px;\">\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/div>\n<ol style=\"margin: 0; padding-left: 18px; line-height: 1.8;\">\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section1\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf JAK2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section2\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 JAK2 V617F<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section3\">\u0386\u03bb\u03bb\u03bf\u03b9 \u03c4\u03cd\u03c0\u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd JAK2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section4\">\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 JAK2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section5\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf JAK2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section6\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section7\">\u03a0\u03ce\u03c2 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section8\">\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03b7 JAK2 V617F \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section9\">\u03a6\u03bf\u03c1\u03c4\u03af\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5 (allele burden) \u03ba\u03b1\u03b9 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section10\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section11\">\u03a1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (Ruxolitinib) \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section12\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 (monitoring)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section13\">JAK2 \u03ba\u03b1\u03b9 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section14\">\u0395\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae; \u0393\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section15\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section16\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section17\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: 0; border-top: 2px solid #d1d5db; margin: 14px 0 24px;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<section id=\"section1\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf JAK2<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a4\u03bf <strong>JAK2 (Janus Kinase 2)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03bc\u03af\u03b1 \u03c4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7 \u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03b9\u03bd\u03ce\u03bd \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5. \u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03c4\u03bf JAK2 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c4\u03bf \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03bd\u03b1 \u00ab\u03ba\u03b1\u03c4\u03b1\u03bb\u03ac\u03b2\u03b5\u03b9\u00bb \u03c0\u03cc\u03c4\u03b5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03c4\u03b5\u03af, \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03ae \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b9\u03ce\u03c3\u03b5\u03b9.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03b1\u03c5\u03c4\u03cc \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 <strong>JAK\/STAT<\/strong>, \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7. \u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 <strong>\u03b5\u03c1\u03c5\u03b8\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03af\u03bd\u03b7 (EPO)<\/strong>, \u03b7 <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03af\u03bd\u03b7 (TPO)<\/strong> \u03ba\u03b1\u03b9 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03b9\u03bd\u03c4\u03b5\u03c1\u03bb\u03b5\u03c5\u03ba\u03af\u03bd\u03b5\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac:<\/strong> \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf JAK2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b5\u03c1\u03c5\u03b8\u03c1\u03ce\u03bd, \u03bb\u03b5\u03c5\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac. \u038c\u03c4\u03b1\u03bd \u03b1\u03c0\u03bf\u03ba\u03c4\u03ac \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7, \u03c4\u03bf \u03c3\u03ae\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03ad\u03bd\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ce\u03c2 \u00ab\u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03cc\u00bb.<\/div>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u03a1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u03b5\u03b9\u03b4\u03b5\u03af\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ad\u03c2.<\/li>\n<li>\u03a3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd STAT \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd.<\/li>\n<li>\u03a0\u03b1\u03af\u03b6\u03b5\u03b9 \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7.<\/li>\n<li>\u0395\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ad\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 SOCS \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a4\u03bf <strong>JAK2<\/strong> \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf <strong>\u03c7\u03c1\u03c9\u03bc\u03cc\u03c3\u03c9\u03bc\u03b1 9p24<\/strong>. \u03a3\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2 \u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b5\u03be\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac \u03c3\u03ae\u03bc\u03b1\u03c4\u03b1. \u0391\u03c5\u03c4\u03cc \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03af\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b7 <strong>V617F<\/strong>.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 2 ==================== --><\/p>\n<section id=\"section2\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 JAK2 V617F<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 <strong>JAK2 V617F<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 JAK2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03c3\u03c4\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 <strong>\u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 (MPNs)<\/strong>. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf <strong>\u03b5\u03be\u03ce\u03bd\u03b9\u03bf 14<\/strong>, \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03b2\u03b1\u03bb\u03af\u03bd\u03b7 (V) \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c6\u03b1\u03b9\u03bd\u03c5\u03bb\u03b1\u03bb\u03b1\u03bd\u03af\u03bd\u03b7 (F) \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 617.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 JAK2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 <strong>\u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7<\/strong>, \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b5\u03c1\u03ad\u03b8\u03b9\u03c3\u03bc\u03b1 \u03b1\u03c0\u03cc \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03af\u03bd\u03b5\u03c2. \u0388\u03c4\u03c3\u03b9 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ad\u03c2 \u03c3\u03ae\u03bc\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd, \u03bc\u03b5 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03ba\u03bb\u03ce\u03bd\u03bf\u03c5.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u0395\u03af\u03bd\u03b1\u03b9 <strong>\u03c3\u03b7\u03bc\u03b5\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<\/strong> (1849 G&gt;T).<\/li>\n<li>\u0391\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf <strong>\u03b5\u03be\u03ce\u03bd\u03b9\u03bf 14<\/strong> \u03c4\u03bf\u03c5 JAK2.<\/li>\n<li>\u039f\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 <strong>\u03b1\u03c5\u03c4\u03cc\u03bd\u03bf\u03bc\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7<\/strong> \u03c4\u03bf\u03c5 \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd JAK\/STAT.<\/li>\n<li>\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 <strong>\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc, \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf<\/strong> \u03b4\u03b5\u03af\u03ba\u03c4\u03b7.