{"id":10507,"date":"2026-03-25T22:56:57","date_gmt":"2026-03-25T20:56:57","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=10507"},"modified":"2026-03-25T22:56:57","modified_gmt":"2026-03-25T20:56:57","slug":"eleftheres-kai-l-alisides-orou","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/eleftheres-kai-l-alisides-orou\/","title":{"rendered":"\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u0391\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u039f\u03c1\u03bf\u03cd: \u039b\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb, \u03a4\u03b9\u03bc\u03ad\u03c2 &#038; \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1"},"content":{"rendered":"<div style=\"max-width: 1000px; margin: 0 auto; font-family: system-ui,-apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif; color: #111827;\">\n<h1 style=\"font-size: 44px; line-height: 1.15; font-weight: 800; margin: 0 0 14px; color: #111827;\">\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u0391\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u039f\u03c1\u03bf\u03cd (Free Light Chains): \u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u0391\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u039b\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb, \u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03a4\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/h1>\n<div style=\"margin: 10px 0 12px; font-size: 13px; color: #6b7280;\">\u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: <time datetime=\"2026-03-25\">25 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time> \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: <time datetime=\"2026-03-25\">25 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time><\/div>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 0 0 16px;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03ba\u03c1\u03b1\u03c4\u03ae\u03c3\u03b5\u03c4\u03b5:<\/strong> \u039f\u03b9 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03b1\u03b8\u03b5\u03b9\u03ce\u03bd, \u03cc\u03c0\u03c9\u03c2 MGUS, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b9 AL \u03b1\u03bc\u03c5\u03bb\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7. \u03a4\u03bf \u03c0\u03b9\u03bf \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b7 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 \u03ba \u03ae \u03c4\u03b7\u03c2 \u03bb, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03bf <strong>\u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb<\/strong>, \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bd\u03b1 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/div>\n<nav id=\"toc\" style=\"background: #f9fafb; border-radius: 14px; padding: 18px 20px; margin: 0 0 14px;\">\n<div style=\"font-weight: 800; font-size: 18px; margin-bottom: 10px;\">\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/div>\n<ol style=\"margin: 0; padding-left: 18px; line-height: 1.8;\">\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section1\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section2\">\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section3\">\u03a0\u03bf\u03b9\u03b1 \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03ba, \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section4\">\u03a4\u03b9 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section5\">\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03c9\u03bd<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section6\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section7\">\u03a0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section8\">\u03a0\u03cc\u03c4\u03b5 \u03c4\u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section9\">\u0397 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section10\">\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section11\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section12\">\u03a0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section13\">\u03a0\u03ce\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section14\">\u03a3\u03c5\u03c7\u03bd\u03ac \u03bb\u03ac\u03b8\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section15\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section16\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section17\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: 0; border-top: 2px solid #d1d5db; margin: 0 0 18px;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<section id=\"section1\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">1<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd<\/span><\/h2>\n<p>\u039f\u03b9 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ac \u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b1 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03b5\u03b4\u03b5\u03bc\u03ad\u03bd\u03b1 \u03bc\u03b5 \u03b2\u03b1\u03c1\u03b9\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2. \u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2.<\/p>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03bc\u03b5\u03c4\u03c1\u03ac \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac \u03c4\u03b9\u03c2 <strong>free \u03ba<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 <strong>free \u03bb<\/strong> \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf\u03bd <strong>\u03bb\u03cc\u03b3\u03bf \u03ba\/\u03bb<\/strong>. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03c6\u03b1\u03bd\u03b5\u03af \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae, \u03b4\u03b7\u03bb\u03b1\u03b4\u03ae \u03c5\u03c0\u03b5\u03c1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b5\u03bd\u03cc\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ba\u03bb\u03ce\u03bd\u03bf \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd.<\/p>\n<p>\u0393\u03b9\u03b1 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03c0\u03b9\u03bf \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03b7\u03c4\u03cc, \u03bf\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b2\u03b1\u03c1\u03b9\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2. \u039f\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03cd\u03bf \u03c4\u03cd\u03c0\u03c9\u03bd: <strong>\u03ba<\/strong> \u03ba\u03b1\u03b9 <strong>\u03bb<\/strong>. \u038c\u03c4\u03b1\u03bd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2, \u03ad\u03bd\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03ad\u03bd\u03b5\u03b9 \u00ab\u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf\u00bb \u03ba\u03b1\u03b9 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03b5\u03af \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1. \u038c\u03c4\u03b1\u03bd \u03cc\u03bc\u03c9\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03c9\u03bd \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c7\u03b8\u03b5\u03af \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1\u03c2.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03b8\u03ad\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1. \u0394\u03b5\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b1\u03bd \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ae \u03b1\u03bd \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf <strong>MGUS<\/strong>, \u03c4\u03bf <strong>\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/strong>, \u03c4\u03bf <strong>light-chain multiple myeloma<\/strong> \u03ba\u03b1\u03b9 \u03b7 <strong>AL \u03b1\u03bc\u03c5\u03bb\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7<\/strong>.