{"id":2935,"date":"2025-05-31T23:24:33","date_gmt":"2025-05-31T20:24:33","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=2935"},"modified":"2026-01-29T13:51:13","modified_gmt":"2026-01-29T11:51:13","slug":"znt8-antisomata-o-neos-viodeiktis-gia-ton-diaviti-typou-1","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/znt8-antisomata-o-neos-viodeiktis-gia-ton-diaviti-typou-1\/","title":{"rendered":"ZnT8 \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1: \u03a4\u03b9 \u0395\u03af\u03bd\u03b1\u03b9, \u03a0\u03cc\u03c4\u03b5 \u0395\u03bb\u03ad\u03b3\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 &#038; \u03a0\u03ce\u03c2 \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 (\u03a3\u03941 &#038; LADA)"},"content":{"rendered":"<article>\n<h1 style=\"font-size: 30px; font-weight: 800; margin: 18px 0 6px; line-height: 1.2;\">ZnT8 \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1: \u0397 \u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u0391\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u0394\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03a4\u03cd\u03c0\u03bf\u03c5 1 &amp; LADA (\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2)<\/h1>\n<p style=\"font-size: 14px; color: #6b7280; margin: 6px 0 12px;\">\u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7:<br \/>\n<time datetime=\"2026-01-29\">29 \u0399\u03b1\u03bd\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2026<\/time><\/p>\n<p><!-- ==================== H1 MINI INFOBOX ==================== --><\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong> \u03a4\u03b1 <strong>ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 ZnT8 \u03c3\u03c4\u03b1 \u03b2-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 <strong>\u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7<\/strong>. \u0395\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 <strong>\u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1<\/strong> \u03cc\u03c4\u03b1\u03bd \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (GAD, IA-2, IAA) \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03c3\u03c4\u03b7 <strong>\u03b4\u03b9\u03ac\u03ba\u03c1\u03b9\u03c3\u03b7 LADA<\/strong> \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2.<\/div>\n<p><!-- ==================== TABLE OF CONTENTS ==================== --><\/p>\n<nav id=\"toc\" style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 14px; padding: 16px 18px; margin: 22px 0;\" aria-label=\"\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1\"><strong>\ud83d\udcd1 \u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/strong><\/p>\n<ol style=\"margin: 10px 0 0 18px; line-height: 1.9;\">\n<li><a style=\"color: #dc2626;\" href=\"#sec1\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec2\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf ZnT8 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec3\">\u0393\u03b9\u03b1\u03c4\u03af \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03bd \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec4\">\u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (GAD, IA-2, IAA)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec5\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec6\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec7\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 (\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\/\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\/\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec8\">ZnT8 \u03ba\u03b1\u03b9 LADA: \u03c0\u03cc\u03c4\u03b5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec9\">ZnT8 \u03c3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c6\u03ae\u03b2\u03bf\u03c5\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec10\">ZnT8 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a3\u03941: \u03c4\u03b9 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec11\">ZnT8 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 (SLC30A8)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec12\">\u03a0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bb\u03ac\u03b8\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec13\">\u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u03ba\u03cd\u03c1\u03b9\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#sec14\">\u03a0\u03cc\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03b9\u03bb\u03ae\u03c3\u03b5\u03c4\u03b5 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03b5 \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#faq\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#cta\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd<\/a><\/li>\n<li><a style=\"color: #dc2626;\" href=\"#biblio\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: 0; border-top: 2px solid #d1d5db; margin: 14px 0 18px;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<h2 id=\"sec1\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/span><\/h2>\n<p>\u03a4\u03b1 <strong>ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> (Zinc Transporter 8 antibodies) \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 <strong>\u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 ZnT8<\/strong> \u03c3\u03c4\u03b1 \u03b2-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2. \u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 <strong>\u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1<\/strong> \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c9\u03bd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u2014 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ae \u03bc\u03b5 <strong>\u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1<\/strong> \u03ae \u03bc\u03b5 <strong>LADA<\/strong> (\u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03b5\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd).<\/p>\n<p>\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2 \u03ae HbA1c, \u03c4\u03b1 ZnT8 \u03b4\u03b5\u03bd \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u00ab\u03c0\u03cc\u03c3\u03bf \u03c5\u03c8\u03b7\u03bb\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf <a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/sakcharo-aimatos-odigos-asthenon\/\">\u03c3\u03ac\u03ba\u03c7\u03b1\u03c1\u03bf<\/a>\u00bb, \u03b1\u03bb\u03bb\u03ac <strong>\u03b3\u03b9\u03b1\u03c4\u03af \u03b1\u03bd\u03b5\u03b2\u03b1\u03af\u03bd\u03b5\u03b9<\/strong>. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae <strong>\u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2.<\/p>\n<p>\u0397 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03c9\u03bd ZnT8 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03a3\u03941, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03bd \u00ab\u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03af\u00bb (\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac GAD \u03ba\u03b1\u03b9 IA-2), \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c0\u03b9\u03bf \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7.<\/p>\n<p>\u0391\u03c0\u03cc \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac\u03c2, \u03c4\u03b1 ZnT8 \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03c9\u03bd \u00ab\u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd\u00bb, \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 GAD, IA-2 \u03ba\u03b1\u03b9 IAA. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c0\u03af\u03b8\u03b5\u03c3\u03b7 \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03c4\u03c9\u03bd \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2.<\/p>\n<p>\u03a3\u03b5 \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03c4\u03b1 ZnT8 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03b7 \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03ae \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 \u03ae \u03bb\u03af\u03b3\u03bf \u03c0\u03c1\u03b9\u03bd, \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c9\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2. \u0391\u03c5\u03c4\u03cc \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03bf\u03c5 C-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n<p>\u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u00ab\u03ac\u03c4\u03c5\u03c0\u03bf\u03c5\u00bb \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7: \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1, \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03b1\u03bb\u03bb\u03ac \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7 \u03ae \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03a3\u03941. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03b1, \u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 ZnT8 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03bd\u03cc\u03b7\u03bc\u03b1:<\/strong> \u03a4\u03b1 ZnT8 \u03b4\u03b5\u03bd \u00ab\u03bc\u03b5\u03c4\u03c1\u03bf\u03cd\u03bd\u00bb \u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7. \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd <strong>\u03b1\u03bd \u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b2\u03ac\u03c3\u03b7<\/strong>, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03be\u03b5\u03ba\u03ac\u03b8\u03b1\u03c1\u03bf\u03c2 (\u03c0.