{"id":3222,"date":"2025-06-12T10:05:54","date_gmt":"2025-06-12T07:05:54","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=3222"},"modified":"2026-03-18T21:12:37","modified_gmt":"2026-03-18T19:12:37","slug":"jak2-to-gonidio-i-metallaxi-v617f-kai-i-therapeftiki-tou-simasia","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/jak2-to-gonidio-i-metallaxi-v617f-kai-i-therapeftiki-tou-simasia\/","title":{"rendered":"JAK2 V617F: \u03a0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7, \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, Ruxolitinib &#038; \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1"},"content":{"rendered":"<div style=\"max-width: 1000px; margin: 0 auto;\">\n<h1 style=\"font-size: 32px; font-weight: 900; color: #111827; margin-bottom: 10px;\">JAK2 V617F \u03ba\u03b1\u03b9 \u039c\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u039d\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1: \u03a0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7, \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2<\/h1>\n<div style=\"margin: 10px 0 12px; color: #6b7280; font-size: 13px;\">\u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: <time datetime=\"2026-03-18\">18 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time> \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: <time datetime=\"2026-03-18\">18 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time><\/div>\n<div style=\"background: #f8fafc; border-left: 5px solid #b70000; padding: 16px 18px; border-radius: 12px; margin: 18px 0;\">\n<p><strong>\u03a3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03c0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7:<\/strong><\/p>\n<ul style=\"margin: 10px 0 0; padding-left: 18px; line-height: 1.7;\">\n<li>\u0397 <strong>JAK2 V617F<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03ae \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1. \u03a3\u03c4\u03b1 <strong>\u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 (MPNs)<\/strong> \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7\u03bd <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification)<\/strong>, \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2.<\/li>\n<li>\u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong>, \u03c3\u03c4\u03b7\u03bd <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong>.<\/li>\n<li>\u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03b4\u03b5\u03bd \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c3\u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2, \u03c3\u03c4\u03b7 \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1, \u03c3\u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd.<\/li>\n<li>\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b7 <strong>\u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (Ruxolitinib)<\/strong>, \u03b7 <strong>\u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1<\/strong>, \u03b7 <strong>\u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7<\/strong> \u03ba\u03b1\u03b9, \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 <strong>\u03bc\u03b5\u03c4\u03b1\u03bc\u03cc\u03c3\u03c7\u03b5\u03c5\u03c3\u03b7 \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/strong> \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification)<\/strong>.<\/li>\n<li>\u0391\u03bd \u03b8\u03ad\u03bb\u03b5\u03c4\u03b5 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 <strong>\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 JAK2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7, \u03c0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03ce\u03c2 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9<\/strong>, \u03b4\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03c4\u03bf\u03bd \u03ba\u03cd\u03c1\u03b9\u03bf \u03bf\u03b4\u03b7\u03b3\u03cc \u03bc\u03b1\u03c2: <a style=\"color: #b70000; font-weight: bold; text-decoration: none;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/jak2-metallaxi\/\">JAK2 \u039c\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 (V617F): \u03c0\u03bb\u03ae\u03c1\u03b7\u03c2 \u03bf\u03b4\u03b7\u03b3\u03cc\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1\u03c2<\/a>.<\/li>\n<\/ul>\n<\/div>\n<nav id=\"toc\" style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 14px; padding: 16px 18px; margin: 18px 0;\">\n<div style=\"font-weight: 800; font-size: 18px; color: #111827; margin-bottom: 10px;\">\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/div>\n<ol style=\"margin: 0; padding-left: 18px; line-height: 1.8;\">\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section1\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 JAK2 V617F \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 (MPN)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section2\">JAK2 V617F \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section3\">JAK2 V617F \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section4\">JAK2 V617F \u03ba\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section5\">\u03a0\u03ce\u03c2 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03cc\u03c4\u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 JAK2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section6\">\u0395\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification) \u03c3\u03c4\u03b7\u03bd \u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section7\">\u0395\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification) \u03c3\u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section8\">\u0395\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification) \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section9\">\u03a0\u03cc\u03c4\u03b5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section10\">\u03a1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (Ruxolitinib): \u03c0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section11\">\u0386\u03bb\u03bb\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2: \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1, \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7, \u03b1\u03bd\u03b1\u03b3\u03c1\u03b5\u03bb\u03af\u03b4\u03b7 (anagrelide), \u03bc\u03b5\u03c4\u03b1\u03bc\u03cc\u03c3\u03c7\u03b5\u03c5\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section12\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 (monitoring) \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 