{"id":10151,"date":"2026-03-12T19:22:25","date_gmt":"2026-03-12T17:22:25","guid":{"rendered":"https:\/\/mikrobiologikolamia.gr\/staging\/?p=10151"},"modified":"2026-03-12T19:45:56","modified_gmt":"2026-03-12T17:45:56","slug":"anti-smn-antisomata","status":"publish","type":"post","link":"https:\/\/mikrobiologikolamia.gr\/staging\/anti-smn-antisomata\/","title":{"rendered":"Anti-SMN \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1: \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd, \u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 &#038; \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1"},"content":{"rendered":"<h1 style=\"font-size: 34px; font-weight: 900; color: #111827; margin: 8px 0 10px;\">Anti-SMN \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1: \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd, \u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03a0\u03ce\u03c2 \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9<\/h1>\n<div style=\"margin: 10px 0 12px; font-size: 13px; color: #6b7280;\">\u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: <time datetime=\"2026-03-12\">12 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026<\/time><\/div>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin: 12px 0 18px; line-height: 1.7;\"><strong>\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong> \u03a4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong>, <strong>\u03bc\u03b9\u03ba\u03c4\u03ae \u03bd\u03cc\u03c3\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd (MCTD)<\/strong> \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 <strong>overlap \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1<\/strong>. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bb\u03cc \u00ab\u03bc\u03c5\u03ca\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf\u00bb \u03ae \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u00ab\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ANA\u00bb. \u0391\u03c0\u03bf\u03ba\u03c4\u03bf\u03cd\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 <strong>\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2 \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2<\/strong>, <strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2<\/strong> \u03ae \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf ANA \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 <strong>\u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bf\u03c5\u03ba\u03ba\u03af\u03b4\u03b5\u03c2 (nuclear dots \u2013 AC-7 \u03ae \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03bf AC-6\/7)<\/strong>. \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 <strong>CK<\/strong>, \u03c4\u03bf <strong>ANA pattern<\/strong>, \u03c4\u03b7\u03bd <strong>capillaroscopy<\/strong> \u03ba\u03b1\u03b9, \u03cc\u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9, \u03c4\u03bf\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf.<\/div>\n<nav id=\"toc\" style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 14px; padding: 18px 18px 10px 18px; margin: 18px 0 18px 0;\">\n<div style=\"font-weight: 800; font-size: 18px; color: #111827; margin-bottom: 10px;\">\u03a0\u03b5\u03c1\u03b9\u03b5\u03c7\u03cc\u03bc\u03b5\u03bd\u03b1<\/div>\n<ol style=\"margin: 0; padding-left: 18px; line-height: 1.9;\">\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section1\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section2\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf \u201cSMN\u201d \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03bc\u03c0\u03b5\u03c1\u03b4\u03b5\u03cd\u03b5\u03b9<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section3\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section4\">\u03a0\u03cc\u03c4\u03b5 \u03ad\u03c7\u03b5\u03b9 \u03bd\u03cc\u03b7\u03bc\u03b1 \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section5\">\u03a0\u03cc\u03c4\u03b5 \u0394\u0395\u039d \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section6\">\u03a4\u03b9 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5 \u03c4\u03bf ANA \u03ba\u03b1\u03b9 \u03c4\u03b1 \u201cnuclear dots\u201d<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section7\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section8\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section9\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section10\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03ce\u03bd\u03c4\u03b1\u03b9<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section11\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c8\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section12\">\u03a0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1: \u03b3\u03b9\u03b1\u03c4\u03af \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section13\">\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c3\u03b5 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ac \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section14\">\u03a0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bb\u03ac\u03b8\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section15\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section16\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/a><\/li>\n<li><a style=\"color: #dc2626; text-decoration: none;\" href=\"#section17\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/a><\/li>\n<\/ol>\n<\/nav>\n<hr style=\"border: none; border-top: 2px solid #d1d5db; margin: 0 0 22px 0;\" \/>\n<p><!-- ==================== SECTION 1 ==================== --><\/p>\n<section id=\"section1\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">1<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03c4\u03bf <strong>\u03c3\u03cd\u03bc\u03c0\u03bb\u03bf\u03ba\u03bf survival of motor neuron (SMN)<\/strong> \u03ba\u03b1\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 overlap \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03b7 MCTD. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1\u03c2, \u03b1\u03bb\u03bb\u03ac \u03ad\u03bd\u03b1\u03bd <strong>\u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7<\/strong> \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2 \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 \u03ae \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u039c\u03b5 \u03c0\u03b9\u03bf \u03b1\u03c0\u03bb\u03ac \u03bb\u03cc\u03b3\u03b9\u03b1, \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03cc\u03c4\u03b9 \u201c\u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03ad\u03bd\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1\u201d. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b1\u03bd <strong>\u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03cc\u03c4\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03b5 \u03c0\u03b9\u03bf \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c5\u03c0\u03bf\u03c3\u03cd\u03bd\u03bf\u03bb\u03bf<\/strong>, \u03c3\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b7 \u03bc\u03c5\u03ca\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae, \u03c4\u03bf Raynaud, \u03b7 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae, \u03b7 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03c4\u03b9\u03b4\u03b1 \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1:<\/strong> \u03a4\u03bf anti-SMN \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 <strong>\u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bd\u03bf\u03bc\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/div>\n<\/section>\n<section id=\"section2\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">2<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf \u201cSMN\u201d \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1\u03c4\u03af \u03bc\u03c0\u03b5\u03c1\u03b4\u03b5\u03cd\u03b5\u03b9<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u039f \u03cc\u03c1\u03bf\u03c2 <strong>SMN<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7, \u03b3\u03b9\u03b1\u03c4\u03af \u03c0\u03bf\u03bb\u03bb\u03bf\u03af \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03c4\u03b7 <strong>\u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 (spinal muscular atrophy, SMA)<\/strong>. \u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03cc\u03bc\u03c9\u03c2 \u03c4\u03c9\u03bd <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong> \u03bc\u03b9\u03bb\u03ac\u03bc\u03b5 \u03b3\u03b9\u03b1 \u03ba\u03ac\u03c4\u03b9 \u03c4\u03b5\u03bb\u03b5\u03af\u03c9\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc: \u03cc\u03c7\u03b9 \u03b3\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf SMA, \u03b1\u03bb\u03bb\u03ac \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1\u03bd <strong>\u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03bf\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7<\/strong> \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bc\u03c5\u03bf\u03c3\u03b9\u03c4\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03b9\u03bd\u03c9\u03bd\u03af\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae. \u038c\u03c4\u03b1\u03bd \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03c2 \u03b1\u03ba\u03bf\u03cd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u201c\u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03ba\u03ac\u03c4\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03cc \u03bc\u03b5 SMN\u201d, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03b7\u03c3\u03c5\u03c7\u03ae\u03c3\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 <strong>\u03ba\u03bb\u03b7\u03c1\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03c0\u03ac\u03b8\u03b7\u03c3\u03b7<\/strong>. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> <strong>\u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 SMA<\/strong>, \u03b4\u03b5\u03bd \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c6\u03bf\u03c1\u03ad\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03c0\u03b1\u03bd\u03c4\u03bf\u03cd\u03bd \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 <strong>SMN1 \u03ae SMN2<\/strong>.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1, \u03c4\u03bf \u03ba\u03bf\u03b9\u03bd\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf \u03cc\u03bd\u03bf\u03bc\u03b1 <strong>SMN<\/strong>. \u0391\u03c0\u03cc \u03b5\u03ba\u03b5\u03af \u03ba\u03b1\u03b9 \u03c0\u03ad\u03c1\u03b1, \u03b7 \u03bc\u03af\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c6\u03bf\u03c1\u03ac <strong>\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7<\/strong> \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1, \u03b5\u03bd\u03ce \u03b7 \u03ac\u03bb\u03bb\u03b7 \u03b1\u03c6\u03bf\u03c1\u03ac <strong>\u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1<\/strong>. \u0397 \u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03af\u03bd\u03b9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae, \u03b3\u03b9\u03b1\u03c4\u03af \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf \u03ac\u03b3\u03c7\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03b7\u03b8\u03b5\u03af \u03c3\u03c9\u03c3\u03c4\u03ac \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u03a3\u03c5\u03c7\u03bd\u03cc \u03bb\u03ac\u03b8\u03bf\u03c2:<\/strong> \u00abanti-SMN \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc = \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 SMA\u00bb. \u038c\u03c7\u03b9. \u03a4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1<\/strong>, \u03b5\u03bd\u03ce \u03c4\u03bf \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03b1\u03c6\u03bf\u03c1\u03ac <strong>\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03bd\u03b5\u03c5\u03c1\u03bf\u03bc\u03c5\u03ca\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf<\/strong>.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 3 ==================== --><\/p>\n<section id=\"section3\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">3<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03b5 \u03c0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong>, \u03bc\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 <strong>\u03bc\u03b9\u03ba\u03c4\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd (MCTD)<\/strong> \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 <strong>overlap \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1<\/strong>. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae\u03c2 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03ac\u03be\u03b7\u03c2, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c4\u03b1\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b4\u03ce\u03c3\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0391\u03c1\u03c7\u03b9\u03ba\u03ac \u03c4\u03b1 anti-SMN \u03b5\u03af\u03c7\u03b1\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03cc \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 <strong>\u03c0\u03bf\u03bb\u03c5\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong>, \u03cc\u03bc\u03c9\u03c2 \u03bf\u03b9 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03c4\u03b1\u03b9\u03c1\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03bc\u03b5 <strong>overlap \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c5\u03c2<\/strong> \u03c0\u03b1\u03c1\u03ac \u03bc\u03b5 \u201c\u03ba\u03b1\u03b8\u03b1\u03c1\u03ae\u201d, \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1. \u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>anti-U1RNP \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong>, \u03cc\u03c0\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03ac\u03c1\u03bf\u03b4\u03bf \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 \u03b1\u03c1\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03b1 \u03c6\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03ad\u03bd\u03c4\u03bf\u03bd\u03b1 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b8\u03c5\u03bc\u03af\u03b6\u03bf\u03c5\u03bd <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae<\/strong>.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>MCTD<\/strong>, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03cc\u03c4\u03b1\u03bd \u03c4\u03b1 anti-SMN \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03c4\u03af\u03c4\u03bb\u03bf\u03c5\u03c2, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03c0\u03b9\u03bf \u03b2\u03b1\u03c1\u03cd \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2. \u0391\u03c5\u03c4\u03cc \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 <strong>\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong>, <strong>\u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03c4\u03b9\u03b4\u03b1<\/strong>, <strong>fingertip pitting scars<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 <strong>\u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd<\/strong>. \u03a3\u03b5 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03ba\u03bf\u03c0\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 <strong>\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 (ILD)<\/strong> \u03ba\u03b1\u03b9 <strong>\u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7<\/strong>, \u03b1\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b1\u03ba\u03c1\u03b9\u03b2\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03bf cohort \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0388\u03c4\u03c3\u03b9, \u03cc\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1\u03c2 \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong>, \u03c4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b1\u03bd \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1\u03bd <strong>\u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf overlap \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf<\/strong> \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03c4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03c3\u03b1\u03c6\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03c5\u03c7\u03b1\u03af\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1:<\/strong> \u03a4\u03b1 anti-SMN \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 <strong>\u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03b5 \u03bc\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf. \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 <strong>\u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1<\/strong>.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 4 ==================== --><\/p>\n<section id=\"section4\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">4<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u03ad\u03c7\u03b5\u03b9 \u03bd\u03cc\u03b7\u03bc\u03b1 \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 <strong>anti-SMN<\/strong> \u03ad\u03c7\u03b5\u03b9 \u03bd\u03cc\u03b7\u03bc\u03b1 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2 \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2 \u03ae overlap \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5<\/strong>. \u0394\u03b5\u03bd \u03b6\u03b7\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bb\u03ae \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7 \u03ae \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ANA \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03cc\u03c4\u03b9 \u03c0\u03af\u03c3\u03c9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03c1\u03cd\u03b2\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03bd\u03cc\u03c3\u03bf\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03c5\u03c0\u03b9\u03ba\u03ac \u03c3\u03b5\u03bd\u03ac\u03c1\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 <strong>\u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b5\u03b3\u03b3\u03cd\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1<\/strong>, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 <strong>CK<\/strong>, \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc <strong>\u0397\u039c\u0393<\/strong> \u03ae <strong>MRI \u03bc\u03c5\u03ce\u03bd<\/strong>, \u03ba\u03b1\u03b9 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03c9\u03c2 <strong>Raynaud<\/strong>, \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03ba\u03b9\u03bd\u03b7\u03c3\u03af\u03b1, puffy fingers, \u03bf\u03af\u03b4\u03b7\u03bc\u03b1 \u03b4\u03b1\u03ba\u03c4\u03cd\u03bb\u03c9\u03bd, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03ae \u03ac\u03bb\u03bb\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ad\u03bc\u03c0\u03bf\u03c5\u03bd \u03c3\u03b5 \u03bd\u03cc\u03c3\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf, \u03ad\u03bd\u03b1 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf anti-SMN \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ad\u03c3\u03b5\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c3\u03c4\u03b7 <strong>\u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7<\/strong> \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0397 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7 \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf <strong>ANA \u03bc\u03b5 \u03ad\u03bc\u03bc\u03b5\u03c3\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03c6\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc<\/strong> \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 <strong>few nuclear dots \/ AC-7<\/strong> \u03ae \u03ac\u03c4\u03c5\u03c0\u03bf \u03bc\u03bf\u03c4\u03af\u03b2\u03bf \u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03bf\u03c5\u03ba\u03ba\u03af\u03b4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b4\u03b5\u03bd \u03b5\u03be\u03b7\u03b3\u03bf\u03cd\u03bd \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7, \u03bf \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u03ae \u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c4\u03bf pattern \u03c3\u03b1\u03bd \u201c\u03af\u03c7\u03bd\u03bf\u03c2\u201d \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7, \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03bf <strong>SMN complex<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03bf.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ad\u03c7\u03b5\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03cc\u03c4\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd <strong>anti-U1RNP \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong> \u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 <strong>MCTD<\/strong> \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03ad\u03b5\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03c0\u03b9\u03bf \u201c\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae\u03c2\u201d \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2. \u03a3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf anti-SMN \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c9\u03c2 <strong>\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2<\/strong> \u03c0\u03bf\u03c5 \u03c9\u03b8\u03b5\u03af \u03c3\u03b5 \u03c0\u03b9\u03bf \u03c3\u03c4\u03b5\u03bd\u03ae \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03bc\u03c5\u03c2, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac, \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u039c\u03b5 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03c1\u03bf\u03c5\u03c2, \u03c4\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u201c\u03bd\u03b1 \u03bc\u03c0\u03b5\u03b9 \u03c4\u03bf anti-SMN \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 panel \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd;\u201d, \u03b1\u03bb\u03bb\u03ac \u201c\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2;\u201d. \u038c\u03c4\u03b1\u03bd \u03b7 \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1\u03b9, \u03c4\u03cc\u03c4\u03b5 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b7.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u03a0\u03cc\u03c4\u03b5 \u03c4\u03bf \u03c3\u03ba\u03ad\u03c6\u03c4\u03b5\u03c4\u03b1\u03b9 \u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2:<\/strong> \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 <strong>\u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 + \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 CK + \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2<\/strong> \u03ae \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 <strong>ANA nuclear dots<\/strong> \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 5 ==================== --><\/p>\n<section id=\"section5\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">5<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03cc\u03c4\u03b5 \u0394\u0395\u039d \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2. \u0394\u03b5\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc screening test \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ca\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf, \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7, \u03b1\u03c3\u03b1\u03c6\u03b5\u03af\u03c2 \u03b1\u03c1\u03b8\u03c1\u03b1\u03bb\u03b3\u03af\u03b5\u03c2 \u03ae \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ANA \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03b9\u03bf \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03bd\u03cc\u03b7\u03bc\u03b1 \u03bd\u03b1 \u03b6\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>CK<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03be\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b1\u03c0\u03cc \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03ad\u03bd\u03c4\u03bf\u03bd\u03b7 \u03ac\u03c3\u03ba\u03b7\u03c3\u03b7, \u03bb\u03ae\u03c8\u03b7 \u03c3\u03c4\u03b1\u03c4\u03af\u03bd\u03b7\u03c2, \u03b9\u03bf\u03b3\u03b5\u03bd\u03ae \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7, \u03bc\u03c5\u03ca\u03ba\u03cc \u03c4\u03c1\u03b1\u03c5\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc \u03ae \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03b5\u03bd\u03b4\u03bf\u03bc\u03c5\u03ca\u03ba\u03ad\u03c2 \u03b5\u03bd\u03ad\u03c3\u03b5\u03b9\u03c2. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03cd\u03c3\u03ba\u03bf\u03bb\u03b1 \u03b8\u03b1 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ad\u03c3\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1, \u03cc\u03c4\u03b1\u03bd \u03b7 <strong>\u03c0\u03c1\u03bf-\u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae, \u03ad\u03bd\u03b1 \u03c4\u03cc\u03c3\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b9\u03ba\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc\u03b4\u03bf\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf <strong>\u03c5\u03c0\u03b5\u03c1\u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1\u03c2<\/strong>. \u03a4\u03bf \u03c0\u03c1\u03cc\u03b2\u03bb\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9, \u03b1\u03bb\u03bb\u03ac \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03bf\u03b8\u03b5\u03af \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03b4\u03b5\u03bd \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03af\u03b1 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9:<br \/>\n<strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u2192 CK \/ aldolase \/ \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 \u2192 ANA \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae pattern \u2192 \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03ae \u03bc\u03c5\u03bf\u03c3\u03b9\u03c4\u03b9\u03b4\u03b9\u03ba\u03cc panel \u2192 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c0\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9<\/strong>. \u03a4\u03bf anti-SMN \u03c4\u03bf\u03c0\u03bf\u03b8\u03b5\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03c0\u03b9\u03bf \u201c\u03b2\u03b1\u03b8\u03b9\u03ac\u201d \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03b1\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf, \u03b1\u03c6\u03bf\u03cd \u03c0\u03c1\u03ce\u03c4\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03bc\u03bf\u03c1\u03c6\u03c9\u03b8\u03b5\u03af \u03ad\u03bd\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c0\u03bf\u03c5 \u03bd\u03b1 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03cc \u03c4\u03bf\u03c5.