{"id":3850,"date":"2025-06-28T19:15:52","date_gmt":"2025-06-28T16:15:52","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=3850"},"modified":"2026-03-24T00:30:16","modified_gmt":"2026-03-23T22:30:16","slug":"lrp4-olokliromenos-odigos-domi-leitourgia-therapeies","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/lrp4-olokliromenos-odigos-domi-leitourgia-therapeies\/","title":{"rendered":"LRP4 (Anti-LRP4): \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03b7 \u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u039c\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 Gravis &#038; \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1"},"content":{"rendered":"<p><!-- ==================== PILLAR ARTICLE | LRP4 | WORDPRESS CLASSIC EDITOR ==================== --><\/p>\n<div style=\"font-family: system-ui,-apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif; color: #111827;\">\n<h1 style=\"font-size: 44px; line-height: 1.15; font-weight: 800; margin: 0 0 14px; color: #111827;\">LRP4: \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u039c\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1, \u039d\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03a3\u03cd\u03bd\u03b1\u03c8\u03b7, MuSK &amp; \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03a3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u2013 \u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2<\/h1>\n<div style=\"margin: 10px 0 12px; font-size: 13px; color: #6b7280;\">\u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: <time datetime=\"2025-06-28\">28 \u0399\u03bf\u03c5\u03bd\u03af\u03bf\u03c5 2025<\/time> \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: <time datetime=\"2026-03-23\">23 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time><\/div>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf LRP4;<\/strong><br \/>\n\u03a4\u03bf LRP4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2-\u03ba\u03bb\u03b5\u03b9\u03b4\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2. \u03a3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03c4\u03bf \u03cc\u03bd\u03bf\u03bc\u03ac \u03c4\u03bf\u03c5 \u03b1\u03c0\u03b1\u03c3\u03c7\u03bf\u03bb\u03b5\u03af \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03b6\u03b7\u03c4\u03ac\u03bc\u03b5 <strong>\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 anti-LRP4<\/strong>, <strong>\u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/strong>, <strong>MuSK\/agrin signaling<\/strong> \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 <strong>\u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03bc\u03c5\u03b1\u03c3\u03b8\u03b5\u03bd\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1<\/strong>. \u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03c4\u03bf LRP4 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd <strong>\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7<\/strong>.<\/div>\n<p><!-- TOC --><\/p>\n<nav id=\"toc\" style=\"margin: 20px 0; padding: 16px; background: #f9fafb; border-radius: 14px;\">\n<div style=\"font-weight: 800; margin-bottom: 10px;\">\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/div>\n<ol style=\"margin: 0; padding-left: 18px;\">\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section1\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf LRP4 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section2\">\u03a0\u03bf\u03cd \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf LRP4 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section3\">\u0394\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 LRP4: \u03c4\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b5<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section4\">\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c3\u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section5\">LRP4, agrin \u03ba\u03b1\u03b9 MuSK: \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section6\">\u0393\u03b9\u03b1\u03c4\u03af \u03c4\u03bf LRP4 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section7\">Anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1: \u03c4\u03b9 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section8\">\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section9\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section10\">LRP4 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03bc\u03c5\u03b1\u03c3\u03b8\u03b5\u03bd\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section11\">LRP4, Wnt signaling \u03ba\u03b1\u03b9 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section12\">\u03a1\u03cc\u03bb\u03bf\u03c2 \u03c3\u03c4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section13\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03b5\u03ba\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section14\">\u03a3\u03c5\u03c7\u03bd\u03ac \u03bb\u03ac\u03b8\u03b7, \u03c0\u03b1\u03b3\u03af\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03c5\u03bc\u03b5<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section15\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section16\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section17\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: none; border-top: 2px solid #d1d5db; margin: 18px 0 24px;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<section id=\"section1\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf LRP4 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/span><\/h2>\n<p><strong>\u03a4\u03bf LRP4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7-\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7<\/strong>, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03cc\u03c0\u03bf\u03c5 \u03c4\u03bf \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cd\u03c1\u03bf \u03bc\u03b5\u03c4\u03b1\u03b4\u03af\u03b4\u03b5\u03b9 \u03c4\u03bf \u03c3\u03ae\u03bc\u03b1 \u03c3\u03c4\u03bf\u03bd \u03bc\u03c5 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03c3\u03cd\u03c3\u03c0\u03b1\u03c3\u03b7.<\/p>\n<p>\u03a4\u03bf <strong>LRP4<\/strong> \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 <strong>Lipoprotein Receptor-Related Protein 4<\/strong>. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03af\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03c4\u03b7\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>\u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2<\/strong>. \u03a7\u03c9\u03c1\u03af\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 LRP4, \u03b7 \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03bd\u03b5\u03cd\u03c1\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03c5\u03cc\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c3\u03c4\u03b1\u03b8\u03ae\u03c2 \u03ae \u03b1\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1.<\/p>\n<p>\u0397 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 LRP4 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae. \u03a3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03ba\u03b5\u03bd\u03c4\u03c1\u03bf \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae <strong>\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03c4\u03cc\u03c7\u03bf \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong> \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 <strong>\u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf\u03c7\u03bf\u03bb\u03af\u03bd\u03b7\u03c2 (<strong>AChR<\/strong>) \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 <strong>MuSK<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac. \u0388\u03c4\u03c3\u03b9, \u03c4\u03b1 <strong>anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>\u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2<\/strong>.