JAK2 V617F<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section13\">\u03a6\u03bf\u03c1\u03c4\u03af\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5 (allele burden) \u03ba\u03b1\u03b9 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section14\">JAK2 V617F \u03ba\u03b1\u03b9 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 (MPN)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section15\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section16\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section17\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: 0; border-top: 2px solid #d1d5db; margin: 14px 0 24px;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<section id=\"section1\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 JAK2 V617F \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 (MPN)<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u038c\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 <strong>\u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 (MPN)<\/strong>, \u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>JAK2 V617F<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03bc\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03bf\u03c4\u03ad \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1. \u0394\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 <strong>\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 (CBC)<\/strong>, \u03b7 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd \u03ba\u03b1\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b7\u03b8\u03bf\u03cd\u03bd \u03bc\u03b1\u03b6\u03af.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03c5\u03c8\u03b7\u03bb\u03cc \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7<\/strong>, <strong>\u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7<\/strong>, <strong>\u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1<\/strong> \u03ae \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u0394\u03b5\u03bd \u03bb\u03ad\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u00ab\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u00bb, \u03b1\u03bb\u03bb\u03ac \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 vera (PV)<\/strong>, \u03c4\u03b7\u03c2 <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03cd\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 (ET)<\/strong> \u03ae \u03c4\u03b7\u03c2 <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03bf\u03cd\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7\u03c2 (PMF)<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039a\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03b9\u03b4\u03ad\u03b1:<\/strong> \u03b7 JAK2 V617F \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/strong>, \u03cc\u03c7\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03ad\u03bd\u03b1 \u00ab\u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1\u00bb.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u0393\u03b9\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2, \u03c4\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bb\u03b3\u03bf\u03c1\u03af\u03b8\u03bc\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03ae \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b4\u03b5\u03af\u03c4\u03b5 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd <a style=\"color: #b70000; font-weight: bold; text-decoration: none;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/jak2-metallaxi\/\">\u03ba\u03cd\u03c1\u03b9\u03bf \u03bf\u03b4\u03b7\u03b3\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b7 JAK2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<\/a>.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 2 ==================== --><\/p>\n<section id=\"section2\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">JAK2 V617F \u03ba\u03b1\u03b9 \u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03c0\u03b9\u03bf \u03c3\u03c4\u03b5\u03bd\u03ae \u03c3\u03c7\u03ad\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>JAK2 V617F<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong>. \u03a3\u03c4\u03b7\u03bd PV \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c0\u03bb\u03b5\u03b9\u03bf\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b8\u03b5\u03bc\u03b5\u03bb\u03b9\u03ce\u03b4\u03b5\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7\u03c2 \u03ae \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac, \u03bf JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 PV \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 <strong>\u03c5\u03c0\u03b5\u03c1\u03b3\u03bb\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong>, \u03ba\u03b5\u03c6\u03b1\u03bb\u03b1\u03bb\u03b3\u03af\u03b1, \u03b5\u03c1\u03c5\u03b8\u03c1\u03bf\u03bc\u03b5\u03bb\u03b1\u03bb\u03b3\u03af\u03b1, \u03ba\u03bd\u03b7\u03c3\u03bc\u03cc, \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1 \u03ae \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1. \u03a4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b6\u03b7\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03bf <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u0397 JAK2 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7.<\/li>\n<li>\u0397 PV \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af <strong>\u03c6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ad\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae.<\/li>\n<li>\u03a3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 <strong>\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<\/strong>.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf, \u03b7 JAK2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1. \u0395\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c0\u03cc\u03c3\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 3 ==================== --><\/p>\n<section id=\"section3\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">3<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">JAK2 V617F \u03ba\u03b1\u03b9 \u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong>, \u03b7 JAK2 V617F \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb<\/strong> \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <strong>CALR<\/strong>.