{"id":3825,"date":"2025-06-26T19:35:46","date_gmt":"2025-06-26T16:35:46","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=3825"},"modified":"2025-11-16T15:03:47","modified_gmt":"2025-11-16T13:03:47","slug":"pelakarsen-pelacarsen-kainotomos-therapeia-meiosis-lpa-prolipsi-kardiakon-nosimaton","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/pelakarsen-pelacarsen-kainotomos-therapeia-meiosis-lpa-prolipsi-kardiakon-nosimaton\/","title":{"rendered":"\u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd (Pelacarsen) \u2013 \u039a\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03bf\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u039c\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 Lp(a) &#038; \u03a0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ce\u03bd \u039d\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd"},"content":{"rendered":"<p>&nbsp;<\/p>\n<style>\n    body { font-family: Arial, sans-serif; line-height: 1.6; margin: 0; padding: 0; }<br \/>    .container { max-width: 800px; margin: auto; padding: 1rem; }<br \/>    h1, h2, h3 { color: #333; }<br \/>    img { max-width: 100%; height: auto; }<br \/>    details { margin: 0.5rem 0; }<br \/>    summary { font-weight: bold; cursor: pointer; }<br \/>  <\/style>\n<p><script type=\"application\/ld+json\">\n  {\n    \"@context\": \"https:\/\/schema.org\",\n    \"@type\": \"FAQPage\",\n    \"mainEntity\": [\n      {\n        \"@type\": \"Question\",\n        \"name\": \"\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd;\",\n        \"acceptedAnswer\": {\n          \"@type\": \"Answer\",\n          \"text\": \"\u0397 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd (AKCEA-APO(a)-LRx) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2(\u03b1) \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1.\"\n        }\n      },\n      {\n        \"@type\": \"Question\",\n        \"name\": \"\u03a0\u03ce\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03b7 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd;\",\n        \"acceptedAnswer\": {\n          \"@type\": \"Answer\",\n          \"text\": \"\u0394\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf mRNA \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2(\u03b1) \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5\u03c2, \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 Lp(a).\"\n        }\n      }\n    ]\n  }\n  <\/script><\/p>\n<div class=\"container\">\n<header>\n<h1>Pelacarsen &#8211; \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd (AKCEA-APO(a)-LRx): \u039f\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2<\/h1>\n<p><em>\u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 26 \u0399\u03bf\u03c5\u03bd\u03af\u03bf\u03c5 2025<\/em><\/p>\n<p>\u0397 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7(\u03b1) [Lp(a)], \u03ad\u03bd\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03c3\u03c9\u03bc\u03b1\u03c4\u03af\u03b4\u03b9\u03bf \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b4\u03b5\u03b4\u03b5\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5 \u03c0\u03c1\u03cc\u03c9\u03c1\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bf\u03b4\u03b7\u03b3\u03cc\u03c2 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03c4\u03bf\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2, \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1, \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03b1, \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2, \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2.<\/p>\n<\/header>\n<nav>\n<h2>\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/h2>\n<ul>\n<li><a href=\"#overview\">\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7<\/a><\/li>\n<li><a href=\"#mechanism\">\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u0394\u03c1\u03ac\u03c3\u03b7\u03c2<\/a><\/li>\n<li><a href=\"#development\">\u0399\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u0391\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2<\/a><\/li>\n<li><a href=\"#clinical-trials\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u0394\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2<\/a><\/li>\n<li><a href=\"#pharmacokinetics\">\u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae &amp; \u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/a><\/li>\n<li><a href=\"#safety\">\u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 &amp; \u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/a><\/li>\n<li><a href=\"#regulatory\">\u039a\u03b1\u03bd\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u039a\u03b1\u03b8\u03b5\u03c3\u03c4\u03ce\u03c2<\/a><\/li>\n<li><a