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong> \u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 V617F \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 MPN, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03b8\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae. \u0397 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9, \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9, \u03c4\u03b7 \u03b2\u03b9\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03ae \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera<\/strong> \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7<\/strong>. \u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 JAK2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 MPN.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 3 ==================== --><\/p>\n<section id=\"section3\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">3<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0386\u03bb\u03bb\u03bf\u03b9 \u03c4\u03cd\u03c0\u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd JAK2<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03bd \u03ba\u03b1\u03b9 \u03b7 <strong>JAK2 V617F<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b9\u03bf \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03cc\u03bd\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03bf\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5. \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03ba\u03c4\u03bf\u03cd\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 MPN \u03b1\u03bb\u03bb\u03ac \u03b7 V617F \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b5\u03be\u03c9\u03bd\u03af\u03bf\u03c5 12<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 <strong>\u03b5\u03be\u03c9\u03bd\u03af\u03bf\u03c5 12<\/strong> \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera<\/strong> \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03af \u03b3\u03b9\u03b1 V617F. \u03a3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03b5\u03c1\u03c5\u03b8\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03bc\u03b9\u03ba\u03c1\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd PV.<\/li>\n<li>\u0394\u03b5\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c8\u03ac\u03c7\u03bd\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf V617F.<\/li>\n<li>\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7.<\/li>\n<\/ul>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a3\u03c0\u03b1\u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ae \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b1\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 <strong>R683<\/strong> \u03ae \u03c3\u03c0\u03b1\u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c4\u03bf\u03c5 JAK2. \u0391\u03c5\u03c4\u03ad\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03ae \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03ac\u03c4\u03c5\u03c0\u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u0394\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf:<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 vera \u03ba\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae V617F, \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>JAK2 \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 12<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c4\u03bf \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc \u03b2\u03ae\u03bc\u03b1.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 JAK2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03ba\u03b1\u03b9 \u03c3\u03b5 <strong>\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7<\/strong> \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd, \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03ad\u03c4\u03bf\u03b9\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7. \u0393\u03b9\u03b1 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>, \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c3\u03c4\u03b1 JAK2-positive MPNs, \u03b4\u03b5\u03af\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03c4\u03bf <a style=\"color: #b70000; font-weight: bold; text-decoration: none;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/jak2-to-gonidio-i-metallaxi-v617f-kai-i-therapeftiki-tou-simasia\/\">\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03ac\u03c1\u03b8\u03c1\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 JAK2 V617F \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1<\/a>.<\/p>\n<\/section>\n<section id=\"section4\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">4<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 JAK2<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 <strong>JAK2<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc. \u0396\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b3\u03b9\u03b1 <strong>\u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 (MPN)<\/strong> \u03ae \u03b3\u03b9\u03b1 \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b7 \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03b7 JAK2 \u03bc\u03c0\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03cc\u03c4\u03b1\u03bd \u03b7 <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong> \u03ae \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b4\u03b5\u03bd \u03b5\u03be\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b1\u03c0\u03cc \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03b9\u03c4\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b8\u03ad\u03bb\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03c3\u03b5\u03b9 \u03ae \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03c3\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 <strong>\u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7\u03c2<\/strong> \u03ae <strong>\u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7<\/strong> \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03bf\u03c6\u03b1\u03bd\u03ae \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03c0\u03b1\u03b8\u03ae \u03b1\u03b9\u03c4\u03af\u03b1.<\/li>\n<li>\u0395\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7<\/strong>.<\/li>\n<li><strong>\u03a3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1<\/strong> \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03af\u03bc\u03b1.<\/li>\n<li>\u0391\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b1 <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b5\u03c2 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2.<\/li>\n<li>\u03a5\u03c0\u03bf\u03c8\u03af\u03b1 <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 vera (PV)<\/strong>, <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03cd\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 (ET)<\/strong> \u03ae <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03bf\u03cd\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7\u03c2 (PMF)<\/strong> \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7:<\/strong> \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf \u03ae \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c0\u03b1\u03c1\u03b1\u03c0\u03bf\u03bc\u03c0\u03ae, \u03cc\u03c4\u03b1\u03bd \u03bc\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b5\u03be\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c6\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7, \u03ba\u03ac\u03c0\u03bd\u03b9\u03c3\u03bc\u03b1, \u03c5\u03c0\u03bf\u03be\u03af\u03b1, \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03ae \u03c3\u03b9\u03b4\u03b7\u03c1\u03bf\u03c0\u03b5\u03bd\u03af\u03b1.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera<\/strong>, \u03b7 JAK2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b8\u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7. \u03a3\u03c4\u03b7\u03bd <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7<\/strong>, \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bb\u03b3\u03bf\u03c1\u03af\u03b8\u03bc\u03bf\u03c5.