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u039f \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 ET \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 JAK2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification)<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ae \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u0397 JAK2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 ET \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7.<\/li>\n<li>\u0394\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03c0\u03b1\u03b8\u03ce\u03bd \u03b1\u03b9\u03c4\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c9\u03c3\u03c4\u03ae \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/li>\n<li>\u0395\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ae \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03af\u03c9\u03c3\u03b7.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd ET, \u03bf \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bd\u03b1 \u00ab\u03c0\u03ad\u03c3\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1\u00bb, \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c9\u03c3\u03c4\u03cc \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification)<\/strong> \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 4 ==================== --><\/p>\n<section id=\"section4\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">4<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">JAK2 V617F \u03ba\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong>, \u03b7 JAK2 V617F \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 <strong>\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2-\u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03c2 (driver mutations)<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03cd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03b1\u03c0\u03bb\u03cc \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1. \u0395\u03b4\u03ce \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd <strong>\u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/strong>, \u03c4\u03b7 <strong>\u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1<\/strong>, \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03b9\u03c2 \u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2, \u03c4\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c0\u03b5\u03bd\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 PMF, \u03b7 JAK2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b5 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03bd\u03c5\u03c7\u03c4\u03b5\u03c1\u03b9\u03bd\u03ad\u03c2 \u03b5\u03c6\u03b9\u03b4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03ba\u03b1\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03ba\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf \u03b1\u03c0\u03bf\u03ba\u03c4\u03bf\u03cd\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03c6\u03bf\u03c1\u03c4\u03af\u03bf \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a3\u03c4\u03b7\u03bd PMF:<\/strong> \u03b7 JAK2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb<\/strong> \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<section id=\"section5\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">5<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03cc\u03c4\u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 JAK2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 <strong>JAK2 V617F<\/strong> \u03b4\u03b5\u03bd \u03b4\u03af\u03bd\u03b5\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong>. \u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03be\u03b5\u03c7\u03c9\u03c1\u03af\u03c3\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae <strong>\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2<\/strong> \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7 \u03ae \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03b3\u03b9\u03b1\u03c4\u03af \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2. \u039f JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03ad\u03bd\u03b1\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c3\u03c4\u03b7 <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 (CBC)<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae <strong>\u03b1\u03bd\u03c4\u03b9\u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae<\/strong>.<\/li>\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 <strong>\u03c6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ad\u03c2<\/strong> \u03ae \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2.<\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 <strong>\u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 (monitoring)<\/strong>.<\/li>\n<li>\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03cc\u03c1\u03b9\u03bf \u03b5\u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03c3\u03b7\u03c2 \u03cc\u03c4\u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bd\u03ad\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7:<\/strong> \u03b7 JAK2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1. \u0395\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u00ab\u03b1\u03c1\u03b9\u03b8\u03bc\u03b7\u03c4\u03b9\u03ba\u03ac\u00bb.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1, \u03b7 \u03af\u03b4\u03b9\u03b1 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03c1\u03c5\u03b8\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7, \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7, \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1, \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ae \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c3\u03c5\u03bd\u03c4\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b9 \u03b7 JAK2 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<section id=\"section6\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">6<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification) \u03c3\u03c4\u03b7\u03bd \u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong>, \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03c4\u03b7\u03c2 <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03c3\u03c4\u03b5\u03af \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bf <strong>\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2<\/strong>. \u039f\u03b9 \u03b4\u03cd\u03bf \u03c0\u03b9\u03bf \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03af \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03bf\u03af \u03ac\u03be\u03bf\u03bd\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 <strong>\u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf <strong>\u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2<\/strong>.