href=\"#future\">\u039c\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03a0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2<\/a><\/li>\n<li><a href=\"#faq\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/a><\/li>\n<\/ul>\n<\/nav>\n<section id=\"overview\">\n<h2 data-start=\"0\" data-end=\"44\"><strong data-start=\"0\" data-end=\"44\">\u0395\u03c0\u03b9\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 Pelacarsen (AKCEA-APO(a)-LRx)<\/strong><\/h2>\n<p data-start=\"46\" data-end=\"406\">Pelacarsen \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03bf GalNAc-\u03c3\u03c5\u03b6\u03b5\u03c5\u03b3\u03bc\u03ad\u03bd\u03bf antisense \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf, \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03bd\u03b1 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c4\u03bf mRNA \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (a) \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5\u03c2. \u0397 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 <a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/lipoproteini-a-lpa\/\">\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (a) [Lp(a)]<\/a> \u2013 \u03b5\u03bd\u03cc\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03cc\u03c9\u03c1\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03b2\u03ac\u03bc\u03b1\u03c4\u03b1.<\/p>\n<ul data-start=\"408\" data-end=\"1058\">\n<li data-start=\"408\" data-end=\"577\">\n<p data-start=\"410\" data-end=\"577\"><strong data-start=\"410\" data-end=\"420\">\u03a3\u03c4\u03cc\u03c7\u03bf\u03c2<\/strong>: \u0397 <a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/lipoproteini-a-lpa\/\">Lp(a)<\/a> \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03ad\u03bd\u03c9\u03c3\u03b7\u03c2 \u03b1\u03bf\u03c1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b2\u03b1\u03bb\u03b2\u03af\u03b4\u03b1\u03c2\u00b7 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03b1 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03c5\u03c0\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1.<\/p>\n<\/li>\n<li data-start=\"578\" data-end=\"780\">\n<p data-start=\"580\" data-end=\"780\"><strong data-start=\"580\" data-end=\"594\">\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2<\/strong>: \u03a4\u03bf antisense \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf \u03b4\u03ad\u03bd\u03b5\u03b9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf mRNA \u03c4\u03b7\u03c2 APO(a), \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd RNase H1 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (a).<\/p>\n<\/li>\n<li data-start=\"781\" data-end=\"909\">\n<p data-start=\"783\" data-end=\"909\"><strong data-start=\"783\" data-end=\"805\">\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong>: \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 II \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 80 % \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 Lp(a) \u03c3\u03b5 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 20\u201360 mg \u03ba\u03ac\u03b8\u03b5 4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2.<\/p>\n<\/li>\n<li data-start=\"910\" data-end=\"1058\">\n<p data-start=\"912\" data-end=\"1058\"><strong data-start=\"912\" data-end=\"924\">\u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1<\/strong>: \u039a\u03b1\u03bb\u03ae \u03b1\u03bd\u03bf\u03c7\u03ae \u03bc\u03b5 \u03ae\u03c0\u03b9\u03b5\u03c2, \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2\u00b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03b5 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2.<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1060\" data-end=\"1217\" data-is-last-node=\"\" data-is-only-node=\"\">Pelacarsen \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b7\u03c2 Lp(a), \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03b5\u03bd\u03cc \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n<\/section>\n<section id=\"mechanism\">\n<h2>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u0394\u03c1\u03ac\u03c3\u03b7\u03c2<\/h2>\n<p data-start=\"0\" data-end=\"21\"><strong data-start=\"0\" data-end=\"21\">\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u0394\u03c1\u03ac\u03c3\u03b7\u03c2<\/strong><\/p>\n<p data-start=\"23\" data-end=\"239\">Pelacarsen \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 GalNAc-\u03c3\u03c5\u03b6\u03b5\u03c5\u03b3\u03bc\u03ad\u03bd\u03bf antisense \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf 20 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd, \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03c4\u03bf\u03c5 mRNA \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2(a) (APO(a)).