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 2 ==================== --><\/p>\n<section id=\"section2\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">2<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/span><\/h2>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 \u03ae \u03cc\u03c4\u03b1\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b5\u03af \u03ae \u03bd\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03b8\u03b5\u03af \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03c9\u03bd \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03bf\u03cd check-up \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03bb\u03cc \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03ba\u03ad\u03c4\u03bf \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7.<\/p>\n<p>\u03a3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03c2 \u03bb\u03cc\u03b3\u03bf\u03b9 \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03b5\u03bb\u03af\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8;\">\n<li>\u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd,<\/li>\n<li>\u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03bf\u03c3\u03c4\u03b9\u03ba\u03ac \u03ac\u03bb\u03b3\u03b7 \u03ae \u03c5\u03c0\u03b5\u03c1\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1 \u03bc\u03b5 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2,<\/li>\n<li>\u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 MGUS, light-chain MGUS \u03ae light-chain multiple myeloma,<\/li>\n<li>\u03c5\u03c0\u03bf\u03c8\u03af\u03b1 AL \u03b1\u03bc\u03c5\u03bb\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7\u03c2,<\/li>\n<li>\u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae\u03c2 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03ba\u03c1\u03b1\u03c3\u03af\u03b1\u03c2.<\/li>\n<\/ul>\n<p>\u03a3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03bf \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03ae\u03c3\u03b5\u03b9 free light chains \u03cc\u03c4\u03b1\u03bd \u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03b5\u03c5\u03c1\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b5\u03be\u03b7\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b1\u03c0\u03cc \u03c3\u03c5\u03bd\u03b7\u03b8\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2. \u0388\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7, \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03a4\u039a\u0395, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bf\u03bb\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf. \u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c4\u03cc\u03c4\u03b5 \u03bc\u03c0\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1.<\/p>\n<p>\u0395\u03c0\u03af\u03c3\u03b7\u03c2, \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ae\u03b4\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1, \u03bf\u03b9 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03ce\u03c3\u03bf\u03c5\u03bd \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b7 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03c4\u03b7\u03c2 involved \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2, \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b9\u03c3\u03bf\u03c1\u03c1\u03bf\u03c0\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bb\u03cc\u03b3\u03bf\u03c5 \u03ba\/\u03bb \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 3 ==================== --><\/p>\n<section id=\"section3\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">3<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bf\u03b9\u03b1 \u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03ba, \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac<\/span><\/h2>\n<p>\u0397 \u03c6\u03c1\u03ac\u03c3\u03b7 \u00ab\u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2\u00bb \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd. \u038c\u03bc\u03c9\u03c2 \u03bf\u03b9 <strong>\u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2<\/strong> \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7: \u03bc\u03b5\u03c4\u03c1\u03ac \u03c4\u03bf \u03c4\u03bc\u03ae\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03b5\u03af \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1.<\/p>\n<p>\u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03bd\u03ad\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c4\u03b1\u03b8\u03b5\u03af \u03be\u03b5\u03c7\u03c9\u03c1\u03b9\u03c3\u03c4\u03ac \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf \u00ab\u03ba, \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2\u00bb. \u0395\u03b4\u03ce \u03c4\u03bf \u03ba\u03ad\u03bd\u03c4\u03c1\u03bf \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd <strong>serum free light chains<\/strong>, \u03cc\u03c7\u03b9 \u03b7 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b5\u03c5\u03c1\u03b5\u03c4\u03ae\u03c1\u03b9\u03bf \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd. \u0388\u03bd\u03b1 \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03ac\u03c1\u03b8\u03c1\u03bf \u00ab\u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2\u00bb \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03c9\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1, \u03c0\u03ce\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2 \u03ae \u03c4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba- \u03ae \u03bb-\u03c4\u03cd\u03c0\u03bf\u03c2 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1, \u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 <strong>\u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd<\/strong> \u03b1\u03c6\u03bf\u03c1\u03ac \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03c3\u03b1\u03c6\u03ae \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7.<\/p>\n<p>\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03b4\u03b5\u03bd \u03bc\u03b9\u03bb\u03ac\u03bc\u03b5 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03ba \u03ae \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd, \u03b1\u03bb\u03bb\u03ac \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ae \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf\u03c5 \u03ba\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03cc\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03ba\u03bf\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03af\u03b4\u03b9\u03b5\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 4 ==================== --><\/p>\n<section id=\"section4\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">4<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb<\/span><\/h2>\n<p>\u039f \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b4\u03c5\u03c3\u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03bf\u03c5 \u03b5\u03bd\u03cc\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b7\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03ac\u03bb\u03bb\u03bf. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03bf \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7\u03c2.<\/p>\n<p>\u0391\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b7 \u03ba \u03ba\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03b1\u03bd\u03b5\u03b2\u03b1\u03af\u03bd\u03b5\u03b9, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba-\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae. \u0391\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b7 \u03bb \u03ba\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03ad\u03c6\u03c4\u03b5\u03b9, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bb-\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae. \u03a0\u03b1\u03c1\u2019 \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac, \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc, \u03c4\u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03c4\u03b7\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7.