<\/p>\n<p>\u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03c4\u03bf LRP4 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1. \u03a3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf <strong>Wnt signaling<\/strong>, \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bf\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd, \u03b5\u03bd\u03ce \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c1\u03cc\u03bb\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf <strong>\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1<\/strong>. \u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03c4\u03bf LRP4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7-\u03b3\u03ad\u03c6\u03c5\u03c1\u03b1 \u03b1\u03bd\u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u03c4\u03b7\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1, \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 2 ==================== --><\/p>\n<section id=\"section2\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bf\u03cd \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf LRP4 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<\/span><\/h2>\n<p><strong>\u0397 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 LRP4 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03bd \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b5\u03ba\u03b5\u03af.<\/p>\n<p>\u0397 \u03c0\u03b9\u03bf \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 LRP4 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03bd <strong>\u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2. \u0395\u03ba\u03b5\u03af \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c3\u03b1\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u201c\u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03c4\u03ae\u03c2\u201d \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c3\u03ae\u03bc\u03b1 \u03c4\u03b7\u03c2 <strong>agrin<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03b9\u03b2\u03ac\u03b6\u03b5\u03b9 \u03c3\u03c4\u03bf <strong>MuSK<\/strong>, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03b8\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac \u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1. \u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b8\u03ad\u03c3\u03b7 \u03bf\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf\u03c7\u03bf\u03bb\u03af\u03bd\u03b7\u03c2, \u03ce\u03c3\u03c4\u03b5 \u03c4\u03bf \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03b5\u03c1\u03ad\u03b8\u03b9\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b1 \u03c3\u03b5 \u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03cd\u03c3\u03c0\u03b1\u03c3\u03b7.<\/p>\n<p>\u0397 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 LRP4 \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf\u03bd \u03bc\u03c5. \u0388\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf <strong>\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1<\/strong>, \u03cc\u03c0\u03bf\u03c5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7, \u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b4\u03b9\u03b1\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03ac\u03c8\u03b5\u03c9\u03bd. \u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5 LRP4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7.<\/p>\n<p>\u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03c4\u03bf LRP4 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2<\/strong>, \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd \u03bc\u03b5 \u03bc\u03cc\u03c1\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd Wnt \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03c3\u03c4\u03af\u03bd\u03b7<\/strong>. \u0388\u03c4\u03c3\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c3\u03c4\u03bf\u03cd.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong><br \/>\n\u038c\u03c4\u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ae \u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03b1\u03bd\u03b1\u03b6\u03b7\u03c4\u03ac \u201cLRP4\u201d, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 <strong>\u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/strong>, <strong>anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03ae, \u03c0\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1, <strong>\u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2<\/strong>.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 3 ==================== --><\/p>\n<section id=\"section3\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">3<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0394\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 LRP4: \u03c4\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b5<\/span><\/h2>\n<p><strong>\u03a4\u03bf LRP4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03bc\u03b5 \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae, \u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03cc \u03c4\u03bc\u03ae\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03bf\u03c5\u03c1\u03ac<\/strong>, \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae \u03b7 \u03b4\u03bf\u03bc\u03ae \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03b1\u03c3\u03c4\u03b5\u03af \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03cc \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1.<\/p>\n<p>\u03a4\u03bf LRP4 \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd <strong>LDL receptor-related proteins<\/strong>. \u0397 \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 <strong>\u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae<\/strong>, \u03bc\u03b9\u03b1 <strong>\u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ae \u03ad\u03bb\u03b9\u03ba\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03bc\u03b9\u03b1 <strong>\u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03bf\u03c5\u03c1\u03ac<\/strong>. \u0397 \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b5\u03ba\u03b5\u03af \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 ligands \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf\u03c5 \u03c7\u03ce\u03c1\u03bf\u03c5.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03b1\u03c5\u03c4\u03ae \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03ae\u03c8\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 <strong>\u03b2-propeller domains<\/strong> \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>agrin<\/strong> \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 LRP4 \u03bc\u03b5 \u03c4\u03bf <strong>MuSK<\/strong>. \u0397 <strong>\u03b4\u03b9\u03b1\u03bc\u03b5\u03bc\u03b2\u03c1\u03b1\u03bd\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae<\/strong> \u03b1\u03b3\u03ba\u03c5\u03c1\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7, \u03b5\u03bd\u03ce \u03b7 <strong>\u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03bf\u03c5\u03c1\u03ac<\/strong> \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03b1\u03b9 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2.