{"id":3029,"date":"2025-06-05T12:21:53","date_gmt":"2025-06-05T09:21:53","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=3029"},"modified":"2026-03-14T17:04:57","modified_gmt":"2026-03-14T15:04:57","slug":"brca1-brca2-ola-osa-prepei-na-gnorizete-gia-tis-gonidiakes-metallaxeis-kai-ton-kindyno-karkinou","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/brca1-brca2-ola-osa-prepei-na-gnorizete-gia-tis-gonidiakes-metallaxeis-kai-ton-kindyno-karkinou\/","title":{"rendered":"BRCA1 &#038; BRCA2: \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2, \u039a\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 &#038; \u0393\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2"},"content":{"rendered":"<h1 style=\"font-size: 32px; line-height: 1.2; font-weight: 900; color: #111827; margin: 0 0 14px;\">BRCA1 \u03ba\u03b1\u03b9 BRCA2: \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2, \u039a\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u0393\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/h1>\n<div style=\"font-size: 13px; color: #6b7280; margin: 10px 0 12px;\">\u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: <time datetime=\"2026-03-14\">14 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time><\/div>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 0 0 16px;\"><strong>\u03a3\u03cd\u03bd\u03bf\u03c8\u03b7:<\/strong> \u03a4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA1 \u03ba\u03b1\u03b9 BRCA2 \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf. \u038c\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7, \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd, \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2. \u039f \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 BRCA \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03bf\u03c5\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03ba\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae.<\/div>\n<nav id=\"toc\" style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 14px; padding: 16px 18px; margin: 18px 0;\">\n<div style=\"font-weight: 800; font-size: 18px; margin-bottom: 10px; color: #111827;\">\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/div>\n<ol style=\"margin: 0; padding-left: 18px; line-height: 1.8;\">\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section1\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA;<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section2\">\u03a4\u03b9 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA;<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section3\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 BRCA1 \u03ba\u03b1\u03b9 BRCA2;<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section4\">\u03a0\u03cc\u03c3\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf;<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section5\">BRCA \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section6\">BRCA \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section7\">BRCA \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u2013 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section8\">\u03a0\u03bf\u03b9\u03bf\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf BRCA;<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section9\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2;<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section10\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc, \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03ae \u03b1\u03b2\u03ad\u03b2\u03b1\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1;<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section11\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 screening \u03c3\u03b5 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 BRCA<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section12\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7\u03c2;<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section13\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u2013 PARP inhibitors<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section14\">\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1, \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section15\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section16\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section17\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: none; border-top: 2px solid #d1d5db; margin: 14px 0 24px;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<section id=\"section1\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA;<\/span><\/h2>\n<p>\u03a4\u03b1 <strong>\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA1 \u03ba\u03b1\u03b9 BRCA2<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5. \u0391\u03bd\u03ae\u03ba\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1 \u03bb\u03b5\u03b3\u03cc\u03bc\u03b5\u03bd\u03b1 <strong>\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03cc\u03b3\u03ba\u03c9\u03bd<\/strong>, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03b2\u03bb\u03b1\u03b2\u03ce\u03bd \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n<p>\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03c4\u03b1 BRCA \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c3\u03b1\u03bd \u03ad\u03bd\u03b1\u03c2 \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u00ab\u03b5\u03c0\u03b9\u03c3\u03ba\u03b5\u03c5\u03ae\u03c2\u00bb \u03c4\u03bf\u03c5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c5\u03bb\u03b9\u03ba\u03bf\u03cd. \u038c\u03c4\u03b1\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c3\u03c9\u03c3\u03c4\u03ac, \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03bd\u03b1 \u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03b5\u03b9 \u03bb\u03ac\u03b8\u03b7 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c5\u03c4\u03ac \u03b3\u03af\u03bd\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03b1. \u038c\u03c4\u03b1\u03bd \u03cc\u03bc\u03c9\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<\/strong>, \u03b7 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c5\u03c4\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9.<\/p>\n<p>\u03a4\u03bf \u03cc\u03bd\u03bf\u03bc\u03b1 BRCA \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03cc\u03c1\u03bf <strong>BReast CAncer gene<\/strong>, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03ad\u03b3\u03b9\u03bd\u03b1\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03b3\u03bd\u03c9\u03c3\u03c4\u03ad\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae\u03c2 \u03c3\u03c7\u03ad\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd. \u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5 <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd<\/strong>, <strong>\u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/strong>, <strong>\u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b5\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03c1\u03b1\u03c4\u03ae\u03c3\u03b5\u03c4\u03b5:<\/strong> \u038c\u03bb\u03bf\u03b9 \u03bf\u03b9 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd BRCA1 \u03ba\u03b1\u03b9 BRCA2. \u03a4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03ae \u03c4\u03bf\u03c5\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 2 ==================== --><\/p>\n<section id=\"section2\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA;<\/span><\/h2>\n<p>\u03a4\u03b1 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03bd\u03b1 <strong>\u03b5\u03c0\u03b9\u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03b5\u03b9 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c3\u03c4\u03bf DNA<\/strong> \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03bb\u03b1\u03b8\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf. \u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03bf\u03c5\u03c2 \u03b5\u03be\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae\u03c2.