<\/p>\n<p>\u039f \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf\u03c2 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03be\u03b5\u03c7\u03c9\u03c1\u03af\u03b6\u03b5\u03b9, \u03c9\u03c2 \u03ad\u03bd\u03b1\u03bd \u03b2\u03b1\u03b8\u03bc\u03cc, \u03bc\u03b9\u03b1 <strong>\u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7<\/strong> \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 <strong>\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03c1\u03bf\u03c0\u03ae<\/strong>. \u03a3\u03b5 \u03bc\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c5\u03be\u03b7\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b4\u03cd\u03bf \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c7\u03ad\u03c3\u03b7\u03c2. \u03a3\u03b5 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1, \u03cc\u03bc\u03c9\u03c2, \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03b5\u03bd\u03cc\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bc\u03b5\u03c4\u03b1\u03c4\u03cc\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 ratio.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2. \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03be\u03af\u03b6\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7, \u03c5\u03c0\u03b5\u03c1\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1, \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf M-spike \u03c3\u03c4\u03b7\u03bd \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc:<\/strong> \u03c3\u03c4\u03b9\u03c2 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03b4\u03b5\u03bd \u03ba\u03bf\u03b9\u03c4\u03ac\u03bc\u03b5 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03c4\u03b9\u03bc\u03ae. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 <strong>free \u03ba + free \u03bb + \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb + \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b9\u03bf \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<section id=\"section5\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">5<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03c9\u03bd<\/span><\/h2>\n<p>\u039f\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03b3\u03b9\u03b1 free \u03ba, free \u03bb \u03ba\u03b1\u03b9 \u03bb\u03cc\u03b3\u03bf \u03ba\/\u03bb <strong>\u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03ac\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03be\u03ad\u03bd\u03bf site<\/strong>. \u0395\u03be\u03b1\u03c1\u03c4\u03ce\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf assay, \u03c4\u03bf\u03bd \u03b1\u03bd\u03b1\u03bb\u03c5\u03c4\u03ae, \u03c4\u03b7 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b1 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03cd\u03c1\u03bf\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c5\u03b9\u03bf\u03b8\u03b5\u03c4\u03ae\u03c3\u03b5\u03b9 \u03c4\u03bf \u03ba\u03ac\u03b8\u03b5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b5\u03b9 \u03c9\u03c2 \u03ba\u03cd\u03c1\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b1 <strong>\u03cc\u03c1\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03c4\u03bf \u03b4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf<\/strong>. \u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c3\u03c4\u03b9\u03c2 free light chains, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03bf\u03c5\u03bd \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03cd\u03c1\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1.<\/p>\n<p>\u0388\u03bd\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03b5\u03ba\u03c4\u03cc\u03c2 \u03c4\u03c9\u03bd \u03c4\u03c5\u03c0\u03b9\u03ba\u03ce\u03bd \u03bf\u03c1\u03af\u03c9\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae. \u0388\u03bd\u03b1\u03c2 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03c2 \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03ba\u03b1\u03b8\u03b1\u03c1\u03ae \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03b1\u03c1\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03cc\u03c0\u03c9\u03c2 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03ae \u03ae\u03b4\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin-top: 10px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div style=\"overflow-x: auto; margin-top: 10px;\">\n<table style=\"width: 100%; min-width: 760px; border-collapse: collapse; font-size: 14px;\">\n<thead>\n<tr style=\"background: #f9fafb;\">\n<th style=\"text-align: left; padding: 10px; border: 1px solid #e5e7eb;\">\u03a0\u03b1\u03c1\u03ac\u03bc\u03b5\u03c4\u03c1\u03bf\u03c2<\/th>\n<th style=\"text-align: left; padding: 10px; border: 1px solid #e5e7eb;\">\u03a4\u03b9 \u03bc\u03b5\u03c4\u03c1\u03ac<\/th>\n<th style=\"text-align: left; padding: 10px; border: 1px solid #e5e7eb;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac<\/th>\n<th style=\"text-align: left; padding: 10px; border: 1px solid #e5e7eb;\">\u03a4\u03b9 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03ad\u03be\u03b5\u03c4\u03b5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">Free \u03ba<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u03a4\u03b7\u03bd \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03c9\u03bd \u03ba \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c5\u03be\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03ae \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0394\u03b5\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">Free \u03bb<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u03a4\u03b7\u03bd \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03c9\u03bd \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u03a7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03b9\u03b4\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03bf\u03c8\u03b9\u03b1\u03b6\u03cc\u03bc\u03b1\u03c3\u03c4\u03b5 \u03bb-\u03ba\u03bb\u03ce\u03bd\u03bf<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u03a3\u03c5\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03bc\u03b5 free \u03ba<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u039b\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u03a4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u03a3\u03c5\u03c7\u03bd\u03ac \u03c4\u03bf \u03c0\u03b9\u03bf \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03b3\u03b9\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0395\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u03a3\u03b5 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae, \u03c4\u03bf \u03c0\u03b9\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03b5\u03be\u03ae\u03c2: \u03ba\u03bf\u03b9\u03c4\u03ac\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c4\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c4\u03ad\u03bb\u03b5\u03c3\u03b5 \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03ba\u03ac\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u00ab\u03b5\u03ba\u03c4\u03cc\u03c2 \u03bf\u03c1\u03af\u03c9\u03bd\u00bb, \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<section id=\"section6\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">6<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/span><\/h2>\n<p>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c0\u03bb\u03ae \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 \u03b1\u03c0\u03cc \u03c6\u03bb\u03ad\u03b2\u03b1. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b1\u03bd\u03b1\u03bb\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03bf\u03c1\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03b2\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2: free \u03ba, free \u03bb \u03ba\u03b1\u03b9 ratio \u03ba\/\u03bb.<\/p>\n<p>\u03a3\u03c5\u03c7\u03bd\u03ac \u03c0\u03b1\u03c1\u03b1\u03b3\u03b3\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 <strong>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03bf\u03c1\u03bf\u03cd<\/strong>, <strong>\u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u03bf\u03c1\u03bf\u03cd<\/strong>, \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7, \u03b1\u03c3\u03b2\u03ad\u03c3\u03c4\u03b9\u03bf \u03ba\u03b1\u03b9 \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bf\u03cd\u03c1\u03c9\u03bd, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1.<\/p>\n<p>\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae, \u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ae. \u0394\u03b5\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b5\u03bc\u03b2\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03ae \u03b3\u03b9\u03b1 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2. \u0397 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b1 \u03b4\u03b5\u03bd \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03c4\u03bf\u03c5 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c3\u03c4\u03b7\u03bd \u03bf\u03c1\u03b8\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bf\u03b9 free light chains \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b6\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03ae\u03b4\u03b7 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1. \u0386\u03c1\u03b1 \u03b7 \u03b1\u03be\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5\u03b3\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b6\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<section id=\"section7\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">7<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03b1\u03b9\u03bc\u03bf\u03bb\u03b7\u03c8\u03af\u03b1<\/span><\/h2>\n<p>\u03a3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 free light chains. \u03a0\u03b1\u03c1\u2019 \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac, \u03b1\u03bd \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03b9\u03c2, \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03ce\u03c3\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2.<\/p>\n<p>\u03a7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03ba\u03bf\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7, \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7, \u03b3\u03b9\u03b1\u03c4\u03af \u03b7 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b1\u03be\u03af\u03b1. \u03a3\u03c4\u03b9\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2, \u03b7 \u03c4\u03ac\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c7\u03c1\u03cc\u03bd\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c0\u03b9\u03bf \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1.<\/p>\n<p>\u0391\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf, \u03b1\u03bd \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03c3\u03b5 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03ae \u03b1\u03bd \u03ad\u03c7\u03b5\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf, \u03ba\u03b1\u03bb\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c4\u03bf \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9. \u0391\u03c5\u03c4\u03cc \u03b2\u03bf\u03b7\u03b8\u03ac \u03c4\u03bf\u03bd \u03b8\u03b5\u03c1\u03ac\u03c0\u03bf\u03bd\u03c4\u03b1 \u03b9\u03b1\u03c4\u03c1\u03cc \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03c3\u03b5\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bb\u03bb\u03b1\u03b3\u03ae \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03cd\u03b3\u03b5\u03b9 \u03bb\u03ac\u03b8\u03bf\u03c2 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac:<\/strong> \u03ba\u03c1\u03b1\u03c4\u03ae\u03c3\u03c4\u03b5 \u03bc\u03b1\u03b6\u03af \u03c3\u03b1\u03c2 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7\u03c2, \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7\u03c2, \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 free light chains. \u0397 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c0\u03b1\u03bb\u03b1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 8 ==================== --><\/p>\n<section id=\"section8\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">8<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03c4\u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/span><\/h2>\n<p>\u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 free light chains \u03b4\u03b5\u03bd \u03b9\u03c3\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03bf\u03cd\u03bd \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7, \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae, \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2, \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03bd\u03b1 \u00ab\u03bb\u03af\u03b3\u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u00bb \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03b1\u03c6\u03ce\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03bb\u03cc\u03b3\u03bf \u03ba\/\u03bb \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03bf\u03b4\u03ac \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ae \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1.<\/p>\n<p>\u03a0\u03bf\u03bb\u03bb\u03bf\u03af \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03bf\u03cd\u03bd \u03cc\u03c4\u03b1\u03bd \u03b2\u03bb\u03ad\u03c0\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03c4\u03b9\u03bc\u03ae \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03cc\u03c1\u03b9\u03bf. \u03a3\u03c4\u03b9\u03c2 free light chains, \u03cc\u03bc\u03c9\u03c2, \u03b1\u03c5\u03c4\u03cc \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af. \u0397 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03c0\u03cc\u03c3\u03bf \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c4\u03b9\u03bc\u03ae, \u03b1\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7 \u03bc\u03af\u03b1 \u03ae \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b4\u03cd\u03bf \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2, \u03b1\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb \u03ba\u03b1\u03b9 \u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2.<\/p>\n<p>\u039c\u03b5 \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03bc\u03b9\u03b1 \u03ae\u03c0\u03b9\u03b1 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03b1\u03c6\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 involved \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 \u03bc\u03b5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ce\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc ratio. \u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc\u03bd, \u03bf\u03b9 free light chains \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c0\u03bf\u03bb\u03cd, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03b2\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c4\u03b1\u03bd \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03ba\u03c4\u03cc\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c0\u03bb\u03b1\u03b9\u03c3\u03af\u03bf\u03c5.