<\/p>\n<p>\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03b4\u03b5\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03bc\u03bd\u03b7\u03bc\u03bf\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03b4\u03bf\u03bc\u03b9\u03ba\u03cc domain. \u0395\u03af\u03bd\u03b1\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03bf\u03c5\u03c3\u03b9\u03ce\u03b4\u03b5\u03c2 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03b7\u03c4\u03cc \u03cc\u03c4\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03be\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03c1\u03b1 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03cd\u03c0\u03bf\u03c5 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03c4\u03bf LRP4 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc<\/strong>, <strong>\u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc<\/strong> \u03ba\u03b1\u03b9 <strong>\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc<\/strong> \u03ba\u03cc\u03bc\u03b2\u03bf. \u0391\u03bd \u03b1\u03bb\u03bb\u03bf\u03b9\u03c9\u03b8\u03b5\u03af \u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03bf \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae, \u03b7 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac. \u0391\u03bd \u03bc\u03c0\u03bb\u03bf\u03ba\u03b1\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03b7 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03bc\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 4 ==================== --><\/p>\n<section id=\"section4\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">4<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c3\u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7<\/span><\/h2>\n<p><strong>\u03a4\u03bf LRP4 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c4\u03bf\u03bd \u03bc\u03c5 \u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03c3\u03b5\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03cc \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2<\/strong>, \u03ce\u03c3\u03c4\u03b5 \u03c4\u03bf \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03cd\u03c3\u03c0\u03b1\u03c3\u03b7.<\/p>\n<p>\u0397 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03b5\u03c0\u03b1\u03c6\u03ae\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03c5\u03c1\u03ce\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03af\u03bd\u03b1\u03c2. \u0393\u03b9\u03b1 \u03bd\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac, \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bd\u03b1 \u03c6\u03c4\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03b5\u03c1\u03ad\u03b8\u03b9\u03c3\u03bc\u03b1 \u03c3\u03c4\u03bf\u03bd \u03bc\u03c5. \u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u201c\u03c7\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7\u201d, \u03bc\u03b5 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03c0\u03c5\u03ba\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf\u03c7\u03bf\u03bb\u03af\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b8\u03ad\u03c3\u03b7.<\/p>\n<p>\u0395\u03b4\u03ce \u03b4\u03c1\u03b1 \u03c4\u03bf LRP4. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03c0\u03bf\u03c5 \u03bb\u03ad\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03c5\u03ca\u03ba\u03ae \u03af\u03bd\u03b1 <strong>\u03c0\u03bf\u03cd<\/strong> \u03ba\u03b1\u03b9 <strong>\u03c0\u03ce\u03c2<\/strong> \u03b8\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03cc \u03b5\u03be\u03bf\u03c0\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2. \u038c\u03c4\u03b1\u03bd \u03c4\u03bf LRP4 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf\u03c7\u03bf\u03bb\u03af\u03bd\u03b7\u03c2, \u03c3\u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7\u03c2.<\/p>\n<p>\u038c\u03c4\u03b1\u03bd \u03b1\u03c5\u03c4\u03cc\u03c2 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b5\u03af, \u03c4\u03bf \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1 \u03b4\u03b5\u03bd \u201c\u03c0\u03b9\u03ac\u03bd\u03b5\u03b9\u201d \u03c3\u03c4\u03bf\u03bd \u03bc\u03c5 \u03cc\u03c0\u03c9\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9. \u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03ae \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1, \u03b5\u03cd\u03ba\u03bf\u03bb\u03b7 \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ad\u03bc\u03c0\u03bf\u03c5\u03bd \u03c3\u03b5 <strong>\u03bc\u03c5\u03b1\u03c3\u03b8\u03b5\u03bd\u03b9\u03ba\u03cc \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf<\/strong>.<\/p>\n<p>\u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03b7 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 LRP4 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03ba\u03b4\u03b7\u03bb\u03c9\u03b8\u03b5\u03af \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03cc\u03c0\u03c9\u03c2 <strong>\u03b2\u03bb\u03b5\u03c6\u03b1\u03c1\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7<\/strong>, <strong>\u03b4\u03b9\u03c0\u03bb\u03c9\u03c0\u03af\u03b1<\/strong>, \u03b5\u03cd\u03ba\u03bf\u03bb\u03b7 \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7, \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b1 \u03c3\u03c4\u03b7 \u03bc\u03ac\u03c3\u03b7\u03c3\u03b7, <strong>\u03b4\u03c5\u03c3\u03ba\u03b1\u03c4\u03b1\u03c0\u03bf\u03c3\u03af\u03b1<\/strong>, \u03b5\u03b3\u03b3\u03cd\u03c2 \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03ae \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03be\u03ac\u03bd\u03c4\u03bb\u03b7\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<section id=\"section5\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">5<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">LRP4, agrin \u03ba\u03b1\u03b9 MuSK: \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2<\/span><\/h2>\n<p><strong>\u039f \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ac\u03be\u03bf\u03bd\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c4\u03c1\u03af\u03b3\u03c9\u03bd\u03bf agrin\u2013LRP4\u2013MuSK<\/strong>, \u03c0\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7.<\/p>\n<p>\u0397 <strong>agrin<\/strong> \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cd\u03c1\u03bf \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c3\u03b1\u03bd \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf \u03c3\u03ae\u03bc\u03b1 \u03c0\u03bf\u03c5 \u201c\u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03ce\u03bd\u03b5\u03b9\u201d \u03c4\u03bf\u03bd \u03bc\u03c5 \u03cc\u03c4\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03c3\u03b5\u03b9 \u03ae \u03bd\u03b1 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7. \u03a4\u03bf <strong>LRP4<\/strong> \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03ae\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf <strong>MuSK<\/strong>, \u03bc\u03b9\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf\u03c7\u03bf\u03bb\u03af\u03bd\u03b7\u03c2.<\/p>\n<p>\u0388\u03c4\u03c3\u03b9 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03bc\u03b9\u03b1 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c5\u03bd\u03b1\u03c0\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2. \u0391\u03bd \u03b7 agrin \u03b4\u03b5\u03bd \u03c3\u03c5\u03bd\u03b4\u03b5\u03b8\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac \u03bc\u03b5 \u03c4\u03bf LRP4 \u03ae \u03b1\u03bd \u03c4\u03bf LRP4 \u03b4\u03b5\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf MuSK, \u03b7 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7 \u03c7\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03b7\u03c2.