<\/p>\n<ul>\n<li>\u0395\u03c0\u03b9\u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03bf\u03c5\u03bd <strong>\u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c3\u03c4\u03bf DNA<\/strong><\/li>\n<li>\u03a3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd <strong>\u03bf\u03bc\u03bf\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7<\/strong><\/li>\n<li>\u0392\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9 \u03bf <strong>\u03b1\u03bd\u03b5\u03be\u03ad\u03bb\u03b5\u03b3\u03ba\u03c4\u03bf\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2<\/strong><\/li>\n<li>\u03a3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 <strong>\u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c5\u03bb\u03b9\u03ba\u03bf\u03cd<\/strong> \u03b1\u03c0\u03cc \u03b3\u03b5\u03bd\u03b9\u03ac \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 \u03b3\u03b5\u03bd\u03b9\u03ac \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/li>\n<\/ul>\n<p>\u038c\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03ad\u03c7\u03b5\u03b9 <strong>\u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<\/strong>, \u03c4\u03bf \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03b4\u03b5\u03bd \u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c4\u03bf\u03c5 DNA \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac. \u0388\u03c4\u03c3\u03b9, \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd, \u03bd\u03b1 \u03c3\u03c5\u03c3\u03c3\u03c9\u03c1\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf \u03bc\u03b5 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 BRCA \u03b8\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03b5\u03b9 \u03bf\u03c0\u03c9\u03c3\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf. \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03cc\u03c4\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>\u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>, <strong>\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9, \u03cc\u03c4\u03b1\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9, <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1:<\/strong> \u03a4\u03b1 BRCA \u03b4\u03b5\u03bd \u00ab\u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd\u00bb \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03b4\u03c1\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac. \u039f \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 3 ==================== --><\/p>\n<section id=\"section3\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">3<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 BRCA1 \u03ba\u03b1\u03b9 BRCA2;<\/span><\/h2>\n<p>\u039f\u03b9 <strong>\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 BRCA1 \u03ba\u03b1\u03b9 BRCA2<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03bf DNA \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b7\u03b8\u03bf\u03cd\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03b3\u03bf\u03bd\u03b5\u03af\u03c2. \u0391\u03bd \u03ad\u03bd\u03b1\u03c2 \u03b3\u03bf\u03bd\u03ad\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03bf\u03c1\u03ad\u03b1\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 BRCA, \u03ba\u03ac\u03b8\u03b5 \u03c0\u03b1\u03b9\u03b4\u03af \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>50% \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong> \u03bd\u03b1 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03ae\u03c3\u03b5\u03b9.<\/p>\n<p>\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 DNA. \u038c\u03c4\u03b1\u03bd \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03b4\u03b5\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac, \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03c3\u03bf\u03c5\u03bd \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n<p>\u0394\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1. \u03a3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03c4\u03b1\u03be\u03b9\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2:<\/p>\n<ul>\n<li><strong>\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/strong> \u2013 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ce\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/li>\n<li><strong>\u03a0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/strong> \u2013 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b9\u03c3\u03c7\u03c5\u03c1\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/li>\n<li><strong>\u03a0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03b1\u03b2\u03ad\u03b2\u03b1\u03b9\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 (VUS)<\/strong> \u2013 \u03b4\u03b5\u03bd \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b1\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1:<\/strong> \u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 BRCA \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf. \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 4 ==================== --><\/p>\n<section id=\"section4\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">4<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c3\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf;<\/span><\/h2>\n<p>\u039f\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 BRCA1 \u03ba\u03b1\u03b9 BRCA2 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc. \u039f\u03b9 \u03c0\u03b9\u03bf \u03ba\u03b1\u03bb\u03ac \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03bc\u03bf\u03af \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd<\/strong>.<\/p>\n<p>\u03a4\u03b1 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03ac \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03ce\u03bd, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac \u03bf\u03b9 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 BRCA \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac\u03c3\u03b9\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7.