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<section id=\"section5\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">5<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf JAK2<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 <strong>\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 (MPNs)<\/strong>. \u0391\u03c5\u03c4\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03b3\u03b9\u03b1\u03c4\u03af \u03b5\u03ba\u03b5\u03af \u03b7 JAK2 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 JAK2 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c0\u03bb\u03b5\u03b9\u03bf\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd. \u0397 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b1\u03c0\u03cc <strong>\u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c1\u03c5\u03b8\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7<\/strong>, \u03c5\u03c8\u03b7\u03bb\u03cc \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7, \u03c5\u03c0\u03b5\u03c1\u03b3\u03bb\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u0399\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u0388\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 ET \u03b5\u03af\u03bd\u03b1\u03b9 JAK2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03af. \u0397 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf <strong>\u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd PMF, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 JAK2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b1\u03bd\u03c4\u03ac\u03c4\u03b1\u03b9. \u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac <strong>\u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1, \u03ba\u03b1\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae, \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03bc\u03c5\u03b5\u03bb\u03b9\u03ba\u03ae \u03af\u03bd\u03c9\u03c3\u03b7.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u0386\u03bb\u03bb\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 JAK2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03c5\u03b8\u03b5\u03af \u03c3\u03c0\u03b1\u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 <strong>\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7<\/strong> \u03ae \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bd\u03c4\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2. \u03a0\u03b1\u03c1\u2019 \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac, \u03b7 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03b1\u03be\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac <strong>Philadelphia-negative MPNs<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong> \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc JAK2 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03bc\u03af\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf. \u039f \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c0\u03bf\u03b9\u03b1 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7, \u03c0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03bd \u03b8\u03ad\u03bb\u03b5\u03c4\u03b5 \u03c0\u03b9\u03bf \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7, \u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2<\/strong> \u03c3\u03c4\u03b1 JAK2-positive MPNs, \u03b4\u03b5\u03af\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03c4\u03bf <a style=\"color: #b70000; font-weight: bold; text-decoration: none;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/jak2-to-gonidio-i-metallaxi-v617f-kai-i-therapeftiki-tou-simasia\/\">\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03ac\u03c1\u03b8\u03c1\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 JAK2 V617F \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/a>.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<section id=\"section6\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">6<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u039f \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 JAK2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 <strong>\u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong> \u03ba\u03b1\u03b9, \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03c3\u03b5 <strong>\u03bc\u03c5\u03b5\u03bb\u03cc \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd<\/strong>. \u0397 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ae \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b8\u03ad\u03bb\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9 \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2: \u03b1\u03c0\u03bb\u03ae \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7, \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ae \u03b5\u03ba\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03bf panel \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li><strong>PCR<\/strong> \u03b3\u03b9\u03b1 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 JAK2 V617F.<\/li>\n<li><strong>qPCR<\/strong> \u03b3\u03b9\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 <strong>\u03c6\u03bf\u03c1\u03c4\u03af\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5 (allele burden)<\/strong>.<\/li>\n<li><strong>\u0391\u03bb\u03bb\u03b7\u03bb\u03bf\u03cd\u03c7\u03b9\u03c3\u03b7 \u03bd\u03ad\u03b1\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 (NGS)<\/strong> \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd.<\/li>\n<li><strong>RT-PCR \/ HRM \/ sequencing<\/strong> \u03c3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b5\u03c2 \u03ae \u03ac\u03c4\u03c5\u03c0\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 <strong>\u03b2\u03b9\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd<\/strong> \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03af\u03c3\u03c4\u03b1\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 JAK2. \u0399\u03b4\u03af\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd <strong>ET<\/strong> \u03ba\u03b1\u03b9 prefibrotic \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7\u03c2, \u03b7 \u03b9\u03c3\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b5\u03b9\u03c1\u03ac \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5:<\/strong> \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u2192 JAK2 V617F \u2192 \u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03ba\u03b1\u03b9\/\u03ae \u03b2\u03b9\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<section id=\"section7\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">7<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bd \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9, \u03c3\u03b5 \u03c0\u03bf\u03b9\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2. \u0388\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc<\/strong> \u03ae <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc<\/strong> \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div style=\"overflow-x: auto;\">\n<table style=\"width: 100%; border-collapse: collapse; margin-top: 10px; font-size: 15px;\">\n<thead>\n<tr style=\"background: #f3f4f6;\">\n<th style=\"padding: 10px; border: 1px solid #d1d5db; text-align: left;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"padding: 10px; border: 1px solid #d1d5db; text-align: left;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #d1d5db;\">\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc JAK2 V617F<\/td>\n<td style=\"padding: 10px; border: 1px solid #d1d5db;\">\u0394\u03b5\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7. \u0391\u03c5\u03c4\u03cc \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 MPN, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #d1d5db;\">\u0398\u03b5\u03c4\u03b9\u03ba\u03cc JAK2 V617F<\/td>\n<td style=\"padding: 10px; border: 1px solid #d1d5db;\">\u03a5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2, \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c9\u03c3\u03c4\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #d1d5db;\">\u03a0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \/ allele burden<\/td>\n<td style=\"padding: 10px; border: 1px solid #d1d5db;\">\u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03bf\u03c5 \u03ba\u03bb\u03ce\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1\u03c2.