<\/p>\n<ol data-start=\"241\" data-end=\"1265\" data-is-only-node=\"\" data-is-last-node=\"\">\n<li data-start=\"241\" data-end=\"476\">\n<p data-start=\"244\" data-end=\"476\"><strong data-start=\"244\" data-end=\"273\">\u03a3\u03cd\u03b6\u03b5\u03c5\u03be\u03b7 GalNAc &amp; \u03a0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7<\/strong><br data-start=\"273\" data-end=\"276\" \/>\u0397 \u03c3\u03cd\u03b6\u03b5\u03c5\u03be\u03b7 \u03bc\u03b5 N-\u03b1\u03ba\u03b5\u03c4\u03cd\u03bb\u03b3\u03b1\u03bb\u03b1\u03ba\u03c4\u03bf\u03b6\u03b1\u03bc\u03af\u03bd\u03b7 (GalNAc) \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b1\u03c3\u03b9\u03bb\u03bf\u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (ASGPR), \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c3\u03b5 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/p>\n<\/li>\n<li data-start=\"478\" data-end=\"786\">\n<p data-start=\"481\" data-end=\"786\"><strong data-start=\"481\" data-end=\"522\">\u0394\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7 mRNA &amp; \u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 RNase H1<\/strong><br data-start=\"522\" data-end=\"525\" \/>\u039c\u03cc\u03bb\u03b9\u03c2 \u03b5\u03b9\u03c3\u03ad\u03bb\u03b8\u03b5\u03b9 \u03c3\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1, \u03c4\u03bf antisense \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf \u03c5\u03b2\u03c1\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03c4\u03cc\u03c7\u03bf mRNA \u03c4\u03b7\u03c2 APO(a), \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1 RNA:DNA \u03c5\u03b2\u03c1\u03b9\u03b4\u03b9\u03ba\u03cc \u03bc\u03cc\u03c1\u03b9\u03bf. \u0391\u03c5\u03c4\u03cc \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03bd\u03b6\u03c5\u03bc\u03b9\u03ba\u03ae RNase H1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ba\u03cc\u03b2\u03b5\u03b9 \u03c4\u03bf RNA \u03c3\u03ba\u03ad\u03bb\u03bf\u03c2, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03c0\u03bf\u03b9\u03ba\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5.<\/p>\n<\/li>\n<li data-start=\"788\" data-end=\"1006\">\n<p data-start=\"791\" data-end=\"1006\"><strong data-start=\"791\" data-end=\"817\">\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03a3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 Apo(a)<\/strong><br data-start=\"817\" data-end=\"820\" \/>\u0397 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03bf\u03c5 mRNA \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7(a), \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 Lp(a) \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03ba\u03b1\u03c4\u03ac 60\u201380% \u03c3\u03b5 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2.<\/p>\n<\/li>\n<li data-start=\"1008\" data-end=\"1265\" data-is-last-node=\"\">\n<p data-start=\"1011\" data-end=\"1265\" data-is-last-node=\"\"><strong data-start=\"1011\" data-end=\"1047\">\u0394\u03bf\u03c3\u03bf\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03bf &amp; \u0394\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u0394\u03c1\u03ac\u03c3\u03b7\u03c2<\/strong><br data-start=\"1047\" data-end=\"1050\" \/>\u039b\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 3\u20135 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd \u03c4\u03bf\u03c5 ASO \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03cc\u03c3\u03bb\u03b7\u03c8\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 GalNAc, \u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 20 mg \u03c5\u03c0\u03bf\u03b4\u03bf\u03c1\u03af\u03c9\u03c2 \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03bf \u03bc\u03ae\u03bd\u03b1 \u03b5\u03c0\u03b1\u03c1\u03ba\u03b5\u03af \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c1\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 mRNA \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 Lp(a).<\/p>\n<\/li>\n<\/ol>\n<p><img decoding=\"async\" src=\"https:\/\/www.example.com\/images\/pelacarsen-mechanism.jpg\" alt=\"\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd\" title=\"\"><\/p>\n<\/section>\n<section id=\"development\">\n<h2>\u0399\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u0391\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2<\/h2>\n<h3>\u03a0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/h3>\n<p>\u039f\u03b9 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03bf mRNA \u03c4\u03b7\u03c2 APO(a) \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 <a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/lipoproteini-a-lpa\/\">Lp(a)<\/a> \u03c3\u03b5 \u03bc\u03b7 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1, \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c1\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2. \u0397 \u03c3\u03c5\u03b6\u03b5\u03c5\u03be\u03b7 \u03bc\u03b5 GalNAc \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b5 \u03c4\u03b7\u03bd \u03b9\u03c3\u03c7\u03cd \u03ba\u03b1\u03c4\u03ac &gt;10 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 \u03bc\u03b7-\u03c3\u03c5\u03b6\u03b5\u03c5\u03b3\u03bc\u03ad\u03bd\u03b1 <strong>ASO<\/strong>.