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li><strong>\u03a7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5:<\/strong> \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2.<\/li>\n<li><strong>\u03a5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5:<\/strong> \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9\/\u03ae \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 <strong>JAK2 V617F<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c0\u03ac\u03bd\u03c4\u03bf\u03c4\u03b5 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7 \u03c4\u03b7\u03c2 PV, \u03b1\u03bb\u03bb\u03ac \u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03bd \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae. \u03a4\u03bf \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b1\u03c1\u03ba\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03af\u03bd\u03b5\u03b9 \u03c3\u03b5 <strong>\u03c6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7\u03c2<\/strong> \u03ae \u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>\u03c0\u03b9\u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03ae \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7:<\/strong> \u03b4\u03cd\u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 PV \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae JAK2 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf. \u0397 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c0\u03cc\u03c3\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03b8\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u0395\u03ba\u03c4\u03cc\u03c2 \u03b1\u03c0\u03cc \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7, \u03bf \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf\u03bd \u03b2\u03b1\u03b8\u03bc\u03cc \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7, \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03c6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ad\u03c2, \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<section id=\"section7\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">7<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification) \u03c3\u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong>, \u03b7 <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae\u03c2, \u03b3\u03b9\u03b1\u03c4\u03af \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03b5\u03af \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>. \u0395\u03b4\u03ce \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c0\u03b1\u03af\u03b6\u03bf\u03c5\u03bd \u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2, \u03bf\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 <strong>JAK2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2<\/strong>.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf <strong>IPSET-thrombosis<\/strong>, \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c3\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03ae \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5. \u0397 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 JAK2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1, \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 <strong>\u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7<\/strong> \u03ae \u03b3\u03b9\u03b1 <strong>\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<\/strong>.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u0397 JAK2 \u03c3\u03c4\u03b7\u03bd ET \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf.<\/li>\n<li>\u03a3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2.<\/li>\n<li>\u039f \u03af\u03b4\u03b9\u03bf\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03af\u03b4\u03b9\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03bd\u03cc\u03b7\u03bc\u03b1:<\/strong> \u03c3\u03c4\u03b7\u03bd ET \u03b4\u03b5\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03bf\u03c5\u03bc\u03b5 \u03bc\u03cc\u03bd\u03bf \u03bc\u03b9\u03b1 \u00ab\u03c5\u03c8\u03b7\u03bb\u03ae \u03c4\u03b9\u03bc\u03ae \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd\u00bb. \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03cd\u03bf\u03c5\u03bc\u03b5 \u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b9 \u03b7 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2. \u03a5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c4\u03bf \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc, \u03bf\u03b9 \u03c3\u03c5\u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03ae \u03bc\u03b9\u03ba\u03c1\u03bf\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 8 ==================== --><\/p>\n<section id=\"section8\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">8<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification) \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong>, \u03b7 <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b7 \u03b1\u03c0\u03cc \u03cc,\u03c4\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>PV<\/strong> \u03ae \u03c3\u03c4\u03b7\u03bd <strong>ET<\/strong>. \u0395\u03b4\u03ce \u03bf \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03b5\u03c6\u03b8\u03b5\u03af \u03b7 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7, \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03cc\u03c0\u03c9\u03c2 <strong>IPSS<\/strong>, <strong>DIPSS<\/strong> \u03ba\u03b1\u03b9 <strong>DIPSS-Plus<\/strong>, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c3\u03c5\u03bd\u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b6\u03bf\u03c5\u03bd:<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u03b7\u03bb\u03b9\u03ba\u03af\u03b1,<\/li>\n<li>\u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1,<\/li>\n<li>\u03bb\u03b5\u03c5\u03ba\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7,<\/li>\n<li>\u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1,<\/li>\n<li>\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2,<\/li>\n<li>\u03bc\u03b5\u03c4\u03b1\u03b3\u03b3\u03b9\u03c3\u03b9\u03bf\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c3\u03b7 \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b2\u03b1\u03c1\u03c5\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 JAK2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c4\u03b7\u03bd PMF \u03b7 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd. \u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03cd\u03bf JAK2-\u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 PMF \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b5\u03bb\u03b5\u03af\u03c9\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a4\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03c1\u03b1\u03c4\u03ae\u03c3\u03b5\u03c4\u03b5:<\/strong> \u03c3\u03c4\u03b7\u03bd PMF \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c8\u03b5\u03b9 \u03c4\u03b7 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u0397 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03c4\u03af\u03bf.