<\/p>\n<p>\u039f\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf\u03c7\u03bf\u03bb\u03af\u03bd\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03b8\u03bf\u03cd\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2, \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03b5\u03bc\u03b7\u03b8\u03bf\u03cd\u03bd \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ae \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03b5\u03ba\u03b5\u03af \u03cc\u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9. \u0391\u03c5\u03c4\u03cc \u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7\u03c2. \u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03c4\u03b1 anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 <strong>LRP4<\/strong>, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ad\u03c2 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03ad\u03c1\u03b5\u03b9\u03b5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03bc\u03b5 \u03c3\u03b1\u03c6\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03cd\u03c0\u03c9\u03bc\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039c\u03b5 \u03bc\u03af\u03b1 \u03c6\u03c1\u03ac\u03c3\u03b7:<\/strong><br \/>\n\u0397 agrin \u03b4\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c3\u03ae\u03bc\u03b1, \u03c4\u03bf LRP4 \u03c4\u03bf \u201c\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9\u201d, \u03c4\u03bf MuSK \u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03ac\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03bc\u03c5\u03ca\u03ba\u03ae \u03af\u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<section id=\"section6\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">6<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0393\u03b9\u03b1\u03c4\u03af \u03c4\u03bf LRP4 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/span><\/h2>\n<p><strong>\u03a4\u03bf LRP4 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c3\u03c4\u03cc\u03c7\u03bf \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03af \u03b3\u03b9\u03b1 AChR \u03ba\u03b1\u03b9 MuSK.<\/p>\n<p>\u0397 <strong>\u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2. \u03a3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b1\u03ba\u03b5\u03c4\u03c5\u03bb\u03bf\u03c7\u03bf\u03bb\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 <strong>MuSK<\/strong>. \u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03af \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2.<\/p>\n<p>\u03a3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd <strong>\u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd<\/strong> \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03c9\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af <strong>anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong>, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03be\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03ac\u03be\u03bf\u03bd\u03b1 <strong>agrin\u2013LRP4\u2013MuSK<\/strong>.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf LRP4 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ad\u03bc\u03c0\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2.<\/p>\n<p>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac, \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>LRP4-positive \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ac, \u03b2\u03bf\u03bb\u03b2\u03b9\u03ba\u03ac \u03ae \u03b3\u03b5\u03bd\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u0397 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03af\u03b4\u03b9\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ad\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd, \u03b5\u03bd\u03ce \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<section id=\"section7\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">7<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">Anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1: \u03c4\u03b9 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd<\/span><\/h2>\n<p><strong>\u03a4\u03b1 anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03be\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 gravis<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03bf\u03c4\u03ad \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1.<\/p>\n<p>\u03a4\u03b1 <strong>anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf LRP4 \u03c9\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf. \u0398\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd agrin-mediated \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2. \u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1, \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b1\u03c0\u03bb\u03ce\u03c2 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-LRP4 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 <strong>\u03b4\u03b5\u03bd \u03b4\u03b9\u03b1\u03b3\u03b9\u03b3\u03bd\u03ce\u03c3\u03ba\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5<\/strong> \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1. \u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc, \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1. \u03a0\u03b1\u03c1\u2019 \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac, \u03c3\u03b5 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd\u03c4\u03b9\u03bc\u03bf \u03ba\u03bf\u03bc\u03bc\u03ac\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03b6\u03bb, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd <strong>AChR<\/strong> \u03ba\u03b1\u03b9 <strong>MuSK<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac.<\/p>\n<p>\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae. \u0397 <strong>\u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03bb\u03cd\u03c4\u03c9\u03c2 \u03bf\u03bc\u03bf\u03b9\u03cc\u03bc\u03bf\u03c1\u03c6\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03c9\u03bd<\/strong> \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u0386\u03c1\u03b1, \u03c4\u03bf anti-LRP4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03ac\u03ba\u03c1\u03b9\u03c4\u03b7 \u03ae \u03bc\u03b1\u03b6\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 8 ==================== --><\/p>\n<section id=\"section8\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">8<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/span><\/h2>\n<p><strong>\u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 gravis \u03b1\u03bb\u03bb\u03ac \u03bf\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03bf\u03af \u03bf\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03af \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03af \u03ae \u03bc\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03af.<\/strong><\/p>\n<p>\u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 <strong>\u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/strong>. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>AChR<\/strong> \u03ba\u03b1\u03b9 <strong>MuSK<\/strong>, \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/p>\n<p>\u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 anti-LRP4 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03bb\u03bb\u03ac \u03bf\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ae \u03b4\u03b5\u03bd \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03b1\u03c6\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7.