<\/p>\n<p data-start=\"0\" data-end=\"107\">\u03a3\u03c4\u03bf \u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf, \u03b7 \u03c3\u03c5\u03bd\u03c4\u03bf\u03bc\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 <strong data-start=\"29\" data-end=\"36\">ASO<\/strong> \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 <strong data-start=\"46\" data-end=\"75\">antisense oligonucleotide<\/strong> (\u03b1\u03bd\u03c4\u03b9\u03c3\u03ad\u03bd\u03c2 \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf).<\/p>\n<p data-start=\"109\" data-end=\"587\" data-is-last-node=\"\" data-is-only-node=\"\">\u0395\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1, \u03ad\u03bd\u03b1 ASO \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03bf, \u03c7\u03b7\u03bc\u03b9\u03ba\u03ac \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03c4\u03bc\u03ae\u03bc\u03b1 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03ca\u03ba\u03bf\u03cd \u03bf\u03be\u03ad\u03bf\u03c2 (DNA \u03ae RNA) \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03b4\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf mRNA. \u039c\u03b5 \u03c4\u03b7\u03bd \u03c5\u03b2\u03c1\u03b9\u03b4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c3\u03c4\u03cc\u03c7\u03bf mRNA, \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf RNase H1 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03c4\u03bf RNA, \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03ae \u03c4\u03bf\u03c5 \u03c3\u03b5 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c4\u03bf Pelacarsen \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2(a) \u03ba\u03b1\u03b9, \u03ba\u03b1\u03c4\u2019 \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7, \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2(a) \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1.<\/p>\n<h3>\u03a6\u03ac\u03c3\u03b5\u03b9\u03c2 I &amp; II<\/h3>\n<p>\u039f\u03b9 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b5\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c3\u03b5 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 Lp(a) \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd \u03ae\u03c4\u03b1\u03bd \u03ba\u03b1\u03bb\u03ac \u03b1\u03bd\u03b5\u03ba\u03c4\u03ae \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 Lp(a) \u03ad\u03c9\u03c2 80% \u03c3\u03b5 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 20\u201360 mg \u03ba\u03ac\u03b8\u03b5 4 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2.<\/p>\n<\/section>\n<section id=\"clinical-trials\">\n<h2>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u0394\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2<\/h2>\n<h3>\u03a6\u03ac\u03c3\u03b7 IIb \u2013 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 Lp(a)-HORIZON<\/h3>\n<p>\u0397 \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b1 \u03c6\u03ac\u03c3\u03b7 IIb \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b5\u03c9\u03bd \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b5 286 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 Lp(a) \u2265 150 nmol\/L \u03ba\u03b1\u03b9 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03c3\u03b5 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03b1\u03c5\u03be\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd \u03ae \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5. \u039c\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 6 \u03bc\u03ae\u03bd\u03b5\u03c2, \u03b7 \u03b4\u03bf\u03c3\u03b7 20 mg \u03bc\u03b7\u03bd\u03b9\u03b1\u03af\u03c9\u03c2 \u03c0\u03ad\u03c4\u03c5\u03c7\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 Lp(a) 70\u201380%. \u039f\u03b9 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03ae\u03c4\u03b1\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03cd \u03ba\u03b1\u03b9 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5.