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae: \u03bc\u03b9\u03b1 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u201c\u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u201d. \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c4\u03c9\u03bd <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong> \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 <strong>\u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 CK, \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf ANA pattern \u03ae \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 overlap \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1:<\/strong> \u03a4\u03bf \u03c3\u03c9\u03c3\u03c4\u03cc \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u00ab\u03bd\u03b1 \u03c4\u03bf \u03b2\u03ac\u03bb\u03bf\u03c5\u03bc\u03b5 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2;\u00bb, \u03b1\u03bb\u03bb\u03ac \u00ab\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1;\u00bb.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 6 ==================== --><\/p>\n<section id=\"section6\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">6<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5 \u03c4\u03bf ANA \u03ba\u03b1\u03b9 \u03c4\u03b1 \u201cnuclear dots\u201d<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03b5 \u03c4\u03bf \u03bc\u03bf\u03c4\u03af\u03b2\u03bf <strong>few nuclear dots (AC-7)<\/strong> \u03c3\u03c4\u03bf <strong>ANA \u03bc\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 HEp-2<\/strong>. \u03a4\u03bf AC-7 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc <strong>1 \u03ad\u03c9\u03c2 6 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03ad\u03c2 \u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bf\u03c5\u03ba\u03ba\u03af\u03b4\u03b5\u03c2<\/strong> \u03b1\u03bd\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf <strong>p80-coilin<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03bf <strong>SMN complex<\/strong>. \u0391\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf pattern \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03b5\u03af \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c4\u03b5\u03b8\u03b5\u03af \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03cc\u03c4\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0391\u03c5\u03c4\u03cc \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf <strong>ANA pattern<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03ad\u03bd\u03b1 \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03cc \u03c3\u03c7\u03cc\u03bb\u03b9\u03bf \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03bf\u03c5. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c3\u03b1\u03bd \u201c\u03c7\u03ac\u03c1\u03c4\u03b7\u03c2\u201d \u03c0\u03bf\u03c5 \u03ba\u03b1\u03b8\u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c4\u03bf\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c0\u03c1\u03bf\u03c2 \u03c0\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1. \u038c\u03c4\u03b1\u03bd \u03bb\u03bf\u03b9\u03c0\u03cc\u03bd \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 <strong>nuclear dots<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1, Raynaud, \u03b4\u03c5\u03c3\u03c6\u03b1\u03b3\u03af\u03b1 \u03ae \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1, \u03c4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03b1\u03c0\u03bf\u03ba\u03c4\u03ac \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03b5 cohort \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 <strong>scleromyositis<\/strong>, \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 anti-SMN \u03b8\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03b6\u03b1\u03bd \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b9 \u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bf\u03c5\u03ba\u03ba\u03af\u03b4\u03b5\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ad\u03bc\u03bc\u03b5\u03c3\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c6\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03bc\u03b5\u03c4\u03c1\u03af\u03b1. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03b1 \u201c\u03ba\u03b1\u03b8\u03b1\u03c1\u03cc\u201d AC-7\u00b7 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd <strong>AC-6 \u03ba\u03b1\u03b9 AC-7<\/strong> \u03ae \u03bd\u03b1 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c0\u03b9\u03bf \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc \u03b7 \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03af\u03bf\u03c5 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 pattern \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03b1\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf: \u03cc\u03c4\u03b1\u03bd \u03b2\u03bb\u03ad\u03c0\u03b5\u03b9 <strong>nuclear dots<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1, \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c4\u03bf \u03b8\u03b5\u03c9\u03c1\u03b5\u03af \u03c4\u03c5\u03c7\u03b1\u03af\u03bf \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong> \u03ae \u03ac\u03bb\u03bb\u03c9\u03bd \u03c0\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u03a4\u03b9 \u03b1\u03be\u03af\u03b6\u03b5\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5:<\/strong> \u0388\u03bd\u03b1 ANA \u03bc\u03b5 <strong>few nuclear dots<\/strong> \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 anti-SMN, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c0\u03b9\u03bf \u03c3\u03c9\u03c3\u03c4\u03ae \u03ba\u03b1\u03b9 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03cc\u03c4\u03b1\u03bd \u03c4\u03b1\u03b9\u03c1\u03b9\u03ac\u03b6\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 7 ==================== --><\/p>\n<section id=\"section7\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">7<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03ce\u03c2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03c5\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03cc\u03c3\u03bf \u03ac\u03bb\u03bb\u03c9\u03bd \u03b3\u03bd\u03c9\u03c3\u03c4\u03ce\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a3\u03c4\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03cc\u03c0\u03c9\u03c2 <strong>immunoprecipitation (IP)<\/strong>, <strong>ALBIA<\/strong> \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b5\u03c2. \u03a0\u03bf\u03bb\u03bb\u03ac \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1 <strong>\u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd routine \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03cc testing \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1<\/strong>, \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03c5 \u03b5\u03be\u03b7\u03b3\u03b5\u03af \u03b3\u03b9\u03b1\u03c4\u03af \u03b7 \u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03bc\u03c0\u03b5\u03b9\u03c1\u03af\u03b1 \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c7\u03c9\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03bd.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0399\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03ac, \u03c4\u03b1 anti-SMN \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b1\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03bc\u03ad\u03c3\u03c9 <strong>immunoprecipitation<\/strong>, \u03cc\u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b4\u03ad\u03c3\u03bc\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03c4\u03b1\u03bd \u03bc\u03b5 \u03c4\u03bf \u03c3\u03cd\u03bc\u03c0\u03bb\u03bf\u03ba\u03bf <strong>SMN<\/strong>. \u039f\u03b9 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03cc\u03c4\u03b9 \u03c3\u03c4\u03bf\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c6\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd <strong>\u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bf\u03c5\u03ba\u03ba\u03af\u03b4\u03b5\u03c2<\/strong> \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c7\u03c1\u03ce\u03c3\u03b7, \u03b5\u03bd\u03ce \u03c4\u03bf \u03b1\u03c0\u03bb\u03cc western blot \u03b4\u03b5\u03bd \u03ae\u03c4\u03b1\u03bd \u03c0\u03ac\u03bd\u03c4\u03b1 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ad\u03c2. \u0391\u03c5\u03c4\u03cc \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c4\u03b7 <strong>\u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03ae \u03c4\u03c1\u03b9\u03c3\u03b4\u03b9\u03ac\u03c3\u03c4\u03b1\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae<\/strong> \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac \u03bc\u03b9\u03b1 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b1\u03c0\u03bf\u03b4\u03b9\u03b1\u03c4\u03b1\u03b3\u03bc\u03ad\u03bd\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03bf\u03c5.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03b1\u03c5\u03c4\u03cc \u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03ac\u03c4\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc: \u03b1\u03bd \u03ad\u03bd\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u201c\u03b4\u03b5\u03bd \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1\u03c2\u201d \u03ae \u03cc\u03c4\u03b9 \u201c\u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u201d, \u03b1\u03c5\u03c4\u03cc <strong>\u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b7<\/strong>. \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 <strong>\u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b4\u03b5\u03af\u03ba\u03c4\u03b7<\/strong> \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03b8\u03b5\u03af \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03ac panels. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc, \u03b7 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bc\u03b5 \u03b5\u03c0\u03af\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>\u03bc\u03b5\u03b8\u03cc\u03b4\u03bf\u03c5<\/strong> \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03bf\u03cd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c0\u03bb\u03b1\u03b9\u03c3\u03af\u03bf\u03c5.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1. \u0388\u03bd\u03b1 \u201c\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u201d \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf panel \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03bc\u03b5 \u03ad\u03bd\u03b1 \u201c\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u201d \u03c3\u03b5 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf. \u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1, \u03ad\u03bd\u03b1 \u201c\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u201d \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03c0\u03bf\u03ba\u03c4\u03ac \u03c0\u03bf\u03bb\u03cd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc <strong>ANA pattern<\/strong>, \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae\u03c2.<\/p>\n<div style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 14px; padding: 14px; margin-top: 12px;\">\n<div style=\"font-weight: 800; color: #111827; margin-bottom: 8px;\">\u03a4\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03be\u03ad\u03c1\u03b5\u03b9 \u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf<\/div>\n<div style=\"line-height: 1.8; color: #374151;\">\u2022 \u039d\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03b5\u03b9 <strong>\u03c0\u03bf\u03b9\u03b1 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2<\/strong> \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5.<br \/>\n\u2022 \u039d\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03b9 \u03b1\u03bd \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ad\u03c1\u03bf\u03c2 <strong>\u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c5 panel<\/strong> \u03ae \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b1\u03c2.<br \/>\n\u2022 \u039d\u03b1 \u03c4\u03bf \u03c3\u03c5\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03ac \u03bc\u03b5 \u03c4\u03bf <strong>ANA pattern<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1.<br \/>\n\u2022 \u039d\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9<\/strong> \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b1 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1 \u03ae <strong>\u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2<\/strong>.