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 9 ==================== --><\/p>\n<section id=\"section9\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">9<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 <strong>JAK2-positive \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 (MPN)<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae. \u0391\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03bf <strong>\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2<\/strong>, \u03cc\u03c4\u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03b9\u03c2<\/strong>, \u03cc\u03c4\u03b1\u03bd \u03b4\u03b5\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ac \u03bf \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7\u03c2 \u03ae \u03c4\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1, \u03cc\u03c4\u03b1\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03cc\u03c4\u03b1\u03bd \u03b5\u03c0\u03b9\u03b4\u03b5\u03b9\u03bd\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b6\u03c9\u03ae\u03c2.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a0\u03b1\u03c1\u03b1\u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 <strong>PV<\/strong> \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bf\u03bb\u03bf\u03ad\u03bd\u03b1 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ad\u03c2,<\/li>\n<li>\u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 <strong>ET<\/strong> \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03bd\u03ac \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5,<\/li>\n<li>\u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 <strong>PMF<\/strong> \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03b5\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1 \u03ae \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1,<\/li>\n<li>\u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1\u03c2 \u03ae \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae\u03c2 \u03c3\u03b5 \u03ae\u03b4\u03b7 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03b3\u03c9\u03b3\u03ae.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bf \u03af\u03b4\u03b9\u03bf\u03c2 \u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2: \u03b1\u03c0\u03cc \u03b1\u03c0\u03bb\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03b9\u03bc\u03ce\u03bd \u03c3\u03b5 \u03c0\u03b9\u03bf \u03b5\u03bd\u03b5\u03c1\u03b3\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd \u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u0386\u03c1\u03b1:<\/strong> \u03b7 JAK2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b5\u03bd \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03cc\u03c4\u03b5 \u03b8\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 10 ==================== --><\/p>\n<section id=\"section10\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">10<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (Ruxolitinib): \u03c0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 <strong>\u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (Ruxolitinib)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 <strong>JAK1\/2<\/strong> \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf \u03c0\u03b9\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03b5\u03b4\u03af\u03bf. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong> \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd <strong>\u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03ae \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1<\/strong>.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 \u03b1\u03be\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9:<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u03c4\u03b7 <strong>\u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1<\/strong>,<\/li>\n<li>\u03c4\u03b1 <strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 (B-symptoms)<\/strong>,<\/li>\n<li>\u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2,<\/li>\n<li>\u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u0394\u03b5\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c0\u03bf\u03c5 \u00ab\u03c3\u03b2\u03ae\u03bd\u03b5\u03b9\u00bb \u03b1\u03c0\u03bb\u03ce\u03c2 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 <strong>\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ae \u03b1\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf:<\/strong> \u03b7 \u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 \u03b4\u03b5\u03bd \u03b4\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 JAK2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c4\u03b1\u03bd \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u0391\u03c0\u03b1\u03b9\u03c4\u03b5\u03af, \u03cc\u03bc\u03c9\u03c2, \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 <strong>\u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/strong>, <strong>\u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03c9\u03bd. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u00ab\u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b7\u00bb \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae, \u03b1\u03bb\u03bb\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c0\u03bf\u03c5 \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc timing \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03b1\u03c6\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03cc\u03c7\u03bf.