\u03c7. \u03bd\u03b5\u03b1\u03c1\u03cc\u03c2 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b1\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1, \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03ae \u03c0\u03c1\u03cc\u03c9\u03c1\u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7).<\/div>\n<p><!-- ==================== SECTION 2 ==================== --><\/p>\n<h2 id=\"sec2\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf ZnT8 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03bf\u03c5<\/span><\/h2>\n<p>\u039f <strong>ZnT8 (Zinc Transporter 8)<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7-\u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ad\u03b1\u03c2 \u03c8\u03b5\u03c5\u03b4\u03b1\u03c1\u03b3\u03cd\u03c1\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf <strong>SLC30A8<\/strong>. \u0395\u03bd\u03c4\u03bf\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 <strong>\u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ac \u03ba\u03bf\u03ba\u03ba\u03af\u03b1 \u03c4\u03c9\u03bd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/strong> \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03b9 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac \u03c8\u03b5\u03c5\u03b4\u03b1\u03c1\u03b3\u03cd\u03c1\u03bf\u03c5, \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7 <strong>\u03c3\u03c9\u03c3\u03c4\u03ae \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03af\u03b1, \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2<\/strong>.<\/p>\n<p>\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u03b1\u03c0\u03bf\u03b8\u03b7\u03ba\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03bf\u03c1\u03c6\u03ae \u03ba\u03c1\u03c5\u03c3\u03c4\u03b1\u03bb\u03bb\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03c8\u03b5\u03c5\u03b4\u03ac\u03c1\u03b3\u03c5\u03c1\u03bf. \u038c\u03c4\u03b1\u03bd \u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 ZnT8 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2, \u03b7 \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03bf\u03ba\u03ba\u03af\u03c9\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9, \u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bb\u03b9\u03b3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b2-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c3\u03b5 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03c1\u03b5\u03b8\u03af\u03c3\u03bc\u03b1\u03c4\u03b1.<\/p>\n<p>\u03a3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7, \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u00ab\u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03b5\u03b9\u00bb \u03c4\u03b7 ZnT8 \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 <strong>\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03af \u03c4\u03b7\u03c2<\/strong>. \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b5\u03af \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03ae \u03b5\u03c0\u03b9\u03c4\u03ac\u03c7\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 <strong>\u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2<\/strong>, \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03bf\u03c0\u03c4\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03bc\u03b5 \u03c0\u03c4\u03ce\u03c3\u03b7 \u03c4\u03bf\u03c5 <strong>C-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5<\/strong>.<\/p>\n<p>\u0397 \u03b1\u03bd\u03b1\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 \u03c4\u03bf\u03c5 ZnT8 \u03c9\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03bf\u03cd \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5 \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03b1\u03c6\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1 \u03ae\u03c4\u03b1\u03bd \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03af \u03c3\u03c4\u03b1 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (GAD, IA-2) \u03ba\u03b1\u03b9 \u03b1\u03bd\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03bd\u03b5\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03b8\u03ad\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 LADA.<\/p>\n<p>\u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03b7 ZnT8 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c4\u03c9\u03bd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03be\u03c9\u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2, \u03b7 ZnT8 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c4\u03c9\u03bd \u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03bf\u03ba\u03ba\u03af\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2. \u0391\u03c5\u03c4\u03cc \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03c4\u03b1 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c5\u03c8\u03b7\u03bb\u03ae \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7.<\/p>\n<p>\u03a0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03cc\u03c4\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c8\u03b5\u03c5\u03b4\u03b1\u03c1\u03b3\u03cd\u03c1\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c4\u03b7\u03c2 \u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2, \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd ZnT8 \u03ad\u03bd\u03b1\u03bd \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u00ab\u03ba\u03cc\u03bc\u03b2\u03bf\u00bb \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03a3\u03941. \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac, \u03b1\u03c5\u03c4\u03cc \u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7\u03c2 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03c0\u03c1\u03b9\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b5\u03be\u03b1\u03bd\u03c4\u03bb\u03b7\u03b8\u03b5\u03af \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b7 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2.<\/p>\n<p><!-- ==================== SECTION 3 ==================== --><\/p>\n<h2 id=\"sec3\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">3<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0393\u03b9\u03b1\u03c4\u03af \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03bd \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1<\/span><\/h2>\n<p>\u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd <strong>\u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1<\/strong> \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03bd\u03b5\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03b8\u03ad\u03bd\u03c4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03af \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> (GAD, IA-2, IAA). \u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03c4\u03b1 ZnT8 \u03b2\u03bf\u03b7\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03be\u03b5\u03ba\u03b1\u03b8\u03b1\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03b1\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 <strong>\u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7<\/strong> \u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03bf\u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2.<\/p>\n<p>\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03b8\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd (\u03c0.\u03c7. ZnT8 + GAD) \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03bf \u03c1\u03c5\u03b8\u03bc\u03cc \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/strong> \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1.<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li><strong>\u03a0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03af\u03c9\u03c3\u03b7<\/strong> \u03c4\u03bf\u03c5 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7.<\/li>\n<li><strong>\u0394\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/strong> \u03c4\u03cd\u03c0\u03bf\u03c5 1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03cd\u03c0\u03bf\u03c5 2 \u03c3\u03b5 \u03b5\u03c6\u03ae\u03b2\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03b1\u03c1\u03bf\u03cd\u03c2 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03c3\u03b1\u03c6\u03ae \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf.<\/li>\n<li><strong>\u0399\u03c3\u03c7\u03c5\u03c1\u03ae \u03c5\u03c0\u03bf\u03c3\u03c4\u03ae\u03c1\u03b9\u03be\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2 LADA<\/strong>, \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2.<\/li>\n<li><strong>\u0395\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1.<\/li>\n<\/ul>\n<p>\u03a0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03b1\u03be\u03af\u03b1, \u03c4\u03b1 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03c5\u03c7\u03af\u03b1 \u03c0\u03bf\u03c5 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03b1\u03c1\u03ba\u03b5\u03c4\u03ac \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c0\u03c1\u03b9\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7.<\/p>\n<p>\u03a3\u03c4\u03b1 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b1 \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1, \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03b1\u03c1\u03c7\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (\u03c3\u03c5\u03c7\u03bd\u03ac IAA \u03ae GAD). \u039c\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9, \u03cc\u03c0\u03c9\u03c2 IA-2 \u03ba\u03b1\u03b9 ZnT8, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03bf\u03c0\u03c4\u03c1\u03af\u03b6\u03b5\u03b9 <strong>\u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7\u03c2<\/strong> (epitope spreading).