<\/p>\n<div style=\"overflow-x: auto; -webkit-overflow-scrolling: touch; margin: 14px 0;\">\n<div style=\"font-size: 13px; color: #6b7280; margin: 0 0 8px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<table style=\"width: 100%; min-width: 520px; border-collapse: collapse;\">\n<thead>\n<tr>\n<th style=\"text-align: left; border: 1px solid #e5e7eb; padding: 10px; background: #f9fafb;\"><span style=\"color: #000000;\">\u039c\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7<\/span><\/th>\n<th style=\"text-align: left; border: 1px solid #e5e7eb; padding: 10px; background: #f9fafb;\"><span style=\"color: #000000;\">\u039a\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/span><\/th>\n<th style=\"text-align: left; border: 1px solid #e5e7eb; padding: 10px; background: #f9fafb;\"><span style=\"color: #000000;\">\u039a\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\"><strong>BRCA1<\/strong><\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">55\u201372%<\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">39\u201344%<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\"><strong>BRCA2<\/strong><\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">45\u201369%<\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">11\u201317%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; padding: 12px 14px; border-radius: 10px; margin-top: 12px;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong> \u039f\u03b9 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 BRCA \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03b1\u03bb\u03bb\u03ac \u03c4\u03bf \u03b1\u03ba\u03c1\u03b9\u03b2\u03ad\u03c2 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03c0\u03cc \u03ac\u03c4\u03bf\u03bc\u03bf \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf \u03ba\u03b1\u03b9 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2.<\/div>\n<\/section>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b4\u03b5\u03bd \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 BRCA, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf <strong>\u03c0\u03bf\u03b9\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<\/strong>, \u03c4\u03bf <strong>\u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc<\/strong>, \u03c4\u03b7\u03bd <strong>\u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/strong>, \u03c4\u03bf <strong>\u03c6\u03cd\u03bb\u03bf<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03ae \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03b4\u03cd\u03bf \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 BRCA \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03ac\u03bd\u03c4\u03b1 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ae \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c0\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac. \u0388\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b2\u03b1\u03c1\u03cd \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c3\u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1. \u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03c1\u03bf\u03c6\u03b1, \u03ad\u03bd\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03cc\u03c4\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b7\u03b4\u03b5\u03bd\u03b9\u03ba\u03cc\u03c2, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf \u03b3\u03b9\u03b1 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf.<\/p>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<section id=\"section5\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">5<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">BRCA \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/span><\/h2>\n<p>\u039f \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <strong>BRCA1<\/strong> \u03ae <strong>BRCA2<\/strong> \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 <strong>\u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03c3\u03c4\u03bf\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc.<\/p>\n<p>\u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <strong>BRCA1<\/strong>, \u03bf \u03cc\u03b3\u03ba\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7.<\/p>\n<ul>\n<li>\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 <strong>\u03c4\u03c1\u03b9\u03c0\u03bb\u03ac \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/strong><\/li>\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af <strong>\u03c0\u03c1\u03b9\u03bd \u03c4\u03b1 40 \u03ad\u03c4\u03b7<\/strong><\/li>\n<li>\u0388\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af <strong>\u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b4\u03cd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd\u03c2<\/strong><\/li>\n<\/ul>\n<p>\u0397 \u03b3\u03bd\u03ce\u03c3\u03b7 \u03c4\u03bf\u03c5 <strong>BRCA status<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7, \u03cc\u03c0\u03c9\u03c2:<\/p>\n<ul>\n<li>\u03c0\u03b9\u03bf \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5<\/li>\n<li>\u03c3\u03c5\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2<\/li>\n<li>\u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd (\u03c0.\u03c7. <strong>PARP inhibitors<\/strong>)<\/li>\n<\/ul>\n<\/section>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<section id=\"section6\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">6<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">BRCA \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd<\/span><\/h2>\n<p>\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <strong>BRCA1<\/strong> \u03ba\u03b1\u03b9 <strong>BRCA2<\/strong> \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 <strong>\u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03c9\u03bd \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c4\u03cd\u03c0\u03bf \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>\u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd \u03bf\u03c1\u03ce\u03b4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1<\/strong>.<\/p>\n<p>\u0388\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd \u03c3\u03c5\u03c7\u03bd\u03ac \u03b4\u03b5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ae \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b7 \u03c3\u03c4\u03b7\u03bd \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<ul>\n<li>\u03a3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 <strong>\u03bf\u03c1\u03ce\u03b4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1<\/strong><\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac <strong>\u03b4\u03b9\u03b1\u03b3\u03b9\u03b3\u03bd\u03ce\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf<\/strong><\/li>\n<li>\u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bd\u03b5\u03c4\u03b1\u03b9 <strong>\u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b1\u03bb\u03c0\u03b9\u03b3\u03b3\u03bf-\u03c9\u03bf\u03b8\u03b7\u03ba\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae<\/strong><\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae:<\/strong> \u03a3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 BRCA, \u03b7 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b1\u03bb\u03c0\u03af\u03b3\u03b3\u03c9\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03bf\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03b5\u03ba\u03bd\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<section id=\"section7\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">7<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">BRCA \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u2013 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/span><\/h2>\n<p>\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <strong>BRCA<\/strong> \u03b4\u03b5\u03bd \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03bc\u03cc\u03bd\u03bf \u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2. \u039a\u03b1\u03b9 \u03bf\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 <strong>BRCA2<\/strong>, \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/h3>\n<ul>\n<li>\u0397 <strong>BRCA2<\/strong> \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf<\/li>\n<li>\u039f \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03b5 <strong>\u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/strong><\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 <strong>\u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac<\/strong><\/li>\n<\/ul>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2<\/h3>\n<ul>\n<li>\u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf\u03c2 \u03c3\u03c4\u03bf\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc<\/li>\n<li>\u0397 <strong>BRCA2<\/strong> \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf<\/li>\n<\/ul>\n<h3 style=\"font-size: 20px; font-weight: 800; color: #111827; margin: 18px 0 8px;\">\u0386\u03bb\u03bb\u03bf\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf\u03b9 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03b9<\/h3>\n<p>\u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>\u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf<\/strong>, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 <strong>BRCA2<\/strong>, \u03b3\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1.<\/p>\n<\/section>\n<p>\u0388\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c5\u03c0\u03bf\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 BRCA \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 <strong>\u03b1\u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03c4\u03b5\u03c2<\/strong>, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03c0\u03bf\u03bb\u03bb\u03bf\u03af \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b1 \u03cc\u03c4\u03b9 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03bc\u03cc\u03bd\u03bf \u03c4\u03b9\u03c2 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03bf\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bd\u03b1 <strong>\u03bc\u03b5\u03c4\u03b1\u03b2\u03b9\u03b2\u03ac\u03c3\u03bf\u03c5\u03bd<\/strong> \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03c4\u03bf\u03c5\u03c2, \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/strong>, <strong>\u03b1\u03bd\u03b4\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/strong> \u03ae <strong>\u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/strong>. \u03a3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ac\u03bd\u03b4\u03c1\u03b1 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03b3\u03b9\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac, \u03b1\u03b4\u03ad\u03bb\u03c6\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd. \u039f\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03b5 BRCA2 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7, \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 NCCN \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd screening \u03b3\u03b9\u03b1 BRCA2 carriers \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03c4\u03c9\u03bd 40 \u03b5\u03c4\u03ce\u03bd. :contentReference[oaicite:1]{index=1}<\/p>\n<p><!-- ==================== SECTION 8 ==================== --><\/p>\n<section id=\"section8\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">8<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bf\u03b9\u03bf\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03ac\u03bd\u03bf\u03c5\u03bd \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf BRCA;<\/span><\/h2>\n<p>\u039f <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 BRCA<\/strong> \u03b4\u03b5\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc<\/strong>, <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03ae \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd \u03c3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/strong>, <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b1<\/strong> \u03ae \u03ae\u03b4\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae <strong>\u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 BRCA \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1<\/strong>.<\/p>\n<ul>\n<li>\u0393\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 <strong>\u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc<\/strong> \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd \u03ae \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/li>\n<li>\u0386\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/strong><\/li>\n<li>\u0386\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03b5 <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03ae \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/strong><\/li>\n<li>\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03bc\u03b5 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 BRCA<\/li>\n<li>\u0386\u03c4\u03bf\u03bc\u03b1 Ashkenazi \u03b5\u03b2\u03c1\u03b1\u03ca\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2, \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u03a3\u03c5\u03c7\u03bd\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03bb\u03ac\u03b8\u03bf\u03c2:<\/strong> \u039d\u03b1 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03bf\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ae \u03bb\u03ae\u03c8\u03b7 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 9 ==================== --><\/p>\n<section id=\"section9\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">9<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2;<\/span><\/h2>\n<p>\u039f <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 BRCA<\/strong> \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03b5 <strong>\u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1<\/strong>, \u03b5\u03bd\u03ce \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03ba\u03b1\u03b9 \u03bc\u03b5 <strong>\u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03af\u03c7\u03c1\u03b9\u03c3\u03bc\u03b1 \u03ae \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03c3\u03ac\u03bb\u03b9\u03bf\u03c5<\/strong>. \u03a4\u03bf \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03b1\u03bd\u03b1\u03bb\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b5\u03c2 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 <strong>BRCA1<\/strong> \u03ba\u03b1\u03b9 <strong>BRCA2<\/strong>.<\/p>\n<p>\u0394\u03b5\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03bc\u03b9\u03b1 \u03ba\u03bf\u03b9\u03bd\u03ae \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2. \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc<\/strong>.