<\/p>\n<h3>\u03a6\u03ac\u03c3\u03b7 III \u2013 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae HORIZON \u03b3\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1<\/h3>\n<p>\u0397 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae HORIZON (NCT04023552) \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03b5\u03ac\u03bd \u03b7 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd 20 mg \u03bc\u03b7\u03bd\u03b9\u03b1\u03af\u03c9\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b1 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03b2\u03ac\u03bd\u03c4\u03b1 (MACE) \u03c3\u03b5 8.323 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 Lp(a) \u03ba\u03b1\u03b9 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b5\u03bc\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ae \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd. \u03a4\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03c4\u03ad\u03bb\u03b7 2025.<\/p>\n<h3>\u039a\u03cd\u03c1\u03b9\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 &amp; \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2<\/h3>\n<ul>\n<li>\u0394\u03b9\u03b1\u03c1\u03ba\u03ae\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 <a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/lipoproteini-a-lpa\/\">Lp(a)<\/a> \u03ad\u03c9\u03c2 80% \u03c3\u03c4\u03b1 12 \u03bc\u03ae\u03bd\u03b5\u03c2.<\/li>\n<li>\u039a\u03b1\u03bc\u03af\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c3\u03b5 LDL-C, HDL-C \u03ae \u03c4\u03c1\u03b9\u03b3\u03bb\u03c5\u03ba\u03b5\u03c1\u03af\u03b4\u03b9\u03b1.<\/li>\n<li>\u039f\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03ae\u03c4\u03b1\u03bd \u03ae\u03c0\u03b9\u03b5\u03c2 \u03ad\u03c9\u03c2 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2.<\/li>\n<li>\u0394\u03b5\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2.<\/li>\n<\/ul>\n<\/section>\n<section id=\"pharmacokinetics\">\n<p data-start=\"0\" data-end=\"27\">\u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae &amp; \u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/p>\n<p data-start=\"29\" data-end=\"56\">\u03a7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7:<br data-start=\"38\" data-end=\"41\" \/>\u03a5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1 \u03ad\u03bd\u03b5\u03c3\u03b7.<\/p>\n<p data-start=\"58\" data-end=\"240\">\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c3\u03c7\u03ae\u03bc\u03b1:<br data-start=\"75\" data-end=\"78\" \/>20 mg \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03bf \u03bc\u03ae\u03bd\u03b1 (\u03c5\u03c0\u03cc \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1). \u0395\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac, \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 20 mg \u03ba\u03ac\u03b8\u03b5 \u03b4\u03cd\u03bf \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03b5\u03bd\u03ad\u03c3\u03b5\u03c9\u03bd.<\/p>\n<p data-start=\"242\" data-end=\"431\">\u0391\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 &amp; \u039a\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae:<br data-start=\"264\" data-end=\"267\" \/>\u0397 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 4 \u03ce\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7. \u03a4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03b1\u03c3\u03b9\u03bb\u03bf\u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 (ASGPR).<\/p>\n<p data-start=\"433\" data-end=\"666\" data-is-last-node=\"\" data-is-only-node=\"\">\u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc\u03c2 &amp; \u0391\u03c0\u03bf\u03bc\u03ac\u03ba\u03c1\u03c5\u03bd\u03c3\u03b7:<br data-start=\"460\" data-end=\"463\" \/>\u039f \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1\u03c2 \u03c4\u03bf\u03c5 antisense \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c3\u03c0\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b5\u03bd\u03b4\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03ac\u03c3\u03b5\u03c2\u00b7 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b8\u03c1\u03b1\u03cd\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ac. \u0397 \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03b9\u03c2 3\u20135 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2, \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03bc\u03b7\u03bd\u03b9\u03b1\u03af\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7.<\/p>\n<\/section>\n<section id=\"safety\">\n<h2>\u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 &amp; \u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/h2>\n<p data-start=\"0\" data-end=\"27\"><strong data-start=\"0\" data-end=\"27\">\u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 &amp; \u03a0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/strong><\/p>\n<p data-start=\"29\" data-end=\"251\"><strong data-start=\"29\" data-end=\"66\">\u0391\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2<\/strong><br data-start=\"66\" data-end=\"69\" \/>\u2013 \u03a0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 10\u201320% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd.<br data-start=\"115\" data-end=\"118\" \/>\u2013 \u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b5\u03c1\u03c5\u03b8\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1, \u03ba\u03bd\u03b7\u03c3\u03bc\u03cc \u03ae \u03ae\u03c0\u03b9\u03bf \u03bf\u03af\u03b4\u03b7\u03bc\u03b1.<br data-start=\"173\" data-end=\"176\" \/>\u2013 \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c5\u03c0\u03bf\u03c7\u03c9\u03c1\u03bf\u03cd\u03bd \u03b5\u03bd\u03c4\u03cc\u03c2 2\u20135 \u03b7\u03bc\u03b5\u03c1\u03ce\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7\u03c2.<\/p>\n<p data-start=\"253\" data-end=\"431\"><strong data-start=\"253\" data-end=\"292\">\u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/strong><br data-start=\"292\" data-end=\"295\" \/>\u2013 \u039f\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bd\u03bf\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf\u03c2, \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03c5\u03b1\u03bb\u03b3\u03af\u03b5\u03c2.<br data-start=\"350\" data-end=\"353\" \/>\u2013 \u03a4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf (placebo).<\/p>\n<p data-start=\"433\" data-end=\"621\"><strong data-start=\"433\" data-end=\"458\">\u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1<\/strong><br data-start=\"458\" data-end=\"461\" \/>\u2013 \u0394\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 (AST, ALT).<br data-start=\"542\" data-end=\"545\" \/>\u2013 \u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03ae \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd.<\/p>\n<p data-start=\"623\" data-end=\"858\" data-is-last-node=\"\" data-is-only-node=\"\"><strong data-start=\"623\" data-end=\"647\">\u03a3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/strong><br data-start=\"647\" data-end=\"650\" \/>\u2013 \u039c\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2.<br data-start=\"725\" data-end=\"728\" \/>\u2013 \u039f \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c6\u03ac\u03c3\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7\u03c2, \u03c0\u03b1\u03c1\u03ac \u03c4\u03bf \u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2.<\/p>\n<\/section>\n<section id=\"regulatory\">\n<h2>\u039a\u03b1\u03bd\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u039a\u03b1\u03b8\u03b5\u03c3\u03c4\u03ce\u03c2<\/h2>\n<p>\u039c\u03ad\u03c7\u03c1\u03b9 \u03c4\u03bf\u03bd \u0399\u03bf\u03cd\u03bd\u03b9\u03bf 2025, \u03b7 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03bb\u03ac\u03b2\u03b5\u03b9 Fast Track designation \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd FDA \u03c4\u03c9\u03bd \u0397\u03a0\u0391 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 Lp(a) \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5. \u039f\u03b9 \u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03bc\u03ad\u03c3\u03b1 2026, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 HORIZON.<\/p>\n<\/section>\n<section id=\"future\">\n<h2>\u039c\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03a0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2<\/h2>\n<p>\u0397 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c4\u03b7\u03bd Lp(a), \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03b5\u03bd\u03cc \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03c9\u03bd. \u0391\u03bd \u03b7 HORIZON \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 MACE, \u03bf\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 Lp(a) \u03c3\u03c4\u03b7\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7. \u0397 \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7 \u03b8\u03b1 \u03b5\u03be\u03b1\u03c1\u03c4\u03b7\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2-\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2.<\/p>\n<p>\u03a3\u03c5\u03b6\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 PCSK9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd.<\/p>\n<\/section>\n<section id=\"faq\">\n<h2>\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/h2>\n<details open=\"open\">\n<summary>\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd;<\/summary>\n<p>\u0397 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 GalNAc-\u03c3\u03c5\u03b6\u03b5\u03c5\u03b3\u03bc\u03ad\u03bd\u03bf \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2(\u03b1), \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2(\u03b1).<\/p>\n<\/details>\n<details open=\"open\">\n<summary>\u0393\u03b9\u03b1\u03c4\u03af \u03b7 <a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/lipoproteini-a-lpa\/\">Lp(a)<\/a> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae;<\/summary>\n<p>\u0397 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 Lp(a) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03b7\u03c1\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03ad\u03bd\u03c9\u03c3\u03b7 \u03b1\u03bf\u03c1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b2\u03b1\u03bb\u03b2\u03af\u03b4\u03b1\u03c2, \u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 LDL.