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 11 ==================== --><\/p>\n<section id=\"section11\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">11<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0386\u03bb\u03bb\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2: \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1, \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7, \u03b1\u03bd\u03b1\u03b3\u03c1\u03b5\u03bb\u03af\u03b4\u03b7 (anagrelide), \u03bc\u03b5\u03c4\u03b1\u03bc\u03cc\u03c3\u03c7\u03b5\u03c5\u03c3\u03b7<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 <strong>\u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (Ruxolitinib)<\/strong>, \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd <strong>JAK2-positive \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd (MPNs)<\/strong> \u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2. \u039a\u03ac\u03b8\u03b5 \u03bc\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b8\u03ad\u03c3\u03b7 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf, \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7, \u03c4\u03bf\u03bd \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03ae \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03b3\u03c9\u03b3\u03ae.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li><strong>\u03a5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1:<\/strong> \u03c3\u03c5\u03c7\u03bd\u03ae \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c3\u03b5 <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong> \u03ba\u03b1\u03b9 <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong>.<\/li>\n<li><strong>\u0399\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7:<\/strong> \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03c3\u03b5 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ae \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03b1, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2.<\/li>\n<li><strong>\u0391\u03bd\u03b1\u03b3\u03c1\u03b5\u03bb\u03af\u03b4\u03b7 (anagrelide):<\/strong> \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03c3\u03b5 ET.<\/li>\n<li><strong>\u039c\u03b5\u03c4\u03b1\u03bc\u03cc\u03c3\u03c7\u03b5\u03c5\u03c3\u03b7 \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd:<\/strong> \u03b7 \u03bc\u03cc\u03bd\u03b7 \u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c1\u03b9\u03b6\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong> \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>PV<\/strong>, \u03b7 <strong>\u03c6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ae<\/strong> \u03ba\u03b1\u03b9 \u03b7 <strong>\u03c7\u03b1\u03bc\u03b7\u03bb\u03ae \u03b4\u03cc\u03c3\u03b7 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7\u03c2<\/strong> \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03b1. \u0394\u03b7\u03bb\u03b1\u03b4\u03ae, \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u00ab\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae\u00bb, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03b9 \u03b1\u03c0\u03bb\u03ad\u03c2, \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/strong> \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 JAK2, \u03b1\u03bb\u03bb\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 PV, ET \u03ae PMF, \u03c0\u03bf\u03b9\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b9\u03ce\u03ba\u03b5\u03c4\u03b1\u03b9.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 12 ==================== --><\/p>\n<section id=\"section12\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">12<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 (monitoring) \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 JAK2 V617F<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03b5 <strong>JAK2-positive \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 (MPN)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03ae\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c0\u03b1\u03bd\u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7. \u039f \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 (CBC)<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1.<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li><strong>\u0393\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 (CBC):<\/strong> \u03b3\u03b9\u03b1 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7, \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7, \u03bb\u03b5\u03c5\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1.<\/li>\n<li><strong>\u0393\u03b1\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03c6\u03c5\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03ac\u03c3\u03b7 (LDH):<\/strong> \u03cc\u03c4\u03b1\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ae \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/li>\n<li><strong>\u03a6\u03b5\u03c1\u03c1\u03b9\u03c4\u03af\u03bd\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03b9\u03b4\u03ae\u03c1\u03bf\u03c5, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03c6\u03bb\u03b5\u03b2\u03bf\u03c4\u03bf\u03bc\u03ad\u03c2.<\/li>\n<li>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 <strong>\u03c3\u03c0\u03bb\u03b7\u03bd\u03bf\u03bc\u03b5\u03b3\u03b1\u03bb\u03af\u03b1<\/strong>, \u03ba\u03bd\u03b7\u03c3\u03bc\u03cc, \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2, \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03b2\u03ac\u03bc\u03b1\u03c4\u03b1.<\/li>\n<li>\u0395\u03b9\u03b4\u03b9\u03ba\u03ac \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf <strong>MPN-SAF<\/strong> \u03c3\u03b5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u0393\u03b9\u03b1 \u03c4\u03bf follow-up:<\/strong> \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bd\u03b1 \u00ab\u03c6\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03bb\u03ac \u03c4\u03b1 \u03bd\u03bf\u03cd\u03bc\u03b5\u03c1\u03b1\u00bb. \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c2, \u03b1\u03bd \u03bc\u03b5\u03b9\u03ce\u03b8\u03b7\u03ba\u03b1\u03bd \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b5\u03ba\u03c4\u03ae \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae.<\/div>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac, \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b1\u03bd\u03b5\u03bb\u03ad\u03b3\u03c7\u03c9\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b4\u03c1\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1, \u03cc\u03c4\u03b1\u03bd \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ae \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7\u03c2. \u0388\u03c4\u03c3\u03b9, \u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c9\u03c2 \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03c9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03b9\u03bc\u03ce\u03bd.