<\/p>\n<ul>\n<li>\u0391\u03bd\u03b1\u03b6\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 <strong>\u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/strong> \u03ae \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2<\/li>\n<li>\u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 <strong>multigene panel<\/strong> \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b1 \u03bc\u03b5 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf<\/li>\n<li>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03b9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac<\/strong><\/li>\n<\/ul>\n<p>\u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03c3\u03c4\u03ae<\/strong>, <strong>\u03bf\u03b3\u03ba\u03bf\u03bb\u03cc\u03b3\u03bf<\/strong> \u03ae \u03ac\u03bb\u03bb\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b9\u03b1\u03c4\u03c1\u03cc.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 10 ==================== --><\/p>\n<section id=\"section10\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">10<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc, \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03ae \u03b1\u03b2\u03ad\u03b2\u03b1\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1;<\/span><\/h2>\n<p>\u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 BRCA \u03c4\u03b1\u03be\u03b9\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03ac<\/strong>, <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac<\/strong> \u03ae <strong>\u03b1\u03b2\u03ad\u03b2\u03b1\u03b9\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2<\/strong>. \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc.<\/p>\n<p><strong>\u0398\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b8\u03b7\u03ba\u03b5 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf. \u0394\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c4\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c3\u03c7\u03ad\u03b4\u03b9\u03bf \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7\u03c2.<\/p>\n<ul>\n<li>\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 <strong>\u03c0\u03b9\u03bf \u03c3\u03c4\u03b5\u03bd\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong><\/li>\n<li>\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03b6\u03b7\u03c4\u03b7\u03b8\u03bf\u03cd\u03bd <strong>\u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2<\/strong><\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 <strong>\u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ce\u03bd \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd<\/strong><\/li>\n<\/ul>\n<p><strong>\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c4\u03b5\u03c3\u03c4. \u0391\u03c5\u03c4\u03cc \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03bd \u03bc\u03b7\u03b4\u03b5\u03bd\u03af\u03b6\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03bf \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n<p><strong>\u0391\u03b2\u03ad\u03b2\u03b1\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 (VUS \u2013 Variant of Uncertain Significance)<\/strong> \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b5\u03bd\u03c4\u03bf\u03c0\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c4\u03b7\u03c2 \u03bf\u03c0\u03bf\u03af\u03b1\u03c2 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03b1\u03c6\u03ae\u03c2. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b4\u03b5\u03bd \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03cc\u03bd\u03bf \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 11 ==================== --><\/p>\n<section id=\"section11\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">11<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 screening \u03c3\u03b5 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 BRCA<\/span><\/h2>\n<p>\u03a4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 <strong>BRCA1<\/strong> \u03ae <strong>BRCA2<\/strong> \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 <strong>\u03c0\u03b9\u03bf \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2<\/strong> \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03bd \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03b9\u03ce\u03bd.<\/p>\n<p>\u039f \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae\u03c2 \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <strong>\u03b7\u03bb\u03b9\u03ba\u03af\u03b1<\/strong>, \u03c4\u03bf <strong>\u03c6\u03cd\u03bb\u03bf<\/strong>, \u03c4\u03bf <strong>\u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc<\/strong>, \u03c4\u03bf\u03bd <strong>\u03c4\u03cd\u03c0\u03bf \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03bd \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1.<\/p>\n<ul>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 <strong>MRI \u03bc\u03b1\u03c3\u03c4\u03ce\u03bd<\/strong> \u03ba\u03b1\u03b9 <strong>\u03bc\u03b1\u03c3\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/strong> \u03c3\u03b5 \u03c4\u03b1\u03ba\u03c4\u03ac \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1<\/li>\n<li>\u03a3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c4\u03b5\u03bd\u03ae <strong>\u03bf\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/li>\n<li>\u03a3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>\u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf<\/strong><\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; padding: 12px 14px; border-radius: 10px; margin-top: 12px;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong> \u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 BRCA. \u0397 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae screening \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7.<\/div>\n<\/section>\n<p>\u0397 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c6\u03bf\u03c1\u03ad\u03c9\u03bd BRCA \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u201c\u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2\u201d, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 <strong>\u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5 screening<\/strong> \u03b3\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 <strong>MRI \u03bc\u03b1\u03c3\u03c4\u03ce\u03bd<\/strong> \u03ba\u03b1\u03b9 <strong>\u03bc\u03b1\u03c3\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1\u03c2<\/strong>, \u03b5\u03bd\u03ce \u03c3\u03b5 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03bc\u03b5 BRCA2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03c3\u03c5\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 <strong>\u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/strong>. \u03a3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03bc\u03b5 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7\u03c2. :contentReference[oaicite:2]{index=2}<\/p>\n<p>\u0395\u03be\u03af\u03c3\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf. \u0388\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c5\u03b3\u03b9\u03ad\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03c3\u03b5 \u03bb\u03af\u03b3\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03bb\u03cc\u03b3\u03c9 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2, \u03bd\u03ad\u03bf\u03c5 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03bf\u03cd \u03ae \u03bd\u03ad\u03c9\u03bd \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03c9\u03bd \u03bf\u03b4\u03b7\u03b3\u03b9\u03ce\u03bd. \u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03bf\u03b9 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 BRCA \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03c4\u03b5\u03c3\u03c4, \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c0\u03bf\u03c5 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1.