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 9 ==================== --><\/p>\n<section id=\"section9\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">9<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0397 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2<\/span><\/h2>\n<p>\u0397 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1. \u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03bf\u03b9 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03bc\u03b1\u03ba\u03c1\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b5\u03c6\u03c1\u03bf\u03cd\u03c2, \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b5\u03b2\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b5\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c4\u03bf\u03c0\u03af\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03ba\/\u03bb.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7 \u03ae \u03c4\u03bf eGFR \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03cc\u03c0\u03c9\u03c2 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf \u03bc\u03b5 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1. \u0395\u03ba\u03b5\u03af \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ad\u03bc\u03c6\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/p>\n<p>\u0391\u03c5\u03c4\u03cc \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03b4\u03cd\u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03af\u03b4\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03b9\u03bc\u03ad\u03c2 free \u03ba \u03b4\u03b5\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf. \u0391\u03bd \u03bf \u03ad\u03bd\u03b1\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03bd\u03b5\u03c6\u03c1\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03bf \u03ac\u03bb\u03bb\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b2\u03b1\u03c1\u03cd\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03af\u03b4\u03b9\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae.<\/p>\n<p>\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae, \u03c4\u03bf \u03c0\u03b9\u03bf \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 free light chains \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c0\u03bf\u03c4\u03ad \u03b4\u03b5\u03bd \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03bc\u03b1\u03c4\u03b9\u03ac \u03c3\u03b5 <strong>\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7<\/strong> \u03ba\u03b1\u03b9 <strong>eGFR<\/strong>. \u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc, \u03cc\u03c4\u03b1\u03bd \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03ae \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03b8\u03ad\u03c3\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 10 ==================== --><\/p>\n<section id=\"section10\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">10<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7<\/span><\/h2>\n<p>\u039f\u03b9 free light chains \u03b4\u03b5\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2. \u0391\u03bd\u03c4\u03b9\u03b8\u03ad\u03c4\u03c9\u03c2, \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c9\u03c2 \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<p>\u0397 <strong>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bf\u03c1\u03bf\u03cd<\/strong> \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03c6\u03b1\u03bd\u03b5\u03af \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03ba\u03bf\u03c1\u03c5\u03c6\u03ae \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03b5\u03af \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ac \u03ad\u03bd\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc. \u0397 <strong>\u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c0\u03bf\u03b9\u03bf\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 \u03ae \u03b5\u03bb\u03b1\u03c6\u03c1\u03ac\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9. \u039f\u03b9 <strong>free light chains<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b5\u03c2 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b5\u03bb\u03b1\u03c6\u03c1\u03ad\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03ae \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03c4\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b1\u03bb\u03bb\u03b9\u03ce\u03c2.<\/p>\n<p>\u0393\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc, \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2, \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03af\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7. \u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b1\u03c5\u03be\u03b7\u03b8\u03b5\u03af \u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c7\u03b1\u03b8\u03bf\u03cd\u03bd \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 light-chain disease.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\">\u2194\ufe0f \u03a3\u03cd\u03c1\u03b5\u03c4\u03b5 \u03bf\u03c1\u03b9\u03b6\u03cc\u03bd\u03c4\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03c3\u03c4\u03ae\u03bb\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03af\u03bd\u03b1\u03ba\u03b1<\/div>\n<div style=\"overflow-x: auto; margin-top: 10px;\">\n<table style=\"width: 100%; min-width: 820px; border-collapse: collapse; font-size: 14px;\">\n<thead>\n<tr style=\"background: #f9fafb;\">\n<th style=\"text-align: left; padding: 10px; border: 1px solid #e5e7eb;\">\u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/th>\n<th style=\"text-align: left; padding: 10px; border: 1px solid #e5e7eb;\">\u03a4\u03b9 \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9<\/th>\n<th style=\"text-align: left; padding: 10px; border: 1px solid #e5e7eb;\">\u03a0\u03cc\u03c4\u03b5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7<\/th>\n<th style=\"text-align: left; padding: 10px; border: 1px solid #e5e7eb;\">\u03a4\u03b9 \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bd\u03b1 \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0397\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03bf\u03c1\u03bf\u03cd<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u039c\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03ba\u03bf\u03c1\u03c5\u03c6\u03ae \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03bc\u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0391\u03c1\u03c7\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7 \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03ba\u03b1\u03bb\u03ac \u03bd\u03cc\u03c3\u03bf \u03bc\u03cc\u03bd\u03bf \u03bc\u03b5 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0391\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u03bf\u03c1\u03bf\u03cd<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u03a4\u03cd\u03c0\u03bf \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0395\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7 \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf\u03c5 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0394\u03b5\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03b7\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0391\u03c0\u03cc\u03bb\u03c5\u03c4\u03b5\u03c2 \u03c4\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03bb\u03cc\u03b3\u03bf \u03ba\/\u03bb<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b5\u03c2 \u03c3\u03b5 light-chain \u03bd\u03cc\u03c3\u03bf<\/td>\n<td style=\"padding: 10px; border: 1px solid #e5e7eb;\">\u0394\u03b5\u03bd \u03b8\u03ad\u03c4\u03bf\u03c5\u03bd \u03bc\u03cc\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd free light chains \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u00ab\u03b1\u03bd\u03c4\u03af\u00bb \u03c4\u03b7\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7\u03c2 \u03ae \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7\u03c2. \u0395\u03af\u03bd\u03b1\u03b9 \u00ab\u03bc\u03b1\u03b6\u03af \u03bc\u03b5\u00bb \u03b1\u03c5\u03c4\u03ad\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 11 ==================== --><\/p>\n<section id=\"section11\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">11<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/span><\/h2>\n<p>\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03c3\u03b5:<\/p>\n<ul style=\"padding-left: 18px; line-height: 1.8;\">\n<li>MGUS,<\/li>\n<li>light-chain MGUS,<\/li>\n<li>\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1,<\/li>\n<li>light-chain multiple myeloma,<\/li>\n<li>\u03c3\u03bc\u03bf\u03bb\u03b4\u03b5\u03cd\u03bf\u03bd \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1,<\/li>\n<li>AL \u03b1\u03bc\u03c5\u03bb\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7,<\/li>\n<li>\u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2.