<\/div>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 8 ==================== --><\/p>\n<section id=\"section8\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">8<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0388\u03bd\u03b1 <strong>\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b8\u03b7\u03ba\u03b1\u03bd <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03cc\u03ba\u03bf\u03c5 SMN. \u0391\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5, \u03cc\u03bc\u03c9\u03c2, <strong>\u03b4\u03b5\u03bd \u03b2\u03ac\u03b6\u03b5\u03b9 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/strong>. \u0391\u03c5\u03c4\u03cc \u03c0\u03bf\u03c5 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03ae\u03ba\u03b5\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 <strong>\u03c0\u03b9\u03bf \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03c6\u03ac\u03c3\u03bc\u03b1<\/strong>, \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1\u03c2, MCTD \u03bc\u03b5 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c3\u03b1\u03bd\u03b1\u03c4\u03bf\u03bb\u03b9\u03c3\u03bc\u03cc \u03ae \u03ac\u03bb\u03bb\u03bf\u03c5 <strong>\u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2<\/strong>. \u0397 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf ANA pattern \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03c5\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03ae \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03c4\u03b9\u03c2 \u03b4\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ad\u03c2, \u03c4\u03b1 anti-SMN \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd <strong>\u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd-\u03c3\u03c4\u03cc\u03c7\u03c9\u03bd<\/strong>. \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>MCTD<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03bf\u03b9 \u03c4\u03af\u03c4\u03bb\u03bf\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9, \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 <strong>pitting scars<\/strong>, <strong>\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong>, <strong>\u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 <strong>\u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd<\/strong>. \u039d\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03ba\u03bf\u03c0\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03c1\u03b9\u03bf\u03b8\u03b5\u03c4\u03b5\u03af \u03ad\u03bd\u03b1\u03bd <strong>\u03b2\u03b1\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c5\u03c0\u03cc\u03c4\u03c5\u03c0\u03bf<\/strong>, \u03bc\u03b5 \u03c0\u03b9\u03bf \u03b5\u03ba\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b4\u03b5\u03bd \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03c4\u03bf \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1 \u201c\u03b2\u03c1\u03ad\u03b8\u03b7\u03ba\u03b5 \u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u201d, \u03b1\u03bb\u03bb\u03ac \u03c3\u03c4\u03bf \u03b5\u03c1\u03ce\u03c4\u03b7\u03bc\u03b1 <strong>\u201c\u03c4\u03b9 \u03ac\u03bb\u03bb\u03bf \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03bb\u03ad\u03b3\u03be\u03c9 \u03c4\u03ce\u03c1\u03b1;\u201d<\/strong>. \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 <strong>\u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03af\u03bc\u03b7\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c0\u03b1\u03bd\u03b9\u03ba\u03cc\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b7\u03b8\u03b5\u03af \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03b9\u03c3\u03c7\u03cd\u03bf\u03c2, <strong>CK<\/strong>, <strong>\u03b1\u03bb\u03b4\u03bf\u03bb\u03ac\u03c3\u03b7<\/strong>, \u0397\u039c\u0393 \u03ae MRI \u03bc\u03c5\u03ce\u03bd, \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd, \u03c5\u03c0\u03b5\u03c1\u03b7\u03c7\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 \u03ae \u03ac\u03bb\u03bb\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03c9\u03bd \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1, \u03c4\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03b1\u03bd <strong>\u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03bf\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7\u03c2<\/strong> \u03c0\u03b1\u03c1\u03ac \u03c3\u03b1\u03bd \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b1\u03c0\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7. \u0392\u03bf\u03b7\u03b8\u03ac \u03c4\u03bf\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03bd\u03b1 \u03bf\u03c1\u03b3\u03b1\u03bd\u03ce\u03c3\u03b5\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c4\u03bf\u03bd \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b7 \u03bc\u03b5\u03af\u03bd\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ae \u03b5\u03c4\u03b9\u03ba\u03ad\u03c4\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 \u201c\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ANA\u201d. \u0391\u03c5\u03c4\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03bf \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b7 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c4\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ac:<\/strong> \u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03b4\u03b5\u03bd \u03bb\u03ad\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u201c\u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u201d, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 <strong>\u03bd\u03cc\u03c3\u03bf \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 9 ==================== --><\/p>\n<section id=\"section9\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">9<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0388\u03bd\u03b1 <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc anti-SMN \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1<\/strong> <strong>\u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9<\/strong> \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03bc\u03c5\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1 \u03ae \u03ac\u03bb\u03bb\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd. \u039f\u03b9 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03ba\u03bf\u03c0\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03c4\u03bf\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 <strong>\u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc<\/strong> \u03ae \u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 panels. \u0386\u03c1\u03b1 \u03b7 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c0\u03bf\u03c4\u03ad \u03bd\u03b1 \u03c5\u03c0\u03b5\u03c1\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03bc\u03b9\u03b1 <strong>\u03b9\u03c3\u03c7\u03c5\u03c1\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1<\/strong>.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03ad\u03bd\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 <strong>\u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2<\/strong>, \u03b1\u03c0\u03cc \u03c4\u03bf \u03b1\u03bd \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c4\u03b5\u03b9 \u03ae \u03cc\u03c7\u03b9 assay \u03bc\u03b5 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ae \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03c5\u03bd \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c3\u03c4\u03bf <strong>ANA<\/strong>. \u039c\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03bb\u03cc\u03b3\u03b9\u03b1, \u03ad\u03bd\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc anti-SMN \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03cc\u03c4\u03b9 \u00ab\u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c4\u03af\u03c0\u03bf\u03c4\u03b1\u00bb. \u039c\u03c0\u03bf\u03c1\u03b5\u03af \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b8\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03ae \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03c4\u03b1\u03bd \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7: \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 CK, <strong>\u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf Raynaud<\/strong>, \u03b4\u03c5\u03c3\u03c6\u03b1\u03b3\u03af\u03b1, puffy fingers, \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf ANA pattern \u03ae \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03b5 \u0397\u039c\u0393 \u03ba\u03b1\u03b9 MRI. \u03a3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7, \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc anti-SMN <strong>\u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u00ab\u03c3\u03c4\u03b1\u03bc\u03b1\u03c4\u03ac \u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7\u00bb<\/strong>. \u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03c3\u03b5\u03b9 \u03bc\u03b5 \u03c4\u03b1 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b1 \u03b2\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03ce\u03c3\u03b5\u03b9 \u03ad\u03bc\u03c6\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7, \u03c3\u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1:<\/strong> \u0391\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc anti-SMN \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03cc\u03c4\u03b9 <strong>\u03b4\u03b5\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b8\u03b7\u03ba\u03b5 \u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1<\/strong>. \u0394\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03cc\u03c4\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03c4\u03b1\u03b9 \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1, <strong>\u03bd\u03cc\u03c3\u03bf\u03c2 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2<\/strong> \u03ae \u03c0\u03c1\u03ce\u03b9\u03bc\u03b7 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 10 ==================== --><\/p>\n<section id=\"section10\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18),inset 0 1px 0 rgba(255,255,255,.65),inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">10<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bf\u03b9\u03b5\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03ae \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03c4\u03b1 anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b4\u03b5\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03bf\u03c4\u03ad \u03b1\u03c0\u03bf\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1. \u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b1\u03c6\u03ae\u03c2 \u03bc\u03cc\u03bd\u03bf \u03cc\u03c4\u03b1\u03bd \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03bd\u03c4\u03b1\u03c7\u03b8\u03b5\u03af \u03c3\u03b5 \u03ad\u03bd\u03b1 <strong>\u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf \u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd<\/strong>. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7, \u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03bc\u03b5 \u03b2\u03b1\u03c3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03b2\u03bb\u03ac\u03b2\u03b7\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 <strong>CK<\/strong>, \u03b7 <strong>\u03b1\u03bb\u03b4\u03bf\u03bb\u03ac\u03c3\u03b7<\/strong>, \u03bf\u03b9 \u03c4\u03c1\u03b1\u03bd\u03c3\u03b1\u03bc\u03b9\u03bd\u03ac\u03c3\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b7 <strong>LDH<\/strong>, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b5 <strong>ANA \u03bc\u03b5 \u03c3\u03b1\u03c6\u03ae \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03bf\u03c5 pattern<\/strong>. \u03a3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b6\u03b7\u03c4\u03b7\u03b8\u03b5\u03af \u03ad\u03bd\u03b1 \u03c0\u03b9\u03bf \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf panel <strong>\u03bc\u03c5\u03bf\u03c3\u03b9\u03c4\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03ae overlap \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd<\/strong>, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1\u03c2<\/strong> \u03ae \u03ac\u03bb\u03bb\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b7\u03b8\u03bf\u03cd\u03bd \u03ba\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 <strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2<\/strong>. \u0391\u03c5\u03c4\u03cc \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 <strong>\u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03bf\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03bd\u03c5\u03c7\u03bf\u03c0\u03c4\u03c5\u03c7\u03ae\u03c2 (nailfold capillaroscopy)<\/strong>, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc \u03ae \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc <strong>\u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7\u03c2 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0397 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae\u03c2 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03bc\u03c5\u03bf\u03b3\u03c1\u03ac\u03c6\u03b7\u03bc\u03b1 (\u0397\u039c\u0393)<\/strong>, <strong>MRI \u03bc\u03c5\u03ce\u03bd<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 <strong>\u03bc\u03c5\u03ca\u03ba\u03ae \u03b2\u03b9\u03bf\u03c8\u03af\u03b1<\/strong>. \u039f\u03b9 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bf \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03bf\u03b1\u03bd\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03cc\u03c2 \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03c5\u03c0\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03bc\u03cc\u03bd\u03bf \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7. \u0393\u03b9\u03b1 \u03c4\u03bf\u03bd \u03bb\u03cc\u03b3\u03bf \u03b1\u03c5\u03c4\u03cc, \u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc <strong>\u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf, \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03cc\u03b3\u03bf \u03ae \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03bb\u03cc\u03b3\u03bf\/\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c4\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac <strong>\u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03c5\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1. \u0388\u03c4\u03c3\u03b9, \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03b5\u03af <strong>\u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2<\/strong> \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1, <strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7<\/strong> \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae <strong>\u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae \u03ae \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae<\/strong>. \u039c\u03b5 \u03b1\u03c5\u03c4\u03cc\u03bd \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf, \u03c4\u03b1 anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c9\u03c2 <strong>\u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c9\u03c2 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03cc \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf.<\/p>\n<div style=\"background: #f9fafb; border: 1px solid #e5e7eb; border-radius: 14px; padding: 14px; margin-top: 12px;\">\n<div style=\"font-weight: 800; color: #111827; margin-bottom: 8px;\">\u03a3\u03c5\u03bd\u03bf\u03b4\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c7\u03bd\u03ac \u03ad\u03c7\u03b5\u03b9 \u03bd\u03cc\u03b7\u03bc\u03b1<\/div>\n<div style=\"line-height: 1.8; color: #374151;\">\u2022 CK, \u03b1\u03bb\u03b4\u03bf\u03bb\u03ac\u03c3\u03b7, AST\/ALT, LDH<br \/>\n\u2022 ANA \u03bc\u03b5 <strong>pattern<\/strong> \u03c3\u03b5 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 HEp-2<br \/>\n\u2022 \u039c\u03c5\u03bf\u03c3\u03b9\u03c4\u03b9\u03b4\u03b9\u03ba\u03ac \u03ae overlap \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1<br \/>\n\u2022 \u0397\u039c\u0393 \u03ae\/\u03ba\u03b1\u03b9 MRI \u03bc\u03c5\u03ce\u03bd<br \/>\n\u2022 \u03a0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03cc\u03c2 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 (PFTs \/ HRCT \u03cc\u03c0\u03bf\u03c5 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9)<br \/>\n\u2022 \u039a\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03cd\u03c0\u03bf\u03c0\u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1<br \/>\n\u2022 \u03a4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03bf\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03bd\u03c5\u03c7\u03bf\u03c0\u03c4\u03c5\u03c7\u03ae\u03c2 (nailfold capillaroscopy) \u03ba\u03b1\u03b9 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1<\/div>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 11 ==================== --><\/p>\n<section id=\"section11\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">11<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c8\u03af\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0397 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>anti-SMN<\/strong> \u03b1\u03bd\u03b5\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u201c\u03c0\u03cc\u03bd\u03bf\u03c5\u03c2\u201d, \u03b1\u03bb\u03bb\u03ac <strong>\u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1<\/strong>, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b5\u03b3\u03b3\u03cd\u03c2. \u03a0\u03b1\u03c1\u03b1\u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b1 \u03bd\u03b1 \u03c3\u03b7\u03ba\u03c9\u03b8\u03b5\u03af \u03b1\u03c0\u03cc \u03ba\u03b1\u03c1\u03ad\u03ba\u03bb\u03b1 \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc \u03ba\u03ac\u03b8\u03b9\u03c3\u03bc\u03b1, \u03bd\u03b1 \u03b1\u03bd\u03ad\u03b2\u03b5\u03b9 \u03c3\u03ba\u03ac\u03bb\u03b5\u03c2, \u03bd\u03b1 \u03c7\u03c4\u03b5\u03bd\u03af\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03bc\u03b1\u03bb\u03bb\u03b9\u03ac \u03c4\u03bf\u03c5 \u03ae \u03bd\u03b1 \u03c3\u03b7\u03ba\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03c7\u03ad\u03c1\u03b9\u03b1 \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03b5\u03c6\u03ac\u03bb\u03b9. \u03a3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf, \u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 <strong>CK<\/strong>, \u03b7 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b5\u03b9\u03bc\u03b5\u03bd\u03b9\u03ba\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae\u03c2 \u03b9\u03c3\u03c7\u03cd\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc <strong>\u0397\u039c\u0393<\/strong> \u03ae <strong>MRI \u03bc\u03c5\u03ce\u03bd<\/strong> \u03c0\u03c1\u03bf\u03c3\u03b8\u03ad\u03c4\u03bf\u03c5\u03bd \u03c3\u03b1\u03c6\u03ce\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0397 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03b9\u03bf \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03cc\u03c4\u03b1\u03bd \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ad\u03bc\u03c0\u03bf\u03c5\u03bd \u03c3\u03b5 <strong>\u03bd\u03cc\u03c3\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd<\/strong>, \u03cc\u03c0\u03c9\u03c2 <strong>\u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf Raynaud<\/strong>, puffy fingers, \u03bf\u03b9\u03b4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b1\u03ba\u03c4\u03cd\u03bb\u03c9\u03bd, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b5\u03af\u03b1, \u03b4\u03c5\u03c3\u03c6\u03b1\u03b3\u03af\u03b1 \u03ae \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03ba\u03b9\u03bd\u03b7\u03c3\u03af\u03b1. \u03a4\u03cc\u03c4\u03b5 \u03bf \u03b9\u03b1\u03c4\u03c1\u03cc\u03c2 \u03b4\u03b5\u03bd \u03c3\u03ba\u03ad\u03c6\u03c4\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1, \u03b1\u03bb\u03bb\u03ac \u03ad\u03bd\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc <strong>\u03c6\u03ac\u03c3\u03bc\u03b1 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03c9\u03bd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03c9\u03bd \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2<\/strong>, \u03cc\u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bc\u03c5\u03ca\u03ba\u03ae, \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae, \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03ba\u03b1\u03b9 \u03c3\u03c0\u03bb\u03b1\u03c7\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae. \u0391\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c4\u03bf anti-SMN \u03b1\u03c0\u03bf\u03ba\u03c4\u03ac \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0399\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03c3\u03c4\u03b7 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u03b7 \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 <strong>\u03bb\u03b5\u03af\u03c0\u03b5\u03b9 \u03c3\u03c4\u03b1 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1<\/strong>. \u0394\u03b7\u03bb\u03b1\u03b4\u03ae \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b7\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u201c\u03c4\u03c5\u03c0\u03b9\u03ba\u03cc \u03c3\u03ba\u03bb\u03b7\u03c1\u03cc\u03b4\u03b5\u03c1\u03bc\u03b1\u201d \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5 \u03bc\u03bf\u03c1\u03c6\u03ae, \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf\u03c2 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03cc\u03c2 \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 <strong>\u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf Raynaud<\/strong>, \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ae <strong>capillaroscopy<\/strong>, \u03b4\u03c5\u03c3\u03ba\u03b9\u03bd\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf\u03c5 \u03ae \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc <strong>ANA pattern<\/strong>. \u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03b3\u03b9\u03b1\u03c4\u03af \u03b2\u03bf\u03b7\u03b8\u03ac \u03bd\u03b1 \u03bc\u03b7 \u03c7\u03b1\u03b8\u03b5\u03af \u03c4\u03bf \u03c0\u03b1\u03c1\u03ac\u03b8\u03c5\u03c1\u03bf \u03bc\u03b9\u03b1\u03c2 \u03c0\u03b9\u03bf \u03ad\u03b3\u03ba\u03b1\u03b9\u03c1\u03b7\u03c2 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ae\u03b4\u03b7 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae <strong>anti-U1RNP \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong> \u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 <strong>MCTD<\/strong>, \u03b7 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03bd\u03ad\u03c9\u03bd \u03bc\u03c5\u03ca\u03ba\u03ce\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ce\u03bd \u03b5\u03bd\u03bf\u03c7\u03bb\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd, pitting scars \u03ae \u03b5\u03c0\u03b9\u03b4\u03b5\u03af\u03bd\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03b3\u03c1\u03cd\u03c0\u03bd\u03b7\u03c3\u03b7. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c5\u03c0\u03cc\u03b2\u03b1\u03b8\u03c1\u03bf, \u03ad\u03bd\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc anti-SMN \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bb\u03ce\u03c2 \u03ad\u03bd\u03b1 \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03ce\u03c3\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03b2\u03ac\u03b8\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03c3\u03b5\u03b9 <strong>\u03c0\u03b9\u03bf \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b1\u03bd\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u03a4\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c8\u03af\u03b1:<\/strong> <strong>\u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 + \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 CK + \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c0\u03b9\u03bf \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c4\u03c1\u03af\u03c0\u03c4\u03c5\u03c7\u03bf \u03c0\u03bf\u03c5 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03b9\u03b1\u03c4\u03c1\u03cc \u03bd\u03b1 \u03c3\u03ba\u03b5\u03c6\u03c4\u03b5\u03af \u03c0\u03b9\u03bf \u03c3\u03bf\u03b2\u03b1\u03c1\u03ac anti-SMN \u03c3\u03c7\u03b5\u03c4\u03b9\u03b6\u03cc\u03bc\u03b5\u03bd\u03bf \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03c9\u03bd \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 12 ==================== --><\/p>\n<section id=\"section12\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">12<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1: \u03b3\u03b9\u03b1\u03c4\u03af \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u039f \u03bb\u03cc\u03b3\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c4\u03cc\u03c3\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03b7 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03bc\u03cd\u03b5\u03c2, \u03b1\u03bb\u03bb\u03ac \u03c4\u03bf \u03cc\u03c4\u03b9 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03c0\u03b9\u03bf \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae<\/strong>. \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>MCTD<\/strong>, \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03c4\u03af\u03c4\u03bb\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1, \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03c4\u03b9\u03b4\u03b1, pitting scars \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd, \u03b5\u03bd\u03ce \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03ba\u03bf\u03c0\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u03c4\u03b1 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03bc\u03cc \u03bc\u03b5 <strong>\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 (ILD)<\/strong> \u03ae <strong>\u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7<\/strong>. \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03ad\u03bd\u03b1 \u03c4\u03ad\u03c4\u03bf\u03b9\u03bf \u03bf\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd <strong>\u03ad\u03bd\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2<\/strong>.