<\/p>\n<p>\u0395\u03b9\u03b4\u03b9\u03ba\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5:<\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u03ba\u03c5\u03bc\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1,<\/li>\n<li>\u03b2\u03bb\u03b5\u03c6\u03b1\u03c1\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7 \u03ae \u03b4\u03b9\u03c0\u03bb\u03c9\u03c0\u03af\u03b1,<\/li>\n<li>\u03b2\u03bf\u03bb\u03b2\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1,<\/li>\n<li>\u03b5\u03cd\u03ba\u03bf\u03bb\u03b7 \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7,<\/li>\n<li>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ac \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7\u03c2,<\/li>\n<li>\u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7.<\/li>\n<\/ul>\n<p>\u03a3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b5\u03ba\u03c4\u03b1\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03b1 <strong>agrin antibodies<\/strong>, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd assays.<\/p>\n<div style=\"background: #fff7ed; border-left: 4px solid #ea580c; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac:<\/strong><br \/>\n\u03a4\u03bf \u03c0\u03cc\u03c4\u03b5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03c4\u03bf anti-LRP4 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c6\u03b1\u03c3\u03af\u03b6\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bf \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2. \u0388\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c9\u03c3\u03c4\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03c0\u03b5\u03c1\u03b4\u03ad\u03c8\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c0\u03b1\u03c1\u03ac \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 9 ==================== --><\/p>\n<section id=\"section9\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">9<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7<\/span><\/h2>\n<p><strong>\u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-LRP4 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bc\u03cc\u03bd\u03bf \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1<\/strong>, \u03b5\u03bd\u03ce \u03ad\u03bd\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03c4\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1.<\/p>\n<p>\u0388\u03bd\u03b1 <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-LRP4<\/strong> \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c0\u03bf\u03ba\u03c4\u03ac \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03bd\u03cc\u03b7\u03bc\u03b1 \u03cc\u03c4\u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ae \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03b9\u03ba\u03c4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ae \u03bd\u03b5\u03c5\u03c1\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2.<\/p>\n<p>\u0394\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03cc\u03c4\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03bf\u03cd\u03c4\u03b5 \u03cc\u03c4\u03b9 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ae \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2.<\/p>\n<p>\u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1, \u03ad\u03bd\u03b1 <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03c4\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1. \u039f \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ac\u03bb\u03bb\u03bf \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03cc \u03c3\u03c4\u03cc\u03c7\u03bf, \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc \u03c4\u03af\u03c4\u03bb\u03bf \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03ae \u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1. \u0397 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bf\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae.<\/p>\n<p>\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03b9:<\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc,<\/li>\n<li>\u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7,<\/li>\n<li>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b5\u03c2,<\/li>\n<li>\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf AChR \/ MuSK \/ \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 LRP4,<\/li>\n<li>\u03ba\u03b1\u03b9, \u03cc\u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9, \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ae \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/li>\n<\/ul>\n<p>\u03a4\u03bf \u03c0\u03b9\u03bf \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c2 \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b5\u03be\u03ae\u03c2: <strong>\u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b2\u03bf\u03b7\u03b8\u03ac, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03c5\u03c0\u03bf\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7<\/strong>.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 10 ==================== --><\/p>\n<section id=\"section10\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">10<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">LRP4 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03bc\u03c5\u03b1\u03c3\u03b8\u03b5\u03bd\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1<\/span><\/h2>\n<p><strong>\u03a4\u03bf LRP4 \u03b4\u03b5\u03bd \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bc\u03b5 <strong>\u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03bc\u03c5\u03b1\u03c3\u03b8\u03b5\u03bd\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1<\/strong> \u03bc\u03ad\u03c3\u03c9 \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf <strong>LRP4<\/strong>.<\/p>\n<p>\u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b1\u03bb\u03bb\u03ac \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc. \u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bb\u03b1\u03c4\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03ae \u03b4\u03b5\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03cc\u03c0\u03c9\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ae \u03c3\u03c5\u03bd\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2. \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03bd\u03c9\u03c1\u03af\u03c2 \u03c3\u03c4\u03b7 \u03b6\u03c9\u03ae, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03af\u03b4\u03b9\u03b5\u03c2 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac.<\/p>\n<p>\u039f\u03b9 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 domains \u03c4\u03bf\u03c5 LRP4 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5 \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf <strong>agrin-mediated MuSK signaling<\/strong>. \u0388\u03c4\u03c3\u03b9, \u03b7 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b4\u03b5\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03be\u03b1\u03c1\u03c7\u03ae\u03c2.<\/p>\n<p>\u0397 \u03b4\u03b9\u03ac\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03b3\u03b9\u03b1\u03c4\u03af:<\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae,<\/li>\n<li>\u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03c4\u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf,<\/li>\n<li>\u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7.<\/li>\n<\/ul>\n<p>\u03a3\u03b5 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7, \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03ae \u03ac\u03c4\u03c5\u03c0\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 11 ==================== --><\/p>\n<section id=\"section11\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">11<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">LRP4, Wnt signaling \u03ba\u03b1\u03b9 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/span><\/h2>\n<p><strong>\u03a4\u03bf LRP4 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c3\u03c4\u03bf\u03cd<\/strong>, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac \u03bc\u03b5 \u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 <strong>Wnt\/\u03b2-catenin<\/strong> \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03c3\u03c4\u03af\u03bd\u03b7<\/strong>.