<\/p>\n<p>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac, \u03b1\u03c5\u03c4\u03ae \u03b7 \u00ab\u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7\u00bb \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u039c\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1, \u03b7 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03b3\u03ae.<\/li>\n<li>\u039c\u03b5 \u03b4\u03cd\u03bf \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03a3\u03941 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac.<\/li>\n<li>\u0397 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 ZnT8 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5 <strong>\u03b5\u03c0\u03b9\u03c4\u03ac\u03c7\u03c5\u03bd\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/strong>.<\/li>\n<\/ul>\n<p>\u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03b1 ZnT8 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u00ab\u03cc\u03c8\u03b9\u03bc\u03bf \u03b1\u03bb\u03bb\u03ac \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u00bb \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c3\u03ae\u03bc\u03b1: \u03c3\u03b5 \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ae \u03bb\u03af\u03b3\u03bf \u03c0\u03c1\u03b9\u03bd, \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c9\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03c0\u03b5\u03c1\u03ac\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf.<\/p>\n<p>\u03a3\u03b5 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b5\u03b9\u03c2 (\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd), \u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 ZnT8 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li><strong>\u03a7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2:<\/strong> \u03ad\u03bd\u03b1 \u03bc\u03cc\u03bd\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03c4\u03af\u03c4\u03bb\u03bf\u03c5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1.<\/li>\n<li><strong>\u039c\u03ad\u03c4\u03c1\u03b9\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2:<\/strong> \u03b4\u03cd\u03bf \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf.<\/li>\n<li><strong>\u03a5\u03c8\u03b7\u03bb\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2:<\/strong> \u22652 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (\u03c0.\u03c7. ZnT8 + GAD) \u03bc\u03b5 \u03c4\u03ac\u03c3\u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7\u03c2 C-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5.<\/li>\n<\/ul>\n<p>\u0391\u03c5\u03c4\u03ae \u03b7 \u03c3\u03c4\u03b1\u03b4\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2, \u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03ba\u03b1\u03bc\u03c0\u03cd\u03bb\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b5\u03ba\u03c0\u03b1\u03af\u03b4\u03b5\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03ae \u03c4\u03b7\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf:<\/strong> \u03a4\u03b1 ZnT8 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u00ab\u03ad\u03bd\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1\u00bb. \u038c\u03c4\u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03bf\u03cd\u03bd \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03b8\u03b5\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03ac\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03c6\u03ac\u03c3\u03b7 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2.<\/div>\n<p><!-- ==================== SECTION 4 ==================== --><\/p>\n<h2 id=\"sec4\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">4<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (GAD, IA-2, IAA)<\/span><\/h2>\n<p>\u03a3\u03c4\u03bf\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7, \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 <strong>\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b4\u03b5\u03af\u03ba\u03c4\u03b7. \u03a4\u03b1 ZnT8 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03b3\u03b9\u03b1\u03c4\u03af <strong>\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bd\u03bf\u03c5\u03bd<\/strong> \u03c4\u03b1 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (GAD, IA-2, IAA) \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03bd \u00ab\u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03af\u00bb.<\/p>\n<p>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac, \u03cc\u03c3\u03bf \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9, \u03c4\u03cc\u03c3\u03bf <strong>\u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03bf \u03c1\u03c5\u03b8\u03bc\u03cc\u03c2 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03bd\u03c9\u03c1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc, \u03b7 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 ZnT8 \u03bc\u03b5 GAD, IA-2 \u03ba\u03b1\u03b9 IAA \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03c0\u03b9\u03bf \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7:<\/strong> \u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac ZnT8 \u03ba\u03b1\u03b9 GAD \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 C-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03cc\u03c3\u03bf\u03c5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03bf \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1.<\/div>\n<p><!-- mobile table notice --><\/p>\n<div style=\"background: #fff7ed; border: 1px solid #fed7aa; border-radius: 10px; padding: 10px 12px; margin: 12px 0 10px; font-size: 13px; line-height: 1.5;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div style=\"overflow-x: auto; -webkit-overflow-scrolling: touch; border: 1px solid #e5e7eb; border-radius: 12px;\">\n<table style=\"border-collapse: collapse; width: 100%; min-width: 760px; font-size: 14px;\">\n<thead>\n<tr>\n<th style=\"text-align: left; padding: 10px 12px; border-bottom: 1px solid #e5e7eb; background: #f9fafb;\">\u0391\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1<\/th>\n<th style=\"text-align: left; padding: 10px 12px; border-bottom: 1px solid #e5e7eb; background: #f9fafb;\">\u03a3\u03c4\u03cc\u03c7\u03bf\u03c2<\/th>\n<th style=\"text-align: left; padding: 10px 12px; border-bottom: 1px solid #e5e7eb; background: #f9fafb;\">\u03a3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c2 (\u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ac)<\/th>\n<th style=\"text-align: left; padding: 10px 12px; border-bottom: 1px solid #e5e7eb; background: #f9fafb;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03c7\u03cc\u03bb\u03b9\u03bf<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">GAD<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u0393\u03bb\u03bf\u03c5\u03c4\u03b1\u03bc\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03ba\u03b1\u03c1\u03b2\u03bf\u03be\u03c5\u03bb\u03ac\u03c3\u03b7<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">~70\u201380%<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u03a3\u03c5\u03c7\u03bd\u03cc \u03c3\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 LADA<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">IA-2<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u03a4\u03c5\u03c1\u03bf\u03c3\u03b9\u03bd\u03b9\u03ba\u03ae \u03c6\u03c9\u03c3\u03c6\u03b1\u03c4\u03ac\u03c3\u03b7 (IA-2)<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">~50\u201360%<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u03a3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c7\u03bd\u03cc \u03c3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac\/\u03bd\u03b5\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03b8\u03ad\u03bd\u03c4\u03b5\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">IAA<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u0399\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">~60\u201370% (\u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac)<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03ae \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px 12px;\"><strong>ZnT8<\/strong><\/td>\n<td style=\"padding: 10px 12px;\">Zinc transporter 8<\/td>\n<td style=\"padding: 10px 12px;\">~60\u201380%<\/td>\n<td style=\"padding: 10px 12px;\">\u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03cc\u03c4\u03b1\u03bd \u03c4\u03b1 \u03ac\u03bb\u03bb\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<h2 id=\"sec5\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">5<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/span><\/h2>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 ZnT8 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03bd\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf\u03c2<\/strong> \u03ae \u03cc\u03c4\u03b1\u03bd \u03bf \u03c4\u03cd\u03c0\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ae\u03c2 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7.<\/p>\n<p>\u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 <strong>\u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7<\/strong> \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ae \u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2.