<\/p>\n<section id=\"section12\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">12<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7\u03c2;<\/span><\/h2>\n<p>\u0397 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c3\u03b5 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 <strong>BRCA1<\/strong> \u03ae <strong>BRCA2<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 <strong>\u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf<\/strong>, <strong>\u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2<\/strong> \u03ba\u03b1\u03b9, \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, <strong>\u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>. \u039f\u03b9 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c3\u03c5\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03bf\u03bc\u03ac\u03b4\u03b1.<\/p>\n<div style=\"overflow-x: auto; -webkit-overflow-scrolling: touch; margin: 14px 0;\">\n<div style=\"font-size: 13px; color: #6b7280; margin: 0 0 8px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<table style=\"width: 100%; min-width: 560px; border-collapse: collapse;\">\n<thead>\n<tr>\n<th style=\"text-align: left; border: 1px solid #e5e7eb; padding: 10px; background: #f9fafb;\"><span style=\"color: #000000;\">\u03a0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7<\/span><\/th>\n<th style=\"text-align: left; border: 1px solid #e5e7eb; padding: 10px; background: #f9fafb;\"><span style=\"color: #000000;\">\u03a3\u03c4\u03cc\u03c7\u03bf\u03c2<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">\u0391\u03bc\u03c6\u03bf\u03c4\u03b5\u03c1\u03cc\u03c0\u03bb\u03b5\u03c5\u03c1\u03b7 \u03c0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03bc\u03b1\u03c3\u03c4\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae<\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03ad\u03c9\u03c2 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 90%<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">\u03a0\u03c1\u03bf\u03c6\u03c5\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b1\u03bb\u03c0\u03b9\u03b3\u03b3\u03bf-\u03c9\u03bf\u03b8\u03b7\u03ba\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae<\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/td>\n<\/tr>\n<tr>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">\u03a4\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 (MRI \u03bc\u03b1\u03c3\u03c4\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b1\u03c3\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1)<\/td>\n<td style=\"border: 1px solid #e5e7eb; padding: 10px;\">\u0388\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 13 ==================== --><\/p>\n<section id=\"section13\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">13<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u2013 PARP inhibitors<\/span><\/h2>\n<p>\u039f\u03b9 <strong>PARP \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <strong>BRCA1<\/strong> \u03ae <strong>BRCA2<\/strong>. \u0394\u03c1\u03bf\u03c5\u03bd \u03b5\u03ba\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b5\u03c5\u03cc\u03bc\u03b5\u03bd\u03bf\u03b9 \u03c4\u03b7\u03bd \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03bf\u03c5\u03bd \u03c3\u03c9\u03c3\u03c4\u03ac \u03c4\u03bf DNA \u03c4\u03bf\u03c5\u03c2.<\/p>\n<p>\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03cc\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03cc \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 DNA \u03bb\u03cc\u03b3\u03c9 BRCA \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2, \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03bf\u03b4\u03bf\u03cd <strong>PARP<\/strong> \u03c4\u03bf \u03ba\u03ac\u03bd\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03b9\u03bf \u03b5\u03c5\u03ac\u03bb\u03c9\u03c4\u03bf \u03ba\u03b1\u03b9 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03ae \u03c4\u03bf\u03c5.<\/p>\n<ul>\n<li>\u03a3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 DNA<\/li>\n<li>\u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/strong>, <strong>\u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd<\/strong>, <strong>\u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03b1 <strong>\u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2<\/strong><\/li>\n<li>\u039c\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2<\/li>\n<\/ul>\n<p>\u0397 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03af\u03b4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 BRCA. \u0395\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf <strong>\u03b5\u03af\u03b4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/strong>, \u03c4\u03bf <strong>\u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5<\/strong>, \u03c4\u03b9\u03c2 <strong>\u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03ba\u03ac\u03c3\u03c4\u03bf\u03c4\u03b5 <strong>\u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong> \u039f\u03b9 PARP inhibitors \u03b4\u03b5\u03bd \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 BRCA. \u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03b1 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<section id=\"section14\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">14<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039f\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1, \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae<\/span><\/h2>\n<p>\u0388\u03bd\u03b1 <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 BRCA<\/strong> \u03b4\u03b5\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf \u03ac\u03c4\u03bf\u03bc\u03bf \u03c0\u03bf\u03c5 \u03ad\u03ba\u03b1\u03bd\u03b5 \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7. \u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 <strong>\u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b5\u03af\u03c4\u03b1\u03b9<\/strong>, \u03c4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd, \u03cc\u03c0\u03c9\u03c2 <strong>\u03c0\u03b1\u03b9\u03b4\u03b9\u03ac<\/strong>, <strong>\u03b1\u03b4\u03ad\u03bb\u03c6\u03b9\u03b1<\/strong> \u03ba\u03b1\u03b9 <strong>\u03b3\u03bf\u03bd\u03b5\u03af\u03c2<\/strong>.