{"id":2803,"date":"2025-05-27T21:54:56","date_gmt":"2025-05-27T18:54:56","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=2803"},"modified":"2026-01-11T15:57:02","modified_gmt":"2026-01-11T13:57:02","slug":"pcsk9-anastoleis","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/pcsk9-anastoleis\/","title":{"rendered":"PCSK9 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2: \u03a0\u03bb\u03ae\u03c1\u03b7\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc\u03c2 \u039f\u03b4\u03b7\u03b3\u03cc\u03c2 \u03b3\u03b9\u03b1 \u039c\u03b5\u03af\u03c9\u03c3\u03b7 LDL &#038; \u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u039a\u03af\u03bd\u03b4\u03c5\u03bd\u03bf"},"content":{"rendered":"<h1>PCSK9 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2: \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2, \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03a7\u03c1\u03ae\u03c3\u03b7 &amp; \u039c\u03b5\u03af\u03c9\u03c3\u03b7 LDL \u03a7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 (Therapeutic Knowledge Hub)<\/h1>\n<p style=\"font-size: 14px; color: #6b7280; margin: 6px 0 0;\">\u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7:<br \/>\n<time datetime=\"2026-01-11\">11 \u0399\u03b1\u03bd\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2026<\/time><\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin: 14px 0 18px;\"><strong>\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc Knowledge Hub.<\/strong><br \/>\n\u0397 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd <strong>\u03ba\u03bb\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd<\/strong> (\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 siRNA),<br \/>\n\u03c4\u03bf\u03bd <strong>\u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2<\/strong>, \u03c4\u03b7\u03bd <strong>\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong>, \u03c4\u03b9\u03c2 <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>\u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 <strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>.<\/div>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 18px;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong><br \/>\n\u039f\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd <strong>LDL<\/strong> \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 <strong>50\u201365%<\/strong> (\u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1\/\u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2).<br \/>\n\u03a7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 <strong>ASCVD<\/strong> \u03ba\u03b1\u03b9\/\u03ae <strong>\u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1<\/strong> \u03cc\u03c4\u03b1\u03bd \u03bf\u03b9 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 LDL \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/div>\n<nav id=\"toc\" style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 14px; padding: 14px; margin: 16px 0;\" aria-label=\"\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1\"><strong>\ud83d\udcd1 \u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/strong><\/p>\n<ol style=\"margin: 10px 0 0 18px; line-height: 1.9;\">\n<li><a href=\"#ti-einai\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2<\/a><\/li>\n<li><a href=\"#pcsk9-physiology\">PCSK9 \u03ba\u03b1\u03b9 LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2: \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/a><\/li>\n<li><a href=\"#molecular-context\">\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf<\/a><\/li>\n<li><a href=\"#mechanismos\">\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2<\/a><\/li>\n<li><a href=\"#available\">\u0394\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/a><\/li>\n<li><a href=\"#endixeis\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2<\/a><\/li>\n<li><a href=\"#targets\">\u03a3\u03c4\u03cc\u03c7\u03bf\u03b9 LDL<\/a><\/li>\n<li><a href=\"#effectiveness\">\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/a><\/li>\n<li><a href=\"#cv-outcomes\">\u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03b2\u03ac\u03bc\u03b1\u03c4\u03b1<\/a><\/li>\n<li><a href=\"#comparison\">\u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd<\/a><\/li>\n<li><a href=\"#residual-risk\">\u03a5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2<\/a><\/li>\n<li><a href=\"#safety\">\u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1<\/a><\/li>\n<li><a href=\"#special-groups\">\u0395\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2<\/a><\/li>\n<li><a href=\"#lpa\">Lp(a)<\/a><\/li>\n<li><a href=\"#practical\">\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03b8\u03ad\u03bc\u03b1\u03c4\u03b1<\/a><\/li>\n<li><a href=\"#pitfalls\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03b3\u03af\u03b4\u03b5\u03c2<\/a><\/li>\n<li><a href=\"#faq\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/a><\/li>\n<li><a href=\"#cta\">\u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 &amp; \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/a><\/li>\n<li><a href=\"#bibliography\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<hr style=\"border: none; border-top: 2px solid #d1d5db; margin: 12px 0 0;\" \/>\n<\/nav>\n<p>&nbsp;<\/p>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<h2 id=\"ti-einai\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2<br \/>\n<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u039f\u03b9 <strong>PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c5\u03c0\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5<br \/>\n\u03c0\u03b1\u03c1\u03b5\u03bc\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03bd <strong>\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/strong> \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1.<br \/>\n\u039c\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 <strong>PCSK9<\/strong>,<br \/>\n\u03b1\u03c0\u03bf\u03c4\u03c1\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd,<br \/>\n\u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03b5\u03b9<br \/>\n<strong>\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac\u03c3\u03b9\u03b1 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2<\/strong> \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1.<br \/>\n\u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1<br \/>\n<strong>\u03b9\u03c3\u03c7\u03c5\u03c1\u03ae, \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c8\u03b9\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03bf\u03c3\u03bf\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL<\/strong>.<\/p>\n<p style=\"margin: 6px 0 0; line-height: 1.7;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac, \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03bb\u03ac\u03bd\u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5<br \/>\n\u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd <strong>\u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b5\u03c0\u03b9\u03b8\u03c5\u03bc\u03b7\u03c4\u03cc \u03c3\u03c4\u03cc\u03c7\u03bf LDL<\/strong><br \/>\n\u03c0\u03b1\u03c1\u03ac \u03c4\u03b7 <strong>\u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<\/strong><br \/>\n(\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2 \u00b1 ezetimibe),<br \/>\n\u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2<br \/>\n<strong>\u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2<\/strong>,<br \/>\n\u03cc\u03c4\u03b1\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5<br \/>\n<strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>.<\/p>\n<p><!-- ==================== SECTION 2 ==================== --><\/p>\n<h2 id=\"pcsk9-physiology\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">PCSK9 \u03ba\u03b1\u03b9 LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2: \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<br \/>\n<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u03a4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03c9\u03bd<br \/>\n<strong>LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/strong> \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd,<br \/>\n\u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03bf\u03c5\u03bd LDL \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1.