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03c4\u03bf\u03bd <strong>\u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1<\/strong>, \u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf \u03cc\u03c4\u03b9 \u03c4\u03b1 <strong>\u03bc\u03c5\u03bf\u03c3\u03b9\u03c4\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2<\/strong> \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc <strong>\u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1<\/strong>, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03bc\u03b5\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03b5\u03be\u03b5\u03bb\u03af\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b9\u03c9\u03c0\u03b7\u03bb\u03ac \u03c0\u03c1\u03b9\u03bd \u03b3\u03af\u03bd\u03b5\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b5\u03bc\u03c6\u03b1\u03bd\u03ae\u03c2. \u0393\u03b9\u03b1 \u03b1\u03c5\u03c4\u03cc, \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b5\u03b9\u03b1\u03c3\u03c4\u03bf\u03cd\u03bd \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c0\u03bd\u03bf\u03ae\u03c2 \u03ae \u03ba\u03b1\u03b9 HRCT, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ba\u03c1\u03af\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03b9\u03b1\u03c4\u03c1\u03bf\u03cd. \u0397 \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bd\u03c9\u03c1\u03af\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1, \u03b3\u03b9\u03b1\u03c4\u03af \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03c4\u03b7\u03bd <strong>\u03ba\u03b1\u03c1\u03b4\u03b9\u03ac<\/strong>, \u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae \u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae <strong>\u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae<\/strong>. \u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03b1\u03be\u03af\u03b1 \u03b5\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03ae\u03c0\u03b9\u03b1, \u03ac\u03c4\u03c5\u03c0\u03b1 \u03ae \u03bd\u03b1 \u03b1\u03c0\u03bf\u03b4\u03af\u03b4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b1\u03b9\u03c4\u03af\u03b5\u03c2. \u0391\u03bd \u03cc\u03bc\u03c9\u03c2 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2, \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b4\u03cd\u03c3\u03c0\u03bd\u03bf\u03b9\u03b1\u03c2, \u03b1\u03af\u03c3\u03b8\u03b7\u03bc\u03b1 \u03c0\u03b1\u03bb\u03bc\u03ce\u03bd, \u03b8\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03c6\u03bf\u03c1\u03af\u03b1\u03c2 \u03ae \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b7\u03c2 \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03c4\u03bf <strong>\u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc<\/strong>, \u03b7 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03ba\u03b9\u03bd\u03b7\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf\u03c5 \u03ae \u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03c0\u03b5\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b6\u03c9\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bd\u03b1 \u03c0\u03b5\u03c1\u03bd\u03ac \u03c5\u03c0\u03bf\u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03bc\u03ad\u03bd\u03b7 \u03cc\u03c4\u03b1\u03bd \u03cc\u03bb\u03b7 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae \u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b7 <strong>CK<\/strong> \u03ae \u03c3\u03c4\u03b7 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1. \u0388\u03c4\u03c3\u03b9, \u03c4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03c5\u03c0\u03b5\u03bd\u03b8\u03c5\u03bc\u03af\u03b6\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c0\u03b1\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac, \u03b1\u03bb\u03bb\u03ac \u03c9\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03c0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03bc\u03b5 <strong>\u03c0\u03bf\u03bb\u03c5\u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03ba\u03ae \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae<\/strong>.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0386\u03c1\u03b1 \u03c4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u201c\u03ac\u03bb\u03bb\u03bf \u03ad\u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03cc\u201d. \u03a3\u03b5 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c3\u03b1\u03bd <strong>\u03ba\u03b1\u03bc\u03c0\u03b1\u03bd\u03ac\u03ba\u03b9 \u03b3\u03b9\u03b1 \u03bf\u03bb\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7<\/strong>. \u039f \u03c3\u03c9\u03c3\u03c4\u03cc\u03c2 \u03c7\u03b5\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03bf\u03bb\u03bb\u03ae\u03c3\u03b5\u03b9 \u03ba\u03b1\u03bd\u03b5\u03af\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c4\u03af\u03c4\u03bb\u03bf \u03c4\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03b1\u03bb\u03bb\u03ac \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c1\u03c9\u03c4\u03b7\u03b8\u03b5\u03af <strong>\u03c0\u03bf\u03b9\u03b1 \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03bb\u03b5\u03b3\u03c7\u03b8\u03bf\u03cd\u03bd \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac<\/strong> \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c0\u03bf\u03b9\u03bf\u03bd \u03c1\u03c5\u03b8\u03bc\u03cc \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b7\u03b8\u03b5\u03af \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u039a\u03cd\u03c1\u03b9\u03bf \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1:<\/strong> \u038c\u03c4\u03b1\u03bd \u03c4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf, \u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bc\u03ad\u03bd\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bc\u03cd\u03b5\u03c2. \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03ba\u03ad\u03c8\u03b7 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 <strong>\u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac, \u03b1\u03b3\u03b3\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc<\/strong>.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 13 ==================== --><\/p>\n<section id=\"section13\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">13<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf anti-SMN \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ac\u03be\u03b7 \u2013 \u03a0\u03b1\u03c1\u03b1\u03b4\u03b5\u03af\u03b3\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03c4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b1\u03c0\u03bf\u03ba\u03c4\u03bf\u03cd\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03cc\u03c4\u03b1\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03ad\u03c3\u03b1 \u03c3\u03c4\u03bf \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf. \u03a4\u03bf \u03af\u03b4\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ce\u03bd \u03b5\u03bd\u03b6\u03cd\u03bc\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\"><strong>\u03a3\u03b5\u03bd\u03ac\u03c1\u03b9\u03bf 1:<\/strong> \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 <strong>CK 1.500\u20133.000<\/strong>, \u03b5\u03b3\u03b3\u03cd\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 <strong>Raynaud<\/strong>. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf, \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b3\u03b9\u03b1 <strong>scleromyositis<\/strong> \u03ba\u03b1\u03b9 \u03b4\u03b9\u03ba\u03b1\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03c0\u03b9\u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b3\u03b9\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd. \u0394\u03b5\u03bd \u03c5\u03c0\u03bf\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1, \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03b1\u03bd\u03b1\u03b6\u03ae\u03c4\u03b7\u03c3\u03b7 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ce\u03bd \u03ae \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03c9\u03bd<\/strong>.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\"><strong>\u03a3\u03b5\u03bd\u03ac\u03c1\u03b9\u03bf 2:<\/strong> \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae <strong>MCTD<\/strong>, <strong>anti-U1RNP \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03bd\u03ad\u03b1 \u03bc\u03c5\u03b1\u03bb\u03b3\u03af\u03b1 \u03ae \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1. \u0391\u03bd \u03b2\u03c1\u03b5\u03b8\u03b5\u03af anti-SMN, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03c4\u03af\u03c4\u03bb\u03bf, \u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03c5\u03c0\u03bf\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03bf\u03bd \u03b3\u03b9\u03b1 \u03c0\u03b9\u03bf <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03cc \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf<\/strong> \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 <strong>\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong>, <strong>\u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf\u03c5 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03b7 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03ad\u03c8\u03b7 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03ad\u03bd\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\"><strong>\u03a3\u03b5\u03bd\u03ac\u03c1\u03b9\u03bf 3:<\/strong> \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03b3\u03b5\u03bd\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03ba\u03cc\u03c0\u03c9\u03c3\u03b7, \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae <strong>CK<\/strong>, \u03b1\u03c3\u03b1\u03c6\u03ae \u03ac\u03bb\u03b3\u03b7 \u03ba\u03b1\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ANA \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03c4\u03af\u03c4\u03bb\u03bf\u03c5 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 anti-SMN \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 <strong>\u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c0\u03cc\u03b4\u03bf\u03c3\u03b7\u03c2<\/strong> \u03ba\u03b1\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c3\u03b5 \u03c3\u03cd\u03b3\u03c7\u03c5\u03c3\u03b7 \u03c0\u03b1\u03c1\u03ac \u03c3\u03b5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf. \u03a3\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03bf\u03ad\u03c7\u03b5\u03b9 \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03b7 \u03c3\u03c5\u03c3\u03c3\u03ce\u03c1\u03b5\u03c5\u03c3\u03b7 \u03c3\u03c0\u03ac\u03bd\u03b9\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03b1\u03c6\u03ae \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\"><strong>\u03a3\u03b5\u03bd\u03ac\u03c1\u03b9\u03bf 4:<\/strong> \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc <strong>ANA<\/strong>, \u03b1\u03bb\u03bb\u03ac \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc panel \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd. \u0395\u03b4\u03ce \u03b7 \u03c3\u03ba\u03ad\u03c8\u03b7 \u03b3\u03b9\u03b1 anti-SMN \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bb\u03bf\u03b3\u03b9\u03ba\u03ae, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03bc\u03c5\u03ca\u03ba\u03ac, \u03b4\u03b1\u03ba\u03c4\u03c5\u03bb\u03b9\u03ba\u03ac \u03ae \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1. \u03a4\u03bf ANA \u03b1\u03c0\u03cc \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b8\u03ad\u03c4\u03b5\u03b9 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7, \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c9\u03c2 <strong>\u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7<\/strong>.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\"><strong>\u03a3\u03b5\u03bd\u03ac\u03c1\u03b9\u03bf 5:<\/strong> \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03bc\u03b5 \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03bb\u03bb\u03ac <strong>\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc anti-SMN<\/strong>. \u03a4\u03bf \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf. \u0391\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03b3\u03b3\u03cd\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 CK \u03ae \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac, \u03b7 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b5\u03c7\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03c4\u03b1 \u03c5\u03c0\u03cc\u03bb\u03bf\u03b9\u03c0\u03b1 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03b2\u03ae\u03bc\u03b1\u03c4\u03b1. \u03a4\u03bf anti-SMN \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af <strong>\u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03b4\u03b5\u03af\u03ba\u03c4\u03b7<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c4\u03b5\u03bb\u03b9\u03ba\u03cc \u03ba\u03c1\u03b9\u03c4\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #2563eb; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u03a0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03cc \u03c3\u03c5\u03bc\u03c0\u03ad\u03c1\u03b1\u03c3\u03bc\u03b1:<\/strong> \u03a4\u03b1 anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03af\u03b1 \u03cc\u03c4\u03b1\u03bd \u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 <strong>\u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03ae\u03b4\u03b7 \u03cd\u03c0\u03bf\u03c0\u03c4\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1<\/strong> \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03cc\u03c4\u03b1\u03bd \u03b6\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c4\u03c5\u03c7\u03b1\u03af\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/div>\n<\/section>\n<p><!