<\/p>\n<p>\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc, \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c0\u03b9\u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03af\u03c3\u03c9\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ae \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/p>\n<ul>\n<li>\u039f\u03b9 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 <strong>\u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7<\/strong><\/li>\n<li>\u03a3\u03c5\u03c7\u03bd\u03ac \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af <strong>cascade testing<\/strong> \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1<\/li>\n<li>\u0397 <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae<\/strong> \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7\u03bd \u03bf\u03c1\u03b8\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bb\u03ae\u03c8\u03b7 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03c9\u03bd<\/li>\n<\/ul>\n<p>\u0397 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf <strong>\u03c0\u03cc\u03c4\u03b5<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf <strong>\u03c0\u03ce\u03c2<\/strong> \u03b8\u03b1 \u03b5\u03bd\u03b7\u03bc\u03b5\u03c1\u03c9\u03b8\u03bf\u03cd\u03bd \u03bf\u03b9 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1, \u03c3\u03c9\u03c3\u03c4\u03ae \u03bf\u03c1\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 \u03b1\u03c0\u03cc \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b5\u03c0\u03b1\u03b3\u03b3\u03b5\u03bb\u03bc\u03b1\u03c4\u03af\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2. \u0397 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1\u03c4\u03af \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b5\u03c2, \u03ac\u03b3\u03c7\u03bf\u03c2 \u03ae \u03b2\u03b5\u03b2\u03b9\u03b1\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03b9\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1:<\/strong> \u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc BRCA \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03bf\u03bb\u03cc\u03ba\u03bb\u03b7\u03c1\u03b7 \u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1, \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf \u03ac\u03c4\u03bf\u03bc\u03bf \u03c0\u03bf\u03c5 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5. \u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ad\u03c7\u03bf\u03c5\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 15 ==================== --><\/p>\n<section id=\"section15\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">15<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ) \u2013 \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 BRCA1 &amp; BRCA2<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03bd \u03ad\u03c7\u03c9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 BRCA1 \u03ae BRCA2, \u03b8\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03c9 \u03c3\u03af\u03b3\u03bf\u03c5\u03c1\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf;<\/summary>\n<p>\u038c\u03c7\u03b9. \u0397 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b8\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03af\u03b3\u03bf\u03c5\u03c1\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 BRCA \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b1;<\/summary>\n<p>\u038c\u03c7\u03b9. \u039c\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b7\u03b8\u03bf\u03cd\u03bd \u03b5\u03be\u03af\u03c3\u03bf\u03c5 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03b7\u03c4\u03ad\u03c1\u03b1 \u03ae \u03c4\u03bf\u03bd \u03c0\u03b1\u03c4\u03ad\u03c1\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c5\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b1 BRCA;<\/summary>\n<p>\u039a\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd, \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c4\u03b5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03b6\u03b7\u03c4\u03ae\u03c3\u03c9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf BRCA;<\/summary>\n<p>\u038c\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ae \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 BRCA \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 BRCA;<\/summary>\n<p>\u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c4\u03b5\u03c3\u03c4, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 VUS \u03ae \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03b1\u03b2\u03ad\u03b2\u03b1\u03b9\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2;<\/summary>\n<p>\u0395\u03af\u03bd\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c4\u03b7\u03c2 \u03bf\u03c0\u03bf\u03af\u03b1\u03c2 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03b1\u03c6\u03ae\u03c2, \u03b3\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b4\u03b5\u03bd \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03b9\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039f\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 BRCA;<\/summary>\n<p>\u039d\u03b1\u03b9. \u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b7 BRCA2 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7, \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bd\u03b5\u03bf\u03c0\u03bb\u03b1\u03c3\u03af\u03b5\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf\u03b9 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c3\u03b5 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 BRCA;<\/summary>\n<p>\u039d\u03b1\u03b9. \u03a0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf, \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b5\u03bc\u03b2\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/p>\n<\/details>\n<\/section>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03b1 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 BRCA;<\/summary>\n<p>\u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03ae \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c3\u03b5 \u03bd\u03b5\u03b1\u03c1\u03ae \u03b7\u03bb\u03b9\u03ba\u03af\u03b1. \u0397 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c0\u03cc\u03c4\u03b5 \u03b8\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c3\u03bf \u03ba\u03bf\u03c3\u03c4\u03af\u03b6\u03b5\u03b9 \u03bf \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 BRCA;<\/summary>\n<p>\u03a4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03bd \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 BRCA1\/2 \u03ae \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf multigene panel. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b1\u03bc\u03b5\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 BRCA \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03af\u03bc\u03b1 \u03ae \u03c3\u03ac\u03bb\u03b9\u03bf;<\/summary>\n<p>\u039f \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 BRCA \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5 \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03c3\u03ac\u03bb\u03b9\u03bf\u03c5 \u03ae \u03c3\u03c4\u03bf\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03af\u03c7\u03c1\u03b9\u03c3\u03bc\u03b1. \u039a\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03cd\u03bf \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bd\u03b1\u03bb\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf DNA \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA1 \u03ba\u03b1\u03b9 BRCA2.<\/p>\n<\/details>\n<p><!-- ==================== SECTION 16 ==================== --><\/p>\n<section id=\"section16\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">16<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/span><\/h2>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px;\">\n<ul style=\"margin: 0; padding-left: 18px;\">\n<li>\u03a4\u03b1 BRCA1 \u03ba\u03b1\u03b9 BRCA2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03bf DNA.