<br \/>\n\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 <strong>PCSK9<\/strong> \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2<br \/>\n\u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd <strong>\u03b5\u03bd\u03b4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03ae<\/strong> \u03c4\u03bf\u03c5\u03c2,<br \/>\n\u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ce\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7:<\/strong><br \/>\n\u038c\u03c4\u03b1\u03bd \u03b7 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9, \u03bf\u03b9 LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2<br \/>\n<strong>\u03b4\u03b5\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9<\/strong> \u03b1\u03bb\u03bb\u03ac<br \/>\n<strong>\u03b5\u03c0\u03b1\u03bd\u03b1\u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd<\/strong> \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5,<br \/>\n\u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03b5\u03b9<br \/>\n<strong>\u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b7 LDL<\/strong> \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03af\u03bc\u03b1.<\/div>\n<p><!-- ==================== SCHOLARLY EXPANSION ==================== --><\/p>\n<h2 id=\"molecular-context\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">3<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039c\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c4\u03c9\u03bd PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd<br \/>\n<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u0397 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 <strong>PCSK9 (proprotein convertase subtilisin\/kexin type 9)<\/strong><br \/>\n\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03ae \u03c4\u03b7\u03c2 \u03bf\u03bc\u03bf\u03b9\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2.<br \/>\n\u0395\u03ba\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd<br \/>\n<strong>LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 (LDLR)<\/strong> \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<br \/>\n\u038c\u03c4\u03b1\u03bd \u03c4\u03bf \u03c3\u03cd\u03bc\u03c0\u03bb\u03bf\u03ba\u03bf PCSK9\u2013LDLR \u03b5\u03c3\u03c9\u03c4\u03b5\u03c1\u03b9\u03ba\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9,<br \/>\n\u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c2 <strong>\u03bb\u03c5\u03c3\u03bf\u03c3\u03c9\u03bc\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7<\/strong><br \/>\n\u03b1\u03bd\u03c4\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03ba\u03c5\u03ba\u03bb\u03c9\u03b8\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1.<br \/>\n\u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 <strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 LDL<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1.<\/p>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 PCSK9 \u03b1\u03bd\u03b1\u03b4\u03b5\u03af\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03bc\u03ad\u03c3\u03c9<br \/>\n\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd:<br \/>\n\u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 <strong>loss-of-function \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/strong> \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf PCSK9<br \/>\n\u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03cd \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 LDL \u03ba\u03b1\u03b9<br \/>\n\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b5\u03c6\u03b1\u03bd\u03b9\u03b1\u03af\u03b1\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5,<br \/>\n\u03b5\u03bd\u03ce <strong>gain-of-function \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/strong><br \/>\n\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1.<br \/>\n\u0391\u03c5\u03c4\u03ae \u03b7 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03ac \u03c4\u03b7\u03bd PCSK9<br \/>\n\u03b9\u03b4\u03b1\u03bd\u03b9\u03ba\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03cc\u03c7\u03bf.<\/p>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u039f\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03b1\u03be\u03b9\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b3\u03bd\u03ce\u03c3\u03b7<br \/>\n\u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1<br \/>\n\u03c3\u03c4\u03bf \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03c1\u03cc\u03bb\u03bf \u03c9\u03c2 \u00ab\u03ba\u03b1\u03b8\u03b1\u03c1\u03b9\u03c3\u03c4\u03ae\u00bb \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2.<br \/>\n\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2,<br \/>\n\u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2<br \/>\n\u03bc\u03ad\u03c3\u03c9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2,<br \/>\n\u03bf\u03b9 PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2<br \/>\n<strong>\u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2<\/strong>,<br \/>\n\u03b1\u03bb\u03bb\u03ac \u03b4\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03c4\u03b7\u03c2<br \/>\n<strong>\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b1\u03ba\u03cd\u03ba\u03bb\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1<\/strong>.<br \/>\n\u0391\u03c5\u03c4\u03cc \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03bf\u03b9 \u03b4\u03cd\u03bf \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9<br \/>\n<strong>\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2.<\/p>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u0391\u03c0\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bf\u03c0\u03b9\u03ac,<br \/>\n\u03b7 \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1 \u03c4\u03bf\u03c5 <strong>\u00ab\u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5\u00bb<\/strong><br \/>\n\u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae.<br \/>\n\u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03bc\u03b5 LDL \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2,<br \/>\n\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 ASCVD<br \/>\n\u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03ad\u03b1 \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1,<br \/>\n\u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03cc\u03c4\u03b9<br \/>\n\u03c4\u03bf \u03b1\u03b8\u03b7\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf \u03c6\u03bf\u03c1\u03c4\u03af\u03bf \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03be\u03b1\u03bb\u03b5\u03b9\u03c6\u03b8\u03b5\u03af \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2.<br \/>\n\u0397 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03bc\u03ad\u03c3\u03c9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2<br \/>\n\u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5<br \/>\n<strong>\u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7\u03c2 \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd \u03c3\u03c4\u03bf \u03c4\u03bf\u03af\u03c7\u03c9\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03ce\u03bd<\/strong>,<br \/>\n\u03b5\u03c0\u03b9\u03b2\u03c1\u03b1\u03b4\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03ba\u03b1\u03b9<br \/>\n\u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b9\u03c2 \u03b1\u03b8\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03bb\u03ac\u03ba\u03b5\u03c2.<\/p>\n<p style=\"margin: 6px 0 0; line-height: 1.7;\">\u0388\u03c4\u03c3\u03b9, \u03bf\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b1\u03c0\u03bb\u03ce\u03c2<br \/>\n\u03bc\u03b9\u03b1 \u00ab\u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7\u00bb \u03c5\u03c0\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae,<br \/>\n\u03b1\u03bb\u03bb\u03ac \u03bc\u03b9\u03b1 <strong>\u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7<\/strong><br \/>\n\u03c3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7\u03c2,<br \/>\n\u03b3\u03b5\u03c6\u03c5\u03c1\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03b1\u03b8\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<br \/>\n\u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd<br \/>\n<strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>.<\/p>\n<h2 id=\"mechanismos\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">4<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2: \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 siRNA<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u039f \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ce\u03bd \u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd<br \/>\n<strong>\u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b1\u03ba\u03cd\u03ba\u03bb\u03c9\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/strong>.<br \/>\n\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03ba\u03ac\u03b8\u03b5 LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1<br \/>\n\u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03b5\u03b9 LDL \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03af\u03bc\u03b1\u00b7 \u03b7 PCSK9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c9\u03c2 \u00ab\u03c3\u03ae\u03bc\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae\u03c2\u00bb,<br \/>\n\u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c3\u03b5 \u03b1\u03c0\u03bf\u03b4\u03cc\u03bc\u03b7\u03c3\u03b7 \u03b1\u03bd\u03c4\u03af \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1.