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p style=\"line-height: 1.8; color: #111827; margin-top: 14px;\">\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 <strong>\u03c5\u03c8\u03b7\u03bb\u03cc \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7<\/strong>, \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc JAK2 \u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c0\u03c1\u03bf\u03c2 <strong>PV<\/strong>. \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 <strong>\u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7<\/strong>, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 <strong>ET<\/strong>. \u0391\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1, \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03af\u03bd\u03c9\u03c3\u03b7<\/strong>, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 <strong>PMF<\/strong>.<\/p>\n<\/section>\n<section id=\"section8\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">8<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd \u03b7 JAK2 V617F \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0388\u03bd\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b3\u03b9\u03b1 <strong>JAK2 V617F<\/strong> \u03b4\u03b5\u03bd \u03ba\u03bb\u03b5\u03af\u03bd\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7. \u0391\u03bd \u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc MPN, \u03bf \u03b1\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c2 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03ac.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1:<\/strong><br \/>\n1. <strong>JAK2 V617F<\/strong> \u2192 2. \u03b1\u03bd \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 <strong>PV<\/strong>, \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>JAK2 \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 12<\/strong> \u2192 3. \u03c3\u03b5 ET\/PMF \u03ae \u03ac\u03c4\u03c5\u03c0\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>CALR<\/strong> \u03ba\u03b1\u03b9 <strong>MPL<\/strong> \u2192 4. \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9, <strong>NGS panel<\/strong>.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03c5\u03c4\u03ae \u03b7 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03b7 \u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>JAK2-negative PV<\/strong> \u03ae \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>ET\/PMF<\/strong> \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2-\u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03c2.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li><strong>CALR<\/strong>: \u03c3\u03c5\u03c7\u03bd\u03ae \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 ET \u03ba\u03b1\u03b9 PMF.<\/li>\n<li><strong>MPL<\/strong>: \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 ET \u03ba\u03b1\u03b9 PMF.<\/li>\n<li><strong>NGS<\/strong>: \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ae \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03b1\u03c0\u03bf\u03ba\u03c4\u03bf\u03cd\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b7 <strong>\u03b2\u03b9\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd<\/strong>, \u03bf\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b1\u03b9\u03bc\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2\/\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae\u03c2, \u03b7 <strong>EPO<\/strong> \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03c5\u03b8\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 9 ==================== --><\/p>\n<section id=\"section9\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">9<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a6\u03bf\u03c1\u03c4\u03af\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a4\u03bf <strong>\u03c6\u03bf\u03c1\u03c4\u03af\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5<\/strong> \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03bf\u03c5 \u03ba\u03bb\u03ce\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 <strong>JAK2<\/strong>. \u0394\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b8\u03ad\u03c3\u03b5\u03b9 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong> \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0395\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03c6\u03bf\u03c1\u03c4\u03af\u03bf, \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b1 <strong>\u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 (MPNs)<\/strong> \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bd\u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b6\u03bf\u03c5\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2, \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03bc\u03c5\u03b5\u03bb\u03cc.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u03a3\u03c4\u03b7\u03bd <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong> \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2.<\/li>\n<li>\u03a3\u03c4\u03b7\u03bd <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong> \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf <strong>IPSET-thrombosis<\/strong>.<\/li>\n<li>\u03a3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong> \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 <strong>IPSS<\/strong>, <strong>DIPSS<\/strong> \u03ba\u03b1\u03b9 <strong>DIPSS-Plus<\/strong>.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a4\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03c1\u03b1\u03c4\u03ae\u03c3\u03b5\u03c4\u03b5:<\/strong> \u03b7 JAK2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bf\u03bc\u03bc\u03ac\u03c4\u03b9 \u03c4\u03b7\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2, \u03cc\u03c7\u03b9 \u03cc\u03bb\u03b7 \u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u0397 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7, \u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03c9\u03bd, \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 10 ==================== --><\/p>\n<section id=\"section10\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">10<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 <strong>JAK2<\/strong> \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae <strong>\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/strong>, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03cc\u03bb\u03bf\u03b9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b1\u03af\u03c1\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 <strong>\u03bd\u03cc\u03c3\u03bf<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf <strong>\u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1:<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u03a3\u03c4\u03b7\u03bd <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong>, \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/li>\n<li>\u03a3\u03c4\u03b7\u03bd <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong>, \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03ae \u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9.<\/li>\n<li>\u03a3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong>, \u03c4\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c0\u03ad\u03c6\u03c4\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u03c3\u03c4\u03b7 \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1, \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039a\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf:<\/strong> \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 JAK2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u00ab\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03ae \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u00bb. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03b8\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac \u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03b5\u03af \u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03c5\u03c0\u03bf\u03c4\u03cd\u03c0\u03bf MPN.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03bd \u03b8\u03ad\u03bb\u03b5\u03c4\u03b5 \u03c0\u03b9\u03bf \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7, \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2<\/strong> \u03c3\u03c4\u03b1 JAK2-positive MPNs, \u03b4\u03b5\u03af\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03c4\u03bf <a style=\"color: #b70000; font-weight: bold; text-decoration: none;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/jak2-to-gonidio-i-metallaxi-v617f-kai-i-therapeftiki-tou-simasia\/\">\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03ac\u03c1\u03b8\u03c1\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 JAK2 V617F \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/a>.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 11 ==================== --><\/p>\n<section id=\"section11\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">11<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (ruxolitinib) \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c4\u03b9\u03c2 <strong>JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b5\u03c2 (MPNs)<\/strong> \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf <strong>\u03b1\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong>, <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong> \u03ae <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2, \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03bf \u03bc\u03ad\u03b3\u03b5\u03b8\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c0\u03bb\u03ae\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u039c\u03b5 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03c1\u03bf\u03c5\u03c2, \u03b7 <strong>\u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 JAK2<\/strong> \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03b1\u03bb\u03bb\u03ac <strong>\u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/strong>. \u0397 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03ac\u03b8\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03c1\u03b1\u03c4\u03ae\u03c3\u03b5\u03c4\u03b5:<\/strong> \u03c3\u03c4\u03b7 PV \u03ba\u03cd\u03c1\u03b9\u03bf\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03c3\u03c4\u03b7\u03bd ET \u03b7 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03ae \u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03af\u03b1\u03c2, \u03b5\u03bd\u03ce \u03c3\u03c4\u03b7\u03bd PMF \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03b7 \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/div>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u039f\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b1\u03c0\u03bb\u03ac \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac \u03bc\u03ad\u03c4\u03c1\u03b1, \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae \u03ae \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2. \u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03ba\u03bf\u03b9\u03bd\u03cc \u03c3\u03c7\u03ae\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li><strong>\u03a6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ae<\/strong> \u03c3\u03c4\u03b7\u03bd <strong>PV<\/strong>, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c3\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1.<\/li>\n<li><strong>\u03a7\u03b1\u03bc\u03b7\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7\u03c2<\/strong> \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>PV<\/strong> \u03ae <strong>ET<\/strong>, \u03cc\u03c4\u03b1\u03bd \u03b1\u03c5\u03c4\u03cc \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/li>\n<li><strong>\u03a5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1<\/strong> \u03c9\u03c2 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03c3\u03b5\u03b9\u03c1\u03ce\u03bd.<\/li>\n<li><strong>\u0399\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03ae \u03cc\u03c4\u03b1\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03ce\u03ba\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb.<\/li>\n<li><strong>Anagrelide<\/strong> \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7\u03c2, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03ac \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1.<\/li>\n<li><strong>\u039c\u03b5\u03c4\u03b1\u03bc\u03cc\u03c3\u03c7\u03b5\u03c5\u03c3\u03b7 \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/strong> \u03c3\u03b5 \u03b1\u03c5\u03c3\u03c4\u03b7\u03c1\u03ac \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b7 <strong>PMF<\/strong> \u03ae \u03c3\u03b5 \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/li>\n<\/ul>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (ruxolitinib): \u03c0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\"><strong>\u0397 \u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (ruxolitinib)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 <strong>\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 JAK1\/2<\/strong> \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>PV<\/strong> \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03ae \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1<\/strong>.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 <strong>\u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (ruxolitinib)<\/strong> \u03b4\u03b5\u03bd \u03b4\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae JAK2. \u03a7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2<\/strong>, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1, \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a4\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b7 \u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (ruxolitinib) \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c0\u03bb\u03b5\u03bf\u03bd\u03ad\u03ba\u03c4\u03b7\u03bc\u03b1 \u03c4\u03b7\u03c2 <strong>\u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7\u03c2 (ruxolitinib)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03c3\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03c4\u03af\u03bf, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c5\u03c4\u03cc \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1\u03b9\u03c1\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7 <strong>\u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03af\u03c3\u03b8\u03b7\u03bc\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03ae \u03c0\u03bb\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bf\u03b9\u03bb\u03b9\u03ac.<\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 <strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>, \u03cc\u03c0\u03c9\u03c2 \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7, \u03bd\u03c5\u03c7\u03c4\u03b5\u03c1\u03b9\u03bd\u03bf\u03af \u03b9\u03b4\u03c1\u03ce\u03c4\u03b5\u03c2, \u03c0\u03c5\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03ba\u03bf\u03c5\u03c7\u03af\u03b1.<\/li>\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c3\u03b5 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 <strong>\u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b6\u03c9\u03ae\u03c2<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ad\u03bd\u03c4\u03bf\u03bd\u03bf \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03c4\u03af\u03bf.<\/li>\n<li>\u0391\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c3\u03c4\u03b5\u03bd\u03ae \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/strong>, <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c5\u03b1\u03bb\u03c9\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 <strong>\u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2<\/strong>.