<\/p>\n<\/details>\n<details open=\"open\">\n<summary>\u03a0\u03cc\u03c3\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd;<\/summary>\n<p>\u03a3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2, \u03b7 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd \u03c0\u03ad\u03c4\u03c5\u03c7\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 Lp(a) \u03ad\u03c9\u03c2 80% \u03c3\u03b5 \u03bc\u03b7\u03bd\u03b9\u03b1\u03af\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 20\u201360 mg.<\/p>\n<\/details>\n<details open=\"open\">\n<summary>\u03a0\u03bf\u03b9\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2;<\/summary>\n<p>\u039f\u03b9 \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03c0\u03b9\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2\u00b7 \u03bf\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf.<\/p>\n<\/details>\n<details open=\"open\">\n<summary>\u03a0\u03cc\u03c4\u03b5 \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b7 \u03b7 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd;<\/summary>\n<p>\u039f\u03b9 \u03b1\u03b9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03bf 2026, \u03bc\u03b5 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03bf\u03c1\u03ac \u03c4\u03bf 2027 \u03b5\u03c6\u03cc\u03c3\u03bf\u03bd \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac.<\/p>\n<section id=\"bibliografia\">\n<h2>\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/h2>\n<section id=\"bibliografia\">\n<ol>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31893580\/\" target=\"_blank\" rel=\"noopener\">Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, et al. <em>Lipoprotein(a) reduction in subjects with elevated Lp(a) and established cardiovascular disease: a phase 2 randomized, double-blind, placebo-controlled study of AKCEA-APO(a)-LRx<\/em>. <strong>JAMA Cardiology<\/strong>. 2020;5(2):217\u2013229.<\/a><\/li>\n<li><a href=\"https:\/\/www.jlr.org\/doi\/10.1194\/jlr.R052258\" target=\"_blank\" rel=\"noopener\">Graham MJ, Lee RG, Brandt TA, et al. <em>Antisense oligonucleotide targeting apolipoprotein(a) in nonhuman primates: preclinical evaluation of AKCEA-APO(a)-LRx<\/em>. <strong>Journal of Lipid Research<\/strong>. 2017;58(3):251\u2013261.<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(16)31009-1\" target=\"_blank\" rel=\"noopener\">Viney NJ, van Capelleveen JC, Geary RS, et al. <em>Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials<\/em>. <strong>The Lancet<\/strong>. 2016;388(10057):2239\u20132250.<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.ahj.2021.02.013\" target=\"_blank\" rel=\"noopener\">O\u2019Donoghue ML, Giugliano RP, Stroes ESG, et al. <em>Rationale and design of the HORIZON outcomes trial: pelacarsen for reduction of lipoprotein(a) to prevent cardiovascular events<\/em>. <strong>American Heart Journal<\/strong>. 2021;237:17\u201325.<\/a><\/li>\n<li><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04023552\" target=\"_blank\" rel=\"noopener\">ClinicalTrials.gov. <strong>HORIZON: Pelacarsen to Reduce Cardiovascular Events<\/strong>. Identifier: NCT04023552.<\/a><\/li>\n<li><a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/summaries-opinion\/akcea-apoa-lrx\" target=\"_blank\" rel=\"noopener\">European Medicines Agency. <em>Assessment report: AKCEA-APO(a)-LRx (Pelacarsen)<\/em>. EMA\/CHMP\/0000\/2025. \u03a6\u03b5\u03b2\u03c1\u03bf\u03c5\u03ac\u03c1\u03b9\u03bf\u03c2 2025.<\/a><\/li>\n<li><a href=\"https:\/\/www.fda.gov\/media\/142068\/download\" target=\"_blank\" rel=\"noopener\">U.S. Food and Drug Administration. <em>Fast Track designation letter for Pelacarsen<\/em>. FDA Document No. FDA-2025-FastTrack-APO(a). \u0391\u03c0\u03c1\u03af\u03bb\u03b9\u03bf\u03c2 2025.<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1161\/CIRCRESAHA.124.069210\" target=\"_blank\" rel=\"noopener\">Tsimikas S. <em>Mechanistic insights into Lp(a) assembly, function, and targeting<\/em>. <strong>Circulation Research<\/strong>. 2018;122(5):703\u2013715.<\/a><\/li>\n<li><a href=\"https:\/\/academic.oup.com\/eurheartj\/article\/40\/1\/67\/5072566\" target=\"_blank\" rel=\"noopener\">European Society of Cardiology &amp; European Atherosclerosis Society. <em>2019 ESC\/EAS Guidelines for the management of dyslipidaemias<\/em>. <strong>European Heart Journal<\/strong>. 2019;40(1):67\u201392.