<\/p>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u03a4\u03b1 <strong>\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (mAbs)<\/strong> \u03b4\u03c1\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03b5\u03be\u03c9\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03b9\u03bf \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd,<br \/>\n\u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd PCSK9 \u03c0\u03bf\u03c5 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03b5\u03af \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03ba\u03b1\u03b9<br \/>\n\u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1.<br \/>\n\u039c\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf, \u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03b4\u03b5\u03bd \u00ab\u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b5\u03af\u03c4\u03b1\u03b9\u00bb \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03ba\u03b1\u03b9<br \/>\n\u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b5\u03b9\u03bb\u03b7\u03bc\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5,<br \/>\n\u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 LDL.<\/p>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u03a4\u03bf <strong>siRNA (inclisiran)<\/strong> \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf:<br \/>\n\u03b5\u03b9\u03c3\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9<br \/>\n<strong>\u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 mRNA \u03c4\u03b7\u03c2 PCSK9<\/strong>,<br \/>\n\u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2.<br \/>\n\u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ac \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 PCSK9<\/strong><br \/>\n\u03b3\u03b9\u03b1 \u03bc\u03ae\u03bd\u03b5\u03c2, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03ac \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2<br \/>\n\u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03c1\u03b1\u03b9\u03ac \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1:<\/strong><br \/>\n\u03b1\u03bd \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b5\u03c2 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bf\u03b4\u03cc,<br \/>\n\u03c4\u03b1 <strong>mAbs<\/strong> \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 PCSK9 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1,<br \/>\n\u03b5\u03bd\u03ce \u03c4\u03bf <strong>siRNA<\/strong> \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c0\u03b9\u03bf<br \/>\n<strong>\u03bc\u03b1\u03ba\u03c1\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae<\/strong> \u03c4\u03b7\u03c2 PCSK9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1.<br \/>\n\u039a\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf, \u03cc\u03bc\u03c9\u03c2, \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5<br \/>\n<strong>\u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c8\u03b9\u03bc\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL<\/strong>.<\/div>\n<h2 id=\"available\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">5<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0394\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2: evolocumab, alirocumab, inclisiran<br \/>\n<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u039f\u03b9 PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b2\u03b1\u03c3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03cd\u03bf \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03c3\u03b5\u03b9\u03c2:<br \/>\n\u03c4\u03b1 <strong>\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (mAbs)<\/strong>, \u03c0\u03bf\u03c5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1 PCSK9 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1,<br \/>\n\u03ba\u03b1\u03b9 \u03c4\u03bf <strong>siRNA<\/strong>, \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 PCSK9 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1.<br \/>\n\u039a\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 <strong>\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ce\u03bd LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03c3\u03b5 <strong>\u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2<\/strong>.<\/p>\n<p><strong>\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (PCSK9 inhibitors \u2013 mAbs)<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px; line-height: 1.85;\">\n<li><strong>Evolocumab (Repatha\u00ae)<\/strong>: \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ba\u03ac\u03b8\u03b5 2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ae \u03bc\u03af\u03b1 \u03c6\u03bf\u03c1\u03ac \u03c4\u03bf\u03bd \u03bc\u03ae\u03bd\u03b1, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1.<\/li>\n<li><strong>Alirocumab (Praluent\u00ae)<\/strong>: \u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ba\u03ac\u03b8\u03b5 2 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ae \u03bc\u03b7\u03bd\u03b9\u03b1\u03af\u03b1, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7.<\/li>\n<\/ul>\n<p style=\"margin-top: 12px;\"><strong>siRNA \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 PCSK9<\/strong><\/p>\n<ul style=\"margin: 8px 0 0 18px; line-height: 1.85;\">\n<li><strong>Inclisiran (Leqvio\u00ae)<\/strong>: \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b1\u03ba\u03c1\u03ac\u03c2 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2 \u03bc\u03b5 \u03b1\u03c1\u03b1\u03b9\u03ad\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2 \u03b5\u03bd\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03ad\u03c4\u03bf\u03c5\u03c2, \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0;\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac:<\/strong><br \/>\n\u03a4\u03b1 <strong>mAbs<\/strong> \u03b4\u03c1\u03bf\u03c5\u03bd \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd PCSK9 \u03c0\u03bf\u03c5 \u03ae\u03b4\u03b7 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03b5\u03af \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1,<br \/>\n\u03b5\u03bd\u03ce \u03c4\u03bf <strong>siRNA<\/strong> \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03b7\u03c2 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1.<br \/>\n\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7<br \/>\n<strong>\u03c3\u03c5\u03bc\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7<\/strong>, \u03c4\u03b1 <strong>\u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b6\u03b7\u03bc\u03af\u03c9\u03c3\u03b7\u03c2<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 <strong>\u03c0\u03c1\u03bf\u03c4\u03b9\u03bc\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2<\/strong>.<\/div>\n<h2 id=\"endixeis\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">6<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u039f\u03b9 <strong>PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2<\/strong> \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5<br \/>\n<strong>\u03c5\u03c8\u03b7\u03bb\u03cc<\/strong> \u03ae <strong>\u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03cc \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf<\/strong>,<br \/>\n\u03cc\u03c4\u03b1\u03bd \u03b7 <strong>LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03cc\u03c7\u03bf<\/strong><br \/>\n\u03c0\u03b1\u03c1\u03ac \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 <strong>\u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2<\/strong><br \/>\n(\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2 \u00b1 ezetimibe).<br \/>\n\u03a3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03bf\u03cd \u03b4\u03b5\u03af\u03ba\u03c4\u03b7,<br \/>\n\u03b1\u03bb\u03bb\u03ac \u03b7 <strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03b7\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03c6\u03bf\u03c1\u03c4\u03af\u03bf\u03c5<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03ad\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1, \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03ae \u03b1\u03b9\u03c6\u03bd\u03af\u03b4\u03b9\u03bf \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03cc \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf.<\/p>\n<ul style=\"margin: 8px 0 0 18px; line-height: 1.85;\">\n<li><strong>\u039a\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03b7\u03c1\u03c9\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2 (ASCVD)<\/strong>:<br \/>\n\u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03c4\u03b5\u03c6\u03b1\u03bd\u03b9\u03b1\u03af\u03b1 \u03bd\u03cc\u03c3\u03bf, \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03ad\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03bf\u03c5,<br \/>\n\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf \u03ae \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf<br \/>\n\u03b1\u03bd\u03ae\u03ba\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 <strong>\u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b1\u03c0\u03cc \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL.<\/li>\n<li><strong>\u039f\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1 (FH)<\/strong>:<br \/>\n\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03bc\u03b5 \u03b4\u03b9\u03b1 \u03b2\u03af\u03bf\u03c5 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ae LDL,<br \/>\n\u03cc\u03c0\u03bf\u03c5 \u03bf\u03b9 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b4\u03b5\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7<br \/>\n\u03b1\u03c3\u03c6\u03b1\u03bb\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2.<\/li>\n<li><strong>\u0391\u03bd\u03b5\u03c0\u03b1\u03c1\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7<\/strong> \u03c3\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u03c5\u03c8\u03b7\u03bb\u03ae\u03c2 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7\u03c2<br \/>\n\u03bc\u03b5 \u03ae \u03c7\u03c9\u03c1\u03af\u03c2 ezetimibe, \u03b9\u03b4\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03b7 LDL \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9<br \/>\n\u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03c4\u03c9\u03bd ESC\/EAS \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/li>\n<li><strong>\u03a0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2<\/strong>,<br \/>\n\u03cc\u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03c5\u03c0\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae<br \/>\n\u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03bc\u03ac\u03c4\u03c9\u03bd.<\/li>\n<\/ul>\n<h2 id=\"targets\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">7<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c4\u03cc\u03c7\u03bf\u03b9 LDL: \u03c0\u03ce\u03c2 \u03bc\u03c0\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7 (ESC\/EAS \u2013 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bb\u03bf\u03b3\u03b9\u03ba\u03ae)<\/span><\/h2>\n<p>\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03bf\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03bc\u03c0\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03bd\u03bf \u03cc\u03c4\u03b1\u03bd:<br \/>\n<strong>\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03cc\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 LDL \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b1 \u201c\u03b2\u03b1\u03c3\u03b9\u03ba\u03ac\u201d (\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u00b1 ezetimibe).<br \/>\n\u039f \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b7 <strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5 \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03b7\u03c1\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c7\u03ae:<\/strong><br \/>\n\u038c\u03c3\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 LDL \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf, \u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03bc\u03ac\u03c4\u03c9\u03bd, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03b7 LDL \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u201c\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac\u201d \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7.<\/div>\n<h2 id=\"effectiveness\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">8<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1: \u03c4\u03b9 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03bf\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2<\/span><\/h2>\n<p><!-- TABLE TITLE BAR --><\/p>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u039f\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c4\u03c9\u03bd PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ce\u03bd \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7<br \/>\n<strong>\u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2<\/strong> \u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5<br \/>\n<strong>\u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5<br \/>\n<strong>\u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03b7\u03c1\u03c9\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf<\/strong> \u03ae<br \/>\n<strong>\u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf<\/strong> \u03c0\u03b1\u03c1\u03ac \u03c4\u03b7 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae.<br \/>\n\u039f \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 \u03c3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03b5\u03b9 \u03c4\u03b1 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03c9\u03bd \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd.<\/p>\n<div style=\"background: #f8fafc; border: 1px solid #e5e7eb; border-left: 4px solid #b70000; border-radius: 12px 12px 0 0; padding: 12px 14px; font-weight: 800; font-size: 15px; color: #111827;\">\ud83d\udcca \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u039c\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 PCSK9 \u2013 \u039c\u03b5\u03af\u03c9\u03c3\u03b7 LDL &amp; \u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u038c\u03c6\u03b5\u03bb\u03bf\u03c2<\/div>\n<div style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-top: 0; padding: 8px 12px; font-size: 13px; color: #374151;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div style=\"overflow-x: auto; border: 1px solid #e5e7eb; border-top: 0; border-radius: 0 0 12px 12px;\">\n<table style=\"border-collapse: collapse; width: 100%; min-width: 720px;\">\n<thead>\n<tr>\n<th style=\"text-align: left; padding: 12px 10px; background: #f3f4f6; border-bottom: 1px solid #e5e7eb; border-left: 4px solid #b70000; font-weight: 800;\"><span style=\"color: #000000;\">\u039c\u03b5\u03bb\u03ad\u03c4\u03b7<\/span><\/th>\n<th style=\"text-align: left; padding: 12px 10px; background: #f3f4f6; border-bottom: 1px solid #e5e7eb; border-left: 4px solid #b70000; font-weight: 800;\"><span style=\"color: #000000;\">\u03a0\u03b1\u03c1\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7<\/span><\/th>\n<th style=\"text-align: left; padding: 12px 10px; background: #f3f4f6; border-bottom: 1px solid #e5e7eb; border-left: 4px solid #b70000; font-weight: 800;\"><span style=\"color: #000000;\">\u039c\u03b5\u03af\u03c9\u03c3\u03b7 LDL<\/span><\/th>\n<th style=\"text-align: left; padding: 12px 10px; background: #f3f4f6; border-bottom: 1px solid #e5e7eb; border-left: 4px solid #b70000; font-weight: 800;\"><span style=\"color: #000000;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">FOURIER<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">Evolocumab<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\"><strong>~59%<\/strong><\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">\u039c\u03b5\u03af\u03c9\u03c3\u03b7 \u03c3\u03c5\u03bc\u03b2\u03b1\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 ASCVD \u03cc\u03c4\u03b1\u03bd \u03b7 LDL \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ae<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">ODYSSEY OUTCOMES<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">Alirocumab<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\"><strong>~62%<\/strong><\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc ACS \u03bc\u03b5 \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 LDL<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px;\">ORION-10 \/ ORION-11<\/td>\n<td style=\"padding: 10px;\">Inclisiran<\/td>\n<td style=\"padding: 10px;\"><strong>~50%<\/strong><\/td>\n<td style=\"padding: 10px;\">\u0399\u03c3\u03c7\u03c5\u03c1\u03ae \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae LDL \u03bc\u03b5 \u03b1\u03c1\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 (long-term outcomes \u03c3\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2 id=\"cv-outcomes\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">9<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03b2\u03ac\u03bc\u03b1\u03c4\u03b1: \u03c4\u03b9 \u03ba\u03b5\u03c1\u03b4\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c0\u03ad\u03c1\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7 LDL<\/span><\/h2>\n<p>\u0397 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5. \u03a3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bc\u03b5 mAbs \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5<br \/>\n<strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03c9\u03bd<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<br \/>\n\u03a4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u201c\u03c5\u03c0\u03cc\u03c3\u03c4\u03c1\u03c9\u03bc\u03b1\u201d \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc (\u03c0.