<\/li>\n<li>\u039f\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd, \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2.<\/li>\n<li>\u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b2\u03ad\u03b2\u03b1\u03b9\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf, \u03b1\u03bb\u03bb\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf.<\/li>\n<li>\u039f \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c3\u03c9\u03c3\u03c4\u03ae \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae.<\/li>\n<li>\u0397 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03ba\u03ac\u03b8\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf \u03ba\u03b1\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1.<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 17 ==================== --><\/p>\n<section id=\"section17\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">17<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<p style=\"margin: 0 0 10px;\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<p style=\"margin: 0 0 10px;\">\u039f \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <strong>BRCA1<\/strong> \u03ba\u03b1\u03b9 <strong>BRCA2<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03bb\u03ae \u00ab\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03ae \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u00bb \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7. \u0397 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae <strong>\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/strong>, \u03c3\u03c4\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf <strong>\u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c0\u03bb\u03ac\u03bd\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03ae \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7\u03c2.<\/p>\n<p style=\"margin: 0 0 12px;\">\u03a3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b2\u03b1\u03c1\u03cd \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc, \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03ae \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd \u03ae \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1, \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03c9\u03bd \u03b3\u03b9\u03b1 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03b2\u03bf\u03c5\u03bb\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center; margin-bottom: 14px;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 BRCA \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\">\n<p><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\"><br \/>\n\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<br \/>\n<\/a><\/p>\n<p><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\"><br \/>\n\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<br \/>\n<\/a><\/p>\n<\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<p style=\"margin: 0 0 8px;\">\u03a0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03b8\u03b1 \u03b2\u03c1\u03b5\u03af\u03c4\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b7\u03b3\u03ad\u03c2 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b5\u03b8\u03bd\u03b5\u03af\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ac\u03c1\u03b8\u03c1\u03bf\u03c5.<\/p>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 4px 0; line-height: 1.28; font-size: 14px;\"><strong>National Cancer Institute (NCI)<\/strong><br \/>\n<em>BRCA Gene Changes: Cancer Risk and Genetic Testing<\/em><br \/>\n<a href=\"https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/genetics\/brca-fact-sheet\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/genetics\/brca-fact-sheet<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 4px 0; line-height: 1.28; font-size: 14px;\"><strong>Centers for Disease Control and Prevention (CDC)<\/strong><br \/>\n<em>Hereditary Breast and Ovarian Cancer<\/em><br \/>\n<a href=\"https:\/\/www.cdc.gov\/breast-ovarian-cancer-hereditary\/index.html\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.cdc.gov\/breast-ovarian-cancer-hereditary\/index.html<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 4px 0; line-height: 1.28; font-size: 14px;\"><strong>NCCN Guidelines for Patients<\/strong><br \/>\n<em>Genetic Testing for Hereditary Breast, Ovarian, Pancreatic, and Prostate Cancers<\/em><br \/>\n<a href=\"https:\/\/www.nccn.org\/patients\/guidelines\/content\/PDF\/genetics-patient.pdf\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nccn.org\/patients\/guidelines\/content\/PDF\/genetics-patient.pdf<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 4px 0; line-height: 1.28; font-size: 14px;\"><strong>FDA Prescribing Information<\/strong><br \/>\n<em>Rucaparib \u2013 PARP inhibitor indications<\/em><br \/>\n<a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2025\/209115s014s015lbl.pdf\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2025\/209115s014s015lbl.pdf<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 4px 0; line-height: 1.28; font-size: 14px;\"><strong>Litton JK, et al.<\/strong><br \/>\n<em>Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation. N Engl J Med.<\/em><br \/>\n<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1706450\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1706450<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 4px 0; line-height: 1.28; font-size: 14px;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 8px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>BRCA1 \u03ba\u03b1\u03b9 BRCA2: \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2, \u039a\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03ba\u03b1\u03b9 \u0393\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc\u03c2 \u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 14 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u03a3\u03cd\u03bd\u03bf\u03c8\u03b7: \u03a4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 BRCA1 \u03ba\u03b1\u03b9 BRCA2 \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf. \u038c\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7, \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd, \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":10184,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2534],"tags":[],"class_list":["post-3029","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exetaseis-aimatos"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/3029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=3029"}],"version-history":[{"count":9,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/3029\/revisions"}],"predecessor-version":[{"id":10187,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/3029\/revisions\/10187"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/10184"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=3029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=3029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=3029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}