<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u03a0\u03b1\u03b9\u03b4\u03b9\u03ac \u03ba\u03b1\u03b9 \u03ad\u03c6\u03b7\u03b2\u03bf\u03b9 \u03bc\u03b5 <strong>\u03bd\u03b5\u03bf\u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7<\/strong>, \u03b3\u03b9\u03b1 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03a3\u03941.<\/li>\n<li>\u039d\u03b5\u03b1\u03c1\u03bf\u03af \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 <strong>\u03b1\u03c3\u03b1\u03c6\u03ae \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf<\/strong> (\u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1, \u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03ae \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2).<\/li>\n<li>\u03a5\u03c0\u03bf\u03c8\u03af\u03b1 <strong>LADA<\/strong> (\u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 2 \u03b1\u03bb\u03bb\u03ac \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc \u03ae \u03c6\u03b8\u03af\u03bd\u03bf\u03bd C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf).<\/li>\n<li>\u03a3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a3\u03941 \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf <strong>\u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5<\/strong> \u03ae \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03ac\u03c4\u03c9\u03bd.<\/li>\n<\/ul>\n<p>\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03c4\u03b1 ZnT8 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b4\u03c5\u03c3\u03b1\u03c1\u03bc\u03bf\u03bd\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2, \u03c3\u03c9\u03bc\u03b1\u03c4\u03cc\u03c4\u03c5\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2 \u2014 \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03cc\u03c4\u03b1\u03bd \u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2 \u00ab\u03b4\u03b5\u03bd \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9\u00bb \u03cc\u03c0\u03c9\u03c2 \u03bf \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7:<\/strong> \u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b1\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b1\u03c7\u03c5\u03c3\u03b1\u03c1\u03ba\u03af\u03b1, \u03bc\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03b1\u03bb\u03bb\u03ac \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7 \u2192 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 ZnT8 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bf\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7 LADA.<\/div>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<h2 id=\"sec6\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">6<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<\/span><\/h2>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03b1\u03c0\u03bb\u03ae \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1<\/strong> (\u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03bf\u03c1\u03bf\u03cd). \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 GAD, IA-2 \u03ba\u03b1\u03b9 IAA \u03ce\u03c3\u03c4\u03b5 \u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7.<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li><strong>\u039d\u03b7\u03c3\u03c4\u03b5\u03af\u03b1:<\/strong> \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9.<\/li>\n<li><strong>\u03a7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2:<\/strong> \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 3\u20135 \u03b5\u03c1\u03b3\u03ac\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b5\u03c2.<\/li>\n<li><strong>\u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1:<\/strong> \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf, \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7, HbA1c, \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03b4\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd.<\/li>\n<\/ul>\n<p>\u0397 \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03ce\u03c1\u03b1 \u03c4\u03b7\u03c2 \u03b7\u03bc\u03ad\u03c1\u03b1\u03c2, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03c4\u03b1 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03ba\u03b9\u03c1\u03ba\u03ac\u03b4\u03b9\u03b5\u03c2 \u03b4\u03b9\u03b1\u03ba\u03c5\u03bc\u03ac\u03bd\u03c3\u03b5\u03b9\u03c2. \u03a4\u03bf \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c9\u03bb\u03b7\u03bd\u03ac\u03c1\u03b9\u03bf \u03bf\u03c1\u03bf\u03cd \u03ba\u03b1\u03b9, \u03b5\u03c6\u03cc\u03c3\u03bf\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03bf\u03bb\u03ae \u03c3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf, \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c8\u03cd\u03be\u03b7 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c3\u03c6\u03b1\u03bb\u03b9\u03c3\u03c4\u03b5\u03af \u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd.<\/p>\n<p>\u0391\u03c0\u03cc \u03c0\u03c1\u03bf\u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac\u03c2, \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03c4\u03c1\u03bf\u03c6\u03ae\u03c2, \u03ba\u03b1\u03c6\u03ad \u03ae \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae. \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ae\u03b4\u03b7 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7, \u03c3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 <strong>C-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5<\/strong>, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 \u03b7 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03bc\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 ZnT8 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b1\u03be\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf \u201c\u03c0\u03b1\u03ba\u03ad\u03c4\u03bf \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u201d \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 GAD, IA-2, IAA, C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf (\u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1\u03c2 \u03ae\/\u03ba\u03b1\u03b9 HbA1c). \u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2, \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2.<\/p>\n<p>\u03a3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bf\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03ae \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1\u03c2 \u03bc\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf, \u03b7 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 3\u20136 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03cd\u03c8\u03b5\u03b9 \u03b5\u03be\u03b5\u03bb\u03b9\u03c3\u03c3\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1.<\/p>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<h2 id=\"sec7\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">7<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 (\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc, \u03bf\u03c1\u03b9\u03b1\u03ba\u03cc, \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc)<\/span><\/h2>\n<p>\u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b4\u03b5\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03bf\u03c4\u03ad \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1. \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (GAD, IA-2, IAA), \u03c4\u03bf <strong>C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf<\/strong>, \u03c4\u03b7 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2. \u03a3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b7 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 <strong>\u03c1\u03c5\u03b8\u03bc\u03bf\u03cd \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd<\/strong>.<\/p>\n<p><!-- mobile table notice --><\/p>\n<div style=\"background: #fff7ed; border: 1px solid #fed7aa; border-radius: 10px; padding: 10px 12px; margin: 12px 0 10px; font-size: 13px; line-height: 1.5;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div style=\"overflow-x: auto; -webkit-overflow-scrolling: touch; border: 1px solid #e5e7eb; border-radius: 12px;\">\n<table style=\"border-collapse: collapse; width: 100%; min-width: 520px; font-size: 14px;\">\n<thead>\n<tr>\n<th style=\"text-align: left; padding: 10px 12px; border-bottom: 1px solid #e5e7eb; background: #f9fafb;\">\u0391\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/th>\n<th style=\"text-align: left; padding: 10px 12px; border-bottom: 1px solid #e5e7eb; background: #f9fafb;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u0394\u03b5\u03bd \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 ZnT8. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03c4\u03b1\u03b9 \u03a3\u03941 \u03b1\u03bd \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03ae \u03b1\u03bd \u03c4\u03bf C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u039f\u03c1\u03b9\u03b1\u03ba\u03cc<\/td>\n<td style=\"padding: 10px 12px; border-bottom: 1px solid #f1f5f9;\">\u03a0\u03b9\u03b8\u03b1\u03bd\u03cc \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2. \u03a3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c3\u03b5 3\u20136 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px 12px;\">\u0398\u03b5\u03c4\u03b9\u03ba\u03cc<\/td>\n<td style=\"padding: 10px 12px;\">\u0399\u03c3\u03c7\u03c5\u03c1\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u2013 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc \u03bc\u03b5 \u03a3\u03941 \u03ae LADA, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong> \u038c\u03c3\u03bf \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac (\u03c0.