\u03c7. \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 ASCVD)<br \/>\n\u03ba\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u201c\u03c7\u03ce\u03c1\u03bf\u03c2\u201d \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 LDL.<\/p>\n<h2 id=\"comparison\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">10<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2, ezetimibe \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2<\/span><\/h2>\n<p style=\"margin: 8px 0 12px; line-height: 1.7;\">\u039f\u03b9 \u03c5\u03c0\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03c3\u03bf\u03b4\u03cd\u03bd\u03b1\u03bc\u03b5\u03c2 \u03c9\u03c2 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7 <strong>\u03b4\u03cd\u03bd\u03b1\u03bc\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 LDL<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf<br \/>\n<strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2<\/strong>.<br \/>\n\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03bf\u03b9 <strong>\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2<\/strong> \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c4\u03b7 \u03b2\u03ac\u03c3\u03b7,<br \/>\n\u03c4\u03bf <strong>ezetimibe<\/strong> \u03c0\u03c1\u03bf\u03c3\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b4\u03b5\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03b5\u03af,<br \/>\n\u03b5\u03bd\u03ce \u03bf\u03b9 <strong>PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2<\/strong> \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9<br \/>\n<strong>\u03c5\u03c8\u03b7\u03bb\u03cc\u03c2 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2<\/strong><br \/>\n\u03c0\u03b1\u03c1\u03ac \u03c4\u03b7 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae.<br \/>\n\u039f \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 \u03c3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03b5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc,<br \/>\n\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac.<\/p>\n<div style=\"background: #fff7ed; border: 1px solid #fed7aa; border-radius: 10px; padding: 10px 12px; margin: 12px 0; font-size: 13px; color: #7c2d12;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div style=\"overflow-x: auto; border: 1px solid #e5e7eb; border-radius: 12px;\">\n<table style=\"border-collapse: collapse; width: 100%; min-width: 780px;\">\n<thead>\n<tr>\n<th style=\"text-align: left; padding: 12px 10px; background: #f3f4f6; border-bottom: 1px solid #e5e7eb; border-left: 4px solid #b70000; font-weight: 800; color: #111827;\">\u03a7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc<\/th>\n<th style=\"text-align: left; padding: 12px 10px; background: #f3f4f6; border-bottom: 1px solid #e5e7eb; border-left: 4px solid #b70000; font-weight: 800; color: #111827;\">\u03a3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2<\/th>\n<th style=\"text-align: left; padding: 12px 10px; background: #f3f4f6; border-bottom: 1px solid #e5e7eb; border-left: 4px solid #b70000; font-weight: 800; color: #111827;\">Ezetimibe<\/th>\n<th style=\"text-align: left; padding: 12px 10px; background: #f3f4f6; border-bottom: 1px solid #e5e7eb; border-left: 4px solid #b70000; font-weight: 800; color: #111827;\">PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\"><strong>\u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2<\/strong><\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">\u2193 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 (HMG-CoA reductase)<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">\u2193 \u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c1\u03c1\u03cc\u03c6\u03b7\u03c3\u03b7 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">\u2191 LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2\/\u03bc\u03b5\u03af\u03c9\u03c3\u03b7\u03c2 PCSK9<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\"><strong>\u039c\u03b5\u03af\u03c9\u03c3\u03b7 LDL<\/strong><\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">~30\u201355% (\u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7)<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">~15\u201325%<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\"><strong>~50\u201365%<\/strong> (\u03c3\u03c5\u03c7\u03bd\u03ac \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c4\u03b7\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2)<\/td>\n<\/tr>\n<tr>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\"><strong>\u0391\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2<\/strong><\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">\u03bc\u03c5\u03b1\u03bb\u03b3\u03af\u03b5\u03c2 (\u03c3\u03b5 \u03bc\u03b5\u03c1\u03af\u03b4\u03b1), \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ac \u03ad\u03bd\u03b6\u03c5\u03bc\u03b1 (\u03c3\u03c0\u03ac\u03bd\u03b9\u03b1)<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03ae\u03c0\u03b9\u03b5\u03c2\/\u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2<\/td>\n<td style=\"border-bottom: 1px solid #e5e7eb; padding: 10px;\">\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px;\"><strong>\u0394\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1<\/strong><\/td>\n<td style=\"padding: 10px;\">\u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ac (per os)<\/td>\n<td style=\"padding: 10px;\">\u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ac (per os)<\/td>\n<td style=\"padding: 10px;\">\u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1, \u03b1\u03c1\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b1 (\u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03c3\u03c7\u03ae\u03bc\u03b1\/\u03bc\u03cc\u03c1\u03b9\u03bf)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2 id=\"residual-risk\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">11<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u00ab\u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2\u00bb<br \/>\n<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u03a0\u03b1\u03c1\u03ac \u03c4\u03b7\u03bd \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2,<br \/>\n\u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03b7\u03c1\u03c9\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf (ASCVD)<br \/>\n\u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03bd\u03ad\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03b2\u03ac\u03bc\u03b1\u03c4\u03b1.<br \/>\n\u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 <strong>\u00ab\u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2\u00bb<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03bf \u03b8\u03b5\u03c9\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03c9\u03bd PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ce\u03bd.<\/p>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u039f\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2,<br \/>\n\u03cc\u03bc\u03c9\u03c2 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 <strong>\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 PCSK9<\/strong> \u03c9\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b1\u03bd\u03ac\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2.<br \/>\n\u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9, \u03cc\u03c3\u03bf \u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 LDL \u03bc\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2,<br \/>\n\u03c4\u03cc\u03c3\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 PCSK9 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd.<br \/>\n\u039f\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03bd\u03b1 \u00ab\u03c3\u03c0\u03ac\u03c3\u03bf\u03c5\u03bd\u00bb \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c6\u03c1\u03ad\u03bd\u03bf,<br \/>\n\u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03bf\u03c5\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03bf\u03af.<\/p>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u03a3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 (FOURIER \u03ba\u03b1\u03b9 ODYSSEY OUTCOMES),<br \/>\n\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03c7\u03b1\u03bd \u03ae\u03b4\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae LDL \u03c5\u03c0\u03cc \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7,<br \/>\n\u03b1\u03bb\u03bb\u03ac \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd PCSK9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1,<br \/>\n\u03b5\u03af\u03b4\u03b1\u03bd \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c0\u03c1\u03cc\u03c4\u03b9\u03bd\u03bf\u03c2 \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03bd \u00ab\u03c0\u03bf\u03bb\u03cd \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac\u00bb.