<\/li>\n<\/ul>\n<p>\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b8\u03ad\u03c4\u03b5\u03b9 \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7. \u0395\u03af\u03bd\u03b1\u03b9 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b1\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf.<\/p>\n<p>\u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03c3\u03c4\u03bf <strong>MGUS<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ae\u03c0\u03b9\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03ac\u03bc\u03b5\u03c3\u03b7 \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03cd \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2. \u03a3\u03c4\u03bf <strong>\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03bf\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b5\u03c2 \u03ae \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7. \u03a3\u03c4\u03bf <strong>light-chain multiple myeloma<\/strong> \u03bf\u03b9 free light chains \u03b1\u03c0\u03bf\u03ba\u03c4\u03bf\u03cd\u03bd \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7\u03bd \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ac \u03bc\u03b5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae M-spike \u03cc\u03c0\u03c9\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2.<\/p>\n<p>\u03a3\u03c4\u03b7\u03bd <strong>AL \u03b1\u03bc\u03c5\u03bb\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7<\/strong>, \u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b5\u03bb\u03b1\u03c6\u03c1\u03ce\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf, \u03b3\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03ba\u03b1\u03b9 \u03bf\u03b9 free light chains \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7. \u03a0\u03b1\u03c1\u2019 \u03cc\u03bb\u03b1 \u03b1\u03c5\u03c4\u03ac, \u03ba\u03ac\u03b8\u03b5 \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03ba\u03ac \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1, \u03b3\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03b9\u03ba\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b1\u03c5\u03c4\u03ac\u03c1\u03ba\u03b7\u03c2.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 12 ==================== --><\/p>\n<section id=\"section12\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">12<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/span><\/h2>\n<p>\u03a0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ce\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb, \u03cc\u03c4\u03b1\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03b7 involved chain, \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7 \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7, \u03ae \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ae \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7, \u03c5\u03c0\u03b5\u03c1\u03b1\u03c3\u03b2\u03b5\u03c3\u03c4\u03b9\u03b1\u03b9\u03bc\u03af\u03b1, \u03bf\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03cc\u03bd\u03bf\u03c2 \u03ae \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b1\u03b9\u03bc\u03af\u03b1.<\/p>\n<p>\u0391\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03bf\u03cd\u03bd \u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b5\u03c2, 24\u03c9\u03c1\u03b7 \u03c3\u03c5\u03bb\u03bb\u03bf\u03b3\u03ae \u03bf\u03cd\u03c1\u03c9\u03bd, \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03bf\u03cd\u03c1\u03c9\u03bd \u03b3\u03b9\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03ae \u03c0\u03b1\u03c1\u03b1\u03c0\u03bf\u03bc\u03c0\u03ae \u03c3\u03b5 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf.<\/p>\n<p>\u0394\u03b5\u03bd \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03bc\u03c9\u03c2 \u03c0\u03b1\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b1\u03c0\u03cc\u03ba\u03bb\u03b9\u03c3\u03b7. \u0395\u03ba\u03b5\u03af\u03bd\u03bf \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b2\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03c5\u03c1\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u03a3\u03b5 \u03ad\u03bd\u03b1\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2, \u03bf \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b9\u03bb\u03ad\u03be\u03b5\u03b9 \u03b5\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf. \u03a3\u03b5 \u03ac\u03bb\u03bb\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae, \u03bc\u03b5 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1, \u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03ac\u03bc\u03b5\u03c3\u03b7.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 12px;\"><strong>\u03a0\u03cc\u03c4\u03b5 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c0\u03bf\u03bc\u03c0\u03ae:<\/strong> \u03cc\u03c4\u03b1\u03bd \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ce\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2, \u03cc\u03c4\u03b1\u03bd \u03b7 involved \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03ae \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03ae \u03b8\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 13 ==================== --><\/p>\n<section id=\"section13\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">13<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7<\/span><\/h2>\n<p>\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03ba\u03c1\u03b1\u03c3\u03af\u03b1, \u03bf\u03b9 free light chains \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03b3\u03b9\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03ad\u03c3\u03c9 light chains. \u0397 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03c4\u03b9\u03bc\u03ae \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc \u03bc\u03b9\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7.<\/p>\n<p>\u0397 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03b4\u03b5\u03bd \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03bf\u03c4\u03ad \u03bc\u03cc\u03bd\u03bf \u03bc\u03b5 \u03bc\u03af\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7. \u039f \u03b8\u03b5\u03c1\u03ac\u03c0\u03c9\u03bd \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03b5\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7, \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7, \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bc\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03c3\u03c4\u03b9\u03c2 free light chains \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/p>\n<p>\u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 \u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ae \u03ae \u03b1\u03bd\u03bf\u03b4\u03b9\u03ba\u03ae \u03c4\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03c9\u03bd \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd \u03b4\u03af\u03bd\u03b5\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03ae \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5. \u0391\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03cc\u03c4\u03b5, \u03cc\u03bc\u03c9\u03c2, \u03bf \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03b1\u03c0\u03bf\u03ba\u03bf\u03bc\u03bc\u03ad\u03bd\u03bf\u03c2, \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<section id=\"section14\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">14<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ac \u03bb\u03ac\u03b8\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/span><\/h2>\n<ul style=\"padding-left: 18px; line-height: 1.8;\">\n<li>\u039d\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03ac\u03b8\u03b5 \u03bc\u03b9\u03ba\u03c1\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 free \u03ba \u03ae free \u03bb \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2.