<\/li>\n<\/ul>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u0386\u03bb\u03bb\u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 JAK<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03b5 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 JAK, \u03cc\u03c0\u03c9\u03c2 <strong>fedratinib<\/strong>, <strong>momelotinib<\/strong> \u03ba\u03b1\u03b9 <strong>pacritinib<\/strong>. \u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ba\u03b1\u03b9 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03bc\u03b5 \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b5\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong> \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c4\u03b9\u03c2 JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u0394\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bd\u03b1 \u03be\u03ad\u03c1\u03bf\u03c5\u03bc\u03b5 \u03bc\u03cc\u03bd\u03bf \u03cc\u03c4\u03b9 \u03b7 JAK2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae\u00b7 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03be\u03ad\u03c1\u03bf\u03c5\u03bc\u03b5 <strong>\u03c0\u03bf\u03b9\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9, \u03c0\u03cc\u03c3\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af<\/strong>.<\/div>\n<\/section>\n<section id=\"section12\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">12<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 monitoring<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03b5 <strong>JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b1<\/strong> \u03b4\u03b5\u03bd \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7. \u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03c4\u03bf follow-up \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2<\/strong>, <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong>, \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ce\u03bd \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bc\u03cc\u03bd\u03bf \u03b1\u03bd \u00ab\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 JAK2\u00bb. \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03b1\u03bd \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae, \u03b1\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03ae \u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03af\u03b1\u03c2, \u03b1\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03ce\u03bd\u03b5\u03b9 \u03bf \u03c3\u03c0\u03bb\u03ae\u03bd\u03b1\u03c2, \u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b5\u03ba\u03c4\u03ae.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a4\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03bf follow-up<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a4\u03bf monitoring \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03c5\u03c0\u03b1\u03c1\u03b1\u03b3\u03bf\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03cc\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c4\u03cd\u03c0\u03bf \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li><strong>\u0393\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 (CBC)<\/strong> \u03c3\u03b5 \u03c4\u03b1\u03ba\u03c4\u03ac \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1, \u03b3\u03b9\u03b1 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7, \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2, \u03bb\u03b5\u03c5\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd.<\/li>\n<li><strong>LDH<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/li>\n<li><strong>\u03a6\u03b5\u03c1\u03c1\u03b9\u03c4\u03af\u03bd\u03b7<\/strong>, \u03c3\u03af\u03b4\u03b7\u03c1\u03bf\u03c2 \u03ae \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd \u03c3\u03b9\u03b4\u03ae\u03c1\u03bf\u03c5, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 <strong>\u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03c6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ad\u03c2<\/strong>.<\/li>\n<li>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 <strong>\u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1<\/strong>, \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03bd\u03c5\u03c7\u03c4\u03b5\u03c1\u03b9\u03bd\u03bf\u03cd\u03c2 \u03b9\u03b4\u03c1\u03ce\u03c4\u03b5\u03c2, \u03ba\u03bd\u03b7\u03c3\u03bc\u03cc, \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1.<\/li>\n<li>\u0391\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ac<\/strong> \u03ae <strong>\u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03b9\u03ba\u03ac \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1<\/strong>, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c4\u03cd\u03c0\u03bf \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03c7\u03ae\u03bc\u03b1.<\/li>\n<li>\u03a3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1, \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf <strong>MPN-SAF<\/strong>.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 PV \u03c0\u03bf\u03c5 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03c6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ad\u03c2, \u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03b5\u03c1\u03c1\u03b9\u03c4\u03af\u03bd\u03b7\u03c2 \u03ae \u03b7 \u03b5\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd \u03c3\u03b9\u03b4\u03ae\u03c1\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2. \u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2.<\/div>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 JAK2;<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 <strong>\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 JAK2<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2. \u03a3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03b1\u03c1\u03ac \u03c3\u03b5 \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03ae\u03c8\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03c4\u03b5\u03c3\u03c4.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03b5\u03c0\u03b1\u03bd\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 <strong>allele burden<\/strong> \u03ae \u03ac\u03bb\u03bb\u03c9\u03bd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03b1, \u03c3\u03b5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1, \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03bc\u03b5\u03c4\u03b1\u03bc\u03cc\u03c3\u03c7\u03b5\u03c5\u03c3\u03b7 \u03ae \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b8\u03b5\u03c1\u03ac\u03c0\u03bf\u03bd\u03c4\u03b1 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a0\u03bf\u03b9\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd monitoring<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a4\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc monitoring \u03c3\u03c4\u03b9\u03c2 JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bc\u03b9\u03b1 <strong>\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/strong> \u03c4\u03c9\u03bd \u03b5\u03c5\u03c1\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd. \u0394\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bd\u03b1 \u03b4\u03bf\u03cd\u03bc\u03b5 \u03bc\u03cc\u03bd\u03bf \u03b1\u03bd \u03bf \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ae \u03b1\u03bd \u03c4\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ac. \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03bf\u03cd\u03bd:<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u03c4\u03bf \u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 (<strong>PV, ET \u03ae PMF<\/strong>),<\/li>\n<li>\u03b7 \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1,<\/li>\n<li>\u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03ae \u03b1\u03b9\u03bc\u03bf\u03c1\u03c1\u03b1\u03b3\u03af\u03b1\u03c2,<\/li>\n<li>\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd,<\/li>\n<li>\u03b7 \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03c3\u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u0393\u03b9\u03b1 \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc follow-up:<\/strong> \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bf\u03b9 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2, \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u0388\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03bd\u03bf\u03cd\u03bc\u03b5\u03c1\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03c1\u03ba\u03b5\u03af \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf.<\/div>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a0\u03b9\u03bf \u03c3\u03c4\u03b5\u03bd\u03cc monitoring \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03cc\u03c4\u03b1\u03bd \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03cc\u03c4\u03b1\u03bd \u03be\u03b5\u03ba\u03b9\u03bd\u03ac <strong>ruxolitinib<\/strong> \u03ae \u03ac\u03bb\u03bb\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae, \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03b4\u03b9\u03b1\u03ba\u03c5\u03bc\u03ac\u03bd\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03cc\u03c4\u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bd\u03ad\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03ac MPNs \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03bc\u03b9\u03b1 <strong>\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1<\/strong> \u03c0\u03b1\u03c1\u03ac \u03ad\u03bd\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc, \u03af\u03b4\u03b9\u03bf \u03b3\u03b9\u03b1 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03bf.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 13 ==================== --><\/p>\n<section id=\"section13\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">13<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">JAK2 \u03ba\u03b1\u03b9 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 <strong>JAK2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2<\/strong> \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03be\u03b5\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03ae\u03c2 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c4\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>\u03c3\u03c4\u03b5\u03bd\u03ae \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong>.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b1 \u03bc\u03b5 <strong>JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf<\/strong> \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03ad\u03bc\u03b2\u03c1\u03c5\u03bf.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 <strong>\u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ce\u03bd<\/strong>, <strong>\u03c0\u03c1\u03bf\u03b5\u03ba\u03bb\u03b1\u03bc\u03c8\u03af\u03b1\u03c2<\/strong> \u03ba\u03b1\u03b9 <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03c9\u03bd<\/strong>.<\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 <strong>\u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 <strong>\u03bc\u03b1\u03b9\u03b5\u03c5\u03c4\u03ae\u03c1\u03b1 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>.<\/li>\n<li>\u03a3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd <strong>\u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7<\/strong> \u03ba\u03b1\u03b9 <strong>LMWH<\/strong>.<\/li>\n<li>\u0397 <strong>\u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7<\/strong> \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b7 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03cc\u03c4\u03b1\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b7 <strong>\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 JAK \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b8\u03b5\u03c1\u03ac\u03c0\u03bf\u03bd \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039f\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2:<\/strong> \u03b7 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b1 \u03bc\u03b5 JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c6\u03b9\u03ba\u03c4\u03ae, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c3\u03cd\u03bb\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03cc\u03bb\u03b7 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03ac \u03c4\u03b7\u03c2.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<section id=\"section14\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">14<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae; \u0393\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 <strong>JAK2 V617F<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7 (somatic)<\/strong> \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae. \u0394\u03b7\u03bb\u03b1\u03b4\u03ae \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 <strong>\u03b4\u03b5\u03bd \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2<\/strong> \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1. \u03a0\u03b1\u03c1\u2019 \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac, \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 \u03b3\u03b9\u03b1 MPNs, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7 \u03cc\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<\/h3>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03bf\u03c1\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd \u03b7 JAK2 \u00ab\u03c0\u03b5\u03c1\u03bd\u03ac\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac\u00bb. \u03a3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03cc\u03c7\u03b9<\/strong>, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b3\u03ad\u03bd\u03bd\u03b7\u03c3\u03b7 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u0397 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 <strong>JAK2 V617F \u03b4\u03b5\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03b9\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<\/strong> \u03cc\u03c0\u03c9\u03c2 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7.<\/li>\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7<\/strong> \u03b3\u03b9\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1, \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c5\u03c4\u03cc \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03cc\u03bb\u03bf\u03b9 \u03bf\u03b9 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd.<\/li>\n<li>\u0397 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ad\u03c7\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c1\u03cc\u03bb\u03bf <strong>\u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7\u03c2<\/strong>, \u03c3\u03c9\u03c3\u03c4\u03ae\u03c2 \u03ba\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03b1\u03c6\u03ae\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03bf \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03bc\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03af\u03b4\u03b9\u03b1\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03bc\u03b5 MPN \u03ae \u03b1\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1, \u03c4\u03cc\u03c4\u03b5 \u03bf \u03b8\u03b5\u03c1\u03ac\u03c0\u03c9\u03bd \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03c1\u03af\u03bd\u03b5\u03b9 \u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/strong> \u03c4\u03bf \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u00ab\u03b8\u03b1 \u03c4\u03bf \u03c0\u03b5\u03c1\u03ac\u03c3\u03c9 \u03c3\u03c4\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03bc\u03bf\u03c5;\u00bb \u03b1\u03c0\u03b1\u03bd\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03b5 <strong>\u03cc\u03c7\u03b9<\/strong>, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf \u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03c3\u03c4\u03ae.<\/div>\n<\/section>\n<section id=\"section15\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">15<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 JAK2 V617F;<\/summary>\n<p>\u0395\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03b1\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf JAK2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd JAK\/STAT \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 PV, ET \u03ba\u03b1\u03b9 PMF.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c4\u03b5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 JAK2;<\/summary>\n<p>\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7\u03c2, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7, \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7, \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1 \u03ae \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b1 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 MPN.