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 13 ==================== --><\/p>\n<section id=\"section13\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">13<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a6\u03bf\u03c1\u03c4\u03af\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5 (allele burden) \u03ba\u03b1\u03b9 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a4\u03bf <strong>\u03c6\u03bf\u03c1\u03c4\u03af\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5 (allele burden)<\/strong> \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03ba\u03bb\u03ce\u03bd\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7. \u0394\u03b5\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03c1\u03b9\u03ad\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7:<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u03cc\u03c4\u03b1\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1,<\/li>\n<li>\u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7, \u03cc\u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b7 \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ba\u03bb\u03ce\u03bd\u03bf,<\/li>\n<li>\u03c3\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bc\u03bf\u03c3\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03ae \u03c3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1,<\/li>\n<li>\u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ae\u03c2 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03c1\u03b5\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03c0\u03ac\u03bd\u03c4\u03c9\u03c2, \u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bd\u03b1 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03b7 <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong>, \u03c3\u03c4\u03b1 <strong>\u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1<\/strong>, \u03c0\u03b1\u03c1\u03ac \u03c3\u03b5 \u03bc\u03af\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1:<\/strong> \u03c4\u03bf allele burden \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<section id=\"section14\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">14<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">JAK2 V617F \u03ba\u03b1\u03b9 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 (MPN)<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 <strong>JAK2-positive \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 (MPN)<\/strong> \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03ae \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u03b3\u03b9\u03b1\u03c4\u03af \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ce\u03bd \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03cc \u03b1\u03c6\u03bf\u03c1\u03ac \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong> \u03ae <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong>.<\/p>\n<p style=\"line-height: 1.8; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ac \u03b7 \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9:<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03b1\u03b9\u03b5\u03c5\u03c4\u03ae\u03c1\u03b1 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5,<\/li>\n<li>\u03b1\u03bd\u03c4\u03b9\u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5 <strong>\u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7<\/strong> \u03ba\u03b1\u03b9\/\u03ae <strong>\u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 (LMWH)<\/strong>, \u03cc\u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9,<\/li>\n<li>\u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7, \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03bc\u03b2\u03c1\u03cd\u03bf\u03c5,<\/li>\n<li>\u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03b1\u03c3\u03c6\u03b1\u03bb\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 <strong>\u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2<\/strong>, \u03cc\u03c4\u03b1\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9.<\/li>\n<\/ul>\n<p style=\"line-height: 1.8; color: #111827;\">\u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03ba\u03ae \u03ad\u03ba\u03b2\u03b1\u03c3\u03b7 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b1\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1\u03c2. \u0391\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03af\u03ba\u03b5\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03ae \u03c3\u03c5\u03bd\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03c4\u03ae\u03c4\u03c9\u03bd.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 15 ==================== --><\/p>\n<section id=\"section15\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">15<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0397 JAK2 V617F \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera;<\/summary>\n<p>\u038c\u03c7\u03b9. \u0397 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong>, <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong> \u03ba\u03b1\u03b9 <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong>. \u0397 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c4\u03b7 \u03b2\u03b9\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (Ruxolitinib);<\/summary>\n<p>\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 \u03ae \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>PV<\/strong> \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03ae \u03b4\u03b5\u03bd \u03b1\u03bd\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0397 JAK2 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf;<\/summary>\n<p>\u039d\u03b1\u03b9, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b7 <strong>PV<\/strong> \u03ba\u03b1\u03b9 \u03b7 <strong>ET<\/strong>. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03b7 JAK2 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification)<\/strong>.