<\/p>\n<p>\u03a4\u03bf LRP4 \u03b4\u03b5\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03bd \u03bc\u03c5. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ae \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 <strong>\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c3\u03c4\u03bf\u03cd<\/strong>, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac \u03bc\u03b5 \u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 <strong>Wnt\/\u03b2-catenin<\/strong>, \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03ba\u03b1\u03c4\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae\u03c2.<\/p>\n<p>\u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03b7 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03c3\u03c4\u03af\u03bd\u03b7<\/strong>, \u03ad\u03bd\u03b1\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2. \u0397 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 <strong>LRP4\u2013sclerostin<\/strong> \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 Wnt signaling \u03ba\u03b1\u03b9, \u03ba\u03b1\u03c4\u2019 \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7, \u03c4\u03b7\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7.<\/p>\n<p>\u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf LRP4 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03b1\u03c3\u03c7\u03bf\u03bb\u03ae\u03c3\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03bf\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b4\u03c5\u03c3\u03bc\u03bf\u03c1\u03c6\u03b9\u03ce\u03bd. \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03bf\u03c5 LRP4 \u03ae \u03c4\u03c9\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03c9\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b5\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03bf\u03c3\u03c4\u03ce\u03bd \u03ae \u03ac\u03ba\u03c1\u03c9\u03bd.<\/p>\n<p>\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c3\u03c4\u03b7, \u03c4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf LRP4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ba\u03cc\u03bc\u03b2\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7 <strong>\u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1<\/strong> \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd <strong>\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7<\/strong>.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 12 ==================== --><\/p>\n<section id=\"section12\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">12<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a1\u03cc\u03bb\u03bf\u03c2 \u03c3\u03c4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1<\/span><\/h2>\n<p><strong>\u03a4\u03bf LRP4 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ac\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1<\/strong>, \u03cc\u03c0\u03bf\u03c5 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03ac\u03c8\u03b5\u03c9\u03bd, \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n<p>\u03a4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03c4\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b3\u03b9\u03b1 \u03c4\u03bf LRP4 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b5\u03ba\u03c4\u03b1\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf <strong>\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1<\/strong>. \u0391\u03bd\u03b1\u03c3\u03ba\u03bf\u03c0\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03b4\u03b5\u03bd\u03b4\u03c1\u03b9\u03c4\u03ce\u03bd, \u03c3\u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03ac\u03c8\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n<p>\u0391\u03c5\u03c4\u03ad\u03c2 \u03bf\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b5\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03bc\u03b5 \u03c4\u03b7 <strong>\u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bd\u03ac\u03c8\u03b5\u03c9\u03bd \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03c5.<\/p>\n<p>\u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac, \u03b1\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b3\u03b9\u03b1 \u03b4\u03cd\u03bf \u03bb\u03cc\u03b3\u03bf\u03c5\u03c2. \u03a0\u03c1\u03ce\u03c4\u03bf\u03bd, \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf LRP4 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03ad\u03bd\u03b1\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03cc\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2 \u03b1\u03bb\u03bb\u03ac \u03bc\u03ad\u03c1\u03bf\u03c2 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03c9\u03bd \u03b4\u03b9\u03ba\u03c4\u03cd\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1\u03c2. \u0394\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf\u03bd, \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf \u03b3\u03b9\u03b1 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03bd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03b5\u03c9\u03bd \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03ae \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03be\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b5\u03c2.<\/p>\n<p>\u0397 \u03c3\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03b3\u03bd\u03ce\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b1\u03c0\u03bb\u03bf\u03c5\u03c3\u03c4\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf LRP4 \u03ad\u03c7\u03b5\u03b9 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 13 ==================== --><\/p>\n<section id=\"section13\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">13<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03b5\u03ba\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1<\/span><\/h2>\n<p><strong>\u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c4\u03bf LRP4 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/strong>, \u03b5\u03bd\u03ce \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ae \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u201c\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 LRP4\u201d \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7.<\/p>\n<p>\u038c\u03c4\u03b1\u03bd \u03c4\u03bf LRP4 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 <strong>\u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/strong>, \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2: \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae, \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03af\u03ba\u03b5\u03c5\u03c3\u03b7 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/p>\n<p>\u0397 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03b3\u03b9\u03b1 <strong>LRP4-positive MG<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ce\u03c2 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03cc \u03cc,\u03c4\u03b9 \u03b3\u03b9\u03b1 <strong>AChR<\/strong>&#8211; \u03ae <strong>MuSK<\/strong>-positive \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1, \u03b3\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ac \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac.<\/p>\n<p>\u03a0\u03b1\u03c1\u03ac \u03c4\u03b1\u03cd\u03c4\u03b1, \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c1\u03cc\u03bb\u03bf\u03c5 \u03c4\u03bf\u03c5 LRP4 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03b5\u03ba\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2. \u0391\u03bd \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03c0\u03bf\u03b9\u03bf\u03c2 \u03ba\u03c1\u03af\u03ba\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bc\u03b5 \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03bd\u03b1 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03c3\u03bf\u03c5\u03bc\u03b5 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1:<\/p>\n<ul style=\"margin: 8px 0 0 18px;\">\n<li>\u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7,<\/li>\n<li>\u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b8\u03b5\u03c3\u03b7,<\/li>\n<li>\u03ae \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd LRP4, agrin \u03ba\u03b1\u03b9 MuSK.<\/li>\n<\/ul>\n<p>\u03a3\u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03c4\u03b7\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1, \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c4\u03b1\u03c5\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 LRP4 positivity \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03be\u03b5\u03c7\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c0\u03bf\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b1.<\/p>\n<p>\u03a3\u03c4\u03b1 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03bc\u03c5\u03b1\u03c3\u03b8\u03b5\u03bd\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1, \u03b7 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c7\u03b1\u03c1\u03c4\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 LRP4 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03c3\u03c4\u03bf \u03bc\u03ad\u03bb\u03bb\u03bf\u03bd \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03c0\u03b9\u03bf \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae <strong>precision medicine<\/strong> \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7. \u03a0\u03c1\u03bf\u03c2 \u03c4\u03bf \u03c0\u03b1\u03c1\u03cc\u03bd, \u03cc\u03bc\u03c9\u03c2, \u03c4\u03bf LRP4 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c9\u03c2 <strong>\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03bb\u03b5\u03b9\u03b4\u03af<\/strong> \u03c0\u03b1\u03c1\u03ac \u03c9\u03c2 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b1\u03c5\u03c4\u03cc\u03bd\u03bf\u03bc\u03bf\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<section id=\"section14\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">14<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ac \u03bb\u03ac\u03b8\u03b7, \u03c0\u03b1\u03b3\u03af\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03c5\u03bc\u03b5<\/span><\/h2>\n<p><strong>\u03a4\u03bf \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03c0\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03cc\u03bb\u03b1 \u03ba\u03ac\u03c4\u03c9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03c4\u03b1\u03bc\u03c0\u03ad\u03bb\u03b1 \u201cLRP4\u201d<\/strong>, \u03b5\u03bd\u03ce \u03ac\u03bb\u03bb\u03bf \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2, \u03ac\u03bb\u03bb\u03bf \u03c4\u03b1 anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf \u03bf\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2.<\/p>\n<p>\u03a4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03c3\u03c5\u03c7\u03bd\u03cc \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf <strong>LRP4<\/strong> \u03c3\u03b1\u03bd \u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03ac\u03bb\u03bb\u03bf \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2, \u03ac\u03bb\u03bb\u03bf \u03c4\u03b1 <strong>anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong>, \u03ac\u03bb\u03bb\u03bf \u03bf\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf <strong>LRP4<\/strong> \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c3\u03c4\u03bf\u03cd \u03ae \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5.<\/p>\n<p>\u03a4\u03bf \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-LRP4 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03b2\u03ad\u03b2\u03b1\u03b9\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1. \u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9. \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf, \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf work-up \u03ba\u03b1\u03b9 \u03b5\u03c0\u03af\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ce\u03bd \u03ba\u03ac\u03b8\u03b5 assay.<\/p>\n<p>\u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03b1, \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf \u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae.<\/p>\n<p>\u03a4\u03c1\u03af\u03c4\u03bf \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c1\u03cc\u03bb\u03bf\u03c5 \u03c4\u03bf\u03c5 LRP4 \u03c3\u03c4\u03bf \u03bf\u03c3\u03c4\u03cc \u03ae \u03c3\u03c4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03c9\u03c2 \u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03bf\u03af \u03bf\u03b9 \u03c1\u03cc\u03bb\u03bf\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03af \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03bf\u03af, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03c3\u03cd\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b4\u03bf\u03b8\u03b5\u03af \u03c3\u03c4\u03bf LRP4.<\/p>\n<p>\u03a4\u03ad\u03c4\u03b1\u03c1\u03c4\u03bf \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 anti-LRP4 \u201c\u03b3\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03b5\u03bd\u03b4\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf\u201d \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c9\u03c3\u03c4\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7. \u039f \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c1\u03c4\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ba\u03b1\u03b9 \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b5\u03c2, \u03ac\u03c3\u03ba\u03bf\u03c0\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 15 ==================== --><\/p>\n<section id=\"section15\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">15<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf LRP4 \u03bc\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1;<\/summary>\n<p>\u03a4\u03bf LRP4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7-\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03b8\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac \u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03cc\u03c0\u03bf\u03c5 \u03c4\u03bf \u03bd\u03b5\u03cd\u03c1\u03bf \u03b4\u03af\u03bd\u03b5\u03b9 \u03c3\u03ae\u03bc\u03b1 \u03c3\u03c4\u03bf\u03bd \u03bc\u03c5 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c3\u03c5\u03c3\u03c0\u03b1\u03c3\u03c4\u03b5\u03af.