\u03c7. ZnT8 + GAD + IA-2), \u03c4\u03cc\u03c3\u03bf \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b1\u03c7\u03b5\u03af\u03b1\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1 \u03ba\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03bd\u03c9\u03c1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7.<\/div>\n<p>\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03c4\u03c9\u03bd ZnT8 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf<\/strong> \u03ba\u03b1\u03b9 <strong>HbA1c<\/strong>, \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1 \u00ab\u03c4\u03c1\u03af\u03b3\u03c9\u03bd\u03bf\u00bb \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2: \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u2013 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03bc\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u2013 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n<p>\u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b9\u03b1\u03c4\u03c1\u03cc \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03c4\u03c1\u03af\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03b5\u03c1\u03c9\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1;<\/li>\n<li>\u03a0\u03cc\u03c3\u03b7 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03bc\u03b5\u03af\u03bd\u03b5\u03b9;<\/li>\n<li>\u03a3\u03b5 \u03c0\u03bf\u03b9\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03ad\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03b5\u03c0\u03b7\u03c1\u03b5\u03b1\u03c3\u03c4\u03b5\u03af \u03bf \u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2;<\/li>\n<\/ul>\n<p>\u03a4\u03c5\u03c0\u03b9\u03ba\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03b1:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li><strong>\u0398\u03b5\u03c4\u03b9\u03ba\u03cc ZnT8 + \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf + \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 HbA1c:<\/strong> \u03b5\u03b3\u03ba\u03b1\u03c4\u03b5\u03c3\u03c4\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2.<\/li>\n<li><strong>\u0398\u03b5\u03c4\u03b9\u03ba\u03cc ZnT8 + \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf + \u03ae\u03c0\u03b9\u03b1 HbA1c:<\/strong> \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c3\u03c4\u03b5\u03bd\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/li>\n<li><strong>\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc ZnT8 + \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf:<\/strong> \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c2 \u03a3\u03941 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ad\u03be\u03b1\u03c1\u03c3\u03b7.<\/li>\n<\/ul>\n<p>\u0399\u03b4\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2, \u03b1\u03c5\u03c4\u03ae \u03b7 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7 \u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c9\u03c2 \u00ab\u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 2\u00bb \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2, \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b2\u03b1\u03c1\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03b7 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<p>\u0391\u03c0\u03cc \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac\u03c2, \u03b7 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c4\u03c9\u03bd ZnT8 \u03b4\u03b5\u03bd \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1 \u03c3\u03b5 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2. \u0388\u03c7\u03b5\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03c3\u03b1\u03c6\u03ae \u03b1\u03be\u03af\u03b1 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ae \u03cc\u03c4\u03b1\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u03a3\u03c5\u03c7\u03bd\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03bb\u03ac\u03b8\u03bf\u03c2:<\/strong> \u039d\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 ZnT8 \u03c7\u03c9\u03c1\u03af\u03c2 C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf. \u03a4\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u00b7 \u03c4\u03bf C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c0\u03cc\u03c3\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03bc\u03b5\u03af\u03bd\u03b5\u03b9.<\/div>\n<h2 id=\"sec8\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">8<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">ZnT8 \u03ba\u03b1\u03b9 LADA: \u03c0\u03cc\u03c4\u03b5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7<\/span><\/h2>\n<p><strong>\u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 ZnT8 \u03c3\u03b5 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b1 \u03bc\u03b5 \u00ab\u03c4\u03cd\u03c0\u03bf\u03c5 2\u00bb \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 (LADA) \u03ba\u03b1\u03b9 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae.<\/strong><\/p>\n<p>\u039f <strong>LADA (Latent Autoimmune Diabetes in Adults)<\/strong> \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b1 30 \u03ad\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03ae \u03bc\u03bf\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 ZnT8 \u03ae\/\u03ba\u03b1\u03b9 GAD \u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 <strong>\u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7<\/strong>, \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n<p>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03c5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03b3\u03b5\u03af\u03c1\u03bf\u03c5\u03bd \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 LADA:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc BMI.<\/li>\n<li>\u0389\u03c0\u03b9\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03af\u03b1 \u03b1\u03bb\u03bb\u03ac \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7.<\/li>\n<li>\u0391\u03c1\u03c7\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03b5 \u03b4\u03b9\u03c3\u03ba\u03af\u03b1 \u03bc\u03b5 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1.<\/li>\n<li>\u03a4\u03b1\u03c7\u03b5\u03af\u03b1 \u03c0\u03c4\u03ce\u03c3\u03b7 C-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5.<\/li>\n<\/ul>\n<p>\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2, \u03bf LADA \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc <strong>\u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae<\/strong> \u03c4\u03c9\u03bd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 ZnT8 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5 <strong>\u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b2\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2<\/strong>, \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03b5 1\u20133 \u03ad\u03c4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<p>\u0397 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u0391\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03bc\u03cc\u03bd\u03bf \u03b4\u03b9\u03c3\u03ba\u03af\u03c9\u03bd.<\/li>\n<li>\u039e\u03b5\u03ba\u03b9\u03bd\u03ac \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b1 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2.<\/li>\n<li>\u0394\u03b9\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b7 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03bc\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03b7\u03bc\u03b5\u03af\u03bf:<\/strong> \u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b1\u03c2 \u03bc\u03b5 \u00ab\u03c4\u03cd\u03c0\u03bf\u03c5 2\u00bb \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf + \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ZnT8 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 LADA \u03bc\u03ad\u03c7\u03c1\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03c9\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03c5.<\/div>\n<p><!-- ==================== SECTION 9 ==================== --><\/p>\n<h2 id=\"sec9\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">9<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">ZnT8 \u03c3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03ba\u03b1\u03b9 \u03b5\u03c6\u03ae\u03b2\u03bf\u03c5\u03c2<\/span><\/h2>\n<p><strong>\u03a3\u03c4\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac, \u03c4\u03b1 ZnT8 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b4\u03b5\u03af\u03ba\u03c4\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03cd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03b5\u03af\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1.<\/strong><\/p>\n<p>\u03a3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03bd\u03b5\u03bf\u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7, \u03c4\u03b1 ZnT8 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd <strong>\u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c3\u03c0\u03b1\u03bd\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03b9\u03c4\u03af\u03b5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03af\u03b1\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 \u03bc\u03bf\u03bd\u03bf\u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2.