<br \/>\n\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03c4\u03b7\u03ba\u03b1\u03bd \u03b1\u03c0\u03cc<br \/>\n<strong>\u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b5\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03ac\u03c4\u03c9\u03bd, \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03c9\u03bd<br \/>\n\u03ba\u03b1\u03b9 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b1\u03b9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7<\/strong>.<br \/>\n\u0391\u03c5\u03c4\u03cc \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b5 \u03cc\u03c4\u03b9 \u03b7 LDL \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u00ab\u03ba\u03b1\u03c4\u03ce\u03c6\u03bb\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b5\u03af\u03b1\u03c2\u00bb \u03c3\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c0\u03b1\u03cd\u03b5\u03b9.<\/p>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u0397 \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae<br \/>\n\u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1<\/strong>,<br \/>\n\u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 <strong>\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03c3\u03b5 \u03cc\u03c3\u03bf\u03c5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd <strong>\u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong><br \/>\n\u03cc\u03c0\u03c9\u03c2 \u03bf \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2 \u03ae \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 Lp(a).<br \/>\n\u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2, \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 LDL \u03c4\u03b9\u03bc\u03ad\u03c2 \u03ba\u03bf\u03bd\u03c4\u03ac \u03c3\u03c4\u03bf\u03c5\u03c2 \u00ab\u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2\u00bb<br \/>\n\u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf.<\/p>\n<p style=\"margin: 6px 0 0; line-height: 1.7;\">\u039f\u03b9 PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2,<br \/>\n\u03b1\u03bb\u03bb\u03ac \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 <strong>\u03c0\u03bf\u03bb\u03c5\u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b7 \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7<\/strong> \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf<br \/>\n\u03c4\u03b7 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03b8\u03b7\u03c1\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b2\u03ac\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2.<br \/>\n\u039c\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf, \u03bc\u03b5\u03c4\u03b1\u03c4\u03c1\u03ad\u03c0\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ae \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 LDL<br \/>\n\u03c3\u03b5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae <strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>,<br \/>\n\u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03b6\u03b7\u03c4\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n<h2 id=\"safety\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">12<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u03a3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac, \u03bf\u03b9 PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd<br \/>\n<strong>\u03c0\u03bf\u03bb\u03cd \u03ba\u03b1\u03bb\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2<\/strong> \u03c3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7.<br \/>\n\u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03ae\u03c0\u03b9\u03b5\u03c2<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd <strong>\u03c5\u03c0\u03bf\u03b4\u03cc\u03c1\u03b9\u03b1 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03b5 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/p>\n<ul style=\"margin: 8px 0 0 18px; line-height: 1.85;\">\n<li>\u0389\u03c0\u03b9\u03bf\u03c2 \u03b5\u03c1\u03b5\u03b8\u03b9\u03c3\u03bc\u03cc\u03c2, \u03b5\u03c1\u03c5\u03b8\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ae \u03c0\u03cc\u03bd\u03bf\u03c2 \u03c3\u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2<\/li>\n<li>\u03a3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 \u201c\u03ba\u03c1\u03c5\u03bf\u03bb\u03bf\u03b3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2\u201d \u03ae \u03c1\u03b9\u03bd\u03bf\u03c6\u03b1\u03c1\u03c5\u03b3\u03b3\u03af\u03c4\u03b9\u03b4\u03b1 \u03c3\u03b5 \u03bc\u03b5\u03c1\u03af\u03b4\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<\/li>\n<li>\u03a3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c3\u03b7:<\/strong><br \/>\n\u03a3\u03b5 \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2, \u03bf\u03b9 PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2<br \/>\n<strong>\u03b4\u03b5\u03bd \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b7\u03c0\u03b1\u03c4\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ae \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/strong>.<br \/>\n\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7<br \/>\n<strong>\u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03cc\u03c4\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03af \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9.<\/div>\n<h2 id=\"special-groups\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">13<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2: \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9, \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae &amp; \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2<br \/>\n<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u039f\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<br \/>\n\u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03cc\u03c4\u03b1\u03bd \u03bf<br \/>\n<strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c2<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2.<\/p>\n<ul style=\"margin: 8px 0 0 18px; line-height: 1.85;\">\n<li><strong>\u0397\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9:<\/strong> \u03c3\u03c5\u03c7\u03bd\u03ac \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03ad\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1 \u03ae \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc, \u03ac\u03c1\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c9\u03c6\u03b5\u03bb\u03b7\u03b8\u03bf\u03cd\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL.<\/li>\n<li><strong>\u03a3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2:<\/strong> \u03bf\u03b9 PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf \u03c3\u03ac\u03ba\u03c7\u03b1\u03c1\u03bf \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b5\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/li>\n<li><strong>\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03ae \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2:<\/strong> \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b4\u03b5\u03bd \u03b2\u03b1\u03c3\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2\u00b7 \u03b7 \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb.<\/li>\n<\/ul>\n<h2 id=\"lpa\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">14<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd Lp(a): \u03c4\u03b9 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5<br \/>\n<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u0397 <strong>\u03bb\u03b9\u03c0\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7(a)<\/strong> \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1\u03bd<br \/>\n<strong>\u03b1\u03bd\u03b5\u03be\u03ac\u03c1\u03c4\u03b7\u03c4\u03bf \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong><br \/>\n\u03c0\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf ezetimibe.<br \/>\n\u03a4\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 PCSK9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9<br \/>\n<strong>\u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03b1\u03bb\u03bb\u03ac \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03ce\u03b3\u03b9\u03bc\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 Lp(a)<\/strong>,<br \/>\n\u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03ac\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 <strong>20\u201330%<\/strong>.