<\/li>\n<li>\u039d\u03b1 \u03b1\u03b3\u03bd\u03bf\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/li>\n<li>\u039d\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7.<\/li>\n<li>\u039d\u03b1 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae \u03c3\u03c4\u03b9\u03c2 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03cc\u03c1\u03b9\u03b1 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ac\u03c2.<\/li>\n<li>\u039d\u03b1 \u03c4\u03c1\u03bf\u03bc\u03ac\u03b6\u03b5\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u00ab\u03b5\u03ba\u03c4\u03cc\u03c2 \u03bf\u03c1\u03af\u03c9\u03bd\u00bb \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03c1\u03b9\u03bd \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03b8\u03b5\u03af \u03b7 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/li>\n<\/ul>\n<p>\u0388\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c6\u03ac\u03bb\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03bf\u03b8\u03b5\u03af \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03c4\u03b9\u03bc\u03ae \u03c4\u03b7\u03c2 \u03ba \u03ae \u03c4\u03b7\u03c2 \u03bb \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03b1\u03c3\u03c4\u03b5\u03af \u03b1\u03bd \u03b7 \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03c1\u03b9\u03ba\u03ae \u03ae \u03b1\u03c3\u03cd\u03bc\u03bc\u03b5\u03c4\u03c1\u03b7. \u0395\u03be\u03af\u03c3\u03bf\u03c5 \u03c3\u03c5\u03c7\u03bd\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc ratio \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc\u03c8\u03b7 \u03cc\u03c4\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b7\u03c1\u03b5\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1.<\/p>\n<p>\u0386\u03bb\u03bb\u03bf \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c3\u03b9\u03b1 \u00ab\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03cc\u03c1\u03b9\u03b1\u00bb \u03b1\u03c0\u03cc \u03c4\u03bf \u03b4\u03b9\u03b1\u03b4\u03af\u03ba\u03c4\u03c5\u03bf \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03c3\u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1. \u03a3\u03c4\u03b9\u03c2 free light chains \u03b1\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03b9\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf, \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03ae \u03c3\u03c4\u03b7 \u03bc\u03bf\u03bd\u03ac\u03b4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03c0\u03b5\u03c1\u03b4\u03ad\u03c8\u03bf\u03c5\u03bd \u03c4\u03cc\u03c3\u03bf \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1\u03bd \u03bc\u03b7 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c3\u03c4\u03b7.<\/p>\n<p>\u03a4\u03ad\u03bb\u03bf\u03c2, \u03ba\u03b1\u03bb\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03bf \u03ac\u03ba\u03c1\u03bf: \u03b7 \u03c5\u03c0\u03bf\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03c3\u03b1\u03c6\u03ce\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2. \u038c\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c4\u03bf\u03c5 \u03bb\u03cc\u03b3\u03bf\u03c5 \u03ba\/\u03bb \u03ae \u03b9\u03c3\u03c7\u03c5\u03c1\u03ac \u03c3\u03c5\u03bd\u03bf\u03b4\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1, \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b1\u03be\u03af\u03b6\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b1\u03c0\u03bb\u03ae \u03b1\u03bd\u03b1\u03bc\u03bf\u03bd\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/p>\n<\/section>\n<p><!-- ==================== SECTION 15 ==================== --><\/p>\n<section id=\"section15\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">15<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039f\u03b9 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2;<\/summary>\n<p>\u038c\u03c7\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c4\u03b5\u03bd\u03ae \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1. \u0395\u03af\u03bd\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03b1\u03b8\u03b5\u03b9\u03ce\u03bd, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03bc\u03cc\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03bd \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2, \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c3\u03af\u03b3\u03bf\u03c5\u03c1\u03b1 \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1;<\/summary>\n<p>\u038c\u03c7\u03b9. \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03bc\u03b5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7, \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7, \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e7eb; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03b7 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1;<\/summary>\n<p>\u039d\u03b1\u03b9. \u0397 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c5\u03be\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03ba\/\u03bb, \u03b3\u03b9\u2019 \u03b1\u03c5\u03c4\u03cc \u03b7 \u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03bd\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf eGFR \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b7\u03c3\u03c4\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7;<\/summary>\n<p>\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03cc\u03c7\u03b9, \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b1\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03b5\u03c4\u03bf\u03b9\u03bc\u03b1\u03c3\u03af\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae, \u03b7 free \u03ba, \u03b7 free \u03bb \u03ae \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2;<\/summary>\n<p>\u03a3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b7 \u03c0\u03b9\u03bf \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c0\u03c1\u03bf\u03ba\u03cd\u03c0\u03c4\u03b5\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03c4\u03c9\u03bd \u03b4\u03cd\u03bf \u03c4\u03b9\u03bc\u03ce\u03bd \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03ba\/\u03bb \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b1\u03c0\u03cc \u03bc\u03af\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c4\u03b9\u03bc\u03ae.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1;<\/summary>\n<p>\u039d\u03b1\u03b9. \u03a0\u03bf\u03bb\u03c5\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7, \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae, \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2, \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u2019 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0393\u03b9\u03b1\u03c4\u03af \u03bc\u03bf\u03c5 \u03b6\u03ae\u03c4\u03b7\u03c3\u03b1\u03bd \u03bc\u03b1\u03b6\u03af \u03ba\u03b1\u03b9 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7;<\/summary>\n<p>\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03bf\u03b9 free light chains \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03c0\u03b9\u03bf \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2.