<\/p>\n<p>\u03a4\u03b1 ZnT8 \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5 <strong>IAA \u03ba\u03b1\u03b9 IA-2<\/strong> \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c5\u03c8\u03b7\u03bb\u03ae \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03b4\u03bf\u03c3\u03b7, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u22652 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd,<\/li>\n<li>\u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b5\u03c4\u03bf\u03be\u03ad\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7,<\/li>\n<li>\u03c0\u03b9\u03bf \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b7 \u00abhoneymoon period\u00bb.<\/li>\n<\/ul>\n<p>\u0397 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03af\u03c9\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u03ac\u03bc\u03b5\u03c3\u03b7 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2,<\/li>\n<li>\u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03ba\u03c0\u03b1\u03af\u03b4\u03b5\u03c5\u03c3\u03b7 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2,<\/li>\n<li>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u03a0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7:<\/strong> \u03a0\u03b1\u03b9\u03b4\u03b9\u03ac \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac ZnT8 + IA-2 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03cc\u03c4\u03bf\u03bc\u03b7 \u03c0\u03c4\u03ce\u03c3\u03b7 C-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5\u03c2 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/div>\n<p><!-- ==================== SECTION 10 ==================== --><\/p>\n<h2 id=\"sec10\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">10<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">ZnT8 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a3\u03941<\/span><\/h2>\n<p>\u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd (\u03c0\u03b1\u03b9\u03b4\u03b9\u03ac, \u03b1\u03b4\u03ad\u03c1\u03c6\u03b9\u03b1, \u03b3\u03bf\u03bd\u03b5\u03af\u03c2) \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03bc\u03b5 \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 <strong>\u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c2 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2<\/strong> \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (GAD, IA-2, IAA).<\/p>\n<p>\u039f \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03c1\u03b1\u03bc\u03bc\u03b9\u03ba\u03cc\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 <strong>\u03b5\u03ba\u03b8\u03b5\u03c4\u03b9\u03ba\u03ac<\/strong> \u03cc\u03c3\u03bf \u03c0\u03c1\u03bf\u03c3\u03c4\u03af\u03b8\u03b5\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03cc\u03c3\u03bf \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b4\u03b9\u03b1\u03ba\u03ac \u03c4\u03bf <strong>C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf<\/strong>, \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03b9\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03c5\u03c0\u03b5\u03c1\u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03af\u03b1. \u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac, \u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03c1\u03bf\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u03ad\u03c4\u03b7.<\/p>\n<p>\u03a3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li><strong>\u03a3\u03c4\u03ac\u03b4\u03b9\u03bf 1:<\/strong> \u22652 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7.<\/li>\n<li><strong>\u03a3\u03c4\u03ac\u03b4\u03b9\u03bf 2:<\/strong> \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 + \u03c0\u03c1\u03ce\u03b9\u03bc\u03b5\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2.<\/li>\n<li><strong>\u03a3\u03c4\u03ac\u03b4\u03b9\u03bf 3:<\/strong> \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2.<\/li>\n<\/ul>\n<p>\u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 ZnT8 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03b5\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c4\u03bf \u03ac\u03c4\u03bf\u03bc\u03bf \u03c3\u03c4\u03b1 \u03a3\u03c4\u03ac\u03b4\u03b9\u03b1 1\u20132, \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<p>\u0391\u03c0\u03cc \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac\u03c2, \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li><strong>\u0395\u03c4\u03ae\u03c3\u03b9\u03bf\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/strong> (ZnT8 \u00b1 GAD\/IA-2\/IAA) \u03c3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03ae \u03b1\u03b4\u03ad\u03c1\u03c6\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd.<\/li>\n<li><strong>\u03a0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7\u03c2<\/strong> \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1\u03c2 \u03ae \u03ba\u03b1\u03bc\u03c0\u03cd\u03bb\u03b7\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9.<\/li>\n<li><strong>\u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5 C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf<\/strong> \u03b3\u03b9\u03b1 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03bc\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2.<\/li>\n<li><strong>\u03a3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/strong> \u03cc\u03c4\u03b1\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u22652 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ae \u03c4\u03ac\u03c3\u03b7 C-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5.<\/li>\n<\/ul>\n<p>\u03a3\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1, \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03bd\u03c4\u03b1\u03c7\u03b8\u03bf\u03cd\u03bd \u03c3\u03b5 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03ae \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7\u03c2, \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b7\u03bd <strong>\u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 \u2013 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u2013 \u03c4\u03b7\u03bd <strong>\u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b5\u03c4\u03bf\u03be\u03ad\u03c9\u03c3\u03b7\u03c2<\/strong> \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1:<\/strong> \u03a3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03a3\u03941, \u03c4\u03b1 ZnT8 \u03b4\u03b5\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u00ab\u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u00bb, \u03b1\u03bb\u03bb\u03ac \u03b3\u03b9\u03b1 <strong>\u03c3\u03c4\u03c1\u03c9\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>. \u039f \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03c4\u03b5\u03af \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b1 \u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03b8\u03b5\u03af \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c0\u03c1\u03b9\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1.<\/div>\n<h2 id=\"sec11\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">11<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">ZnT8 \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7 (SLC30A8)<\/span><\/h2>\n<p>\u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf <strong>SLC30A8<\/strong>, \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ad\u03b1 \u03c8\u03b5\u03c5\u03b4\u03b1\u03c1\u03b3\u03cd\u03c1\u03bf\u03c5 ZnT8, \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u2014 \u03bc\u03b5 \u03c0\u03b9\u03bf \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03bc\u03ad\u03bd\u03bf \u03c4\u03bf\u03bd <strong>Arg325Trp<\/strong> \u2014 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c8\u03b5\u03c5\u03b4\u03b1\u03c1\u03b3\u03cd\u03c1\u03bf\u03c5 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u00ab\u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9\u00bb \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf.<\/p>\n<p>\u039f ZnT8 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03c4\u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c9\u03c1\u03af\u03bc\u03b1\u03bd\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b8\u03ae\u03ba\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2. \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03bf\u03c5 SLC30A8 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c4\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b5\u03ba\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03bf\u03ba\u03ba\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03b5 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b5\u03c1\u03b5\u03b8\u03af\u03c3\u03bc\u03b1\u03c4\u03b1. \u0391\u03c5\u03c4\u03cc \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03ad\u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u03cc\u03c0\u03bf\u03c5 \u03c4\u03b1 \u03b2-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u00ab\u03bf\u03c1\u03b1\u03c4\u03ac\u00bb \u03c3\u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1, \u03b4\u03b9\u03b5\u03c5\u03ba\u03bf\u03bb\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 ZnT8.