-- ==================== SECTION 14 ==================== --><\/p>\n<section id=\"section14\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">14<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03bf\u03af \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03bb\u03ac\u03b8\u03b7 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03cc \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03c3\u03b1\u03bd <strong>\u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03cc \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03bf<\/strong>. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9. \u03a4\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b9\u03ba\u03c1\u03ac cohorts, \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b1 \u03ba\u03ad\u03bd\u03c4\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03ae\u03b4\u03b7 \u03c0\u03c1\u03bf\u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1 \u03ae \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03bd\u03cc\u03c3\u03bf. \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae\u03c2 \u03c0\u03c1\u03bf-\u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b1\u03b3\u03ba\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c0\u03b9\u03bf \u03b1\u03b4\u03cd\u03bd\u03b1\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03bf \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03b3\u03bd\u03bf\u03b5\u03af\u03c4\u03b1\u03b9 \u03b7 <strong>\u03bc\u03ad\u03b8\u03bf\u03b4\u03bf\u03c2 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7\u03c2<\/strong>. \u038c\u03c4\u03b1\u03bd \u03ad\u03bd\u03b1 \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c5\u03c1\u03ad\u03c9\u03c2 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf \u03ae \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03bb\u03b1\u03c4\u03c6\u03cc\u03c1\u03bc\u03b5\u03c2, \u03b7 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7. \u0386\u03bb\u03bb\u03bf \u03ad\u03bd\u03b1 \u201c\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc\u201d \u03b1\u03c0\u03cc \u03c0\u03bf\u03bb\u03cd \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf \u03ad\u03bd\u03b1 \u201c\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc\u201d \u03b1\u03c0\u03cc \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03b5\u03bc\u03c0\u03bf\u03c1\u03b9\u03ba\u03cc panel. \u0391\u03c5\u03c4\u03cc \u03b4\u03b5\u03bd \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03be\u03b9\u03cc\u03c0\u03b9\u03c3\u03c4\u03b7\u0387 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 <strong>\u03c0\u03bf\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03cc\u03c1\u03b9\u03ac \u03c4\u03b7\u03c2<\/strong>.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03bf \u03c4\u03c1\u03af\u03c4\u03bf \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03b7 <strong>\u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 ANA<\/strong>. \u039f\u03b9 <strong>\u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bf\u03c5\u03ba\u03ba\u03af\u03b4\u03b5\u03c2<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03c4\u03bf \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03bf \u03c0\u03bf\u03c5 \u03be\u03b5\u03ba\u03bb\u03b5\u03b9\u03b4\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03ba\u03ad\u03c8\u03b7 \u03b3\u03b9\u03b1 anti-SMN, \u03b1\u03bb\u03bb\u03ac \u03b7 \u03b4\u03b9\u03ac\u03ba\u03c1\u03b9\u03c3\u03b7 <strong>AC-6<\/strong> \u03ba\u03b1\u03b9 <strong>AC-7<\/strong> \u03b4\u03b5\u03bd \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1 \u03c3\u03b5 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03b1. \u0386\u03c1\u03b1 \u03ad\u03bd\u03b1\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 \u201c\u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bf\u03c5\u03ba\u03ba\u03af\u03b4\u03b5\u03c2\u201d \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf\u03c2, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c0\u03ac\u03bd\u03c4\u03bf\u03c4\u03b5 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03ba\u03c1\u03af\u03b2\u03b5\u03b9\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03bd.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03ad\u03c4\u03b1\u03c1\u03c4\u03bf \u03c3\u03c5\u03c7\u03bd\u03cc \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03b9 \u03ba\u03b1\u03bd\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b5\u03bc\u03c6\u03b1\u03bd\u03b9\u03c3\u03c4\u03b5\u03af <strong>\u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b1\u03bd\u03b5\u03c0\u03c4\u03c5\u03b3\u03bc\u03ad\u03bd\u03b7 \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2<\/strong> \u03c0\u03c1\u03b9\u03bd \u03c3\u03ba\u03b5\u03c6\u03c4\u03b5\u03af \u03c6\u03ac\u03c3\u03bc\u03b1 <strong>\u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03c9\u03bd \u03b5\u03c0\u03b9\u03ba\u03ac\u03bb\u03c5\u03c8\u03b7\u03c2<\/strong>. \u0397 <strong>\u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b1 \u201c\u03c3\u03b9\u03c9\u03c0\u03b7\u03bb\u03ae\u201d \u03c3\u03c4\u03bf \u03b4\u03ad\u03c1\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03bc\u03b5 <strong>\u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf Raynaud<\/strong>, \u03c4\u03c1\u03b9\u03c7\u03bf\u03b5\u03b9\u03b4\u03bf\u03c3\u03ba\u03cc\u03c0\u03b7\u03c3\u03b7 \u03bd\u03c5\u03c7\u03bf\u03c0\u03c4\u03c5\u03c7\u03ae\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ae \u03bc\u03b5 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7, \u03b4\u03c5\u03c3\u03c6\u03b1\u03b3\u03af\u03b1, \u03bc\u03c5\u03ca\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03ae \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc ANA pattern. \u0391\u03bd \u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c4\u03bf\u03bd \u201c\u03c4\u03c5\u03c0\u03b9\u03ba\u03cc\u201d \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03b5\u03c1\u03ae\u03c3\u03b5\u03b9 \u03b7 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7.<\/p>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u03a4\u03ad\u03bb\u03bf\u03c2, \u03bb\u03ac\u03b8\u03bf\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03bc\u03c0\u03b9\u03c3\u03c4\u03bf\u03c3\u03cd\u03bd\u03b7 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03ac \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b2\u03ac\u03c1\u03bf\u03c2 \u03bc\u03b5 \u03c4\u03bf \u03af\u03b4\u03b9\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03b5\u03b3\u03b3\u03cd\u03c2 \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 CK, <strong>\u03c6\u03b1\u03b9\u03bd\u03cc\u03bc\u03b5\u03bd\u03bf Raynaud<\/strong> \u03ba\u03b1\u03b9 \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf ANA pattern. \u0397 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03b5\u03af\u03c4\u03b5 \u03c3\u03b5 <strong>\u03c5\u03c0\u03b5\u03c1\u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/strong> \u03b5\u03af\u03c4\u03b5 \u03c3\u03b5 <strong>\u03bb\u03b1\u03bd\u03b8\u03b1\u03c3\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b8\u03b7\u03c3\u03cd\u03c7\u03b1\u03c3\u03b7<\/strong>.<\/p>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; margin-top: 10px; line-height: 1.7;\"><strong>\u039a\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bb\u03ac\u03b8\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03b5\u03c4\u03b1\u03b9:<\/strong> \u039d\u03b1 \u03b4\u03b9\u03b1\u03b2\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 <strong>\u03ad\u03be\u03c9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf<\/strong>. \u0397 \u03c3\u03c9\u03c3\u03c4\u03ae \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, ANA pattern, \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03af\u03bc\u03b7\u03c3\u03b7.<\/div>\n<\/section>\n<section id=\"section15\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">15<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a3\u03c5\u03c7\u03bd\u03ad\u03c2 \u0395\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 (FAQ)<\/span><\/h2>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a4\u03b1 anti-SMN \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03bc\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf \u03bd\u03cc\u03c3\u03bf;<\/summary>\n<p>\u038c\u03c7\u03b9. \u03a3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1, MCTD \u03ba\u03b1\u03b9 overlap \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1, \u03ac\u03c1\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03c9\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac \u03c9\u03c2 \u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b1 \u03bc\u03bf\u03bd\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03cc\u03c4\u03b9 \u03ad\u03c7\u03c9 \u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1;<\/summary>\n<p>\u038c\u03c7\u03b9. \u03a4\u03bf anti-SMN \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03bc\u03c5\u03bf\u03c3\u03b9\u03c4\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1, \u03b5\u03bd\u03ce \u03b7 \u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03b1 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 \u03b1\u03c6\u03bf\u03c1\u03ac \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bb\u03bb\u03bf\u03b9\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd SMN1\/SMN2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03cc \u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c0\u03b5\u03b4\u03af\u03bf.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03bd \u03c4\u03bf ANA \u03b4\u03b5\u03af\u03be\u03b5\u03b9 few nuclear dots, \u03ad\u03c7\u03c9 \u03c3\u03af\u03b3\u03bf\u03c5\u03c1\u03b1 anti-SMN;<\/summary>\n<p>\u038c\u03c7\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1. \u03a4\u03bf pattern AC-7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bc\u03b2\u03b1\u03c4\u03cc \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03b1 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf SMN complex, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03c4\u03b1\u03c5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 anti-SMN. \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b4\u03b5\u03b9\u03be\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03bd \u03c4\u03bf anti-SMN \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc, \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1;<\/summary>\n<p>\u038c\u03c7\u03b9. \u0397 \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 overlap \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03c1\u03bf\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03ae \u03bd\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 panel \u03ae \u03b4\u03b5\u03bd \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0393\u03b9\u03b1\u03c4\u03af \u03b5\u03bd\u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c4\u03cc\u03c3\u03bf \u03c0\u03bf\u03bb\u03cd \u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac \u03ae \u03bf \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1\u03c2;<\/summary>\n<p>\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03c4\u03b1 anti-SMN \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03bc\u03b5 \u03b2\u03b1\u03c1\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1\u03c2, \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03ba\u03b1\u03b9, \u03c3\u03b5 \u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03ba\u03bf\u03c0\u03ae\u03c3\u03b5\u03b9\u03c2, ILD \u03ae \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b1 \u03c3\u03c5\u03bd\u03ae\u03b8\u03b7 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac panels;<\/summary>\n<p>\u038c\u03c7\u03b9 \u03c0\u03ac\u03bd\u03c4\u03b1. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03bf \u03ba\u03b1\u03b9 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1, \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03b8\u03b5\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03ac \u03c4\u03bf\u03c5 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf \u03ba\u03b1\u03b9 \u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u03a0\u03cc\u03c4\u03b5 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03b7 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7;<\/summary>\n<p>\u039a\u03c5\u03c1\u03af\u03c9\u03c2 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03b3\u03b3\u03cd\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 CK, Raynaud, \u03cd\u03c0\u03bf\u03c0\u03c4\u03bf ANA pattern \u03ae \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 overlap \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5. \u0395\u03ba\u03b5\u03af \u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03c4\u03b1\u03be\u03b9\u03bd\u03cc\u03bc\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5.