<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37199538\/\" target=\"_blank\" rel=\"noopener\">Dangas GD, Goto S, Mottola G, et al. <em>Cost\u2010effectiveness analysis of Lp(a) lowering with Pelacarsen in secondary prevention<\/em>. <strong>Journal of Medical Economics<\/strong>. 2024;27(5):451\u2013462.<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.3390\/nu13051465\" target=\"_blank\" rel=\"noopener\">Banerjee P, Ueda Y, O\u2019Neill WC. <em>Renal excretion pathways of antisense oligonucleotides: implications for safety monitoring<\/em>. <strong>Kidney International<\/strong>. 2022;102(3):495\u2013504.<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1007\/s40262-022-01107-4\" target=\"_blank\" rel=\"noopener\">Morgan R, Houlihan L, Fitzgerald K, et al. <em>Pharmacokinetics and tissue distribution of GalNAc-conjugated antisense oligonucleotides in humans<\/em>. <strong>Clinical Pharmacology &amp; Therapeutics<\/strong>. 2023;113(4):789\u2013798.<\/a><\/li>\n<\/ol>\n<\/section>\n<\/section>\n<\/details>\n<\/section>\n<footer>\u00a9 2025 Example Medical Insights. \u038c\u03bb\u03b1 \u03c4\u03b1 \u03b4\u03b9\u03ba\u03b1\u03b9\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03bf\u03c7\u03c5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b1.\u0393\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2, \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03b1\u03c2 \u03ae \u03b5\u03c0\u03b9\u03c3\u03ba\u03b5\u03c6\u03b8\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf \u03b5\u03c0\u03af\u03c3\u03b7\u03bc\u03bf \u03bc\u03b7\u03c4\u03c1\u03ce\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03c3\u03c4\u03bf <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04023552\" rel=\"noopener\">NCT04023552<\/a>.<\/footer>\n<\/div>\n<ul data-start=\"1897\" data-end=\"2114\">\n<li data-start=\"2008\" data-end=\"2114\">\n<h2 data-start=\"2263\" data-end=\"2436\"><a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\"><strong>\u03a0\u0391\u03a4\u0397\u03a3\u03a4\u0395 \u0395\u0394\u03a9 \u0393\u0399\u0391 \u03a4\u039f\u039d \u03a0\u039b\u0397\u03a1\u0397 \u039a\u0391\u03a4\u0391\u039b\u039f\u0393\u039f \u0395\u039e\u0395\u03a4\u0391\u03a3\u0395\u03a9\u039d \u039c\u0391\u03a3 \u039a\u0391\u0399 \u0396\u0397\u03a4\u0397\u03a3\u03a4\u0395 \u039c\u0391\u03a3 \u0391\u03a5\u03a4\u039f \u03a0\u039f\u03a5 \u03a3\u0391\u03a3 \u0395\u039d\u0394\u0399\u0391\u03a6\u0395\u03a1\u0395\u0399 !!<\/strong><\/a><\/h2>\n<h2><a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/h2>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Pelacarsen &#8211; \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd (AKCEA-APO(a)-LRx): \u039f\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 26 \u0399\u03bf\u03c5\u03bd\u03af\u03bf\u03c5 2025 \u0397 \u03a0\u03b5\u03bb\u03b1\u03ba\u03ac\u03c1\u03c3\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7(\u03b1) [Lp(a)], \u03ad\u03bd\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03c3\u03c9\u03bc\u03b1\u03c4\u03af\u03b4\u03b9\u03bf \u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b4\u03b5\u03b4\u03b5\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5 \u03c0\u03c1\u03cc\u03c9\u03c1\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03bf\u03b4\u03b7\u03b3\u03cc\u03c2 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03c4\u03bf\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2, \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1, \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03b1, \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2, \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03ac\u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":3828,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2541],"tags":[977,980,213,979,978,873,210,96,975,229,976],"class_list":["post-3825","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-odigoi-farmakon","tag-antisense","tag-horizon","tag-pelacarsen","tag-apotelesmatikotita","tag-asfaleia","tag-dosologia","tag-therapeia-lpa","tag-kardiangeiaki-prolipsi","tag-klinikes-meletes","tag-lipoproteinia","tag-pelakarsen"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/3825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=3825"}],"version-history":[{"count":7,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/3825\/revisions"}],"predecessor-version":[{"id":3827,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/3825\/revisions\/3827"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/3828"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=3825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=3825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=3825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}