<\/p>\n<\/details>\n<\/section>\n<p><!-- ==================== SECTION 16 ==================== --><\/p>\n<section id=\"section16\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">16<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/span><\/h2>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px;\">\n<ul style=\"margin: 0; padding-left: 18px; line-height: 1.8;\">\n<li>\u039f\u03b9 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03b1\u03b8\u03b5\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03b3\u03c7\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03ad\u03bd\u03bd\u03bf\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd.<\/li>\n<li>\u03a4\u03bf \u03c0\u03b9\u03bf \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bf <strong>\u03bb\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb<\/strong>, \u03cc\u03c7\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bc\u03af\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c1\u03b9\u03b8\u03bc\u03b7\u03c4\u03b9\u03ba\u03ae \u03c4\u03b9\u03bc\u03ae.<\/li>\n<li>\u0397 <strong>\u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1<\/strong> \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc\u03c8\u03b7.<\/li>\n<li>\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ac \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 <strong>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03cc\u03c1\u03b7\u03c3\u03b7 \u03bb\u03b5\u03c5\u03ba\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>, <strong>\u03b1\u03bd\u03bf\u03c3\u03bf\u03ba\u03b1\u03b8\u03ae\u03bb\u03c9\u03c3\u03b7<\/strong>, \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/li>\n<li>\u0388\u03bd\u03b1 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b9\u03c3\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b5\u03af \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b5 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03bf\u03cd \u03bc\u03c5\u03b5\u03bb\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b1\u03be\u03af\u03b6\u03b5\u03b9 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7.<\/li>\n<li>\u03a3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7, \u03b7 <strong>\u03c4\u03ac\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03b9\u03bc\u03ce\u03bd<\/strong> \u03c3\u03c5\u03c7\u03bd\u03ac \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1.<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 17 ==================== --><\/p>\n<section id=\"section17\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.08); flex: 0 0 36px;\"><span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">17<\/span><\/span><span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<p>\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03c9\u03bd \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03c9\u03bd \u03bf\u03c1\u03bf\u03cd \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; width: 200px; height: 44px; white-space: nowrap;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; width: 200px; height: 44px; white-space: nowrap;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<div style=\"margin-top: 18px;\">\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">International Myeloma Work ing Group Criteria for the Diagnosis of Multiple Myeloma. <em>International Myeloma Foundation<\/em><br \/>\n<a href=\"https:\/\/www.myeloma.org\/international-myeloma-working-group-imwg-criteria-diagnosis-multiple-myeloma\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.myeloma.org\/international-myeloma-working-group-imwg-criteria-diagnosis-multiple-myeloma<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies. <em>College of American Pathologists<\/em><br \/>\n<a href=\"https:\/\/documents.cap.org\/documents\/Laboratory-Workup-for-Initial-Diagnosis-of-Monoclonal-Gammopathies-V1-012524.pdf\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/documents.cap.org\/documents\/Laboratory-Workup-for-Initial-Diagnosis-of-Monoclonal-Gammopathies-V1-012524.pdf<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Immunoglobulin Free Light Chains, Serum (FLCS). <em>Mayo Clinic Laboratories<\/em><br \/>\n<a href=\"https:\/\/www.mayocliniclabs.com\/test-catalog\/overview\/608250\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.mayocliniclabs.com\/test-catalog\/overview\/608250<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">A PCP\u2019s Guide to Screening for Monoclonal Gammopathy of Undetermined Significance. <em>Cleveland Clinic Journal\/Consult QD<\/em><br \/>\n<a href=\"https:\/\/consultqd.clevelandclinic.org\/a-pcps-guide-to-screening-for-monoclonal-gammopathy-of-undetermined-significance\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/consultqd.clevelandclinic.org\/a-pcps-guide-to-screening-for-monoclonal-gammopathy-of-undetermined-significance<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">NCCN Guidelines for Patients: Multiple Myeloma. <em>NCCN<\/em><br \/>\n<a href=\"https:\/\/www.nccn.org\/patients\/guidelines\/content\/PDF\/myeloma-patient.pdf\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.nccn.org\/patients\/guidelines\/content\/PDF\/myeloma-patient.pdf<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u0395\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u0391\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u039f\u03c1\u03bf\u03cd (Free Light Chains): \u0395\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u0391\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u039b\u03cc\u03b3\u03bf\u03c2 \u03ba\/\u03bb, \u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03a4\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u0394\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7: 25 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u2022 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 25 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u03a4\u03b9 \u03bd\u03b1 \u03ba\u03c1\u03b1\u03c4\u03ae\u03c3\u03b5\u03c4\u03b5: \u039f\u03b9 \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b5\u03c2 \u03ba \u03ba\u03b1\u03b9 \u03bb \u03b1\u03bb\u03c5\u03c3\u03af\u03b4\u03b5\u03c2 \u03bf\u03c1\u03bf\u03cd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b2\u03bf\u03b7\u03b8\u03ac \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03b1\u03b8\u03b5\u03b9\u03ce\u03bd, \u03cc\u03c0\u03c9\u03c2 MGUS, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b9 AL \u03b1\u03bc\u03c5\u03bb\u03bf\u03b5\u03af\u03b4\u03c9\u03c3\u03b7. \u03a4\u03bf [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":10511,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2534],"tags":[],"class_list":["post-10507","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exetaseis-aimatos"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/10507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=10507"}],"version-history":[{"count":1,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/10507\/revisions"}],"predecessor-version":[{"id":10512,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/10507\/revisions\/10512"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/10511"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=10507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=10507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=10507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}