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03bd \u03b7 JAK2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae, \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2;<\/summary>\n<p>\u038c\u03c7\u03b9. \u0391\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae, \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03c3\u03c5\u03c7\u03bd\u03ac \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b5\u03be\u03ce\u03bd\u03b9\u03bf 12 \u03c4\u03bf\u03c5 JAK2, CALR, MPL \u03ae \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf NGS panel.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03b7 JAK2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7;<\/summary>\n<p>\u03a3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c7\u03b9. \u0397 JAK2 V617F \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03b9\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b3\u03bf\u03bd\u03ad\u03b1 \u03c3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03af \u03cc\u03c0\u03c9\u03c2 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bb\u03bb\u03bf\u03af\u03c9\u03c3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 allele burden;<\/summary>\n<p>\u0395\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ae \u03c4\u03bf\u03c5 \u03ba\u03bb\u03ce\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b5\u03af \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b7 JAK2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7;<\/summary>\n<p>\u0397 \u03af\u03b4\u03b9\u03b1 \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b4\u03b5\u03bd \u00ab\u03b5\u03be\u03b1\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9\u00bb \u03bc\u03b5 \u03b1\u03c0\u03bb\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0397 \u03b1\u03b3\u03c9\u03b3\u03ae \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03bf\u03b9\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd Ruxolitinib;<\/summary>\n<p>\u039a\u03c5\u03c1\u03af\u03c9\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 \u03ae \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03ae \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1, \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 JAK2;<\/summary>\n<p>\u039d\u03b1\u03b9. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, LDH, EPO \u03cc\u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9, \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b2\u03b9\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd \u03ae \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2.<\/p>\n<\/details>\n<\/section>\n<p><!-- ==================== SECTION 16 ==================== --><\/p>\n<section id=\"section16\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">16<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/span><\/h2>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\">\n<ul style=\"margin: 0; padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u0397 <strong>JAK2 V617F<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ce\u03bd <strong>\u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>.<\/li>\n<li>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7 <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong> \u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ae \u03bc\u03b5 <strong>PV, ET \u03ae PMF<\/strong>.<\/li>\n<li>\u0388\u03bd\u03b1 <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b7 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7.<\/li>\n<li>\u0388\u03bd\u03b1 <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b3\u03b9\u03b1 <strong>\u03b5\u03be\u03ce\u03bd\u03b9\u03bf 12, CALR, MPL<\/strong> \u03ae <strong>NGS<\/strong>.<\/li>\n<li>\u0397 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd <strong>\u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong>, \u03c4\u03bf <strong>risk stratification<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03b7 <strong>\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/strong>.<\/li>\n<li>\u0397 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 JAK2 V617F \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 <strong>\u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae<\/strong>.<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 17 ==================== --><\/p>\n<section id=\"section17\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">17<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center; margin: 16px 0 22px;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 JAK2 \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Tefferi A, Vainchenker W. <strong>Myeloproliferative Neoplasms: Molecular Pathophysiology, Essential Clinical Understanding, and Treatment Strategies<\/strong>. <em>J Clin Oncol<\/em>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21220604\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/21220604\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">James C, Ugo V, Le Cou\u00e9dic JP, et al. <strong>A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera<\/strong>. <em>Nature<\/em>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15793561\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15793561\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Grinfeld J, Nangalia J, Baxter EJ, et al. <strong>Classification and personalized prognosis in myeloproliferative neoplasms<\/strong>. <em>N Engl J Med<\/em>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30304645\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30304645\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">NCCN Guidelines. <strong>Myeloproliferative Neoplasms<\/strong>.<br \/>\n<a href=\"https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/mpn.pdf\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/mpn.pdf<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">European LeukemiaNet. <strong>Recommendations for diagnosis and management of MPNs<\/strong>.<br \/>\n<a href=\"https:\/\/www.leukemia-net.org\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.leukemia-net.org<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>JAK2 \u039c\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 (V617F): \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9, \u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9, \u03a0\u03ce\u03c2 \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03a4\u03b9 \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: 18 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 18 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u03a3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03c0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7: \u0397 JAK2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b7 JAK2 V617F, \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 (MPNs), \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV), \u03b7 \u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET) \u03ba\u03b1\u03b9 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":10287,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2534],"tags":[],"class_list":["post-4683","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exetaseis-aimatos"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/4683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=4683"}],"version-history":[{"count":7,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/4683\/revisions"}],"predecessor-version":[{"id":10288,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/4683\/revisions\/10288"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/10287"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=4683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=4683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=4683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}