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03b5\u03c4\u03c1\u03ac\u03bc\u03b5 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c4\u03bf \u03c6\u03bf\u03c1\u03c4\u03af\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5 (allele burden) \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7;<\/summary>\n<p>\u038c\u03c7\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1. \u03a3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03c3\u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03bc\u03b5\u03c4\u03b1\u03bc\u03cc\u03c3\u03c7\u03b5\u03c5\u03c3\u03b7 \u03c3\u03b5 JAK2-positive \u03bd\u03cc\u03c3\u03bf;<\/summary>\n<p>\u039d\u03b1\u03b9, \u03b1\u03bb\u03bb\u03ac \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong> \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c9\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7\u03c2 \u03bb\u03cd\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03bf\u03c5\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a3\u03c4\u03b7\u03bd \u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET) \u03b7 JAK2 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1;<\/summary>\n<p>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9, \u03b3\u03b9\u03b1\u03c4\u03af \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7 \u03ae \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bc\u03b9\u03b1 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b1 \u03bc\u03b5 JAK2-positive \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03bd\u03b5\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1 (MPN) \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03cd\u03b7\u03c3\u03b7;<\/summary>\n<p>\u039d\u03b1\u03b9, \u03b1\u03bb\u03bb\u03ac \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03b1\u03c0\u03cc \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03bf\u03bc\u03ac\u03b4\u03b1.<\/p>\n<\/details>\n<\/section>\n<p><!-- ==================== SECTION 16 ==================== --><\/p>\n<section id=\"section16\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">16<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/span><\/h2>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\">\n<ul style=\"margin: 0; padding-left: 18px; line-height: 1.8; color: #111827;\">\n<li>\u0397 <strong>JAK2 V617F<\/strong> \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 vera (PV)<\/strong>, \u03c3\u03c4\u03b7\u03bd <strong>\u03b9\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b1\u03b9\u03bc\u03af\u03b1 (ET)<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd <strong>\u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ae \u03bc\u03c5\u03b5\u03bb\u03bf\u0390\u03bd\u03c9\u03c3\u03b7 (PMF)<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b1\u03be\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae.<\/li>\n<li>\u03a3\u03c4\u03b7\u03bd <strong>PV<\/strong> \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c4\u03bf\u03c5 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03ba\u03c1\u03af\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/li>\n<li>\u03a3\u03c4\u03b7\u03bd <strong>ET<\/strong> \u03c0\u03b1\u03af\u03b6\u03b5\u03b9 \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7 \u03ae \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03bc\u03b5\u03af\u03c9\u03c3\u03b7.<\/li>\n<li>\u03a3\u03c4\u03b7\u03bd <strong>PMF<\/strong> \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b9\u03bf \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b7 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1.<\/li>\n<li>\u0397 <strong>\u03c1\u03bf\u03c5\u03be\u03bf\u03bb\u03b9\u03c4\u03b9\u03bd\u03af\u03bc\u03c0\u03b7 (Ruxolitinib)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bf\u03cd\u03c4\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/li>\n<li>\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>\u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong>, \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7, <strong>\u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (monitoring)<\/strong> \u03ba\u03b1\u03b9, \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, <strong>\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong>.<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 17 ==================== --><\/p>\n<section id=\"section17\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">17<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<p style=\"line-height: 1.8; color: #111827;\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 JAK2 \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Tefferi A, Vainchenker W. <strong>Myeloproliferative Neoplasms: Molecular Pathophysiology, Essential Clinical Understanding, and Treatment Strategies<\/strong>. <em>J Clin Oncol<\/em>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21220604\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/21220604\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Vannucchi AM. <strong>JAK2 mutation and thrombosis in myeloproliferative neoplasms<\/strong>. <em>Hematology Am Soc Hematol Educ Program<\/em>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22160036\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/22160036\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Mesa RA, Verstovsek S, Gupta V, et al. <strong>Effects of ruxolitinib therapy on myelofibrosis-related symptoms and quality of life<\/strong>. <em>Blood<\/em>.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21536863\/\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/21536863\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">NCCN Guidelines. <strong>Myeloproliferative Neoplasms<\/strong>.<br \/>\n<a href=\"https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/mpn.pdf\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/mpn.pdf<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">European LeukemiaNet. <strong>Recommendations for diagnosis and management of MPNs<\/strong>.<br \/>\n<a href=\"https:\/\/www.leukemia-net.org\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.leukemia-net.org<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>JAK2 V617F \u03ba\u03b1\u03b9 \u039c\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u039d\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1: \u03a0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7, \u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u0395\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: 18 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 18 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u03a3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03c0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7: \u0397 JAK2 V617F \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03ae \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1. \u03a3\u03c4\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03cb\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 (MPNs) \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 (risk stratification), \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2. \u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c4\u03b7\u03c2 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