<\/p>\n<p>\u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03b9 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03af \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5:<\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd,<\/li>\n<li>\u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03c1\u03c5\u03b8\u03bc\u03cc \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1\u03c2 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2,<\/li>\n<li>\u03bc\u03b5\u03c4\u03b1\u03b2\u03bb\u03b7\u03c4\u03ae \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7.<\/li>\n<\/ul>\n<p>\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf \u03bd\u03b1 \u03c4\u03bf\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03cc\u03c4\u03b9 \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 <strong>\u03b4\u03b5\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03b5\u03af \u03b3\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/strong>. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03cd SLC30A8 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03c2 \u03b8\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03b5\u03b9 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7, \u03bf\u03cd\u03c4\u03b5 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf. \u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03c4\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (ZnT8, GAD, IA-2, IAA) \u03ba\u03b1\u03b9 \u03c4\u03bf C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b1\u03c6\u03ce\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1.<\/p>\n<p>\u03a3\u03ae\u03bc\u03b5\u03c1\u03b1, \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 SLC30A8 \u03b1\u03be\u03b9\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03c9\u03c4\u03cc\u03ba\u03bf\u03bb\u03bb\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03b9\u03b1\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b7 \u03b2\u03ac\u03c3\u03b7 \u03b3\u03b9\u03b1 <strong>\u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ac \u03c0\u03bf\u03bb\u03c5\u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ac \u03c0\u03ac\u03bd\u03b5\u03bb \u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c8\u03b7\u03c2<\/strong>, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b8\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03c5\u03bd \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03c4\u03c1\u03bf\u03c5\u03c2, \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b7\u03bd \u03c0\u03b9\u03bf \u03b1\u03ba\u03c1\u03b9\u03b2\u03ae \u03c3\u03c4\u03c1\u03c9\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a3\u03941.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/strong> \u03a4\u03bf SLC30A8 \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03b4\u03b9\u03ac\u03b8\u03b5\u03c3\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c4\u03b1 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bd\u03b5\u03b9 \u2014 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u2014 \u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/div>\n<p><!-- ==================== SECTION 12 ==================== --><\/p>\n<h2 id=\"sec12\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">12<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bb\u03ac\u03b8\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/span><\/h2>\n<p><strong>\u03a4\u03b1 ZnT8 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b1\u03c5\u03c4\u03cc\u03bd\u03bf\u03bc\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf.<\/strong><\/p>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc ZnT8 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd GAD \u03ae IA-2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03ae \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc.<\/li>\n<li>\u0398\u03b5\u03c4\u03b9\u03ba\u03cc ZnT8 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03af\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 <strong>\u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf<\/strong>, \u03cc\u03c7\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7.<\/li>\n<li>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf, \u03b3\u03bb\u03c5\u03ba\u03cc\u03b6\u03b7 \u03ae HbA1c \u2013 \u03ba\u03ac\u03b8\u03b5 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1.<\/li>\n<li>\u039c\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03c5\u03c0\u03b5\u03c1\u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/li>\n<li>\u03a3\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03a3\u03941, \u03c4\u03b1 ZnT8 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03b5\u03bd\u03ce \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03ae.<\/li>\n<\/ul>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c6\u03ac\u03bb\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd ZnT8 \u03c7\u03c9\u03c1\u03af\u03c2 C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03ae \u03b7 \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03b5\u03bd\u03b7\u03bb\u03af\u03ba\u03c9\u03bd \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c9\u03c2 \u00ab\u03c4\u03cd\u03c0\u03bf\u03c5 2\u00bb. \u039a\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b4\u03cd\u03bf \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c4\u03b1\u03c7\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1\u03c2:<\/strong> \u03a4\u03b1 ZnT8 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc. \u03a4\u03bf C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c0\u03cc\u03c3\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03bc\u03b5\u03af\u03bd\u03b5\u03b9. \u0397 HbA1c \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c4\u03bf \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1.<\/div>\n<p>\u0397 \u03bf\u03c1\u03b8\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c0\u03c1\u03bf\u03cb\u03c0\u03bf\u03b8\u03ad\u03c4\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03c5\u03c1\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2, \u03c3\u03c9\u03bc\u03b1\u03c4\u03cc\u03c4\u03c5\u03c0\u03bf, \u03c4\u03b1\u03c7\u03cd\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc.<\/p>\n<p><!-- ==================== SECTION 13 ==================== --><\/p>\n<h2 id=\"sec13\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">13<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u03ba\u03cd\u03c1\u03b9\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd<\/span><\/h2>\n<ul style=\"margin: 10px 0 0 18px; line-height: 1.8;\">\n<li>\u03a4\u03b1 <strong>ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c4\u03c9\u03bd \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc.<\/li>\n<li>\u0391\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf <strong>60\u201380% \u03c4\u03c9\u03bd \u03bd\u03b5\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03b8\u03ad\u03bd\u03c4\u03c9\u03bd \u03bc\u03b5 \u03a3\u03941<\/strong> \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u00ab\u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd\u00bb \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd.<\/li>\n<li>\u03a3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bd\u03bf\u03c5\u03bd GAD, IA-2 \u03ba\u03b1\u03b9 IAA \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1.<\/li>\n<li>\u03a3\u03b5 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2, \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ZnT8 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c2 <strong>LADA<\/strong> \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7.<\/li>\n<li>\u03a3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac, \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b1\u03c7\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03ba\u03b5\u03c4\u03bf\u03be\u03ad\u03c9\u03c3\u03b7\u03c2.<\/li>\n<li>\u03a3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03a3\u03941 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c9\u03c2 <strong>\u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2<\/strong> \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7.<\/li>\n<li>\u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03bc\u03b5\u03b3\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf \u03ba\u03b1\u03b9 HbA1c.<\/li>\n<\/ul>\n<p><strong>\u03a3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/strong> \u03a4\u03b1 ZnT8 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03bd\u03c4\u03bf\u03cd\u03bd \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2 \u2014 \u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd <em>\u03c0\u03bf\u03b9\u03b1\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ae\u03c2<\/em> \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03cc\u03c3\u03bf \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03b5\u03be\u03b5\u03bb\u03af\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9.