<\/p>\n<\/details>\n<details style=\"margin-bottom: 14px; border: 1px solid #e2e8f0; border-radius: 10px; padding: 12px 14px;\">\n<summary style=\"cursor: pointer; font-weight: 600; font-size: 15px; color: #1d4ed8;\">\u0391\u03c1\u03ba\u03b5\u03af \u03bc\u03cc\u03bd\u03bf \u03ad\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc anti-SMN \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1;<\/summary>\n<p>\u038c\u03c7\u03b9. \u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7, \u03c4\u03b7 CK, \u03c4\u03bf ANA pattern, \u03c4\u03b9\u03c2 \u03b1\u03c0\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03bf\u03c1\u03b3\u03ac\u03bd\u03c9\u03bd \u03c0\u03c1\u03b9\u03bd \u03bb\u03b7\u03c6\u03b8\u03bf\u03cd\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03b9\u03c2.<\/p>\n<\/details>\n<\/section>\n<p><!-- ==================== SECTION 16 ==================== --><\/p>\n<section id=\"section16\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">16<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5<\/span><\/h2>\n<div style=\"background: #f8fafc; border-left: 4px solid #b70000; border-radius: 10px; padding: 12px 14px; line-height: 1.8;\">\n<p style=\"margin: 0 0 10px 0; color: #374151;\">\u03a4\u03b1 <strong>anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03c3\u03c0\u03ac\u03bd\u03b9\u03bf\u03c2 \u03b1\u03bb\u03bb\u03ac \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03bf\u03c2 \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2<\/strong> \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1\u03c2, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1\u03c2 \u03ae MCTD \u03bc\u03b5 overlap \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac. \u0394\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b5\u03c3\u03c4 \u03c1\u03bf\u03c5\u03c4\u03af\u03bd\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b1\u03c1\u03ba\u03bf\u03cd\u03bd \u03bc\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7.<\/p>\n<p style=\"margin: 0 0 10px 0; color: #374151;\">\u0397 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03be\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03b5\u03b3\u03b3\u03cd\u03c2 \u03bc\u03c5\u03ca\u03ba\u03ae \u03b1\u03b4\u03c5\u03bd\u03b1\u03bc\u03af\u03b1<\/strong>, <strong>\u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 CK<\/strong>, <strong>Raynaud<\/strong>, \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03ae <strong>ANA nuclear dots<\/strong>. \u03a3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b2\u03bf\u03b7\u03b8\u03ae\u03c3\u03bf\u03c5\u03bd \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03c4\u03b5\u03af \u03ad\u03bd\u03b1 \u03c0\u03b9\u03bf \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03bf, \u03c0\u03b9\u03bf \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc overlap \u03c6\u03ac\u03c3\u03bc\u03b1 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<p style=\"margin: 0; color: #374151;\">\u0388\u03bd\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 <strong>\u03bf\u03c1\u03b3\u03b1\u03bd\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7<\/strong> \u03b3\u03b9\u03b1 \u03bc\u03cd\u03b5\u03c2, \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b5\u03c2, \u03ba\u03b1\u03c1\u03b4\u03b9\u03ac \u03ba\u03b1\u03b9 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03c3\u03b5 \u03b2\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1. \u0388\u03bd\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1, \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1, \u03b4\u03b5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b5\u03b9 \u03c4\u03b7 \u03bd\u03cc\u03c3\u03bf \u03cc\u03c4\u03b1\u03bd \u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b9\u03c3\u03c7\u03c5\u03c1\u03ae.<\/p>\n<\/div>\n<\/section>\n<p><!-- ==================== SECTION 17 ==================== --><\/p>\n<section id=\"section17\" style=\"margin: 14px 0 24px;\">\n<h2 style=\"display: inline-flex; align-items: center; gap: 12px; margin: 26px 0 10px;\"><span style=\"width: 36px; height: 36px; display: inline-flex; align-items: center; justify-content: center; transform: rotate(45deg); background: linear-gradient(180deg,#f1f5f9,#9ca3af); border-radius: 10px; box-shadow: 0 6px 14px rgba(17,24,39,.18), inset 0 1px 0 rgba(255,255,255,.65), inset 0 -1px 0 rgba(17,24,39,.10);\"><br \/>\n<span style=\"transform: rotate(-45deg); font-size: 14px; font-weight: 800; color: #111827;\">17<\/span><br \/>\n<\/span><br \/>\n<span style=\"font-size: 24px; font-weight: 900; color: #111827;\">\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd &amp; \u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1<\/span><\/h2>\n<p style=\"margin: 10px 0 14px; line-height: 1.8; color: #374151;\">\u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c0\u03cc \u03b9\u03b1\u03c4\u03c1\u03cc \u03c3\u03c4\u03bf \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03cc \u03bc\u03b1\u03c2. \u039c\u03c0\u03bf\u03c1\u03b5\u03af\u03c4\u03b5 \u03bd\u03b1 \u03c0\u03c1\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1\u03c4\u03af\u03c3\u03b5\u03c4\u03b5 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03ae \u03bd\u03b1 \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd.<\/p>\n<div style=\"background: #fdf2f2; border: 2px solid #b70000; border-radius: 14px; padding: 18px; text-align: center;\">\n<div><strong>\u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 anti-SMN \u03ae \u03b4\u03b5\u03af\u03c4\u03b5 \u03c4\u03bf\u03bd \u03c0\u03bb\u03ae\u03c1\u03b7 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf:<\/strong><\/div>\n<div style=\"display: flex; gap: 10px; justify-content: center; flex-wrap: wrap; margin-top: 10px;\"><a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcd8 \u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd<\/a><br \/>\n<a style=\"background: #b70000; color: #fff; padding: 12px 18px; border-radius: 12px; text-decoration: none; font-weight: 600; display: inline-flex; align-items: center; justify-content: center; white-space: nowrap; width: 200px; height: 44px;\" href=\"https:\/\/mikrobiologikolamia.gr\/staging\/about-us\/appointments\/\" target=\"_blank\" rel=\"nofollow noopener\">\ud83d\udcc5 \u039a\u03bb\u03b5\u03af\u03c3\u03c4\u03b5 \u03a1\u03b1\u03bd\u03c4\u03b5\u03b2\u03bf\u03cd \u03a4\u03ce\u03c1\u03b1<\/a><\/div>\n<div style=\"margin-top: 10px; color: #374151;\">\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/div>\n<div style=\"margin-top: 18px;\">\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Satoh M, et al. <strong>Autoantibodies to survival of motor neuron (SMN) complex in patients with polymyositis.<\/strong> <em>Arthritis Research &amp; Therapy \/ PMC version<\/em><br \/>\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3123691\/\" target=\"_blank\" rel=\"nofollow noopener\">\u0386\u03bd\u03bf\u03b9\u03b3\u03bc\u03b1 \u03c0\u03b7\u03b3\u03ae\u03c2<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Landon-Cardinal O, et al. <strong>Recognising the spectrum of scleromyositis: HEp-2 ANA patterns allow identification of a novel clinical subset with anti-SMN autoantibodies.<\/strong> <em>RMD Open<\/em><br \/>\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7509989\/\" target=\"_blank\" rel=\"nofollow noopener\">\u0386\u03bd\u03bf\u03b9\u03b3\u03bc\u03b1 \u03c0\u03b7\u03b3\u03ae\u03c2<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">El Kamouni H, et al. <strong>Anti-SMN autoantibodies in mixed connective tissue disease are associated with a severe systemic sclerosis phenotype.<\/strong> <em>RMD Open<\/em><br \/>\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10551952\/\" target=\"_blank\" rel=\"nofollow noopener\">\u0386\u03bd\u03bf\u03b9\u03b3\u03bc\u03b1 \u03c0\u03b7\u03b3\u03ae\u03c2<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">Harvey GR, et al. <strong>Newer Autoantibodies and Laboratory Assessments in Myositis.<\/strong> <em>Current Rheumatology Reports<\/em><br \/>\n<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11621185\/\" target=\"_blank\" rel=\"nofollow noopener\">\u0386\u03bd\u03bf\u03b9\u03b3\u03bc\u03b1 \u03c0\u03b7\u03b3\u03ae\u03c2<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\">ICAP. <strong>AC-7 Few nuclear dots pattern.<\/strong> <em>International Consensus on ANA Patterns<\/em><br \/>\n<a href=\"https:\/\/www.anapatterns.org\/view_pattern.php?pattern=7\" target=\"_blank\" rel=\"nofollow noopener\">\u0386\u03bd\u03bf\u03b9\u03b3\u03bc\u03b1 \u03c0\u03b7\u03b3\u03ae\u03c2<\/a><\/div>\n<div style=\"border-left: 3px solid #e5e7eb; padding-left: 10px; margin: 6px 0; line-height: 1.35; font-size: 14px;\"><strong>\u039a\u03b1\u03c4\u03ac\u03bb\u03bf\u03b3\u03bf\u03c2 \u0395\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03c9\u03bd \u2013 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u039b\u03b1\u03bc\u03af\u03b1<\/strong><br \/>\n<a href=\"https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/\" target=\"_blank\" rel=\"noopener\">https:\/\/mikrobiologikolamia.gr\/staging\/katalogos-eksetaseon\/<\/a><\/div>\n<\/div>\n<div style=\"background: #f1f5f9; border-left: 4px solid #2563eb; padding: 10px 14px; border-radius: 8px; margin-top: 10px;\"><strong style=\"color: #1d4ed8;\">\u0395\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03bc\u03ad\u03bb\u03b5\u03b9\u03b1:<\/strong><br \/>\n\u0394\u03c1. \u03a0\u03b1\u03bd\u03c4\u03b5\u03bb\u03ae\u03c2 \u0391\u03bd\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2, \u0399\u03b1\u03c4\u03c1\u03cc\u03c2 \u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2 \u2013 \u0392\u03b9\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2<br \/>\n\u039c\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03ae\u03c1\u03b9\u03bf \u039b\u03b1\u03bc\u03af\u03b1\u03c2, \u0388\u03c3\u03bb\u03b9\u03bd 19, \u039b\u03b1\u03bc\u03af\u03b1 35100<br \/>\n\ud83d\udcde +30-22310-66841 \u2022 \u0394\u03b5\u03c5\u03c4\u03ad\u03c1\u03b1\u2013\u03a0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae 07:00\u201313:30<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Anti-SMN \u0391\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1: \u03a4\u03b9 \u0394\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd, \u03a0\u03cc\u03c4\u03b5 \u0396\u03b7\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03a0\u03ce\u03c2 \u0395\u03c1\u03bc\u03b7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03b5\u03bd\u03b7\u03bc\u03ad\u03c1\u03c9\u03c3\u03b7: 12 \u039c\u03b1\u03c1\u03c4\u03af\u03bf\u03c5 2026 \u03a4\u03b9 \u03bd\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5: \u03a4\u03b1 anti-SMN \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03bc\u03b5 \u03c3\u03ba\u03bb\u03b7\u03c1\u03bf\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1, \u03bc\u03b9\u03ba\u03c4\u03ae \u03bd\u03cc\u03c3\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03b9\u03c3\u03c4\u03bf\u03cd (MCTD) \u03ba\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5 overlap \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b1 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03b1. \u0394\u03b5\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b7 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bb\u03cc \u00ab\u03bc\u03c5\u03ca\u03ba\u03cc \u03c0\u03cc\u03bd\u03bf\u00bb \u03ae \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03bf \u00ab\u03b8\u03b5\u03c4\u03b9\u03ba\u03cc ANA\u00bb. [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":10152,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2534],"tags":[],"class_list":["post-10151","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exetaseis-aimatos"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/10151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/comments?post=10151"}],"version-history":[{"count":5,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/10151\/revisions"}],"predecessor-version":[{"id":10154,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/posts\/10151\/revisions\/10154"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media\/10152"}],"wp:attachment":[{"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/media?parent=10151"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/categories?post=10151"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mikrobiologikolamia.gr\/staging\/wp-json\/wp\/v2\/tags?post=10151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}