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 anti-LRP4 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc;<\/summary>\n<p>\u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 LRP4, \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 gravis \u03c3\u03b5 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf anti-LRP4, \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1;<\/summary>\n<p>\u038c\u03c7\u03b9. \u0388\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03c3\u03b9\u03bc\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03bf\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03bf LRP4 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1;<\/summary>\n<p>\u038c\u03c7\u03b9. \u0388\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2, \u03c3\u03c4\u03bf Wnt signaling \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1, \u03b5\u03bd\u03ce \u03bc\u03b5\u03bb\u03b5\u03c4\u03ac\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 anti-LRP4;<\/summary>\n<p>\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03cc\u03b3\u03bf \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 gravis \u03b1\u03bb\u03bb\u03ac \u03bf\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03bd\u03b7\u03b8\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2, \u03cc\u03c0\u03c9\u03c2 AChR \u03ba\u03b1\u03b9 MuSK, \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03ce\u03c3\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 LRP4;<\/summary>\n<p>\u039d\u03b1\u03b9. \u03a0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 LRP4 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03bc\u03c5\u03b1\u03c3\u03b8\u03b5\u03bd\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ae \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2.<\/p>\n<\/details>\n<\/section>\n<p><!-- ==================== SECTION 16 ==================== --><\/p>\n<section id=\"section16\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">16<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/span><\/h2>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\">\n<p><strong>\u03a4\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ac\u03c1\u03b8\u03c1\u03bf\u03c5:<\/strong><\/p>\n<ul style=\"margin: 10px 0 0 18px;\">\n<li>\u03a4\u03bf <strong>LRP4<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 <strong>\u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2<\/strong>.<\/li>\n<li>\u039f \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ac\u03be\u03bf\u03bd\u03ac\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c4\u03c1\u03af\u03b3\u03c9\u03bd\u03bf <strong>agrin\u2013LRP4\u2013MuSK<\/strong>.<\/li>\n<li>\u03a4\u03b1 <strong>anti-LRP4 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis<\/strong>, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ae \u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2.<\/li>\n<li>\u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 <strong>\u03b4\u03b5\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1.<\/li>\n<li>\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf <strong>LRP4<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03bf\u03c5\u03bd <strong>\u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ae \u03bc\u03c5\u03b1\u03c3\u03b8\u03b5\u03bd\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1<\/strong>.<\/li>\n<li>\u03a4\u03bf LRP4 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03bf <strong>Wnt signaling<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03bf\u03c3\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/strong>.<\/li>\n<li>\u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae <strong>\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae, \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1<\/strong>.<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<section id=\"section17\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">17<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<p>\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 LRP4 \/ \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<div style=\"margin: 18px 0 0;\">\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Zhang B, Luo S, Wang Q, Suzuki T, Xiong WC, Mei L. <em>LRP4 serves as a coreceptor of agrin<\/em>. Neuron.<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896627308006993\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896627308006993<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Engel AG. <em>The unfolding landscape of the congenital myasthenic syndromes<\/em>. Nat Rev Neurol \/ related review literature via PMC.<br \/>\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5800977\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5800977\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Chuquisana O, et al. <em>Functional Signature of LRP4 Antibodies in Myasthenia Gravis<\/em>. Neurol Neuroimmunol Neuroinflamm. 2024.<br \/>\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10959168\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10959168\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Chen BH, et al. <em>LRP4-related signalling pathways and their regulatory role in the nervous system<\/em>. Biochem Pharmacol. 2024.<br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006899323004766\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006899323004766<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Hu L, et al. <em>Wnt\/\u03b2-catenin signaling components and mechanisms in bone formation, homeostasis, and diseases<\/em>. Bone Research. 2024.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41413-024-00342-8\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nature.com\/articles\/s41413-024-00342-8<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>LRP4: \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u039c\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1, \u039d\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03a3\u03cd\u03bd\u03b1\u03c8\u03b7, MuSK &amp; \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03a3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u2013 \u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2 \u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: 28 \u0399\u03bf\u03c5\u03bd\u03af\u03bf\u03c5 2025 \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 23 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf LRP4; \u03a4\u03bf LRP4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2-\u03ba\u03bb\u03b5\u03b9\u03b4\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03cd\u03bd\u03b1\u03c8\u03b7\u03c2. \u03a3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03c4\u03bf \u03cc\u03bd\u03bf\u03bc\u03ac \u03c4\u03bf\u03c5 \u03b1\u03c0\u03b1\u03c3\u03c7\u03bf\u03bb\u03b5\u03af \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03b6\u03b7\u03c4\u03ac\u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 anti-LRP4, \u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03bc\u03c5\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 gravis, MuSK\/agrin [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":10439,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2534],"tags":[992,985,990,993,988,991,987,989,986],"class_list":["post-3850","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exetaseis-aimatos","tag-cms","tag-lrp4","tag-agrin","tag-gonidiaki-therapeia","tag-domi-lrp4","tag-myastheneia-gravis","tag-nevromyiki-synapsi","tag-simatodotisi-wnt","tag-ypodocheas-lrp4"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/3850","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=3850"}],"version-history":[{"count":8,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/3850\/revisions"}],"predecessor-version":[{"id":10441,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/3850\/revisions\/10441"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/10439"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=3850"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=3850"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=3850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}