<\/p>\n<p style=\"margin: 6px 0 0; line-height: 1.7;\">\u03a0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03b1\u03c5\u03c4\u03ae \u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03c3\u03b1,<br \/>\n\u03b7 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03c4\u03c9\u03bd PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd<br \/>\n\u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b7 <strong>\u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2<\/strong><br \/>\n\u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b7 <strong>\u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong><br \/>\n\u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/p>\n<h2 id=\"practical\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">15<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03b8\u03ad\u03bc\u03b1\u03c4\u03b1: \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7, \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u03c3\u03c5\u03bc\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7<br \/>\n<\/span><\/h2>\n<p style=\"margin: 6px 0 12px; line-height: 1.7;\">\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03ad\u03bd\u03c4\u03b1\u03be\u03b7 \u03b5\u03bd\u03cc\u03c2<br \/>\n<strong>PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1<\/strong> \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03ad\u03bd\u03b1 \u03c3\u03b1\u03c6\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9:<br \/>\n<strong>\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong> \u2192<br \/>\n<strong>\u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b1\u03bd\u03b5\u03ba\u03c4\u03ae \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<\/strong> (\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u00b1 ezetimibe) \u2192<br \/>\n<strong>\u03b5\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 LDL<\/strong> \u2192<br \/>\n\u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae\u03c2 \u03cc\u03c4\u03b1\u03bd \u03bf<br \/>\n<strong>\u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2 \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03b7\u03c1\u03c9\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2<\/strong><br \/>\n\u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c2.<br \/>\n\u039f \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b7 \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd,<br \/>\n\u03b1\u03bb\u03bb\u03ac \u03b7 <strong>\u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03ae \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd<br \/>\n\u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd<\/strong>.<\/p>\n<ul style=\"margin: 8px 0 0 18px; line-height: 1.85;\">\n<li><strong>\u03a0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7:<\/strong><br \/>\n\u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c4\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03bf\u03cd \u03c0\u03c1\u03bf\u03c6\u03af\u03bb,<br \/>\n\u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03af\u03c4\u03b5\u03c5\u03be\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd LDL.<\/li>\n<li><strong>\u03a3\u03c5\u03bc\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7:<\/strong><br \/>\n\u03c4\u03b1 \u03bc\u03b1\u03ba\u03c1\u03ac \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 (\u03b9\u03b4\u03af\u03c9\u03c2 \u03bc\u03b5 inclisiran)<br \/>\n\u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b1\u03c1\u03ac\u03bb\u03b5\u03b9\u03c8\u03b7\u03c2 \u03b4\u03cc\u03c3\u03b5\u03c9\u03bd<br \/>\n\u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03b7.<\/li>\n<li><strong>\u03a3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03af:<\/strong><br \/>\n\u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b5\u03ba\u03c4\u03ac, \u03bf\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9<br \/>\n\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9\/\u03ae ezetimibe,<br \/>\n\u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL<br \/>\n\u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/li>\n<\/ul>\n<h2 id=\"pitfalls\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">16<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03bb\u03ac\u03b8\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b3\u03af\u03b4\u03b5\u03c2 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1\u03c2<br \/>\n<\/span><\/h2>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0;\"><strong>\u03a3\u03c5\u03c7\u03bd\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03bb\u03ac\u03b8\u03bf\u03c2:<\/strong><br \/>\n\u03bd\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac PCSK9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac \u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae<br \/>\n(\u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7 \u00b1 ezetimibe) \u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ae\u03c2 \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/div>\n<ul style=\"margin: 8px 0 0 18px; line-height: 1.85;\">\n<li><strong>\u03a5\u03c0\u03bf\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5:<\/strong> \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf \u03ad\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1 \u03ae \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/li>\n<li><strong>\u0391\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 LDL:<\/strong> \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03ad\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03be\u03ad\u03c1\u03bf\u03c5\u03bc\u03b5 \u03b1\u03bd \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03ad\u03c4\u03c5\u03c7\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c4\u03cc\u03c7\u03bf.<\/li>\n<li><strong>\u0395\u03c3\u03c4\u03af\u03b1\u03c3\u03b7 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc:<\/strong> \u03b7 LDL \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03bf \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03c9\u03bd.<\/li>\n<\/ul>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 14px 0;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong><br \/>\n\u039f\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u00ab\u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae\u00bb \u03c4\u03c9\u03bd \u03c3\u03c4\u03b1\u03c4\u03b9\u03bd\u03ce\u03bd,<br \/>\n\u03b1\u03bb\u03bb\u03ac <strong>\u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03bb\u03b5\u03b9\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong><br \/>\n\u03cc\u03c4\u03b1\u03bd \u03b7 LDL \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c3\u03c4\u03cc\u03c7\u03bf.<br \/>\n\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7, \u03b7 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd LDL \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<br \/>\n\u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ac \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae.<\/div>\n<h2 id=\"faq\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">17<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2;<\/summary>\n<p>\u0395\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd PCSK9 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 LDL \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c3\u03bf \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd LDL;<\/summary>\n<p>\u03a3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd LDL \u03ba\u03b1\u03c4\u03ac \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 50\u201365%, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03bc\u03cc\u03c1\u03b9\u03bf, \u03c4\u03bf \u03c3\u03c7\u03ae\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b7 \u03b1\u03b3\u03c9\u03b3\u03ae.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac mAbs \u03ba\u03b1\u03b9 inclisiran;<\/summary>\n<p>\u03a4\u03b1 mAbs \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1 PCSK9, \u03b5\u03bd\u03ce \u03c4\u03bf inclisiran \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae PCSK9 \u03c3\u03c4\u03bf \u03ae\u03c0\u03b1\u03c1 (siRNA), \u03bc\u03b5 \u03c0\u03b9\u03bf \u03b1\u03c1\u03b1\u03b9\u03ac \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b4\u03cc\u03c3\u03b5\u03c9\u03bd.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1;<\/summary>\n<p>\u039a\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 ASCVD \u03ba\u03b1\u03b9\/\u03ae \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1, \u03cc\u03c4\u03b1\u03bd \u03bf\u03b9 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 LDL \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03b1\u03b3\u03c9\u03b3\u03ae \u03ae \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1 \u03c3\u03b5 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03c6\u03b1\u03bb\u03b5\u03af\u03c2;<\/summary>\n<p>\u03a3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03ba\u03b1\u03bb\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2, \u03bc\u03b5 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03ae\u03c0\u03b9\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03ad\u03bd\u03b5\u03c3\u03b7\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd Lp(a);<\/summary>\n<p>\u03a4\u03b1 mAbs \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 PCSK9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03bc\u03ad\u03c4\u03c1\u03b9\u03b1 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 Lp(a) (\u03c3\u03c5\u03c7\u03bd\u03ac ~20\u201330%), \u03b1\u03bb\u03bb\u03ac \u03bf \u03ba\u03cd\u03c1\u03b9\u03bf\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b7 LDL.