<\/p>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<h2 id=\"sec14\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">14<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03b9\u03bb\u03ae\u03c3\u03b5\u03c4\u03b5 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03b5 \u03b3\u03b9\u03b1\u03c4\u03c1\u03cc<\/span><\/h2>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 16px; font-size: 14px; line-height: 1.6;\">\n<p><strong>\u0391\u03c0\u03b5\u03c5\u03b8\u03c5\u03bd\u03b8\u03b5\u03af\u03c4\u03b5 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03b5 \u03b9\u03b1\u03c4\u03c1\u03cc \u03b1\u03bd \u03b9\u03c3\u03c7\u03cd\u03b5\u03b9 \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9:<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px; line-height: 1.8;\">\n<li>\u0398\u03b5\u03c4\u03b9\u03ba\u03ac ZnT8 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 <strong>\u03c0\u03bf\u03bb\u03c5\u03bf\u03c5\u03c1\u03af\u03b1, \u03c0\u03bf\u03bb\u03c5\u03b4\u03b9\u03c8\u03af\u03b1, \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03ae \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7<\/strong>.<\/li>\n<li>\u039f\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03a3\u03941 \u03ba\u03b1\u03b9 <strong>\u03bd\u03ad\u03bf \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>.<\/li>\n<li>\u0395\u03bd\u03ae\u03bb\u03b9\u03ba\u03b1\u03c2 \u03bc\u03b5 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u00ab\u03c4\u03cd\u03c0\u03bf\u03c5 2\u00bb \u03b1\u03bb\u03bb\u03ac <strong>\u03c4\u03b1\u03c7\u03b5\u03af\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7 \u03b3\u03bb\u03c5\u03ba\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ae \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7<\/strong>.<\/li>\n<li>\u039f\u03c1\u03b9\u03b1\u03ba\u03ac ZnT8 \u03bc\u03b5 <strong>\u03c0\u03c4\u03ce\u03c3\u03b7 C-\u03c0\u03b5\u03c0\u03c4\u03b9\u03b4\u03af\u03bf\u03c5<\/strong> \u03ae \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ac\u03bd\u03bf\u03b4\u03bf <a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/sakcharo-aimatos-odigos-asthenon\/\">\u03c3\u03b1\u03ba\u03c7\u03ac\u03c1\u03bf\u03c5.<\/a><\/li>\n<li>\u03a0\u03b1\u03b9\u03b4\u03af \u03ae \u03ad\u03c6\u03b7\u03b2\u03bf\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03c5\u03bd <strong>\u03b5\u03c0\u03b9\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03b7 \u03ba\u03b5\u03c4\u03bf\u03be\u03ad\u03c9\u03c3\u03b7<\/strong> (\u03bd\u03b1\u03c5\u03c4\u03af\u03b1, \u03ad\u03bc\u03b5\u03c4\u03bf\u03b9, \u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03cc \u03ac\u03bb\u03b3\u03bf\u03c2).<\/li>\n<\/ul>\n<p style=\"margin-top: 10px;\">\u0397 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c9\u03c3\u03c4\u03cc \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03b1\u03c0\u03bf\u03c1\u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2.<\/p>\n<\/div>\n<p><!-- ==================== SECTION 15 FAQ ==================== --><\/p>\n<h2 id=\"faq\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">15<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1;<\/summary>\n<p>\u0391\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 ZnT8 \u03c3\u03c4\u03b1 \u03b2-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7;<\/summary>\n<p>\u03a3\u03b5 \u03bd\u03b5\u03bf\u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7, \u03b1\u03c3\u03b1\u03c6\u03ae \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf, \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 LADA \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03ce\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03a3\u03941.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1;<\/summary>\n<p>\u038c\u03c7\u03b9, \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c0\u03bb\u03ae \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ZnT8;<\/summary>\n<p>\u03a5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03b2-\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc \u03bc\u03b5 \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1 \u03ae LADA, \u03b9\u03b4\u03af\u03c9\u03c2 \u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc C-\u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03c7\u03c9\u03c1\u03af\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7;<\/summary>\n<p>\u039d\u03b1\u03b9, \u03c3\u03b5 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03ae \u03c3\u03b5 \u03c3\u03c5\u03b3\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03b2\u03b1\u03b8\u03bc\u03bf\u03cd, \u03bf\u03c0\u03cc\u03c4\u03b5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03ac\u03bb\u03b7\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2;<\/summary>\n<p>\u03a3\u03c5\u03bd\u03b9\u03c3\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ae \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03ce\u03c2 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03b7 \u03b4\u03b9\u03ac\u03ba\u03c1\u03b9\u03c3\u03b7 LADA \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2;<\/summary>\n<p>\u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 ZnT8 \u03ae GAD \u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c3\u03b5 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 2, \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2.<\/p>\n<\/details>\n<h2 id=\"cta\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">16<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd<\/span><\/h2>\n<p><strong>\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2.<\/strong> \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 ZnT8 \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<p><!-- ==================== SECTION 17 ==================== --><\/p>\n<h2 id=\"biblio\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">17<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin-bottom: 8px; font-size: 14px;\"><strong>1. Wenzlau JM et al.<\/strong> <em>ZnT8 autoantibodies: a major type 1 diabetes autoantibody specificity.<\/em> New England Journal of Medicine, 2007.<br \/>\n<a href=\"https:\/\/doi.org\/10.1056\/NEJMoa073143\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1056\/NEJMoa073143<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin-bottom: 8px; font-size: 14px;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin-bottom: 8px; font-size: 14px;\"><strong>2. Bonifacio E.<\/strong> <em>Predicting type 1 diabetes using biomarkers.<\/em> Diabetes Care, 2015.<br \/>\n<a href=\"https:\/\/doi.org\/10.2337\/dc14-2072\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.2337\/dc14-2072<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin-bottom: 8px; font-size: 14px;\"><strong>3. Lampasona V et al.<\/strong> <em>Autoantibody profile in adult-onset autoimmune diabetes (LADA).<\/em> Diabetologia, 2010.<br \/>\n<a href=\"https:\/\/doi.org\/10.1007\/s00125-010-1926-0\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1007\/s00125-010-1926-0<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin-bottom: 8px; font-size: 14px;\"><strong>4. American Diabetes Association.<\/strong> <em>Standards of Medical Care in Diabetes\u20142024.<\/em> Diabetes Care.<br \/>\n<a href=\"https:\/\/doi.org\/10.2337\/dc24-S001\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.2337\/dc24-S001<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin-bottom: 8px; font-size: 14px;\"><strong>5. Graham J, Hagopian WA.<\/strong> <em>Zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes.<\/em> Clinical and Developmental Immunology, 2012.<br \/>\n<a href=\"https:\/\/doi.org\/10.1155\/2012\/408914\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1155\/2012\/408914<\/a><\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>ZnT8 \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1: \u0397 \u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u0391\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u0394\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03a4\u03cd\u03c0\u03bf\u03c5 1 &amp; LADA (\u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2) \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 29 \u0399\u03b1\u03bd\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2026 \u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5: \u03a4\u03b1 ZnT8 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 ZnT8 \u03c3\u03c4\u03b1 \u03b2-\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7. \u0395\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 1 \u03cc\u03c4\u03b1\u03bd \u03ac\u03bb\u03bb\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (GAD, IA-2, IAA) \u03b5\u03af\u03bd\u03b1\u03b9 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":9475,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2534],"tags":[654,377,374,2912,2914,2913],"class_list":["post-2935","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exetaseis-aimatos","tag-c-peptidio","tag-lada","tag-znt8","tag-znt8-antisomata","tag-avtoanosa-antisomata","tag-sakcharodis-diavitis-typou-1"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/2935","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=2935"}],"version-history":[{"count":8,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/2935\/revisions"}],"predecessor-version":[{"id":9477,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/2935\/revisions\/9477"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/9475"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=2935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=2935"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=2935"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}