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c3\u03bf \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b1 \u03b1\u03c1\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03b1 \u03b4\u03c1\u03bf\u03c5\u03bd \u03bf\u03b9 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2;<\/summary>\n<p>\u03a3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 LDL \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 2\u20134 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1;<\/summary>\n<p>\u039d\u03b1\u03b9, \u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b5\u03ba\u03c4\u03ad\u03c2, \u03bf\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 LDL \u03ba\u03b1\u03b9 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2;<\/summary>\n<p>\u038c\u03c7\u03b9, \u03bf\u03b9 PCSK9 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b5\u03bd \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b7\u03c0\u03b1\u03c4\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c3\u03b5 \u03b4\u03b9\u03b1\u03b2\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2;<\/summary>\n<p>\u039d\u03b1\u03b9, \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03ba\u03b1\u03bb\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7 \u03c4\u03cd\u03c0\u03bf\u03c5 2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2;<\/summary>\n<p>\u039d\u03b1\u03b9, \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 65 \u03b5\u03c4\u03ce\u03bd \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c3\u03bf \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf;<\/summary>\n<p>\u03a3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03c9\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 15\u201320% \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03bf\u03b9\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2;<\/summary>\n<p>\u0395\u03ba\u03b5\u03af\u03bd\u03bf\u03b9 \u03bc\u03b5 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 ASCVD \u03ae \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03ae \u03c5\u03c0\u03b5\u03c1\u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03bf\u03bb\u03b1\u03b9\u03bc\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c3\u03c4\u03cc\u03c7\u03bf LDL \u03c0\u03b1\u03c1\u03ac \u03b2\u03ad\u03bb\u03c4\u03b9\u03c3\u03c4\u03b7 \u03b1\u03b3\u03c9\u03b3\u03ae.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2;<\/summary>\n<p>\u039d\u03b1\u03b9, \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b7\u03b8\u03bf\u03cd\u03bd \u03c9\u03c2 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae.<\/p>\n<\/details>\n<h2 id=\"cta\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">18<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd &amp; \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bb\u03b9\u03c0\u03b9\u03b4\u03af\u03c9\u03bd<br \/>\n<\/span><\/h2>\n<p style=\"margin: 6px 0 14px; line-height: 1.7;\"><strong>\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2.<\/strong><br \/>\n\u0391\u03bd \u03ad\u03c7\u03b5\u03c4\u03b5 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 <strong>LDL \u03c7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2, Lp(a), ApoB \u03ae \u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb<\/strong>,<br \/>\n\u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bc\u03b5 \u03bd\u03b1 \u03c4\u03b9\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03b1\u03c2 \u03ba\u03b1\u03b8\u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b2\u03ae\u03bc\u03b1\u03c4\u03b1.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center;\">\n<div><strong>\u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\"><br \/>\n\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<br \/>\n<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\"><br \/>\n\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<br \/>\n<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<h2 id=\"bibliography\" style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">19<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<br \/>\n<\/span><\/h2>\n<div style=\"font-size: 14px; line-height: 1.6;\">\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 8px 0;\"><strong>1.<\/strong> Sabatine MS et al. <em>Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease<\/em>. N Engl J Med, 2017.<br \/>\n<a href=\"https:\/\/doi.org\/10.1056\/NEJMoa1615664\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1056\/NEJMoa1615664<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 8px 0;\"><strong>2.<\/strong> Schwartz GG et al. <em>Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome<\/em>. N Engl J Med, 2018.<br \/>\n<a href=\"https:\/\/doi.org\/10.1056\/NEJMoa1801174\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1056\/NEJMoa1801174<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 8px 0;\"><strong>3.<\/strong> Raal FJ et al. <em>Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia<\/em>. N Engl J Med, 2020.<br \/>\n<a href=\"https:\/\/doi.org\/10.1056\/NEJMoa1913805\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1056\/NEJMoa1913805<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 8px 0;\"><strong>4.<\/strong> Ray KK et al. <em>Safety and Efficacy of Inclisiran in Patients with ASCVD<\/em>. J Am Coll Cardiol, 2021.<br \/>\n<a href=\"https:\/\/doi.org\/10.1016\/j.jacc.2020.11.065\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1016\/j.jacc.2020.11.065<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 8px 0;\"><strong>5.<\/strong> Mach F et al. <em>2019 ESC\/EAS Guidelines for the management of dyslipidaemias<\/em>. Eur Heart J, 2020.<br \/>\n<a href=\"https:\/\/doi.org\/10.1093\/eurheartj\/ehz455\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1093\/eurheartj\/ehz455<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 8px 0;\"><strong>6.<\/strong> Reiner \u017d et al. <em>PCSK9 Inhibitors \u2014 Mechanisms of Action and Clinical Applications<\/em>. Nat Rev Cardiol, 2022.<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/s41569-021-00595-2\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/doi.org\/10.1038\/s41569-021-00595-2<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 8px 0;\"><strong>7.<\/strong> \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1 \u2013 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"dofollow noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 12px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n","protected":false},"excerpt":{"rendered":"<p>PCSK9 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2: \u039c\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2, \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03a7\u03c1\u03ae\u03c3\u03b7 &amp; \u039c\u03b5\u03af\u03c9\u03c3\u03b7 LDL \u03a7\u03bf\u03bb\u03b7\u03c3\u03c4\u03b5\u03c1\u03cc\u03bb\u03b7\u03c2 (Therapeutic Knowledge Hub) \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 11 \u0399\u03b1\u03bd\u03bf\u03c5\u03b1\u03c1\u03af\u03bf\u03c5 2026 \u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc Knowledge Hub. \u0397 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u03c3\u03b5\u03bb\u03af\u03b4\u03b1 \u03c3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03bb\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd PCSK9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd (\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 siRNA), \u03c4\u03bf\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2, \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c4\u03b9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b9\u03c0\u03b9\u03b4\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5. \u03a4\u03b9 [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":8979,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2541],"tags":[2811,238,2809,215,2810,103,43,2808,2804,41,222,2807],"class_list":["post-2803","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-odigoi-farmakon","tag-alirocumab","tag-ascvd","tag-dyslipidemia","tag-evolocumab","tag-familial-hypercholesterolemia","tag-inclisiran","tag-ldl","tag-ldl-cholesterol","tag-lipoproteina","tag-lpa","tag-pcsk9","tag-pcsk9-inhibitors"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/2803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=2803"}],"version-history":[{"count":9,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/2803\/revisions"}],"predecessor-version":[{"id":8980,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/2803\/revisions\/8980"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/8979"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=2803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=2803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=2803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}